TNF受容体

関: TNF receptor

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/29 20:15:04」(JST)

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The tumor necrosis factor receptor superfamily (TNFRSF) is a group of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain.^[2]^[3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha.^[4] In their active form, the majority of TNF receptors form trimeric complexes in the plasma membrame. Accordingly, most TNF receptors contain transmembrane domains (TMDs), although some can be cleaved into soluble forms (e.g. TNFR1), and some lack a TMD entirely (e.g. DcR3). In addition, most TNF receptors require specific adaptor protein such as TRADD, TRAF, RIP and FADD for downstream signalling. TNF receptors are primarily involved in apoptosis and inflammation, but they can also take part in other signal transduction pathways, such as proliferation, survival, and differentiation. TNF receptors are expressed in a wide variety of tissues in mammals, especially in leukocytes.^[4]

The term death receptor refers to those members of the TNF receptor superfamily that contain a death domain, such as TNFR1, Fas receptor, DR4 and DR5.^[4] They were named after the fact that they seemed to play an important role in apoptosis (programmed cell death), although they are now known to play other roles as well.^[5]

In the strict sense, the term TNF receptor is often used to refer to the archetypal members of the superfamily, namely TNFR1 and TNFR2, which recognize TNF-alpha.

Members

There are 27 family members, numerically classified as TNFRSF#, where # denotes the member number, sometimes followed a letter.^[2]

Type	Protein (member #)	Synonyms	Gene	Ligand(s)
1	Tumor necrosis factor receptor 1 (1A)	CD120a	TNFRSF1A	TNF-alpha (cachectin)
1	Tumor necrosis factor receptor 2 (1B)	CD120b	TNFRSF1B	TNF-alpha (cachectin)
3	Lymphotoxin beta receptor (3)	CD18	LTBR	Lymphotoxin beta (TNF-C)
4	OX40 (4)	CD134	TNFRSF4	OX40L
5	CD40 (5)	Bp50	CD40	CD154
6	Fas receptor (6)	Apo-1, CD95	FAS	FasL
6	Decoy receptor 3 (6B)	TR6, M68	TNFRSF6B	FasL, LIGHT, TL1A
7	CD27 (7)	S152, Tp55	CD27	CD70, Siva
8	CD30 (8)	Ki-1	TNFRSF8	CD153
9	4-1BB (9)	CD137	TNFRSF9	4-1BB ligand
10	Death receptor 4 (10A)	TRAILR1, Apo-2, CD261	TNFRSF10A	TRAIL
	Death receptor 5 (10B)	TRAILR2, CD262	TNFRSF10B
	Decoy receptor 1 (10C)	TRAILR3, LIT, TRID, CD263	TNFRSF10C
	Decoy receptor 2 (10D)	TRAILR4, TRUNDD, CD264	TNFRSF10D
11	RANK (11A)	CD265	TNFRSF11A	RANKL
11	Osteoprotegerin (11B)	OCIF, TR1	TNFRSF11B	RANKL
12	TWEAK receptor (12A)	Fn14, CD266	TNFRSF12A	TWEAK
13	TACI (13B)	IGAD2, CD267	TNFRSF13B	APRIL, BAFF, CAMLG
13	BAFF receptor (13C)	CD268	TNFRSF13C	BAFF
14	Herpesvirus entry mediator (14)	ATAR, TR2, CD270	TNFRSF14	LIGHT
16	Nerve growth factor receptor (16)	p75NTR, CD271	NGFR	NGF, BDNF, NT-3, NT-4
17	B-cell maturation antigen (17)	TNFRSF13A, CD269	TNFRSF17	BAFF
18	Glucocorticoid-induced TNFR-related (18)	AITR, CD357	TNFRSF18	GITR ligand
19	TROY (19)	TAJ, TRADE	TNFRSF19	unknown
21	Death receptor 6 (21)	CD358	TNFRSF21	unknown
25	Death receptor 3 (25)	Apo-3, TRAMP, LARD, WS-1	TNFRSF25	TL1A
27	Ectodysplasin A2 receptor (27)	XEDAR	EDA2R	EDA-A2

References

^ Banner DW, D'Arcy A, Janes W, et al. (May 1993). "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation". Cell 73 (3): 431–45. doi:10.1016/0092-8674(93)90132-A. PMID 8387891.
^ ^a ^b Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.
^ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693.
^ ^a ^b ^c Gravestein, LA; Borst, J (December 1998). "Tumor necrosis factor receptor family members in the immune system.". Seminars in immunology 10 (6): 423–34. doi:10.1006/smim.1998.0144. PMID 9826575.
^ Ashkenazi, A.; Dixit, VM (1998). "Death Receptors: Signaling and Modulation". Science 281 (5381): 1305–8. doi:10.1126/science.281.5381.1305. PMID 9721089.

External links

Tumor Necrosis Factor Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo.

Kreiser S1, Eckhardt J1, Kuhnt C1, Stein M1, Krzyzak L1, Seitz C1, Tucher C1, Knippertz I1, Becker C2, Günther C2, Steinkasserer A1, Lechmann M3.
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The CD83 molecule (CD83) is a well-known surface marker present on mature dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo. Treg-associated molecules including CD25,
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Molecular genomic- and transcriptional-aspects of a teleost TRAF6 homolog: Possible involvement in immune responses of Oplegnathus fasciatus against pathogens.

Umasuthan N1, Bathige SD1, Revathy KS2, Nam BH3, Choi CY4, Lee J5.
Fish & shellfish immunology.Fish Shellfish Immunol.2015 Jan;42(1):66-78. doi: 10.1016/j.fsi.2014.10.022. Epub 2014 Oct 29.
Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) is a crucial docking molecule for TNFR superfamily and Interleukin-1 receptor/Toll-like receptor (IL-1R/TLR) superfamily. As an adaptor protein in pathogen-induced signaling cascades, TRAF6 modulates both adaptive- and innate-immunity
PMID 25449707

Chloroquine Promotes IL-17 Production by CD4+ T Cells via p38-Dependent IL-23 Release by Monocyte-Derived Langerhans-like Cells.

Said A1, Bock S1, Lajqi T1, Müller G1, Weindl G2.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2014 Dec 15;193(12):6135-43. doi: 10.4049/jimmunol.1303276. Epub 2014 Nov 10.
Recent studies suggest a role for autophagy in the secretion of IL-1 cytokines regulating the development of inflammatory diseases. The antimalarial drug and autophagy/lysosome inhibitor chloroquine (CHQ) is considered as potential trigger of drug-induced or drug-aggravated psoriasis, in which Th17
PMID 25385822

Japanese Journal

Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells

Youn HyeSook,Jeong Ji-Cheon,Jeong Young Seok,Kim Eun-Joo,Um Soo-Jong
Biological and Pharmaceutical Bulletin 36(6), 944-951, 2013
… Microarray analysis using H460 cells indicated that quercetin increased the expression of genes associated with death receptor signaling tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAILR), caspase-10, interleukin (IL) 1R DNA fragmentation faotor 45 (DFF45), tumor necrosis factor receptor (TNFR) 1, FAS, inhibitor of kappaBalpha (IκBα)) and cell cycle inhibition growth arrest and DNA-damage inducible 45 (GADD45), p21Cip1), but decreased the expression of genes involved in nuclear factor (NF)-kappaB activation (NF-κB, IKKα). …
NAID 130003361439

2Bp05 ニワトリ卵黄に生産させたTNFR/Fcタンパク質のシアル酸附加(バイオプロセス/センサー,計測工学/セル&ティッシュエンジニアリング,一般講演)

西島謙一,吉田和央,奥嵜雄也,金岡英徳,飯島信司
日本生物工学会大会講演要旨集 64, 28, 2012-09-25
NAID 110009609356

An MD simulation of the decoy action of Epstein–Barr virus LMP1 protein mimicking the CD40 interaction with TRAF3

Chung Wilfredo Credo,Ishida Toshimasa
Theoretical Chemistry Accounts 130(2-3), 401-410, 2011-10-00
… In this paper, the dynamics of the interaction of EBV-expressed latent membrane protein 1 (LMP1) with cellular signaling intermediate tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) is simulated using standard classical molecular dynamics (MD) protocols. … For comparison, the dynamics of the interaction of TRAF3 with CD40, a TNFR mimicked by LMP1 to effect EBV infection is also calculated under similar conditions. …
NAID 120003644395

Related Pictures

Tumor necrosis factor receptor 1 (TNFR-1 Tumor Necrosis Factor (TNF) Ligand and S1P produced by SPHK1 in TNFR signalling Co-stimulatory members of the TNFR family QIAGEN - GeneGlobe Pathways - TNFR1 Apoptosis mediada por TNFR by TNFR Family Molecules | T Cell Biology Figure 1. TNF Signals through TNFR1 and

★リンクテーブル★

リンク元	「腫瘍壊死因子受容体」「TNF receptor」
拡張検索	「TNFR-I」「TNFR-II」「glucocorticoid-induced TNFR-related protein」「グルココルチコイド誘導性TNFR関連タンパク質」
関連記事	「TNF」

「腫瘍壊死因子受容体」

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

TNFR/NGFR cysteine-rich region
	Structure of the soluble human 55 kd TNF receptor-human TNF beta complex.
Identifiers
Symbol	TNFR_c6
Pfam	PF00020
InterPro	IPR011614
PROSITE	PDOC00561
SCOP	1tnr
SUPERFAMILY	1tnr
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

　　[★]

英: tumor necrosis factor receptor、TNF receptor, TNFR
同: 腫瘍壊死因子レセプター、TNF受容体、TNFレセプター
関: 腫瘍壊死因子 tumor necrosis factor TNF

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腫瘍壊死因子受容体 : 約 62,000 件
腫瘍壊死因子レセプター : 約 32,600 件

「TNF receptor」

　　[★]

腫瘍壊死因子受容体、腫瘍壊死因子レセプター、TNF受容体、TNFレセプター

関: TNFR、tumor necrosis factor receptor

「TNFR-I」

　　[★]

腫瘍壊死因子I型受容体

関: TNFR1、tumor necrosis factor receptor、type I tumor necrosis factor receptor

「TNFR-II」

　　[★]

腫瘍壊死因子II型受容体

関: type II tumor necrosis factor receptor

「glucocorticoid-induced TNFR-related protein」

　　[★]

グルココルチコイド誘導性TNFR関連タンパク質

「グルココルチコイド誘導性TNFR関連タンパク質」

　　[★]

英: glucocorticoid-induced TNFR-related protein

「TNF」

　　[★] 腫瘍壊死因子 tumor necrosis factor

[pmid8387891-1] Banner DW, D'Arcy A, Janes W, et al. (May 1993). "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation". Cell 73 (3): 431–45. doi:10.1016/0092-8674(93)90132-A. PMID 8387891.

[pmid11239407-2] Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.

[pmid15819693-3] Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693.

[Gravestein-4] Gravestein, LA; Borst, J (December 1998). "Tumor necrosis factor receptor family members in the immune system.". Seminars in immunology 10 (6): 423–34. doi:10.1006/smim.1998.0144. PMID 9826575.

[5] Ashkenazi, A.; Dixit, VM (1998). "Death Receptors: Signaling and Modulation". Science 281 (5381): 1305–8. doi:10.1126/science.281.5381.1305. PMID 9721089.

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TNFR