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- inflammation of the ear
PrepTutorEJDIC
- ostmark
- mediumの複数形
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/11/25 10:26:02」(JST)
wiki en
| Otitis media | |
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A bulging tympanic membrane which is typical in a case of acute otitis media
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| Classification and external resources | |
| Specialty | Otorhinolaryngology |
| ICD-10 | H65-H67 |
| ICD-9-CM | 017.40, 055.2, 381.0, 381.1, 381.2, 381.3, 381.4, 382 |
| DiseasesDB |
29620 serous, |
| MedlinePlus | 000638 acute, 007010 with effusion, 000619 chronic |
| eMedicine | emerg/351 ent/426 complications, ent/209 with effusion, ent/212 Medical treat., ent/211 Surgical treat. ped/1689 |
| MeSH | D010033 |
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[edit on Wikidata]
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Otitis media is a group of inflammatory diseases of the middle ear.[1] The two main types are acute otitis media (AOM) and otitis media with effusion (OME).[2] AOM is an infection of abrupt onset that usually presents with ear pain. In young children this may result in pulling at the ear, increased crying, and poor sleep. Decreased eating and a fever may also be present. OME is typically not associated with symptoms.[3] Occasionally a feeling of fullness is described. It is defined as the presence of non-infectious fluid in the middle ear for more than three months. Chronic suppurative otitis media (CSOM) is middle ear inflammation of greater than two weeks that results in episodes of discharge from the ear. It may be a complication of acute otitis media. Pain is rarely present.[4] All three may be associated with hearing loss.[1][2] The hearing loss in OME, due to its chronic nature, may affect a child's ability to learn.[4]
The cause of AOM is related to childhood anatomy and immune function. Either bacteria or viruses may be involved. Risk factors include exposure to smoke, use of pacifiers, and attending daycare. It occurs more commonly in those who are Native American or who have Down syndrome.[4] OME frequently occurs following AOM and may be related to viral upper respiratory infections, irritants such as smoke, or allergies.[2][4] Looking at the eardrum is important for making the correct diagnosis.[5] Signs of AOM include bulging or a lack of movement of the tympanic membrane from a puff of air.[3][6] New discharge not related to otitis externa also indicates the diagnosis.[3]
A number of measures decrease the risk of otitis media including pneumococcal and influenza vaccination, exclusive breastfeeding for the first six months of life, and avoiding tobacco smoke.[3] The use of pain medications for AOM is important.[3] This may include paracetamol (acetaminophen), ibuprofen, benzocaine ear drops, or opioids.[3] In AOM, antibiotics may speed recovery but may result in side effects.[7] Antibiotics are often recommended in those with severe disease or under two years old. In those with less severe disease they may only be recommended in those who do not improve after two or three days.[6] The initial antibiotic of choice is typically amoxicillin. In those with frequent infections tympanostomy tubes may decrease recurrence.[3] In children with otitis media with effusion antibiotics may increase resolution of symptoms, but may cause diarrhoea, vomiting and skin rash.[8]
Worldwide AOM affect about 11% of people a year (about 325 to 710 million cases).[9][10] Half the cases involve children less than five years of age and it is more common among males.[4][9] Of those affected about 4.8% or 31 million develop chronic suppurative otitis media.[9] Before the age of ten OME affects about 80% of children at some point.[4] Otitis media resulted in 2,400 deaths in 2013 – down from 4,900 deaths in 1990.[11]
Contents
- 1 Signs and symptoms
- 2 Causes
- 3 Diagnosis
- 3.1 Acute otitis media
- 3.2 Otitis media with effusion
- 3.3 Chronic suppurative otitis media
- 3.4 Adhesive otitis media
- 4 Prevention
- 5 Management
- 5.1 Antibiotics
- 5.2 Tympanostomy tube
- 5.3 Alternative medicine
- 6 Outcomes
- 6.1 Membrane rupture
- 6.2 Hearing loss
- 7 Epidemiology
- 8 Etymology
- 9 References
- 10 External links
Signs and symptoms
Otitis media.
An integral symptom of acute otitis media is ear pain; other possible symptoms include fever, and irritability (in infants). Since an episode of otitis media is usually precipitated by an upper respiratory tract infection (URTI), there often are accompanying symptoms like cough and nasal discharge.[12]
Discharge from the ear can be caused by acute otitis media with perforation of the ear drum, chronic suppurative otitis media, tympanostomy tube otorrhea, or acute otitis externa. Trauma, such as a basilar skull fracture, can also lead to discharge from the ear due to cerebral spinal drainage from the brain and its covering (meninges).
Causes
The common cause of all forms of otitis media is dysfunction of the Eustachian tube.[13] This is usually due to inflammation of the mucous membranes in the nasopharynx, which can be caused by a viral URI, strep throat, or possibly by allergies.[14] Because of the dysfunction of the Eustachian tube, the gas volume in the middle ear is trapped and parts of it are slowly absorbed by the surrounding tissues, leading to negative pressure in the middle ear. Eventually the negative middle-ear pressure can reach a point where fluid from the surrounding tissues is sucked in to the middle ear's cavity (tympanic cavity), causing a middle-ear effusion. This is seen as a progression from a Type A tympanogram to a Type C to a Type B tympanogram.
By reflux or aspiration of unwanted secretions from the nasopharynx into the normally sterile middle-ear space, the fluid may then become infected — usually with bacteria. The virus that caused the initial URI can itself be identified as the pathogen causing the infection.[14]
Diagnosis
Perforation of the right tympanic membrane resulting from a previous severe acute otitis media
As its typical symptoms overlap with other conditions, such as acute external otitis, clinical history alone is not sufficient to predict whether acute otitis media is present; it has to be complemented by visualization of the tympanic membrane.[15][16] Examiners use a pneumatic otoscope with a rubber bulb attached to assess the mobility of the tympanic membrane.
Acute otitis media in children with moderate to severe bulging of the tympanic membrane or new onset of otorrhea (drainage) is not due to external otitis. Also, the diagnosis may be made in children who have mild bulging of the ear drum and recent onset of ear pain (less than 48 hours) or intense erythema (redness) of the ear drum.
To confirm the diagnosis, middle-ear effusion and inflammation of the eardrum have to be identified; signs of these are fullness, bulging, cloudiness and redness of the eardrum.[12] It is important to attempt to differentiate between acute otitis media and otitis media with effusion (OME), as antibiotics are not recommended for OME.[12] It has been suggested that bulging of the tympanic membrane is the best sign to differentiate AOM from OME.[17]
Viral otitis may result in blisters on the external side of the tympanic membrane, which is called bullous myringitis (myringa being Latin for "eardrum").[18]
However, sometimes even examination of the eardrum may not be able to confirm the diagnosis, especially if the canal is small. If wax in the ear canal obscures a clear view of the eardrum it should be removed using a blunt cerumen curette or a wire loop. Also, an upset young child's crying can cause the eardrum to look inflamed due to distension of the small blood vessels on it, mimicking the redness associated with otitis media.
Acute otitis media
The most common bacteria isolated from the middle ear in AOM are Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis,[12] and Staphylococcus aureus.[19]
Otitis media with effusion
Otitis media with effusion (OME), also known as serous otitis media (SOM) or secretory otitis media (SOM), and commonly referred to as glue ear,[20] is a collection of effusion (fluid) that occurs in the middle-ear space due to the negative pressure produced by dysfunction of the Eustachian tube. This can occur purely from a viral URI or bacterial infection, or it can precede and/or follow acute bacterial otitis media.[21] Fluid in the middle ear frequently causes conductive hearing impairment but only when it interferes with the normal vibration of the eardrum by sound waves. Over weeks and months, middle-ear fluid can become very thick and glue-like, which increases the likelihood of its causing conductive hearing impairment.
Early-onset OME is associated with feeding of infants while lying down, early entry into group child care, parental smoking, lack, or too short a period of breastfeeding and greater amounts of time spent in group child care, particularly those with a large number of children, increases the incidences and duration of OME in the first two years of life.[22]
Chronic suppurative otitis media
Chronic suppurative otitis media, incorrectly called chronic otitis media or chronic ear infection, involves a hole in the tympanic membrane and active bacterial infection within the middle-ear space for several weeks or more. There may be enough pus that it drains to the outside of the ear (otorrhea), or the pus may be minimal enough to only be seen on examination using the otoscope or, more effectively, with a binocular microscope. This disease is much more common in persons with poor Eustachian tube function and very common in certain races such as Native North Americans. Hearing impairment often accompanies this disease.
It is a primary cause of hearing loss that newly develops in children. An ear wick may be effective or, if not, antibiotics.[23]
Adhesive otitis media
Adhesive otitis media occurs when a thin retracted ear drum becomes sucked into the middle-ear space and stuck (i.e., adherent) to the ossicles and other bones of the middle ear.
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Acute otitis media
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Acute otitis media, myringitis bullosa
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Myringitis bullosa in influenza
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Chronic otitis media (otitis media chronica mesotympanalis)
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Otitis media chronica mesotympanalis
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Otitis media chronica mesotympanalis
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Otitis media chronica mesotympanalis
Prevention
Long-term antibiotics, while they decrease rates of infection during treatment, have an unknown effect on long-term outcomes such as hearing loss.[24] This method of prevention has been associated with emergence of antibiotic-resistant otitic bacteria. They are thus not recommended.[12]
Pneumococcal conjugate vaccines when given during infancy decrease rates of acute otitis media by 6%–7% and, if implemented broadly, would have a significant public health benefit.[12][25][needs update] Influenza vaccine is recommended annually.[12]
Risk factors such as season, allergy predisposition and presence of older siblings are known to be determinants of recurrent otitis media and persistent middle-ear effusions (MEE).[26] History of recurrence, environmental exposure to tobacco smoke, use of daycare, and lack of breastfeeding have all been associated with increased risk of development, recurrence, and persistent MEE.[27][28] Thus, cessation of smoking in the home should be encouraged, daycare attendance should be avoided or daycare facilities with the fewest attendees should be recommended, and breastfeeding should be promoted.[27][28]
There is some evidence that breastfeeding for the first year of life is associated with a reduction in the number and duration of OM infections.[29][30] Pacifier use, on the other hand, has been associated with more frequent episodes of AOM.[31]
Evidence does not support zinc supplementation as an effort to reduce otitis rates except maybe in those with severe malnutrition such as marasmus.[32]
Management
Oral and topical pain killers are effective to treat the pain caused by otitis media. Oral agents include ibuprofen, paracetamol (acetaminophen), and opiates. Topical agents shown to be effective include antipyrine and benzocaine ear drops.[33] Decongestants and antihistamines, either nasal or oral, are not recommended due to the lack of benefit and concerns regarding side effects.[34] Half of cases of ear pain in children resolve without treatment in three days and 90% resolve in seven or eight days.[35] The use of steroids is not supported by the evidence for acute otitis media.[36]
Antibiotics
It is important to weigh the benefits and harms before using antibiotics for acute otitis media. As over 80% of acute episodes settle without treatment, about 20 children must be treated to prevent one case of ear pain, 33 children to prevent one perforation, and 11 children to prevent one opposite-side ear infection. For every 14 children treated with antibiotics, one child has an episode of either vomiting, diarrhea or a rash.[37][needs update] If pain is present, treatment to reduce it should be initiated.
- Antibiotics should be prescribed for severe bilateral or unilateral disease in all infants and children with severe signs and symptoms, such as moderate to severe ear pain and high fever.
- For bilateral acute otitis media in infants younger than 24 months of age, without severe signs and symptoms, antibiotics should be prescribed.
- When non-severe unilateral acute otitis media is diagnosed in young children either antibiotic therapy is given or observation with close follow-up based on joint decision making between parent(s)/caregiver in infants 6 to 23 months of age. If the child worsens or fails to improve in 2 to 3 days antibiotics should be administered.
- Children 24 months or older with non-severe disease can have either antibiotics or observation.
The first line antibiotic treatment, if warranted, is amoxicillin.[12] If there is resistance or use of amoxicillin in the last 30 days then amoxicillin-clavulanate or another penicillin derivative plus beta lactamase inhibitor is recommended.[12] Taking amoxicillin once a day may be as effective as twice[38] or three times a day. While less than 7 days of antibiotics have less side effects, more than seven days appear to be more effective.[39] If there is no improvement after 2–3 days of treatment a change in therapy may be considered.[12]
A treatment option for chronic suppurative otitis media with discharge is topical antibiotics. A Cochrane review found that topical quinolone antibiotics can improve discharge better than oral antibiotics.[40] Safety is not really clear.[40]
Tympanostomy tube
Tympanostomy tubes (also called "grommets") are recommended in those people who have three or more episodes of acute otitis media in 6 months or four or more in a year, with at least one episode or more attacks in the preceding 6 months.[12] In chronic cases with effusions, insertion of tympanostomy tube into the eardrum reduces recurrence rates in the 6 months after placement[41] but has little effect on long-term hearing.[42] A common complication of having a tympanostomy tube is otorrhea, which is a discharge from the ear.[43]
Oral antibiotics should not be used to treat uncomplicated acute tympanostomy tube otorrhea.[43] Oral antibiotics are not a sufficient response to bacteria that cause this condition and have significant side effects including increased risk of opportunistic infection.[43] In contrast, topical antibiotic eardrops can treat this condition.[43]
Alternative medicine
Complementary and alternative medicine is not recommended for otitis media with effusion because there is no evidence of benefit.[21] An osteopathic manipulation technique called the Galbreath technique[44] was evaluated in one randomized controlled clinical trial; one reviewer concluded that it was promising, but a 2010 evidence report found the evidence inconclusive.[45]
Outcomes
Disability-adjusted life year for otitis media per 100,000 inhabitants in 2004.
|
no data
< 10
10-14
14-18
18-22
22-26
26-30
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30-34
34-38
38-42
42-46
46-50
> 50
|
Deaths from otitis media per million persons in 2012
0-0
1-1
2-4
Complications of acute otitis media consists of perforation of the ear drum, infection of the mastoid space behind the ear (mastoiditis), and more rarely intracranial complications can occur, such as bacterial meningitis, brain abscess, or dural sinus thrombosis.[46] It is estimated that each year 21,000 people die due to complications of otitis media.[47]
Membrane rupture
In severe or untreated cases, the tympanic membrane may perforate, allowing the pus in the middle-ear space to drain into the ear canal. If there is enough, this drainage may be obvious. Even though the perforation of the tympanic membrane suggests a highly painful and traumatic process, it is almost always associated with a dramatic relief of pressure and pain. In a simple case of acute otitis media in an otherwise healthy person, the body's defenses are likely to resolve the infection and the ear drum nearly always heals. An option for severe acute otitis media in which analgesics are not controlling ear pain is to perform a tympanocentesis, i.e., needle aspiration through the tympanic membrane to relieve the ear pain and to identify the causative organism(s).
Hearing loss
Children with recurrent episodes of acute otitis media and those with otitis media with effusion or chronic suppurative otitis media have higher risks of developing conductive and sensorineural hearing loss. Globally approximately 141 million people have mild hearing loss due to otitis media (2.1% of the population).[48] This is more common in males (2.3%) than females (1.8%).[48]
This hearing loss is mainly due to fluid in the middle ear or rupture of the tympanic membrane. Prolonged duration of otitis media is associated with ossicular complications and, together with persistent tympanic membrane perforation, contributes to the severity of the disease and hearing loss. When a cholesteatoma or granulation tissue is present in the middle ear, the degree of hearing loss and ossicular destruction is even greater.[49]
Periods of conductive hearing loss from otitis media may have a detrimental effect on speech development in children.[50] Some studies have linked otitis media to learning problems, attention disorders, and problems with social adaptation.[51] Furthermore, it has been demonstrated that patients with otitis media have more depression/anxiety-related disorders compared to individuals with normal hearing.[52] Once the infections resolve and hearing thresholds return to normal, childhood otitis media may still cause minor and irreversible damage to the middle ear and cochlea.[53]
Epidemiology
Acute otitis media is very common in childhood. It is the most common condition for which medical care is provided in children under five years of age in the US.[14] Acute otitis media affects 11% of people each year (709 million cases) with half occurring in those below five years.[47] Chronic suppurative otitis media affects about 5% or 31 million of these cases with 22.6% of cases occurring annually under the age of five years.[47] Otitis media resulted in 2,400 deaths in 2013 — down from 4,900 deaths in 1990.[11]
Etymology
Otitis media is Latin for "inflammation of the middle ear".
References
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- ^ a b c "Ear Infections". cdc.gov. September 30, 2013. Retrieved 14 February 2015.
- ^ a b c d e f g Lieberthal, AS; Carroll, AE; Chonmaitree, T; Ganiats, TG; Hoberman, A; Jackson, MA; Joffe, MD; Miller, DT; Rosenfeld, RM; Sevilla, XD; Schwartz, RH; Thomas, PA; Tunkel, DE (March 2013). "The diagnosis and management of acute otitis media.". Pediatrics. 131 (3): e964–99. doi:10.1542/peds.2012-3488. PMID 23439909.
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- ^ Coker, TR; Chan, LS; Newberry, SJ; Limbos, MA; Suttorp, MJ; Shekelle, PG; Takata, GS (17 November 2010). "Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review.". JAMA. 304 (19): 2161–9. doi:10.1001/jama.2010.1651. PMID 21081729.
- ^ a b "Otitis Media: Physician Information Sheet (Pediatrics)". cdc.gov. November 4, 2013. Retrieved 14 February 2015.
- ^ Venekamp, RP; Sanders, SL; Glasziou, PP; Del Mar, CB; Rovers, MM (23 June 2015). "Antibiotics for acute otitis media in children.". The Cochrane database of systematic reviews. 6: CD000219. doi:10.1002/14651858.CD000219.pub4. PMID 26099233.
- ^ Venekamp, RP; Burton, MJ; van Dongen, TM; van der Heijden, GJ; van Zon, A; Schilder, AG (12 June 2016). "Antibiotics for otitis media with effusion in children.". The Cochrane database of systematic reviews (6): CD009163. PMID 27290722.
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- ^ a b Macfadyen, CA; Acuin, JM; Gamble, C (Jan 25, 2006). "Systemic antibiotics versus topical treatments for chronically discharging ears with underlying eardrum perforations.". The Cochrane database of systematic reviews (1): CD005608. doi:10.1002/14651858.CD005608. PMID 16437533.
- ^ McDonald S, Langton Hewer CD, Nunez DA (2008). McDonald S, ed. "Grommets (ventilation tubes) for recurrent acute otitis media in children". Cochrane Database Syst Rev (4): CD004741. doi:10.1002/14651858.CD004741.pub2. PMID 18843668.
- ^ Browning GG, Rovers MM, Williamson I, Lous J, Burton MJ (2010). Browning GG, ed. "Grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children". Cochrane Database Syst Rev (10): CD001801. doi:10.1002/14651858.CD001801.pub3. PMID 20927726.
- ^ a b c d American Academy of Otolaryngology – Head and Neck Surgery, "Five Things Physicians and Patients Should Question" (PDF), Choosing Wisely: an initiative of the ABIM Foundation, American Academy of Otolaryngology – Head and Neck Surgery, retrieved August 1, 2013 , which cites
- Rosenfeld, R. M.; Schwartz, S. R.; Pynnonen, M. A.; Tunkel, D. E.; Hussey, H. M.; Fichera, J. S.; Grimes, A. M.; Hackell, J. M.; Harrison, M. F.; Haskell, H.; Haynes, D. S.; Kim, T. W.; Lafreniere, D. C.; LeBlanc, K.; Mackey, W. L.; Netterville, J. L.; Pipan, M. E.; Raol, N. P.; Schellhase, K. G. (2013). "Clinical Practice Guideline: Tympanostomy Tubes in Children". Otolaryngology -- Head and Neck Surgery. 149 (1 Suppl): S1–S35. doi:10.1177/0194599813487302. ISSN 0194-5998. PMID 23818543.
- ^ Pratt-Harrington D (October 2000). "Galbreath technique: a manipulative treatment for otitis media revisited". J Am Osteopath Assoc. 100 (10): 635–9. PMID 11105452.
- ^ Bronfort G, Haas M, Evans R, Leininger B, Triano J (2010). "Effectiveness of manual therapies: the UK evidence report". Chiropr Osteopat. 18 (1): 3. doi:10.1186/1746-1340-18-3. PMC 2841070. PMID 20184717.
- ^ Jung, TT; Alper, CM; Hellstorm, SO; Hunter, LL; Casselbrant, ML; Groth, A; Kemaloglu, YK; Kim, SG; Lim, D; Nittrourer, S; Park, KH; Sabo, D; Sprately, J (April 2013). "Panel 8: Complications and sequelae". Otolaryngol Head Neck Surg. 148 (4 Suppl): E122–43. doi:10.1177/0194599812467425. PMID 23536529.
- ^ a b c Monasta, L; Ronfani, I; Marchetti, F; Montico, M; Vrecchi-Brunetti, L; Bavcar, A; Grasso, D; Barbiero, C; Tamburlini, G (April 30, 2012). "Burden of disease caused by otitis media: systematic review and global estimates". PLoS ONE. 7 (4): e36226. doi:10.1371/journal.pone.0036226. PMC 3340347. PMID 22558393.
- ^ a b Vos, T; Flaxman, A. D.; Naghavi, M; Lozano, R; Michaud, C; Ezzati, M; Shibuya, K; Salomon, J. A.; Abdalla, S; Aboyans, V; Abraham, J; Ackerman, I; Aggarwal, R; Ahn, S. Y.; Ali, M. K.; Alvarado, M; Anderson, H. R.; Anderson, L. M.; Andrews, K. G.; Atkinson, C; Baddour, L. M.; Bahalim, A. N.; Barker-Collo, S; Barrero, L. H.; Bartels, D. H.; Basáñez, M. G.; Baxter, A; Bell, M. L.; Benjamin, E. J.; et al. (Dec 15, 2012). "Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet. 380 (9859): 2163–96. doi:10.1016/S0140-6736(12)61729-2. PMID 23245607.
- ^ Da Costa SS; Rosito, Letícia Petersen Schmidt; Dornelles, Cristina (February 2009). "Sensorineural hearing loss in patients with chronic otitis media". Eur Arch Otorhinolaryngol. 266 (2): 221–4. doi:10.1007/s00405-008-0739-0. PMID 18629531.
- ^ Roberts K (June 1997). "A preliminary account of the effect of otitis media on 15-month-olds' categorization and some implications for early language learning". J Speech Lang Hear Res. 40 (3): 508–18. doi:10.1044/jslhr.4003.508. PMID 9210110.
- ^ Bidadi S, Nejadkazem M, Naderpour M (November 2008). "The relationship between chronic otitis media-induced hearing loss and the acquisition of social skills". Otolaryngol Head Neck Surg. 139 (5): 665–70. doi:10.1016/j.otohns.2008.08.004. PMID 18984261.
- ^ Gouma P, Mallis A, Daniilidis V, Gouveris H, Armenakis N, Naxakis S (January 2011). "Behavioral trends in young children with conductive hearing loss: a case-control study". Eur Arch Otorhinolaryngol. 268 (1): 63–6. doi:10.1007/s00405-010-1346-4. PMID 20665042.
- ^ Yilmaz S, Karasalihoglu AR, Tas A, Yagiz R, Tas M (February 2006). "Otoacoustic emissions in young adults with a history of otitis media". J Laryngol Otol. 120 (2): 103–7. doi:10.1017/S0022215105004871. PMID 16359151.
External links
| Wikimedia Commons has media related to Otitis media. |
- Neff MJ (June 2004). "AAP, AAFP, AAO-HNS release guideline on diagnosis and management of otitis media with effusion". Am Fam Physician. 69 (12): 2929–31. PMID 15222658.
- Secretory otitis media (Ear disorder) at Encyclopædia Britannica
- Otitis media (Pathology) at Encyclopædia Britannica
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UpToDate Contents
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- 1. 成人における急性中耳炎（化膿性および漿液性） acute otitis media in adults suppurative and serous
- 2. 小児における急性中耳炎：治療 acute otitis media in children treatment
- 3. 小児における急性中耳炎：診断 acute otitis media in children diagnosis
- 4. 成人における慢性中耳炎 chronic otitis media in adults
- 5. 小児における急性中耳炎：疫学、微生物学、臨床症状、および合併症 acute otitis media in children epidemiology microbiology clinical manifestations and complications
English Journal
- Divergent expression of α-ENaC in middle ear mucosa in the course of otitis media with effusion induced by barotrauma.
- Xu J1, Zong Y, Li X, Zhang Y, Li J.
- Acta oto-laryngologica.Acta Otolaryngol.2015 Jul;135(7):651-4. doi: 10.3109/00016489.2015.1017888. Epub 2015 Apr 14.
- CONCLUSION: Gene transcription and protein expression of α-ENaC showed a divergent expression in association with the development of OME induced by barotrauma.OBJECTIVES: ENaC was identified to mediate the fluid absorption through epithelia of the middle ear. This study was designed to investigate
- PMID 25873260
- Clinical and audiological findings in children with acute otitis media.
- Kostić M1, Ribarić Jankes K, Trotić R, Ries M, Ledić B, Bedeković V.
- Acta oto-laryngologica.Acta Otolaryngol.2015 Jul;135(7):645-50. doi: 10.3109/00016489.2015.1017887. Epub 2015 Apr 14.
- CONCLUSION: It is recommended to perform follow-up tympanometry and if necessary tonal audiometry in children who have normal plain otoscopy findings after recovering from acute otitis media (AOM). Children with Type B tympanogram, 3 months following the onset of AOM, are very likely to have a condu
- PMID 25873182
- The chorda tympani degenerates during chronic otitis media: an electron microscopy study.
- Berling K1, Mannström P, Ulfendahl M, Danckwardt Lillieström N, von Unge M.
- Acta oto-laryngologica.Acta Otolaryngol.2015 Jun;135(6):542-8. doi: 10.3109/00016489.2014.999875. Epub 2015 Feb 26.
- CONCLUSION: Chorda tympani nerve specimens from ears with chronic inflammatory middle ear disease exhibit structural signs of degeneration. These correlate well with taste disturbance. Simultaneously, they exhibit signs of regeneration, which may explain the ability for taste recovery.OBJECTIVES: Th
- PMID 25719908
Japanese Journal
- 小児急性中耳炎診療ガイドライン
- 片岡 祐子,西﨑 和則
- 岡山医学会雑誌 126(3), 241-243, 2014-12-01
- NAID 120005525329
- 耳鼻科シリーズ 小児急性中耳炎診療ガイドライン
- 片岡 祐子,西﨑 和則
- 岡山医学会雑誌 126(3), 241-243, 2014-12
- NAID 40020294260
- 滲出性中耳炎と混合性難聴で発見された節外性ホジキンリンパ腫例
- 丸山 裕美子,塚田 弥生,笠原 善弥 [他]
- 耳鼻咽喉科臨床 107(12), 957-963, 2014-12
- NAID 40020284994
Related Links
- Complications of acute otitis media consists of perforation of the ear drum, infection of the mastoid space behind the ear (mastoiditis), and more rarely intracranial complications can occur, such as bacterial meningitis, brain abscess, or ...
- otitis media 《病理》中耳炎 - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。 ... 《病理》慢性耳管鼓室化膿性中耳炎 ｛まんせい じか ...
Related Pictures
★リンクテーブル★
| リンク元 | 「Streptococcus pneumoniae」「Haemophilus influenzae」「中耳炎」「middle ear infection」「ot」 |
| 関連記事 | 「media」「med」 |
「Streptococcus pneumoniae」
- first aid step1 2006 p.134,138
細菌学
- グラム陽性球菌
- 西洋槍(ランセット)型の双球菌
- α溶血性。ランスフィールド分類には分類されない
- オプトヒン感受性
- 自己融解 autolysis ← 培養しすぎに注意
- 中心部の陥凹した集落
- 莢膜多糖体を有する ← 抗食菌作用(C3bの付着に抵抗する)
- IgA proteaseを分泌
- 健常人の5-250%の気道に存在するが莢膜がない弱毒の株
感染症
- 肺炎(大葉性肺炎)
- 慢性気道感染症の急性増悪
- 中耳炎、心内膜炎、関節炎、腹膜炎、軟部組織の炎症(SMB.248)
- 髄膜炎(化膿性髄膜炎)
- 敗血症：sickle cell anemia, splenectomy
易感染性宿主
- 2歳以下の乳幼児や老人で重症化しやすい
- 脾臓を受けた患者、急性骨髄性白血病、骨髄移植、HIV感染症で発症しやすい
most common cause of:
MOPS are Most OPtochin Sensitive
診断
- 臨床像から疑い、胸部X線、喀痰のグラム染色、尿中抗原を行う。グラム染色と尿中抗原が陽性であれば特異的な治療を開始する。 (IRE.1010)
- (経験的治療の前に？)診断及び感受性検査のために喀痰培養、血液培養検査を行う。
参考
- 光顕像
USMLE
- Q book p.192 29
「Haemophilus influenzae」
生物的特徴
- グラム陰性桿菌
- パスツレラ科ヘモフィルス属
- 莢膜を有し、血清型はb型である。
- 発育因子として、X因子(プロトポルフィリンIX or プロトヘム) and/or V因子(NAD or NADP)が必要
- 病原因子は莢膜(抗貪食作用)とIgAプロテアーゼ(IgAを分解)が特徴的である。
- PBPの変異による耐性菌(BLNAR, β-lactamase negative ampicillin-resistant Haemophilus)が出現している
感染症
- 続いて敗血症や閉塞性喉頭炎も引き起こす。
血清型と疾患(SMB.191)
- 莢膜型を有するS型菌(b型)
- 髄膜炎菌、結膜炎、喉頭炎、関節炎
- 非莢膜型を有しないR型菌
- 中耳炎、副鼻腔炎、気管支炎
疫学
潜伏期間
感染経路
- 飛沫感染
症状
合併症
経過
治療
検査
培養
予防
- ヒブワクチンの接種
「中耳炎」
- ラ
- otitis media, OM
中耳炎
「middle ear infection」
「ot」
- comb form
- 「耳」の意
「media」
- n.
「med」
- n.