midazolam

ミダゾラム

Versed

 

WordNet

  1. an injectable form of benzodiazepine (trade name Versed) useful for sedation and for reducing pain during uncomfortable medical procedures (同)Versed

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2018/10/22 07:35:02」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

  • Nicotine-like discriminative stimulus effects of acetylcholinesterase inhibitors and a muscarinic receptor agonist in Rhesus monkeys.
  • Moerke MJ, McMahon LR.
  • Drug development and industrial pharmacy. 2019 May;45(5)861-867.
  • Acetylcholinesterase (AChE) inhibitors and positive allosteric nicotinic acetylcholine receptor (nAChR) modulators are potential pharmacotherapies for nicotine dependence. Because some smoking cessation aids (e.g. varenicline) appear to work by mimicking the effects of nicotine, we used drug discrim
  • PMID 30712397
  • Description of Continuous Palliative Sedation Practices in a Large Health Region and Comparison with Clinical Practice Guidelines.
  • Abdul-Razzak A, Lemieux L, Snyman M, Perez G, Sinnarajah A.
  • Journal of palliative medicine. 2019 Apr;().
  • Published reports of continuous palliative sedation therapy (CPST) suggest heterogeneity in practice. There is a paucity of reports that compare practice with clinical guidelines. To assess adherence of continuous palliative sedation practices with criteria set forth in local clinical guidelines, an
  • PMID 30939060
  • Influence of anxiolytic premedication on vasovagal reactions and home readiness following outpatient intrathecal anaesthesia-A retrospective analysis.
  • Gebhardt V, Kiefer K, Weiss C, Schmittner MD.
  • Acta anaesthesiologica Scandinavica. 2019 Apr;63(4)468-474.
  • Vasovagal reactions during application of intrathecal anaesthesia (IA) are associated with high anxiety levels. A high percentage of patients undergoing outpatient surgery suffer from anxiety. Anxiolytic premedication in day-surgery is suspected to delay recovery and discharge and is, therefore, not
  • PMID 30511415

Japanese Journal

  • 松本歯科大学病院歯科麻酔科における精神鎮静法症例の検討
  • 村田 賢司,谷山 貴一,丹羽 萌,大野 忠男,隅田 佐知,石田 麻依子,澁谷 徹
  • 松本歯学 38(1), 36-43, 2012-04-30
  • … The agents used for intravenous sedation were midazolam in 887 and flunitrazepam in 856 patients. …
  • NAID 120004631694
  • マウスにおけるケタミンに代わる三種混合麻酔薬の効果について
  • KAWAI Sumiko,TAKAGI Yasuhiro,KANEKO Shiro,KUROSAWA Tsutomu
  • Experimental animals 60(5), 481-487, 2011-10-01
  • … A combination anesthetic (M/M/B: 0.3/4/5) was prepared with 0.3 mg/kg of medetomidine, 4.0 mg/kg of midazolam, and 5.0 mg/kg of butorphanol. …
  • NAID 10029835431

Related Links

Easy to read patient leaflet for midazolam. Includes indications, proper use, special instructions, precautions, and possible side effects. ... How to use midazolam: Use midazolam as directed by your doctor. Check the label on the ...
Midazolam may cause side effects. Tell your child's doctor if any of these symptoms are severe or do not go away: nausea vomiting rash Some side effects can be serious. If your child experiences any of these ...


Related Pictures

midazolam Injection (мидазолам File:Midazolam.svgMidazolam HCl Injection CIVIl midazolam (nome commerciale Ipnovel o  Midazolam Syrup - Oral MIDAZOLAMMidazolam3Dan.gifMidazolam Injection, USPMidazolam



★リンクテーブル★
リンク元ベンゾジアゼピン系薬物」「ミダゾラム

ベンゾジアゼピン系薬物」

  [★]

benzodiazepine
セロトニン受容体作動薬

特徴

睡眠薬

  • 大脳辺縁系視床下部の抑制に基づく抗不安作用、抗緊張作用によるものであり、自然の睡眠に近い。つまり睡眠パターンをさほど変えない。

抗不安薬

作用機序

  • GABAA受容体のαサブユニットに結合し、Cl-の透過性を更新させる

副作用

睡眠薬

トリアゾラム
ミダゾラム:血漿半減期t1/2=1.9hr
  • 作用時間の長い薬剤を使用した場合、翌日のふらつき、薬効の持ち越しを起こしやすい
ジアゼパム:血漿半減期t1/2=43hr

離脱症候群

ICU.780
  • 長期連用後の中止により生じる。
  • 症状:不安、興奮、失見当識、高血圧、頻脈、幻覚、痙攣

相互作用

ベンゾジアゼピン系誘導体

拮抗薬

ベンゾジアゼピン系薬の切り替え方法

  • NaSSa:レメロン
  • デジレル:抗うつ薬。HT2A blockerが強い。セトロニン債取り込みを阻害。抗ヒスタミン薬強くない。体重増加は軽度。ノルアドレナリン濃度は増加させない。
  • ジプレキサ:抗セロトニン作用、抗ドパミン作用。

ミダゾラム」

  [★]

midazolam
ドルミカム

分類

  • 超短時間型睡眠導入薬

構造

適応

副作用

  • 薬物依存、無呼吸、呼吸抑制、舌根沈下、アナフィラキシーショック、心停止、心室頻拍、心室性頻拍、悪性症候群


添付文書

  • ドルミカム注射液10mg
[display]http://www.info.pmda.go.jp/go/pack/1124401A1052_1_06/1124401A1052_1_06?view=body