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This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (January 2013) |
| Brain: Brainstem |
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| Hind- and mid-brains; postero-lateral view |
| Latin |
truncus encephali |
| Gray's |
subject #187 |
| Part of |
Brain |
| Components |
Medulla, Pons, Midbrain |
| NeuroNames |
ancil-218 |
| MeSH |
Brain+Stem |
| NeuroLex ID |
birnlex_1565 |
In vertebrate anatomy the brainstem (or brain stem) is the posterior part of the brain, adjoining and structurally continuous with the spinal cord. It is usually described as including the medulla oblongata (myelencephalon), pons (part of metencephalon), and midbrain (mesencephalon).[1][2] Less frequently, parts of the diencephalon are included. The brain stem provides the main motor and sensory innervation to the face and neck via the cranial nerves. Though small, this is an extremely important part of the brain as the nerve connections of the motor and sensory systems from the main part of the brain to the rest of the body pass through the brain stem. This includes the corticospinal tract (motor), the posterior column-medial lemniscus pathway (fine touch, vibration sensation and proprioception) and the spinothalamic tract (pain, temperature, itch and crude touch). The brain stem also plays an important role in the regulation of cardiac and respiratory function. It also regulates the central nervous system, and is pivotal in maintaining consciousness and regulating the sleep cycle. The brain stem has many basic functions including heart rate, breathing, sleeping and eating.
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Contents
- 1 General anatomy
- 1.1 Ventral view/medulla and pons
- 1.2 Dorsal view/medulla and pons
- 1.3 Midbrain
- 1.4 Midbrain internal structures
- 2 Embryology
- 3 Functions
- 4 Signs and symptoms of disease
- 5 Additional images
- 6 See also
- 7 References
- 8 External links
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General anatomy[edit]
Ventral view/medulla and pons[edit]
In the medial part of the medulla is the anterior median fissure. Moving laterally on each side are the pyramids. The pyramids contain the fibers of the corticospinal tract (also called the pyramidal tract), or the upper motor neuronal axons as they head inferiorly to synapse on lower motor neuronal cell bodies within the ventral horn of the spinal cord.
The anterolateral sulcus is lateral to the pyramids. Emerging from the anterolateral sulci are the CN XII (hypoglossal nerve) rootlets. Lateral to these rootlets and the anterolateral sulci are the olives. The olives are swellings in the medulla containing underlying inferior nucleary nuclei (containing various nuclei and afferent fibers). Lateral (and dorsal) to the olives are the rootlets for cranial nerves IX (glossopharyngeal), CN X (vagus) and CN XI (accessory nerve). The pyramids end at the pontomedullary junction, noted most obviously by the large basal pons. From this junction, CN VI (abducens nerve), CN VII (facial nerve) and CN VIII (vestibulocochlear nerve) emerge. At the level of the midpons, CN V (the trigeminal nerve) emerges. Cranial nerve III (the occulomotor nerve) emerges ventrally from the midbrain, while the CN IV (the trochlear nerve) emerges out from the dorsal aspect of midbrain.
Dorsal view/medulla and pons[edit]
The most medial part of the medulla is the posterior median fissure. Moving laterally on each side is the fasciculus gracilis, and lateral to that is the fasciculus cuneatus. Superior to each of these, and directly inferior to the obex, are the gracile and cuneate tubercles, respectively. Underlying these are their respective nuclei. The obex marks the end of the 4th ventricle and the beginning of the central canal. The posterior intermediate sulci separates the fasciculi gracilis from the fasciculi cuneatus. Lateral to the fasciculi cuneatus is the lateral funiculus.
Superior to the obex is the floor of the 4th ventricle. In the floor of the 4th ventricle, various nuclei can be visualized by the small bumps that they make in the overlying tissue. In the midline and directly superior to the obex is the vagal trigone and superior to that it the hypoglossal trigone. Underlying each of these are motor nuclei for the respective cranial nerves. Superior to these trigones are fibers running laterally in both directions. These fibers are known collectively as the striae medullares. Continuing in a rostral direction, the large bumps are called the facial colliculi. Each facial colliculus, contrary to their names, do not contain the facial nerve nuclei. Instead, they have facial nerve axons traversing superficial to underlying abducens (CN VI) nuclei. Lateral to all these bumps previously discussed is an indented line, or sulcus that runs rostrally, and is known as the sulcus limitans. This separates the medial motor neurons from the lateral sensory neurons. Lateral to the sulcus limitans is the area collectively known as the vestibular area, which is involved in special sensation. Moving rostrally, the inferior, middle, and superior cerebellar peduncles are found connecting the midbrain to the cerebellum. Directly rostral to the superior cerebellar peduncle, there is the superior medullary velum and then the two trochlear nerves. This marks the end of the pons as the inferior colliculus is directly rostral and marks the caudal midbrain.
Spinal Cord to Medulla Transitional Landmark: From a ventral view, there can be seen a decussation of fibers between the two pyramids. This decussation marks the transition from medulla to spinal cord. Superior to the decussation is the medulla and inferior to it is the spinal cord.
Midbrain[edit]
Main article: Midbrain
The midbrain is divided into three parts. The first is the tectum, which is "roof" in Latin. The tectum includes the superior and inferior colliculi and is the dorsal covering of the cerebral aqueduct. The inferior colliculus, involved in the sense of hearing sends its inferior brachium to the medial geniculate body of the diencephalon. Superior to the inferior colliculus, the superior colliculus marks the rostral midbrain. It is involved in the special sense of vision and sends its superior brachium to the lateral geniculate body of the diencephalon. The second part is the tegmentum and is ventral to the cerebral aqueduct. Several nuclei, tracts and the reticular formation are contained here. Last, the ventral side is composed of paired cerebral peduncles. These transmit axons of upper motor neurons.
Midbrain internal structures[edit]
- Periaqueductal gray: The area around the cerebral aqueduct, which contains various neurons involved in the pain desensitization pathway. Neurons synapse here and, when stimulated, cause activation of neurons in the nucleus raphes magnus, which then project down into the dorsal horn of the spinal cord and prevent pain sensation transmission.
- Occulomotor nerve nucleus: This is the nucleus of CN III.
- Trochlear nerve nucleus: This is the nucleus of CN IV.
- Red Nucleus: This is a motor nucleus that sends a descending tract to the lower motor neurons.
- Substantia nigra: This is a concentration of neurons in the ventral portion of the midbrain that uses dopamine as its neurotransmitter and is involved in both motor function and emotion. Its dysfunction is implicated in Parkinson's Disease.
- Reticular formation: This is a large area in the midbrain that is involved in various important functions of the midbrain. In particular, it contains lower motor neurons, is involved in the pain desensitization pathway, is involved in the arousal and consciousness systems, and contains the locus ceruleus, which is involved in intensive alertness modulation and in autonomic reflexes.
- Central tegmental tract: Directly anterior to the floor of the 4th ventricle, this is a pathway by which many tracts project up to the cortex and down to the spinal cord.
- Ventral tegmental area: is a group of dopaminergic neurons located close to the midline on the floor of the midbrain.
Embryology[edit]
The adult human brain stem emerges from two of the three primary vesicles formed of the neural tube. The mesencephalon is the second of the three primary vesicles, and does not further differentiate into a secondary vesicle. This will become the midbrain. The third primary vesicle, the rhombencephalon, will further differentiate into two secondary vesicles, the metencephalon and the myelencephalon. The metencephalon will become the cerebellum and the pons. The myelencephalon will become the medulla.
Functions[edit]
There are three main functions of the brainstem:
- The brainstem plays a role in conduction. That is, all information relayed from the body to the cerebrum and cerebellum and vice versa, must traverse the brain stem. The ascending pathways coming from the body to the brain are the sensory pathways, and include the spinothalamic tract for pain and temperature sensation and the dorsal column, fasciculus gracilis, and cuneatus for touch, proprioception, and pressure sensation (both of the body). (The facial sensations have similar pathways, and will travel in the spinothalamic tract and the medial lemniscus also). Descending tracts are upper motor neurons destined to synapse on lower motor neurons in the ventral horn and intermediate horn of the spinal cord. In addition, there are upper motor neurons that originate in the brain stem's vestibular, red, tectal, and reticular nuclei, which also descend and synapse in the spinal cord.
- The cranial nerves III-XII emerge from the brainstem.[3] The cranial nerves supply the face, head and viscera.
- The brainstem has integrative functions (it is involved in cardiovascular system control, respiratory control, pain sensitivity control, alertness, awareness, and consciousness). Thus, brain stem damage is a very serious and often life-threatening problem.
Signs and symptoms of disease[edit]
Diseases of the brain stem can result to abnormalities in the function of cranial nerves which may lead to visual disturbances, pupil abnormalities, changes in sensation, muscle weakness, hearing problems, vertigo, swallowing and speech difficulty, voice change, and co-ordination problems. Localizing neurological lesions in the brain stem may be very precise, although it relies on a clear understanding on the functions of brain stem anatomical structures and how to test them.
Additional images[edit]
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The midbrain, pons, and medulla oblongata are labelled on this coronal section of the human brain.
See also[edit]
- Brain stem tumor
- Cranial nerve nucleus
- Triune brain Reptilian brain
References[edit]
- ^ "brainstem" at Dorland's Medical Dictionary
- ^ Brain Stem at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ http://vanat.cvm.umn.edu/NeuroLectPDFs/CranialN-Lect.pdf
External links[edit]
- Comparative Neuroscience at Wikiversity
- http://www.cancerhelp.org.uk/help/default.asp?page=5019
- http://www.meddean.luc.edu/lumen/Meded/Neuro/frames/nlBSsL/nl40fr.htm
- http://biology.about.com/library/organs/brain/blbrainstem.htm
- http://www.waiting.com/brainanatomy.html
- http://www.martindalecenter.com/MedicalAnatomy_3_SAD.html
- NIF Search - Brainstem via the Neuroscience Information Framework
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Nervous system (TA A14, GA 9)
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| Central nervous system |
- Meninges
- Spinal cord
- Brain
- Rhombencephalon
- Medulla oblongata
- Pons
- Cerebellum
- Mesencephalon
- Prosencephalon
- Diencephalon
- Telencephalon
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| Peripheral nervous system |
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Somatic
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- Sensory nerve
- Motor nerve
- Cranial nerve
- Spinal nerve
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Autonomic
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- Sympathetic
- Parasympathetic
- Enteric nervous system
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anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp
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noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr
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proc, drug (N1A/2AB/C/3/4/7A/B/C/D)
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anat (h/r/t/c/b/l/s/a)/phys (r)/devp/prot/nttr/nttm/ntrp
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noco/auto/cong/tumr, sysi/epon, injr
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Human brain: rhombencephalon, myelencephalon: medulla (TA A14.1.04, GA 9.767)
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| Dorsal |
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Surface
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Posterior median sulcus · Posterolateral sulcus · Area postrema · Vagal trigone · Hypoglossal trigone · Medial eminence
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Grey: Cranial nuclei
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afferent: GVA: VII,IX,X: Solitary/tract/Dorsal respiratory group · SVA: Gustatory nucleus · GSA: VIII-v (Lateral, Medial, Inferior)
efferent: GSE: XII · GVE: IX,X,XI: Ambiguus · SVE: X: Dorsal · IX: Inferior salivatory nucleus
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Grey: other
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Gracile nucleus · Cuneate nucleus · Accessory cuneate nucleus
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White: Sensory/ascending
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Sensory decussation · Medial lemniscus · Inferior cerebellar peduncle (Juxtarestiform body) · Ascending dorsal longitudinal fasciculus · MLF, III, IV and VI
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White: Motor/descending
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Descending dorsal longitudinal fasciculus · MLF, III, IV and VI
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| Ventral |
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White: Motor/descending
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Motor decussation · Olivocerebellar tract · Rubro-olivary tract
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Grey matter
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Ventral respiratory group · Arcuate nucleus of medulla · Inferior olivary nucleus · Rostral ventromedial medulla
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Surface
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Anterior median fissure · Anterolateral sulcus · Olive · Pyramid
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Grey: Raphe/
reticular |
Reticular formation (Gigantocellular, Parvocellular, Ventral, Lateral, Paramedian) · Raphe nuclei (Obscurus, Magnus, Pallidus)
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anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp
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noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr
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proc, drug (N1A/2AB/C/3/4/7A/B/C/D)
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Human brain, rhombencephalon, metencephalon: pons (TA A14.1.05.101–604, GA 9.785)
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Dorsal/
(tegmentum) |
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Surface
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Cerebellopontine angle · Superior medullary velum · Sulcus limitans · Medial eminence · Facial colliculus
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White: Sensory/ascending
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Trapezoid body/VIII · Trigeminal lemniscus (Dorsal trigeminal tract, Ventral trigeminal tract) · Medial lemniscus · Lateral lemniscus
MLF, III, IV and VI: Vestibulo-oculomotor fibers
Anterior trigeminothalamic tract · Central tegmental tract
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White: Motor/descending
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ICP (Vestibulocerebellar tract)
MLF, III, IV and VI: Vestibulospinal tract (Medial vestibulospinal tract, Lateral vestibulospinal tract)
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Grey: Cranial nuclei
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afferent: GSA: Principal V/Spinal V · VIII-c (Dorsal, Anterior)/VIII-v (Superior)
efferent: SVE: Motor V · VII · GSE: VI · GVE: VII: Superior salivary nucleus
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Other grey
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Apneustic center · Pneumotaxic center (Medial parabrachial nucleus) · Lateral parabrachial nucleus · Superior olivary nucleus · Caerulean nucleus
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Ventral/
(base) |
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Grey
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Pontine nuclei
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White: Motor/descending
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Corticospinal tract · Corticobulbar tract · Corticopontine fibers
MCP (Pontocerebellar fibers)
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Surface
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Basilar sulcus
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Other grey: Raphe/
reticular |
Reticular formation (Caudal, Oral, Tegmental, Paramedian) · Raphe nuclei (Median)
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anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp
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noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr
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proc, drug (N1A/2AB/C/3/4/7A/B/C/D)
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Human brain: mesencephalon (midbrain) (TA A14.1.06, GA 9.800)
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Tectum
(Dorsal) |
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Surface
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Corpora quadrigemina: Inferior colliculi (Brachium of inferior colliculus), Superior colliculi (Brachium of superior colliculus)
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Grey matter
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Pretectal area
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White: Sensory/ascending
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Spinotectal tract · Central tegmental tract
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White: Motor/descending
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Tectospinal tract
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Peduncle
(Ventral) |
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Tegmentum
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White: Sensory/ascending
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lemnisci (Medial, Lateral) · Ascending MLF (Vestibulo-oculomotor fibers) · Spinothalamic tract · Anterior trigeminothalamic tract · Dentatothalamic tract
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White: Motor/descending
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Rubrospinal tract · Rubro-olivary tract · Descending MLF
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Grey: cranial nuclei
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GSA (V: Mesencephalic) - GSE (III: Oculomotor, IV: Trochlear) - GVE (III: Edinger-Westphal)
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Grey: other
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Periaqueductal gray/Raphe nuclei (Dorsal raphe nucleus)
Ventral tegmental area • Pedunculopontine nucleus • Red nucleus
riMLF
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Ventricular system
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Cerebral aqueduct
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Base
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White: Motor/descending
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Cerebral crus: Corticospinal tract · Corticobulbar tract · Corticopontine tract/Frontopontine fibers/Temporopontine fibers
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Grey: Substantia nigra
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Pars compacta · Pars reticulata
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Surface
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Superior cerebellar peduncle (Decussation of superior cerebellar peduncles) · Interpeduncular fossa
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anat (n/s/m/p/4/e/b/d/c/a/f/l/g)/phys/devp
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noco (m/d/e/h/v/s)/cong/tumr, sysi/epon, injr
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proc, drug (N1A/2AB/C/3/4/7A/B/C/D)
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