- 関
- TNFR、tumor necrosis factor receptor
WordNet
- the 20th letter of the Roman alphabet (同)t
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- tritiumの化学記号
- =sense organ / 受信装置
- Tennessee
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/12 21:50:10」(JST)
[Wiki en表示]
| TNFR/NGFR cysteine-rich region |
|
Structure of the soluble human 55 kd TNF receptor-human TNF beta complex.[1]
|
| Identifiers |
| Symbol |
TNFR_c6 |
| Pfam |
PF00020 |
| InterPro |
IPR011614 |
| PROSITE |
PDOC00561 |
| SCOP |
1tnr |
| SUPERFAMILY |
1tnr |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
The tumor necrosis factor receptor superfamily (TNFRSF) is a group of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain.[2][3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha.[4] In their active form, the majority of TNF receptors form trimeric complexes in the plasma membrame. Accordingly, most TNF receptors contain transmembrane domains (TMDs), although some can be cleaved into soluble forms (e.g. TNFR1), and some lack a TMD entirely (e.g. DcR3). In addition, most TNF receptors require specific adaptor protein such as TRADD, TRAF, RIP and FADD for downstream signalling. TNF receptors are primarily involved in apoptosis and inflammation, but they can also take part in other signal transduction pathways, such as proliferation, survival, and differentiation. TNF receptors are expressed in a wide variety of tissues in mammals, especially in leukocytes.[4]
The term death receptor refers to those members of the TNF receptor superfamily that contain a death domain, such as TNFR1, Fas receptor, DR4 and DR5.[4] They were named after the fact that they seemed to play an important role in apoptosis (programmed cell death), although they are now known to play other roles as well.[5]
In the strict sense, the term TNF receptor is often used to refer to the archetypal members of the superfamily, namely TNFR1 and TNFR2, which recognize TNF-alpha.
Contents
- 1 Members
- 2 References
- 3 Further reading
- 4 External links
Members
There are 27 family members, numerically classified as TNFRSF#, where # denotes the member number, sometimes followed a letter.[2]
| Type |
Protein (member #) |
Synonyms |
Gene |
Ligand(s) |
| 1 |
Tumor necrosis factor receptor 1 (1A) |
CD120a |
TNFRSF1A |
TNF-alpha (cachectin) |
| Tumor necrosis factor receptor 2 (1B) |
CD120b |
TNFRSF1B |
| 3 |
Lymphotoxin beta receptor (3) |
CD18 |
LTBR |
Lymphotoxin beta (TNF-C) |
| 4 |
OX40 (4) |
CD134 |
TNFRSF4 |
OX40L |
| 5 |
CD40 (5) |
Bp50 |
CD40 |
CD154 |
| 6 |
Fas receptor (6) |
Apo-1, CD95 |
FAS |
FasL |
| Decoy receptor 3 (6B) |
TR6, M68 |
TNFRSF6B |
FasL, LIGHT, TL1A |
| 7 |
CD27 (7) |
S152, Tp55 |
CD27 |
CD70, Siva |
| 8 |
CD30 (8) |
Ki-1 |
TNFRSF8 |
CD153 |
| 9 |
4-1BB (9) |
CD137 |
TNFRSF9 |
4-1BB ligand |
| 10 |
Death receptor 4 (10A) |
TRAILR1, Apo-2, CD261 |
TNFRSF10A |
TRAIL |
| Death receptor 5 (10B) |
TRAILR2, CD262 |
TNFRSF10B |
| Decoy receptor 1 (10C) |
TRAILR3, LIT, TRID, CD263 |
TNFRSF10C |
| Decoy receptor 2 (10D) |
TRAILR4, TRUNDD, CD264 |
TNFRSF10D |
| 11 |
RANK (11A) |
CD265 |
TNFRSF11A |
RANKL |
| Osteoprotegerin (11B) |
OCIF, TR1 |
TNFRSF11B |
| 12 |
TWEAK receptor (12A) |
Fn14, CD266 |
TNFRSF12A |
TWEAK |
| 13 |
TACI (13B) |
IGAD2, CD267 |
TNFRSF13B |
APRIL, BAFF, CAMLG |
| BAFF receptor (13C) |
CD268 |
TNFRSF13C |
BAFF |
| 14 |
Herpesvirus entry mediator (14) |
ATAR, TR2, CD270 |
TNFRSF14 |
LIGHT |
| 16 |
Nerve growth factor receptor (16) |
p75NTR, CD271 |
NGFR |
NGF, BDNF, NT-3, NT-4 |
| 17 |
B-cell maturation antigen (17) |
TNFRSF13A, CD269 |
TNFRSF17 |
BAFF |
| 18 |
Glucocorticoid-induced TNFR-related (18) |
AITR, CD357 |
TNFRSF18 |
GITR ligand |
| 19 |
TROY (19) |
TAJ, TRADE |
TNFRSF19 |
unknown |
| 21 |
Death receptor 6 (21) |
CD358 |
TNFRSF21 |
| 25 |
Death receptor 3 (25) |
Apo-3, TRAMP, LARD, WS-1 |
TNFRSF25 |
TL1A |
| 27 |
Ectodysplasin A2 receptor (27) |
XEDAR |
EDA2R |
EDA-A2 |
References
- ^ Banner DW; D'Arcy A; Janes W et al. (May 1993). "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation". Cell 73 (3): 431–45. doi:10.1016/0092-8674(93)90132-A. PMID 8387891.
- ^ a b Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.
- ^ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693.
- ^ a b c Gravestein, LA; Borst, J (December 1998). "Tumor necrosis factor receptor family members in the immune system.". Seminars in immunology 10 (6): 423–34. PMID 9826575.
- ^ Ashkenazi, A.; Dixit, VM (1998). "Death Receptors: Signaling and Modulation". Science 281 (5381): 1305–8. doi:10.1126/science.281.5381.1305. PMID 9721089.
Further reading
- Kavurma MM, Tan NY, Bennett MR. (2008). "Death receptors and their ligands in atherosclerosis". Arterioscler Thromb Vasc Biol. 28 (10): 1694–702. doi:10.1161/ATVBAHA.107.155143. PMID 18669890.
- Hatano, E. (2007). "Tumor necrosis factor signaling in hepatocyte apoptosis". J Gastroenterol Hepatol. 22: S43–44. doi:10.1111/j.1440-1746.2006.04645.x. PMID 17567463.
External links
- Tumor Necrosis Factor Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Membrane proteins, receptors: cell surface receptors
|
|
| G protein-coupled receptor |
| Class A |
- Eicosanoid receptor (Prostaglandin receptor)
- Protease-activated receptor
- Neurotransmitter receptor
- Purinergic receptor
- Biogenic amine receptor
- Olfactory receptor
|
|
| Class B |
|
|
| Class C |
- Metabotropic glutamate receptor
|
|
| Class D |
|
|
| Class E |
|
|
| Class F |
|
|
|
| Ligand-gated ion channel |
|
|
| Enzyme-linked receptor |
- Serine/threonine-specific protein kinase
- Receptor tyrosine kinase
- Guanylate cyclase
|
|
| Other/ungrouped |
- Asialoglycoprotein receptor
- Tumor necrosis factor receptor
- Immunoglobulin superfamily
- N-Acetylglucosamine receptor
- Neuropilins
- Transferrin receptor
- EDAR
- Lipoprotein receptor-related protein
|
|
- See also
- cell surface receptor deficiencies
|
Index of signal transduction
|
|
| Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
|
|
|
|
Apoptosis signaling pathway
|
|
| Fas path |
|
Ligand
|
|
|
|
Receptor
|
|
|
|
Intracellular
|
- Death-inducing signaling complex
- Cytochrome c
- Caspase 9
- Caspase 3
- Pro-apoptotic:
- BAX
- BAK1/Bcl-2 homologous antagonist killer
- Bcl-2-associated death promoter
- Anti-apoptotic:
- Bcl-2
- Bcl-xL
|
|
|
| TNF path |
|
Ligand
|
- Tumor necrosis factor alpha
|
|
|
Receptor
|
- Tumor necrosis factor receptor 1
- Tumor necrosis factor receptor 2
|
|
|
Intracellular
|
- FADD
- Caspase 8
- Caspase 3
- BID
- TRAF2
- ASK-1
- MEKK1
- IKK
- IκBα
- MKK7
- JNK
- NF-κB
|
|
|
| Other |
|
Intracellular
|
- IAPs
- XIAP
- NAIP
- Survivin
- c-IAP-1
- c-IAP-2
- Apoptosis-inducing factor
|
|
|
|
Index of signal transduction
|
|
| Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
|
|
|
UpToDate Contents
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English Journal
- TNF-R1 as a first trimester marker for prediction of pre-eclampsia.
- E Holanda Moura SB1,2,3, Park F4, Murthi P5, Martins WP6, Kane SC3,7, Williams P4, Hyett J4,8, Silva Costa Fd3,7,9.
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.J Matern Fetal Neonatal Med.2016 Mar;29(6):897-903. doi: 10.3109/14767058.2015.1022865. Epub 2015 Mar 17.
- OBJECTIVE: To examine whether the maternal serum concentration of the soluble receptor-1 of tumor necrosis factor-α (TNF-R1) at 11-13 + 6 weeks of gestation is a predictor of development of pre-eclampsia (PE).METHODS: This is a nested case-control study in which the concentration of TNF-R1 at 1
- PMID 25758630
- Intravenous Immunoglobulin (IVIG) Attenuates TNF-Induced Pathologic Bone Resorption and Suppresses Osteoclastogenesis by Inducing A20 Expression.
- Lee MJ1, Lim E1, Mun SH1, Bae S1, Murata K1, Ivashkiv LB1,2,3, Park-Min KH1,3.
- Journal of cellular physiology.J Cell Physiol.2016 Feb;231(2):449-58. doi: 10.1002/jcp.25091.
- Investigations on the therapeutic effects of intravenous immunoglobulin (IVIG) have focused on the suppression of autoantibody and immune complex-mediated inflammatory pathogenesis. Inflammatory diseases such as rheumatoid arthritis are often accompanied by excessive bone erosion but the effect of I
- PMID 26189496
- Cryptoporus volvatus polysaccharides attenuate LPS-induced expression of pro-inflammatory factors via the TLR2 signaling pathway in human alveolar epithelial cells.
- Zhu JP1, Wu K2,3, Li JY2, Guan Y1,2, Sun YH2, Ma WJ2, Xie QM2,3.
- Pharmaceutical biology.Pharm Biol.2016 Feb;54(2):347-53. doi: 10.3109/13880209.2015.1042981. Epub 2015 May 12.
- CONTEXT: Cryptoporus volvatus (Peck) Hubb grows wild in China, and its fruiting bodies have been used traditionally to treat asthma and bronchitis.OBJECTIVES: This study evaluates the anti-inflammatory effect of Cryptoporus polysaccharides (CP) extracted from fruiting bodies of C. volvatus on lipopo
- PMID 25963228
Japanese Journal
- Expression of Fgf23 in activated dendritic cells and macrophages in response to immunological stimuli in mice
- , , , , , ,
- Biological and Pharmaceutical Bulletin advpub(0), 2015
- … Fgfr1c, a potential receptor for Fgf23, was abundantly expressed in macrophages, suggesting that Fgf23 might be involved in signal transduction in these cells. … Our data suggest that Fgf23 potentially increases the number in macrophages and induces expression of TNF-α, a proinflammatory cytokine. …
- NAID 130004872303
- Suppression of experimental arthritis with self-assembling glycol-split heparin nanoparticles via inhibition of TLR4-NF-κB signaling.
- Babazada Hasan,Yamashita Fumiyoshi,Hashida Mitsuru
- Journal of controlled release 194, 295-300, 2014-11-28
- … It has been recently shown that Toll-like receptor4 mediated nuclear factor κB (TLR4-NF-κB) signaling plays a critical role in the pathogenesis of rheumatoid arthritis mediated by pro-inflammatory cytokines in arthritic synovium. … NAHNP significantly inhibited the production of pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β in lipopolysaccharide (LPS)-induced primary mouse macrophages and DC2.4 dendritic cell line. …
- NAID 120005512274
- Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4-NF-κB signaling.
- Babazada Hasan,Yamashita Fumiyoshi,Yanamoto Shinya,Hashida Mitsuru
- Journal of controlled release 194, 332-340, 2014-11-28
- … In the present investigation, we found that heparin nanoparticles are selective Toll-like receptor 4 (TLR-4) antagonists and have a much greater anti-inflammatory effect than native heparin. … Unlike native heparin, NAHNP significantly inhibited lipopolysaccharide-induced activation of MyD88-dependent NF-κB signaling pathway and production of pro-inflammatory cytokines such as TNF-alpha from mouse macrophages with IC50=0.019mg/mL. …
- NAID 120005512273
Related Links
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★リンクテーブル★
[★]
- 英
- tumor necrosis factor receptor、TNF receptor, TNFR
- 同
- 腫瘍壊死因子レセプター、TNF受容体、TNFレセプター
- 関
- 腫瘍壊死因子 tumor necrosis factor TNF
[show details]
[★]
- 英
- tumor necrosis factor receptor、TNF receptor
- 関
- 腫瘍壊死因子受容体、TNF受容体、TNFレセプター
[★]
- 英
- TNF receptor
- 関
- 腫瘍壊死因子受容体、腫瘍壊死因子レセプター、TNF受容体
[★]
- 関
- TNF receptor
[★]
- 関
- TRAF、tumor necrosis factor receptor-associated factor、tumor necrosis factor receptor-associated peptides and proteins
[★]
TNF受容体関連デスドメインタンパク質
- 関
- TRADD
[★]
TNF受容体関連因子3
- 関
- TRAF-3、TRAF3
[★]
1型TNF受容体、1型TNFレセプター
[★]
[★]
腫瘍壊死因子 tumor necrosis factor