Herpesviridae

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Herpesviridae
Virus classification
Group:	Group I (dsDNA)
Order:	Herpesvirales
Family:	Herpesviridae
Genera
Subfamily: Alphaherpesvirinae Iltovirus Mardivirus Simplexvirus Varicellovirus Unassigned Subfamily: Betaherpesvirinae Cytomegalovirus Muromegalovirus Proboscivirus Roseolovirus Unassigned Subfamily: Gammaherpesvirinae Lymphocryptovirus Macavirus Percavirus Rhadinovirus Unassigned Subfamily: Unassigned Unassigned

Herpesviridae is a large family of DNA viruses that cause diseases in animals, including humans. The members of this family are also known as herpesviruses. The family name is derived from the Greek word herpein ("to creep"), referring to the latent, recurring infections typical of this group of viruses. Herpesviridae can cause latent or lytic infections.

At least five species of Herpesviridae – HSV-1 and HSV-2 (both of which can cause orolabial herpes and genital herpes), Varicella zoster virus (which causes chicken-pox and shingles) Epstein-Barr virus (which causes mononucleosis) and Cytomegalovirus – are extremely widespread among humans. More than 90% of adults have been infected with at least one of these, and a latent form of the virus remains in most people. There are 8 herpesvirus types: Herpes simplex viruses 1 and 2, varicella-zoster virus, EBV (Epstein-Barr virus), human cytomegalovirus, human herpesvirus 6, human herpesvirus 7, and Kaposi's sarcoma-associated herpesvirus. There are more than 130 herpesviruses, and some are from mammals, birds, fish, reptiles, amphibians, and molluscs.

Viral structure

Herpesviruses all share a common structure—all herpesviruses are composed of relatively large double-stranded, linear DNA genomes encoding 100-200 genes encased within an icosahedral protein cage called the capsid which is itself wrapped in a protein layer called the tegument containing both viral proteins and viral mRNAs and a lipid bilayer membrane called the envelope. This whole particle is known as a virion.

Herpesvirus life cycle

All herpesviruses are nuclear-replicating—the viral DNA is transcribed to mRNA within the infected cell's nucleus.

Infection is initiated when a viral particle contacts a cell with specific types of receptor molecules on the cell surface. Following binding of viral envelope glycoproteins to cell membrane receptors, the virion is internalized and dismantled, allowing viral DNA to migrate to the cell nucleus. Within the nucleus, replication of viral DNA and transcription of viral genes occurs.

During symptomatic infection, infected cells transcribe lytic viral genes. In some host cells, a small number of viral genes termed latency associated transcript (LAT) accumulate instead. In this fashion the virus can persist in the cell (and thus the host) indefinitely. While primary infection is often accompanied by a self-limited period of clinical illness, long-term latency is symptom-free.

Reactivation of latent viruses has been implicated in a number of diseases (e.g. Shingles, Pityriasis Rosea). Following activation, transcription of viral genes transitions from latency-associated LAT to multiple lytic genes; these lead to enhanced replication and virus production. Often, lytic activation leads to cell death. Clinically, lytic activation is often accompanied by emergence of non-specific symptoms such as low grade fever, headache, sore throat, malaise, and rash as well as clinical signs such as swollen or tender lymph nodes and immunological findings such as reduced levels of natural killer cells.

Taxonomy

The genus Herpesvirus was established in 1971 in the first report of the International Committee on Taxonomy of Viruses (ICTV). This genus consisted of 23 viruses and 4 groups of viruses. In the second ICTV report in 1976 this genus was elevated to family level - the Herpetoviridae. Because of possible confusion with viruses derived from reptiles this name was changed in the third report in 1979 to Herpesviridae. In this report the family Herpesviridae was divided into 3 subfamilies (Alphaherpesvirinae, Betaherpesvirinae and Gammaherpesvirinae) and 5 unnamed genera: 21 viruses were listed. In 2009 the family Herpesviridae was elevated to the order Herpesvirales. This elevation was necessitated by the discovery that the herpes viruses of fish and molluscs were only distantly related to those of birds and mammals. Two new families were created - the family Alloherpesviridae which incorporates bony fish and frog viruses and the family Malacoherpesviridae which contains those of molluscs.

This order currently has 3 families, 3 subfamilies plus 1 unassigned, 17 genera, 90 species and plus 48 as yet unassigned viruses.

Virus naming system

The system of naming herpes viruses was originated in 1973 and has been elaborated considerably since. The recommended naming system specified that each herpes virus should be named after the taxon (family or subfamily) to which its primary natural host belongs. The subfamily name is used for viruses from members of the family Bovidae or from primates (the virus name ending in –ine, e.g. bovine) and the host family name for other viruses (ending in –id, e.g. equid). Human herpes viruses have been treated as an exception (human rather than hominid). Following the host-derived term, the word herpes virus is added, followed by an Arabic numeral (1,2,3,...). These last two additions bear no implied meaning about taxonomic or biological properties of the virus.

Some exceptions to this system exist. A number of viruses' names (e.g. Epstein–Barr virus) are so widely used that it is impractical to attempt to insist on their replacement. This has led to the a dual nomenclature in the literature for some herpes viruses. All herpes viruses described since this system was adopted have been named in accordance with it.

Evolution

The three mammalian subfamilies - Alpha, Beta and Gamma - arose approximately 180 million years ago to 220 million years ago. The major sublineages within these subfamilies were probably generated before the mammalian radiation of 80 million years ago to 60 million years ago. Speciations within sublineages took place in the last 80 million years probably with a major component of cospeciation with host lineages.

Immune system evasions

Herpesviruses are known for their ability to establish lifelong infections. One way this is possible is through immune evasion. Herpesviruses have found many different ways to evade the immune system. One such way is by encoding a protein mimicking human interleukin 10 (hIL-10) and another is by downregulation of the Major Histocompatibility Complex II (MHC II) in infected cells.

cmvIL-10

Research conducted on cytomegalovirus (CMV) indicates that the viral human IL-10 homolog, cmvIL-10, is important in inhibiting pro-inflammatory cytokine synthesis. The cmvIL-10 protein has 27% identity with hIL-10 and only one conserved residue out of the nine amino acids that make up the functional site for cytokine synthesis inhibition on hIL-10. There is, however, much similarity in the functions of hIL-10 and cmvIL-10. Both have been shown to down regulate IFN-γ, IL-1α, GM-CSF, IL-6 and TNF-α, which are all pro-inflammatory cytokines. They have also been shown to play a role in downregulating MHC I and MHC II and up regulating HLA-G (non-classical MHC I). These two events allow for immune evasion by suppressing the cell-mediated immune response and natural killer cell response, respectively. The similarities between hIL-10 and cmvIL-10 may be explained by the fact that hIL-10 and cmvIL-10 both use the same cell surface receptor, the hIL-10 receptor. One difference in the function of hIL-10 and cmvIL-10 is that hIL-10 causes human peripheral blood mononuclear cells (PBMC) to both increase and decrease in proliferation whereas cmvIL-10 only causes a decrease in proliferation of PBMCs. This indicates that cmvIL-10 may lack the stimulatory effects that hIL-10 has on these cells.

It was found that cmvIL-10 functions through phosphorylation of the Stat3 protein. It was originally thought that this phosphorylation was a result of the JAK-STAT pathway. However, despite evidence that JAK does indeed phosphorylate Stat3, its inhibition has no significant influence on cytokine synthesis inhibition. Another protein, PI3K, was also found to phosphorylate Stat3. PI3K inhibition, unlike JAK inhibition, did have a significant impact on cytokine synthesis. The difference between PI3K and JAK in Stat3 phosphorylation is that PI3K phosphorylates Stat3 on the S727 residue whereas JAK phosphorylates Stat3 on the Y705 residue. This difference in phosphorylation positions seems to be the key factor in Stat3 activation leading to inhibition of pro-inflammatory cytokine synthesis. In fact, when a PI3K inhibitor is added to cells, the cytokine synthesis levels are significantly restored. The fact that cytokine levels are not completely restored indicates there is another pathway activated by cmvIL-10 that is inhibiting cytokine synthesis. The proposed mechanism is that cmvIL-10 activates PI3K which in turn activates PKB (Akt). PKB may then activate mTOR, which may target Stat3 for phosphorylation on the S727 residue.

MHC downregulation

Another one of the many ways in which herpes viruses evade the immune system is by down regulation of MHC I and MHC II. This is observed in almost every human herpesvirus. Down regulation of MHC I and MHC II can come about by many different mechanisms, most causing the MHC to be absent from the cell surface. As discussed above, one way is by a viral chemokine homolog such as IL-10. Another mechanism to down regulate MHCs is to encode viral proteins that detain the newly formed MHC in the endoplasmic reticulum (ER). The MHC cannot reach the cell surface and therefore cannot activate the T cell response. The MHCs can also be targeted for destruction in the proteasome or lysosome. The ER protein TAP also plays a role in MHC down regulation. Viral proteins inhibit TAP preventing the MHC from picking up a viral antigen peptide. This prevents proper folding of the MHC and therefore the MHC does not reach the cell surface.

It is important to note that HLA-G is often up regulated in addition to downregulation of MHC I and MHC II. This prevents the natural killer cell response.^{[citation needed]}

Human herpesvirus infections

There are nine distinct viruses in this family known to cause disease in humans.

Human Herpesvirus (HHV) classification
Type	Synonym	Subfamily	Primary Target Cell	Pathophysiology	Site of Latency	Means of Spread
HHV‑1	Herpes simplex virus-1 (HSV-1)	α (Alpha)	Mucoepithelial	Oral and/or genital herpes (predominantly orofacial), as well as other herpes simplex infections	Neuron	Close contact (oral or sexually transmitted infection)
HHV-2	Herpes simplex virus-2 (HSV-2)	α	Mucoepithelial	Oral and/or genital herpes (predominantly genital), as well as other herpes simplex infections	Neuron	Close contact (oral or sexually transmitted disease)
HHV-3	Varicella zoster virus (VZV)	α	Mucoepithelial	Chickenpox and shingles	Neuron	Respiratory and close contact (including sexually transmitted disease)
HHV-4	Epstein-Barr virus (EBV), lymphocryptovirus	γ (Gamma)	B cells and epithelial cells	Infectious mononucleosis, Burkitt's lymphoma, CNS lymphoma in AIDS patients, post-transplant lymphoproliferative syndrome (PTLD), nasopharyngeal carcinoma, HIV-associated hairy leukoplakia	B cell	Close contact, transfusions, tissue transplant, and congenital
HHV-5	Cytomegalovirus (CMV)	β (Beta)	Monocyte, lymphocyte, and epithelial cells	Infectious mononucleosis-like syndrome, retinitis, etc.	Monocyte, lymphocyte, and ?	Saliva, urine, breast milk etc
HHV-6A and 6B	Roseolovirus, Herpes lymphotropic virus	β	T cells and ?	Sixth disease (roseola infantum or exanthem subitum)	T cells and ?	Respiratory and close contact?
HHV-7	Pityriasis Rosea	β	T cells and ?	? (roseola infantum or exanthem subitum)	T cells and ?	?
HHV-8	Kaposi's sarcoma-associated herpesvirus (KSHV), a type of rhadinovirus	γ	Lymphocyte and other cells	Kaposi's sarcoma, primary effusion lymphoma, some types of multicentric Castleman's disease	B cell	Close contact (sexual), saliva?

Herpesviruses of other animals

In addition to the herpesviruses considered endemic in humans, some viruses associated primarily with animals may infect humans. These are zoonotic infections:

Zoonotic Herpesviruses
Species	Type	Synonym	Subfamily	Human Pathophysiology
Macaque monkey	CeHV-1	Cercopithecine herpesvirus-1, (Monkey B virus)	α	Very unusual, with only approximately 25 human cases reported. Untreated infection is often deadly; sixteen of the 25 cases resulted in fatal encephalomyelitis. At least four cases resulted in survival with severe neurologic impairment. Symptom awareness and early treatment are important for laboratory workers facing exposure.
Mouse	MuHV‑4	Murine gammaherpesvirus-68 (MHV-68)	γ	Zoonotic infection found in 4.5% of general population and more common in laboratory workers handling infected mice. ELISA tests show factor-of-four (x4) false positive results, due to antibody cross-reaction with other Herpes viruses.

Animal herpesviruses

In animal virology, the most important herpesviruses belong to the subfamily Alphaherpesvirinae. Research on pseudorabies virus (PrV), the causative agent of Aujeszky's disease in pigs, has pioneered animal disease control with genetically modified vaccines. PrV is now extensively studied as a model for basic processes during lytic herpesvirus infection, and for unraveling molecular mechanisms of herpesvirus neurotropism, whereas bovine herpesvirus 1, the causative agent of bovine infectious rhinotracheitis and pustular vulvovaginitis, is analyzed to elucidate molecular mechanisms of latency. The avian infectious laryngotracheitis virus is phylogenetically distant from these two viruses and serves to underline similarity and diversity within the Alphaherpesvirinae.

• Subfamily Alphaherpesvirinae
  • Genus Simplexvirus
    • Bovine herpesvirus 2 causes bovine mammillitis and pseudo-lumpyskin disease.
    • Cercopithecine herpesvirus 1, also known as Herpes B virus, causes a Herpes simplex-like disease in Macaques, usually fatal if symptomatic and untreated in humans.
    • Ateline herpesvirus 1, Spider monkey herpesvirus.
  • Genus Varicellovirus
    • Bovine herpesvirus 1 causes infectious bovine rhinotracheitis, vaginitis, balanoposthitis, and abortion in cattle.
    • Bovine herpesvirus 5 causes encephalitis in cattle.
    • Caprine herpesvirus 1 causes conjunctivitis and respiratory disease in goats.
    • Porcine herpesvirus 1 causes pseudorabies.
    • Equine herpesvirus 1 causes respiratory disease, neurological disease/paralysis, and spontaneous abortion in horses.
    • Equine herpesvirus 3 causes coital exanthema in horses.
    • Equine herpesvirus 4 causes rhinopneumonitis in horses.
    • Canine herpesvirus 1 causes a severe hemorrhagic disease in puppies.
    • Feline herpesvirus 1 causes feline viral rhinotracheitis and keratitis in cats.
    • Duck herpesvirus 1 causes duck plague.
  • Genus Mardivirus
    • Gallid herpesvirus 2 causes Marek's disease.
    • Gallid herpesvirus 3 (GaHV-3 or MDV-2)
    • Herpesvirus of turkeys (HVT)
  • Genus Iltovirus
    • Gallid herpesvirus 1 causes infectious laryngotracheitis in birds.
• Subfamily Betaherpesvirinae
  • Porcine herpesvirus 2 causes inclusion body rhinitis in swine.
• Subfamily Gammaherpesvirinae
  • Genus Rhadinovirus
    • Alcelaphine herpesvirus 1 causes bovine malignant catarrhal fever.
    • Alcelaphine herpesvirus 2 causes an antelope and hartebeest version of MCF.
    • Bovine herpesvirus 4
    • Equine herpesvirus 2 causes equine cytomegalovirus infection.
    • Equine herpesvirus 5
    • Japanese macaque rhadinovirus
    • Murid herpesvirus 4 Also known as Murine gammaherpesvirus-68 (MHV-68)

Family Herpesviridae

The following genera are included in the family Herpesviridae:

• Subfamily Alphaherpesvirinae
  • Genus Iltovirus; type species: Gallid herpesvirus 1
    • Species: Gallid herpesvirus 1, Psittacid herpesvirus 1
  • Genus Mardivirus; type species: Gallid herpesvirus 2
    • Species: Columbid herpesvirus 1, Gallid herpesvirus 2, Gallid herpesvirus 3, Meleagrid herpesvirus 1
  • Genus Simplexvirus; type species: Human herpesvirus 1
    • Species: Ateline herpesvirus 1, Bovine herpesvirus 2, Cercopithecine herpesvirus 2, Chimpanzee herpesvirus, Human herpesvirus 1, Human herpesvirus 2, Leporid herpesvirus 4, Macacine herpesvirus 1, Macropodid herpesvirus 1, Macropodid herpesvirus 2, Papiine herpesvirus 2, Saimiriine herpesvirus 1
  • Genus Unassigned
    • Species: Chelonid herpesvirus 5, Chelonid herpesvirus 6
  • Genus Varicellovirus; type species: Human herpesvirus 3
    • Species: Bovine herpesvirus 1, Bovine herpesvirus 5, Bubaline herpesvirus 1, Canid herpesvirus 1, Caprine herpesvirus 1, Cercopithecine herpesvirus 9, Cervid herpesvirus 1, Cervid herpesvirus 2, Equid herpesvirus 1, Equid herpesvirus 3, Equid herpesvirus 4, Equid herpesvirus 8, Equid herpesvirus 9, Equine herpesvirus 9, Felid herpesvirus 1, Human herpesvirus 3, Phocid herpesvirus 1, Suid herpesvirus
• Subfamily Betaherpesvirinae
  • Genus Cytomegalovirus; type species: Human herpesvirus 5
    • Species: Cercopithecine herpesvirus 5, Human herpesvirus 5, Macacine herpesvirus 3, Panine herpesvirus 2
  • Genus Muromegalovirus; type species: Murid herpesvirus 1
    • Species: Murid herpesvirus 1, Murid herpesvirus 2
  • Genus Proboscivirus; type species: Elephantid herpesvirus 1
  • Genus Roseolovirus; type species: Human herpesvirus 6
    • Species: Human herpesvirus 6, Human herpesvirus 7
  • Genus Unassigned
    • Species: Caviid herpesvirus 2, Suid herpesvirus 2, Tupaiid herpesvirus 1
• Subfamily Gammaherpesvirinae
  • Genus Lymphocryptovirus; type species: Human herpesvirus 4
    • Species: Callitrichine herpesvirus 3, Cercopithecine herpesvirus 14, Gorilline herpesvirus 1, Human herpesvirus 4, Macacine herpesvirus 4, Panine herpesvirus 1, Papiine herpesvirus 1, Pongine herpesvirus 2
  • Genus Macavirus; type species: Alcelaphine herpesvirus 1
    • Species: Alcelaphine herpesvirus 1, Alcelaphine herpesvirus 2, Bovine herpesvirus 6, Caprine herpesvirus 2, Hippotragine herpesvirus 1, Ovine herpesvirus 2, Suid herpesvirus 3, Suid herpesvirus 4, Suid herpesvirus 5
  • Genus Percavirus; type species: Equid herpesvirus 2
    • Species: Equid herpesvirus 2, Equid herpesvirus 5, Mustelid herpesvirus 1
  • Genus Rhadinovirus; type species: Saimiriine herpesvirus 2
    • Species: Ateline herpesvirus 2, Ateline herpesvirus 3, Bovine herpesvirus 4, Human herpesvirus 8, Macacine herpesvirus 5, Murid herpesvirus 4, Saimiriine herpesvirus 2
  • Genus Unassigned
    • Species: Equid herpesvirus 7, Phocid herpesvirus 2, Saguinine herpesvirus 1
• Subfamily Unassigned
  • Genus Unassigned
    • Species: Duck enteritis virus
    • Species: Iguanid herpesvirus 2

Research

Research is currently ongoing into a variety of side-effect or co-conditions related to the herpesviruses. These include:

• Alzheimer's disease
• atherosclerosis
• cholangiocarcinoma
• Crohn's disease
• chronic fatigue syndrome
• dysautonomia
• fibromyalgia
• Irritable bowel syndrome
• multiple sclerosis
• labile hypertension
• lupus
• pancreatic cancer
• pancreatitis
• pityriasis rosea
• Type II Diabetes

References

External links

• ICTV International Committee on Taxonomy of Viruses (official site)
• Viralzone: Herpesviridae
• Animal viruses
• Article on Cercopithecine herpesvirus
• International Herpes Management Forum
• National B Virus Resource Center
• Pityriasis Rosea overview
• Herpes simplex: Host viral protein interactions.A database of Host/HSV-1 interactions
• Virus Pathogen Database and Analysis Resource (ViPR): Herpesviridae

UpToDate Contents

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• 1. 中枢神経系感染症の分子学的診断 molecular diagnosis of central nervous system infections
• 2. ヒトヘルペスウイルス6型感染症のウイルス学、病因、および疫学 virology pathogenesis and epidemiology of human herpesvirus 6 infection
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English Journal

• Structure-Based Functional Analyses of Domains II and III of Pseudorabies Virus Glycoprotein H.

• Böhm SW1, Eckroth E1, Backovic M2, Klupp BG1, Rey FA2, Mettenleiter TC3, Fuchs W1.
• Journal of virology.J Virol.2015 Jan 15;89(2):1364-76. doi: 10.1128/JVI.02765-14. Epub 2014 Nov 12.
• Enveloped viruses utilize membrane fusion for entry into, and release from, host cells. For entry, members of the Herpesviridae require at least three envelope glycoproteins: the homotrimeric gB and a heterodimer of gH and gL. The crystal structures of three gH homologues, including pseudorabies vir
• PMID 25392216

• Epstein-Barr virus and risk of non-Hodgkin lymphoma in the cancer prevention study-II and a meta-analysis of serologic studies.

• Teras LR1, Rollison DE, Pawlita M, Michel A, Brozy J, de Sanjose S, Blase JL, Gapstur SM.
• International journal of cancer. Journal international du cancer.Int J Cancer.2015 Jan 1;136(1):108-16. doi: 10.1002/ijc.28971. Epub 2014 Jun 5.
• Epstein-Barr virus (EBV) causes rare, malignant lymphomas. The role of EBV in other non-Hodgkin lymphomas (NHLs) remains unclear, but mildly reduced immune function could lead to reactivation of EBV and subsequent NHL. We examined the association between prospectively-collected plasma EBV antibodies
• PMID 24831943

• Epstein-Barr virus: Dermatologic associations and implications: Part I. Mucocutaneous manifestations of Epstein-Barr virus and nonmalignant disorders.

• Hall LD1, Eminger LA2, Hesterman KS3, Heymann WR4.
• Journal of the American Academy of Dermatology.J Am Acad Dermatol.2015 Jan;72(1):1-19. doi: 10.1016/j.jaad.2014.07.034.
• Epstein-Barr virus (EBV) is a ubiquitous virus that has been implicated in a wide range of human diseases, many of which have mucocutaneous manifestations. As a member of the herpesviridae family, EBV causes lifelong infection by establishing latency in B lymphocytes. An intact immune response is cr
• PMID 25497917

Japanese Journal

• Koi herpesvirus represents a third cyprinid herpesvirus (CyHV-3) in the family Herpesviridae

• WALTZEK B. T.
• J. Gen. Virol. 86, 1659-1667, 2005
• NAID 80017326009

• Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan

• ISHIKAWA Kayo,HASEGAWA Kiyoshi,NARITOMI Takuma,KANAI Naoko,OGAWA Miho,KATO Youichiro,KOBAYASHI Makio,TORII Nobuyuki,HAYASHI Naoaki
• Journal of gastroenterology 37(7), 523-530, 2002-07-01
• NAID 50000581938

• マレック病ウイルス血清2型糖蛋白M遺伝子の同定および構造 : ヘルペスウイルス属の糖蛋白M遺伝子との比較

• 察 錦順,張 炯寛,泉屋 吉宏 [他],津嶋 良典,加藤 健太郎,Damiani A.M.,宮沢 孝幸,甲斐 知恵子,高橋 英司,見上 彪
• The journal of veterinary medical science 61(5), 503-511, 1999-05-25
• マレック病ウイルス2型(MDV2)ゲノム上の人単純ヘルペスウイルス1型のUL10遺伝子産物である糖蛋白M(gM)をコードすると考えられるBamHI-C断片の一部の塩基配列決定を行った. その結果, この遺伝子は424アミノ酸残基をコードし, 予想される翻訳産物の分子量は46.9 kDaであった. また, この翻訳産物は人単純ヘルペスウイルス1型(37.5%)及び他のヘルペスウイルス(45.4%から …
• NAID 110003920151

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• Herpesviridae - definition of Herpesviridae by Medical dictionary

Herpesviridae (hər″pēzvi´rô ide), n one of the major virus families, to which the herpes simplex, varicella zoster, and Epstein-Barr viruses belong. Viruses in this family have a double-stranded linear molecular structure with icosahedral ...

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ヘルペスウイルス亜科、ウイルス

• ヘルペスウイルス科に属するウイルスはヘルペスウイルス herpesvirusと呼ばれる

ヘルペス科に属するウイルスによる感染症 (SMB.526)

ヘルペスウイルス亜科 ヘルペスウイルス亜科 ヘルペスウイルス亜科	ヘルペスウイルス		潜伏部位	初感染における 顕性感染率	主な疾患
α	単純ヘルペスウイルス1型	HSV-１	知覚神経節	低	口唇ヘルペス、口内炎、角膜ヘルペス、ヘルペス脳炎、性器ヘルペス、新生児ヘルペス
	単純ヘルペスウイルス2型	HSV-2		低	性器ヘルペス、新生児ヘルペス、ヘルペス?疽、殿部ヘルペス
	水痘・帯状疱疹ウイルス	VZV		高	水痘、帯状疱疹、ラムゼイ・ハント症候群
β	サイトメガロウイルス	CMV	顆粒球/マクロファージ前駆細胞	低	先天性巨細胞封入体症、輸血後CMV単球症、臓器移植後間質性肺炎、肝炎
	ヒトヘルペスウイルス6型	HHV-6	マクロファージ	高	突発性発疹、脳炎
	ヒトヘルペスウイルス7型	HHV-7	唾液腺？	低	突発性発疹
γ	エプスタイン-バーウイルス	EBV	骨髄Bリンパ球	低	伝染性単核症、バーキットリンパ腫、上咽頭癌、日和見リンパ腫
	ヒトヘルペスウイルス8型	HHV-8	Bリンパ球	低	カポジ肉腫、キャッスルマン病

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