体外成熟培養法 IVM
WordNet
- holding office; "the in party"
- to or toward the inside of; "come in"; "smash in the door" (同)inwards, inward
- currently fashionable; "the in thing to do"; "large shoulder pads are in"
- directed or bound inward; "took the in bus"; "the in basket"
- coming to full development; becoming mature (同)ripening, maturement
PrepTutorEJDIC
- 《具体的な場所,位置》 / …『の中に』(『で』) / …『において』,…で / 《intoの代りに移動を表す動詞と共に》…『の中へ』 / (乗り物)『に乗って』 / …『の状熊に』(『で』) / …『に従事して』,に属して / …『を身につけて』,に覆われて / 《『in』do『ing』の形で》…『するときに』,する際に(when) / 《時間》 / …『して』,…『が経過したあと』 / …『の間に』 / …『については』,…の点では / 《方法・手段・材料》…『で』 / 《人を目的語にして,性質・能力があることを示して》…の中に / …の目的で,のつもりで,として / 《比率割合》…のうちで,につき / 《過去分詞に伴って》…に[…されて] / 『中へ』(に) / 『在宅して』,帰って / (乗り物などが)『到着して』,(時期・季節が)来て / 出回って,流行して / 《俗》流行の,当世風の / 《話》特定の人々にのみ理解される
- 成熟,円熟
- indiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/13 01:12:26」(JST)
[Wiki en表示]
In vitro maturation (IVM) is the technique of letting ovarian follicles mature in vitro.
Techniques available
The ability of in IVM depends on how mature the follicle already is. There are several stages in folliculogenesis, starting with a primordial follicle, which then becomes a primary, secondary, early tertiary (antral), late tertiary and eventually a preovulatory follicle. If a follicle has reached the early tertiary or antral stage, IVM can be carried out. A few live births have already been made[1] by taking small early tertiary follicles, letting them mature in vitro and subsequently fertilizing them. However, for follicles that haven't reached the early tertiary stage, IVM is still under development. There are a lot of cellular changes in the oocyte and the rest of the cells in the follicle, which makes it very susceptible. Nevertheless, it is possible to let a primordial follicle mature to a secondary follicle outside the body by growing it in a slice of ovarian tissue.[1] The subsequent maturity from secondary to early tertiary stage can then be supported in test-tubes.[1]
IVM can be expanded with hCG-priming, which is exposing the ovarian tissue to human chorionic gonadotropin (hCG). This results in an expanding or dispersed pattern of the cumulus oophorus around the egg cell, facilitating its identification within follicular fluid.[2] However, the evidence of a clinical effect of hCG priming is still lacking.[2] IVM can also be expanded with intracytoplasmic sperm injection (ICSI), which should be performed at least one hour (and optimally two to four hours) after the first polar body extrusion.[3]
Applications
- Facilitate IVF, and provide an alternative to ovulation induction. Before an IVF, an ovarian hyperstimulation is usually performed. By injecting gonadotropins, multiple oocytes will mature. Similar methods are applied in ovulation induction for other purposes. However, with IVM, injection of gonadotropins into the body isn't essential. Rather, oocytes can mature outside the body, such as prior to IVF.[4] However, there still isn't enough evidence to prove the effectiveness and security of the technique.[4]
- For research. There are a million of oocytes in the ovary at birth, but only about 400 of these will be ovulated. The rest will die by Ovarian follicle atresia. When oocytes destined to die are extracted, IVM enables the maturation of these follicles. Thus, they can be studied to gather more information on folliculogenesis and oocyte maturation.[1]
References
- ^ a b c d NCBI:In vitro maturation of oocytes. Hardy K, Wright CS, Franks S, Winston RM
- ^ a b Son, W. -Y.; Tan, S. L. (2010). "Laboratory and embryological aspects of hCG-primed in vitro maturation cycles for patients with polycystic ovaries". Human Reproduction Update 16 (6): 675. doi:10.1093/humupd/dmq014. PMID 20504873. edit
- ^ Chang-Seop Hyun; Jung-Ho Cha, Weon-Young Son, San-Hyun Yoon, Kyung-Ae Kim, and Jin-Ho Lim (2007-07-07). "Optimal ICSI timing after the first polar body extrusion in in vitro matured human oocytes". Human Reproduction 22 (7): 1991-1995. doi:10.1093/humrep/dem124. PMID 17513319. http://humrep.oxfordjournals.org/content/22/7/1991.full. Retrieved 2012-07-14.
- ^ a b Vejledning om kunstig befrugtning 2006 (Danish)
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Assisted reproductive technology
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| Infertility |
- Female
- Male
- Fertility clinic
- Fertility tourism
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| Fertility medication |
- GnRH agonists
- Estrogen antagonists
- Clomifene
- Aromatase inhibitor
- Gonadotropins
- hCG
- FSH
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In vitro fertilisation (IVF)
and expansions |
- Ovarian hyperstimulation
- Transvaginal ovum retrieval
- Embryo transfer
- Assisted zona hatching
- Intracytoplasmic sperm injection
- Autologous endometrial coculture
- zygote intrafallopian transfer
- Cytoplasmic transfer
- Egg donation
- gestational carrier
- Preimplantation genetic diagnosis
- In vitro maturation
- Oocyte selection
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| Other methods |
- Gamete intrafallopian transfer
- Sex selection
- Artificial insemination
- Surrogacy
- Reproductive surgery
- Semen collection
- Cryopreservation
- oocyte
- semen
- ovarian tissue
- embryos
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| Donation |
- Sperm
- Egg
- Embryo
- Sperm bank
- Donor registration
- Donor Sibling Registry
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| Ethics |
- Religious response to ART
- Accidental incest
- Three-parent babies
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| In fiction |
- See subsections in e.g. surrogacy and sperm donation
- reproduction and pregnancy in speculative fiction
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noco/cong/npls, sysi/epon
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proc/asst, drug (G1/G2B/G3CD)
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UpToDate Contents
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- Immunobiology.Immunobiology.2017 Nov;222(11):989-997. doi: 10.1016/j.imbio.2017.06.002. Epub 2017 Jun 10.
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Japanese Journal
- The Luteinizing Hormone-Testosterone Pathway Regulates Mouse Spermatogonial Stem Cell Self-Renewal by Suppressing WNT5A Expression in Sertoli Cells
- The fertilization ability and developmental competence of bovine oocytes grown in vitro
- The journal of reproduction and development 62(4), 379-384, 2016-08
- NAID 40020922602
- The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages
Related Links
- In Vitro Maturation (IVM) is very similar to in-vitro fertilization (IVF) as both procedures involve egg retrieval. We are one of the only clinics in the United States to offer this treatment as a unique alternative to Conventional IVF. This ...
- Other options If you’re concerned about the risks of OHSS (ovarian hyper-stimulation syndrome) you may want to discuss with your clinician the possibility of receiving natural or mild in vitro fertilisation treatment: Natural cycle IVF
★リンクテーブル★
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[★]
- 英
- in vitro maturation、IVM
- 関
- 生体顕微鏡
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- 関
- ex vivo、vitro
[★]
- 関
- maturational、mature、maturing、ripening
[★]
- 関
- ex vivo、in vitro
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インジウム indium