nitrazepam

ニトラゼパム


Mogadon

 

WordNet

  1. a hypnotic and sedative drug of the benzodiazepine type

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/11/07 16:25:36」(JST)

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English Journal

  • Risk factors for excessive benzodiazepine use in a working age population: a nationwide 5-year survey in Norway.
  • Fride Tvete I1, Bjørner T2, Skomedal T3.
  • Scandinavian journal of primary health care.Scand J Prim Health Care.2015 Dec;33(4):252-9. doi: 10.3109/02813432.2015.1117282.
  • OBJECTIVE: To identify risk factors for becoming an excessive user over time.SETTING: Prescription database study over five years.SUBJECTS AND METHOD: Norwegians between 30 and 60 years with a first dispensation of a benzodiazepine during 2006, encompassing 23 227 individuals. A Cox hazard regressio
  • PMID 26683285
  • The Incidence of Benzodiazepine and Related Drug Use in Persons with and without Alzheimer's Disease.
  • Saarelainen L1,2, Taipale H1,2,3, Koponen M1,2, Tanskanen A4,5,6, Tolppanen AM2,3, Tiihonen J4,6, Hartikainen S1,2.
  • Journal of Alzheimer's disease : JAD.J Alzheimers Dis.2015 Oct 17;49(3):809-18. doi: 10.3233/JAD-150630.
  • BACKGROUND: Benzodiazepines and related drugs (BZDR) are occasionally used to treat certain symptoms of Alzheimer's disease (AD). However, the risks related to BZDR use are high in older persons. Although frequent BZDR use has been reported in persons with AD, no previous study has focused specifica
  • PMID 26484930
  • The Effects of Lithium Carbonate Supplemented with Nitrazepam on Sleep Disturbance during Cannabis Abstinence.
  • Allsop DJ1,2,3, Bartlett DJ4, Johnston J5, Helliwell D6, Winstock A7, McGregor IS1, Lintzeris N2,3.
  • Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.J Clin Sleep Med.2015 Oct 15;11(10):1153-62. doi: 10.5664/jcsm.5090.
  • STUDY OBJECTIVE: Sleep disturbance is a hallmark feature of cannabis withdrawal. In this study we explored the effects of lithium treatment supplemented with nitrazepam on objective and subjective measures of sleep quality during inpatient cannabis withdrawal.METHODS: Treatment-seeking cannabis-depe
  • PMID 26285109

Japanese Journal

  • Notable Pink Excreta and Severe Myocardial Suppression in Superwarfarin (difethialone) Intoxication
  • Kamijo Yoshito,Sato Chie,Yoshimura Kuniko,Soma Kazui
  • Internal Medicine 50(22), 2819-2822, 2011
  • … A 57-year-old woman ingested red-dyed pellets of anticoagulant rodenticide containing difethialone and warfarin as well as tablets of nitrazepam. …
  • NAID 130001288672
  • 薬物分析検査 ベンゾジアゼピン系薬物(クロナゼパム,ニトラゼパム,ジアゼパム) (広範囲 血液・尿化学検査 免疫学的検査(第7版・2)その数値をどう読むか) -- (生化学的検査(2))

Related Links

Nitrazepam is sometimes used for refractory epilepsies. However, long term prophylactic treatment of epilepsy has considerable drawbacks. Most importantly the loss of antiepileptic effects due to tolerance which renders prolonged nitrazepam ...



★リンクテーブル★
リンク元ベンゾジアゼピン系薬物」「ニトラゼパム

ベンゾジアゼピン系薬物」

  [★]

benzodiazepine
セロトニン受容体作動薬

特徴

睡眠薬

  • 大脳辺縁系視床下部の抑制に基づく抗不安作用、抗緊張作用によるものであり、自然の睡眠に近い。つまり睡眠パターンをさほど変えない。

抗不安薬

作用機序

  • GABAA受容体のαサブユニットに結合し、Cl-の透過性を更新させる

副作用

睡眠薬

トリアゾラム
ミダゾラム:血漿半減期t1/2=1.9hr
  • 作用時間の長い薬剤を使用した場合、翌日のふらつき、薬効の持ち越しを起こしやすい
ジアゼパム:血漿半減期t1/2=43hr

離脱症候群

ICU.780
  • 長期連用後の中止により生じる。
  • 症状:不安、興奮、失見当識、高血圧、頻脈、幻覚、痙攣

相互作用

ベンゾジアゼピン系誘導体

拮抗薬

ベンゾジアゼピン系薬の切り替え方法

  • NaSSa:レメロン
  • デジレル:抗うつ薬。HT2A blockerが強い。セトロニン債取り込みを阻害。抗ヒスタミン薬強くない。体重増加は軽度。ノルアドレナリン濃度は増加させない。
  • ジプレキサ:抗セロトニン作用、抗ドパミン作用。

ニトラゼパム」

  [★]

nitrazepam NZP
nitrazepamum
ネルボンベンザリンカルスミンチスボンネルロレンノイクロニックヒルスカミン


  • 麻酔前投薬
  • 抗てんかん薬
  • 中間型

作用機序

  • GABAA受容体のαサブユニットに結合し、GABAの作用を増強する→Cl-の透過↑