WordNet

fasten or secure with chains; "Chain the chairs together"
a unit of length
a necklace made by a stringing objects together; "a string of beads"; "a strand of pearls"; (同)string, strand
a linked or connected series of objects; "a chain of daisies"
a series of (usually metal) rings or links fitted into one another to make a flexible ligament
anything that acts as a restraint
(chemistry) a series of linked atoms (generally in an organic molecule) (同)chemical chain
a series of things depending on each other as if linked together; "the chain of command"; "a complicated concatenation of circumstances" (同)concatenation
(business) a number of similar establishments (stores or restaurants or banks or hotels or theaters) under one ownership
connect or arrange into a chain by linking
first in order of importance; "the alpha male in the group of chimpanzees"; "the alpha star in a constellation is the brightest or main star"
the 1st letter of the Greek alphabet
the beginning of a series or sequence; "the Alpha and Omega, the first and the last, the beginning and the end"--Revelations
early testing stage of a software or hardware product; "alpha version"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
British biochemist (born in Germany) who isolated and purified penicillin, which had been discovered in 1928 by Sir Alexander Fleming (1906-1979) (同)Ernst Boris Chain, Sir Ernst Boris Chain

PrepTutorEJDIC

『鎖』;(装飾用の)鎖 / 《複数形で》『束縛』,拘束;囚人をつなぐ鎖 / (物事の)『連続』,つながり《+『of』+『名』》 / (商店・銀行・ホテルなどの)チェーン(一連の店が同一資本のもとで連携して経営される方式;その店) / チェーン(測量で用いられる単位;約21.7m) / …'を'『鎖でつなぐ』《+『up』(『together』)+『名,』+『名』+『up』(『together』)》
アルファ(ギリシア語アルファベットの第1字A,α;英語のA,aに相当) / アルファ星(星座の主星)
〈U〉〈C〉(…の)(量・額などの)不足,欠乏《+『of』(『in』)+『名』》 / 〈C〉不足分,不足量,不足額 / 〈C〉(精神・肉体などの)欠陥
=sense organ / 受信装置

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1. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
2. T-B-NK+ SCID：臨床症状、診断、および治療 t b nk scid clinical manifestations diagnosis and treatment
3. 原発性免疫不全症のための造血細胞移植 hematopoietic cell transplantation for primary immunodeficiency
4. 症候群をきたす免疫不全症 syndromic immunodeficiencies
5. JAK3欠損を伴う重度複合型免疫不全（SCID） severe combined immunodeficiency scid with jak3 deficiency

Lack of IL7Rα expression in T cells is a hallmark of T-cell immunodeficiency in Schimke immuno-osseous dysplasia (SIOD).

Sanyal M1, Morimoto M2, Baradaran-Heravi A3, Choi K2, Kambham N4, Jensen K5, Dutt S5, Dionis-Petersen KY6, Liu LX6, Felix K7, Mayfield C8, Dekel B9, Bokenkamp A10, Fryssira H11, Guillen-Navarro E12, Lama G13, Brugnara M14, Lücke T15, Olney AH16, Hunley TE17, Polat AI18, Yis U18, Bogdanovic R19, Mitrovic K19, Berry S20, Najera L20, Najafian B21, Gentile M22, Nur Semerci C23, Tsimaratos M24, Lewis DB6, Boerkoel CF25.
Clinical immunology (Orlando, Fla.).Clin Immunol.2015 Dec;161(2):355-65. doi: 10.1016/j.clim.2015.10.005. Epub 2015 Oct 21.
Schimke immuno-osseous dysplasia (SIOD) is an autosomal recessive, fatal childhood disorder associated with skeletal dysplasia, renal dysfunction, and T-cell immunodeficiency. This disease is linked to biallelic loss-of-function mutations of the SMARCAL1 gene. Although recurrent infection, due to T-
PMID 26499378

Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.

Lawson BR1, Gonzalez-Quintial R1, Eleftheriadis T1, Farrar MA2, Miller SD3, Sauer K1, McGavern DB4, Kono DH1, Baccala R1, Theofilopoulos AN5.
Clinical immunology (Orlando, Fla.).Clin Immunol.2015 Dec;161(2):260-9. doi: 10.1016/j.clim.2015.08.007. Epub 2015 Aug 25.
IL-7 is known to be vital for T cell homeostasis but has previously been presumed to be dispensable for TCR-induced activation. Here, we show that IL-7 is critical for the initial activation of CD4(+) T cells in that it provides some of the necessary early signaling components, such as activated STA
PMID 26319414

Tumor-Specific Effector CD8+ T Cells That Can Establish Immunological Memory in Humans after Adoptive Transfer Are Marked by Expression of IL7 Receptor and c-myc.

Chandran SS1, Paria BC1, Srivastava AK1, Rothermel LD1, Stephens DJ1, Kammula US2.
Cancer research.Cancer Res.2015 Aug 15;75(16):3216-26. doi: 10.1158/0008-5472.CAN-15-0584. Epub 2015 Jun 22.
The optimal T-cell attributes for adoptive cancer immunotherapy are unclear. Recent clinical trials of ex vivo-expanded tumor-infiltrating lymphocytes indicated that differentiated T effector cells can elicit durable antitumor responses in some patients with cancer, with their antitumor activity tig
PMID 26100671