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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/07/05 02:16:24」(JST)
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In vitro maturation (IVM) is the technique of letting ovarian follicles mature in vitro.
Techniques available
The ability of in IVM depends on how mature the follicle already is. There are several stages in folliculogenesis, starting with a primordial follicle, which then becomes a primary, secondary, early tertiary (antral), late tertiary and eventually a preovulatory follicle. If a follicle has reached the early tertiary or antral stage, IVM can be carried out. A few live births have already been made[1] by taking small early tertiary follicles, letting them mature in vitro and subsequently fertilizing them. However, for follicles that haven't reached the early tertiary stage, IVM is still under development. There are a lot of cellular changes in the oocyte and the rest of the cells in the follicle, which makes it very susceptible. Nevertheless, it is possible to let a primordial follicle mature to a secondary follicle outside the body by growing it in a slice of ovarian tissue.[1] The subsequent maturity from secondary to early tertiary stage can then be supported in test-tubes.[1]
IVM can be expanded with hCG-priming, which is exposing the ovarian tissue to human chorionic gonadotropin (hCG). This results in an expanding or dispersed pattern of the cumulus oophorus around the egg cell, facilitating its identification within follicular fluid.[2] However, the evidence of a clinical effect of hCG priming is still lacking.[2] IVM can also be expanded with intracytoplasmic sperm injection (ICSI), which should be performed at least one hour (and optimally two to four hours) after the first polar body extrusion.[3]
Applications
- Facilitate IVF, and provide an alternative to ovulation induction. Before an IVF, an ovarian hyperstimulation is usually performed. By injecting gonadotropins, multiple oocytes will mature. Similar methods are applied in ovulation induction for other purposes. However, with IVM, injection of gonadotropins into the body isn't essential. Rather, oocytes can mature outside the body, such as prior to IVF.[4] However, there still isn't enough evidence to prove the effectiveness and security of the technique.[4]
- For research. There are a million of oocytes in the ovary at birth, but only about 400 of these will be ovulated. The rest will die by Ovarian follicle atresia. When oocytes destined to die are extracted, IVM enables the maturation of these follicles. Thus, they can be studied to gather more information on folliculogenesis and oocyte maturation.[1]
References
- ^ a b c d NCBI:In vitro maturation of oocytes. Hardy K, Wright CS, Franks S, Winston RM
- ^ a b Son, W. -Y.; Tan, S. L. (2010). "Laboratory and embryological aspects of hCG-primed in vitro maturation cycles for patients with polycystic ovaries". Human Reproduction Update 16 (6): 675–689. doi:10.1093/humupd/dmq014. PMID 20504873. edit
- ^ Chang-Seop Hyun; Jung-Ho Cha, Weon-Young Son, San-Hyun Yoon, Kyung-Ae Kim, and Jin-Ho Lim (2007-07-07). "Optimal ICSI timing after the first polar body extrusion in in vitro matured human oocytes". Human Reproduction 22 (7): 1991–1995. doi:10.1093/humrep/dem124. PMID 17513319. Retrieved 2012-07-14.
- ^ a b Vejledning om kunstig befrugtning 2006 (Danish)
Assisted reproductive technology
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Infertility |
- Female
- Male
- Fertility testing
- Fertility clinic
- Fertility tourism
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Fertility medication |
- GnRH agonists
- Estrogen antagonists
- Clomifene
- Aromatase inhibitor
- Gonadotropins
- hCG
- FSH
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In vitro fertilisation (IVF)
and expansions |
- Ovarian hyperstimulation
- Transvaginal ovum retrieval
- Embryo transfer
- Assisted zona hatching
- Intracytoplasmic sperm injection
- Autologous endometrial coculture
- zygote intrafallopian transfer
- Cytoplasmic transfer
- Egg donation
- gestational carrier
- Preimplantation genetic diagnosis
- In vitro maturation
- Oocyte selection
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Other methods |
- Gamete intrafallopian transfer
- Sex selection
- Artificial insemination
- Surrogacy
- Reproductive surgery
- Semen collection
- Cryopreservation
- oocyte
- semen
- ovarian tissue
- embryos
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Donation |
- Sperm
- Egg
- Embryo
- Sperm bank
- Donor registration
- Donor Sibling Registry
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Ethics |
- Religious response to ART
- Accidental incest
- Three-parent babies
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In fiction |
- See subsections in e.g. surrogacy and sperm donation
- reproduction and pregnancy in speculative fiction
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noco/cong/npls, sysi/epon
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proc/asst, drug (G1/G2B/G3CD)
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UpToDate Contents
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English Journal
- Inhibition of P-glycoprotein enhances sensitivity of Caenorhabditis elegans to ivermectin.
- Ardelli BF, Prichard RK.SourceBrandon University, Department of Biology, 270-18th Street, Brandon, Manitoba, R7A 6A9, Canada. Electronic address: ardellib@brandonu.ca.
- Veterinary parasitology.Vet Parasitol.2013 Jan 31;191(3-4):264-75. doi: 10.1016/j.vetpar.2012.09.021. Epub 2012 Sep 23.
- In vertebrates, the function of P-glycoprotein (PGP) is to protect against toxic compounds through active efflux of the toxin from target tissues. In clinical oncology, the overexpression of PGP confers drug resistance. The function(s) of PGP in nematode physiology or in conferring drug resistance i
- PMID 23062691
- Effect of MEM vitamins and forskolin on embryo development and vitrification tolerance of in vitro-produced pig embryos.
- Cuello C, Gomis J, Almiñana C, Maside C, Sanchez-Osorio J, Gil MA, Sánchez A, Parrilla I, Vazquez JM, Roca J, Martinez EA.SourceDepartment of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Regional Campus of International Excellence, University of Murcia, E-3007 Murcia, Spain. Electronic address: ccuello@um.es.
- Animal reproduction science.Anim Reprod Sci.2013 Jan 30;136(4):296-302. doi: 10.1016/j.anireprosci.2012.11.003. Epub 2012 Nov 12.
- The aims of this study were (1) to determine the effect of in vitro maturation (IVM) medium supplementation with MEM vitamins on in vitro embryo development and sensitivity to vitrification of Day 6 blastocysts and (2) to evaluate whether the addition of forskolin to in vitro culture (IVC) medium en
- PMID 23238049
- Ivermectin and moxidectin resistance characterization by larval migration inhibition test in field isolates of Cooperia spp. in beef cattle, Mato Grosso do Sul, Brazil.
- Almeida GD, Feliz DC, Heckler RP, Borges DG, Onizuka MK, Tavares LE, Paiva F, Borges FA.SourceUniversidade Federal de Mato Grosso do Sul, UFMS, Campo Grande, MS 79070-900, Brazil.
- Veterinary parasitology.Vet Parasitol.2013 Jan 16;191(1-2):59-65. doi: 10.1016/j.vetpar.2012.08.012. Epub 2012 Aug 25.
- Ivermectin (IVM) resistance of Cooperia spp. in cattle has become an increasing and global problem. The early detection of anthelmintic resistance (AR) is important to propose strategies to slow down the development of resistance and requires sensitive, reliable, economic high-throughput and practic
- PMID 22963710
Japanese Journal
- IVMの現状と将来 (特集 卵子のエイジング) -- (生殖医療の将来)
Related Links
- IVM-IVFが有効な場合 IVM-IVFは向かない場合 ・多のう胞性卵巣症候群(PCO・PCOS)で排卵誘発をしなければ卵胞成長が認められないが、 排卵誘発を行うと卵巣過剰刺激症候群(OHSS)になってしまう方。 ・全ての検査に問題がないが ...
- 体外で卵子を成熟させる、体外成熟培養(IVM)についてご説明します。また通常のIVMだけでなく、当院独自の方法で顕微授精の際、顆粒膜細胞を剥がした時点で未成熟だった卵に緊急で行う、「レスキューIVM」を行っています。
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★リンクテーブル★
[★]
- 英
- involuntary movement IVM
- 関
- 不随意筋
[★]
- 関
- abnormal movement、asterixis、ballismus、dyskinesia、hemiballism、hemiballismus
[★]
- 英
- biomicroscopy、(方法)in vivo microscopy、(道具)in vivo microscope、IVM
- 関
- 体外成熟培養法
[★]
生体顕微鏡
- 関
- in vivo microscope、in vivo microscopy、IVM
[★]
生体顕微鏡
- 関
- biomicroscopy、in vivo microscopy、IVM
[★]
[★]
- 関
- i.v.、intravascular、intravenous、intravenously