- n.
WordNet
- distort adversely; "Jealousy had jaundiced his judgment"
- yellowing of the skin and the whites of the eyes caused by an accumulation of bile pigment (bilirubin) in the blood; can be a symptom of gallstones or liver infection or anemia (同)icterus
- affect with, or as if with, jaundice
- type genus of the Icteridae (同)genus Icterus
PrepTutorEJDIC
- 黄疸(おうだん) / ひがみ,ねたみ,偏見 / 〈人〉‘に'偏見をもたせる;〈見解など〉‘を'ゆがめる
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/21 22:33:06」(JST)
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- 1. 黄疸または無症候性高ビリルビン血症患者に対する診断的アプローチ diagnostic approach to the patient with jaundice or asymptomatic hyperbilirubinemia
- 2. 黄疸または無症候性高ビリルビン血症の分類および原因 classification and causes of jaundice or asymptomatic hyperbilirubinemia
- 3. 正期産児および後期早産児における非抱合型高ビリルビン血症の評価 evaluation of unconjugated hyperbilirubinemia in term and late preterm infants
- 4. 正期産児および後期早産児における非抱合型高ビリルビン血症の治療 treatment of unconjugated hyperbilirubinemia in term and late preterm infants
- 5. 新生児における非抱合型高ビリルビン血症の発症機序および病因 pathogenesis and etiology of unconjugated hyperbilirubinemia in the newborn
English Journal
- Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway.
- Qaisiya M1, Coda Zabetta CD2, Bellarosa C3, Tiribelli C4.Author information 1Fondazione Italiana Fegato ONLUS, Italian Liver Foundation ONLUS, Bldg Q AREA Science Park - Basovizza Campus, 34149 Trieste, Italy. Electronic address: m.qaisiya@csf.units.it.2Fondazione Italiana Fegato ONLUS, Italian Liver Foundation ONLUS, Bldg Q AREA Science Park - Basovizza Campus, 34149 Trieste, Italy. Electronic address: carlos.zabetta@csf.units.it.3Fondazione Italiana Fegato ONLUS, Italian Liver Foundation ONLUS, Bldg Q AREA Science Park - Basovizza Campus, 34149 Trieste, Italy. Electronic address: cristina.bellarosa@csf.units.it.4Fondazione Italiana Fegato ONLUS, Italian Liver Foundation ONLUS, Bldg Q AREA Science Park - Basovizza Campus, 34149 Trieste, Italy; Department of Medical Sciences, University of Trieste, 34100 Trieste, Italy. Electronic address: ctliver@csf.units.it.AbstractUnconjugated bilirubin (UCB) is responsible for neonatal jaundice and high level of free bilirubin (Bf) can lead to kernicterus. Previous studies suggest that oxidative stress is a critical component of UCB-induced neurotoxicity. The Nrf2 pathway is a powerful sensor for cellular redox state and is activated directly by oxidative stress and/or indirectly by stress response protein kinases. Activated Nrf2 translocates to nucleus, binds to Antioxidant Response Element (ARE), and enhances the up-regulation of cytoprotective genes that mediate cell survival. The aim of the present study was to investigate the role of Nrf2 pathway in cell response to bilirubin mediated oxidative stress in the neuroblastoma SH-SY5Y cell line. Cells exposed to a toxic concentration of UCB (140nM Bf) showed an increased intracellular ROS levels and enhanced nuclear accumulation of Nrf2 protein. UCB stimulated transcriptional induction of ARE-GFP reporter gene and induced mRNA expression of multiple antioxidant response genes as: xCT, Gly1, γGCL-m, γGCL-c, HO-1, NQO1, FTH, ME1, and ATF3. Nrf2 siRNA decreased UCB induced mRNA expression of HO1 (75%), NQO1 (54%), and FTH (40%). The Nrf2-related HO-1 induction was reduced to 60% in cells pre-treated with antioxidant (NAC) or specific signaling pathway inhibitors for PKC, P38α and MEK1/2 (80, 40 and 25%, respectively). In conclusion, we demonstrated that SH-SY5Y cells undergo an adaptive response against UCB-mediated oxidative stress by activation of multiple antioxidant response, in part through Nrf2 pathway.
- Cellular signalling.Cell Signal.2014 Mar;26(3):512-20. doi: 10.1016/j.cellsig.2013.11.029. Epub 2013 Dec 2.
- Unconjugated bilirubin (UCB) is responsible for neonatal jaundice and high level of free bilirubin (Bf) can lead to kernicterus. Previous studies suggest that oxidative stress is a critical component of UCB-induced neurotoxicity. The Nrf2 pathway is a powerful sensor for cellular redox state and is
- PMID 24308969
- Hepato-biliary-enteric stent drainage as palliative treatment for proximal malignant obstructive jaundice.
- Pan H, Liang Z, Yin TS, Xie Y, Li DW.Author information Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400000, China.AbstractThe proximal malignant obstructive jaundice remains one of the most challenging problems for hepato-biliary surgeons. Particularly when the findings preclude surgical resection at exploration, the next decision seems hard to make. A novel palliative treatment called "hepato-biliary-enteric stent drainage" was designed for these proximal malignant obstructive jaundice patients. Hepato-biliary-enteric stent drainage was performed with silicone tube whose diameter was determined according to the degree of dilated biliary ducts, and the proximal end of the tube was placed to intrahepatic ducts as far as possible, the distal end was placed across the duodenal papilla. Between February 2011 and August 2012, 23 patients with the proximal malignant obstructive jaundice of unresectable tumors at exploration received hepato-biliary-enteric stent drainage. Patient's liver function results, symptoms, complications, and survival time were documented. The bilirubin levels of all 23 patients had a considerable and persistent decrease after operation and remained low or normal before death except for four cases of recurrent jaundice (two resulted from migration of tube and other two resulted from hepatocellular carcinoma extensively involving liver parenchyma). After effective drainage, clinical symptoms of cholangitis such as fever or pain were markedly relieved. No procedure-related bleeding, bile leakage, pancreatitis were observed. The median survival time was 212 days, half-year and 1-year survival rate were 56.5 and 21.7 %, respectively. Hepato-biliary-enteric stent drainage with less expense, less complications, and easy operation may be an ideal option for patients with unresectable malignancy in the hilar region at exploration.
- Medical oncology (Northwood, London, England).Med Oncol.2014 Mar;31(3):853. doi: 10.1007/s12032-014-0853-3. Epub 2014 Jan 24.
- The proximal malignant obstructive jaundice remains one of the most challenging problems for hepato-biliary surgeons. Particularly when the findings preclude surgical resection at exploration, the next decision seems hard to make. A novel palliative treatment called "hepato-biliary-enteric stent dra
- PMID 24464214
- MACEI and MACawake of sevoflurane in infants with obstructive jaundice.
- Chen SQ, Ye HR, Chen YJ, Wang YW.Author information Department of Anesthesiology and Critical Care Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.AbstractBACKGROUND: The aim of this study was to determine whether the MACEI and MACawake of sevoflurane in infants with obstructive jaundice are different from that observed in nonjaundiced infants.
- Paediatric anaesthesia.Paediatr Anaesth.2014 Mar;24(3):282-9. doi: 10.1111/pan.12322. Epub 2013 Dec 11.
- BACKGROUND: The aim of this study was to determine whether the MACEI and MACawake of sevoflurane in infants with obstructive jaundice are different from that observed in nonjaundiced infants.METHODS: Infants scheduled for abdominal surgery were recruited into the study. General anesthesia was induce
- PMID 24330496
Japanese Journal
- Roux-en-Y再建の輸入脚の悪性狭窄部に対する金属ステント留置の経験
- 木田 明彦,松田 耕一郎,平井 聡,島谷 明義,堀田 洋介,平松 活志,松田 充,荻野 英朗,野田 八嗣
- 日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy 53(3), 1109-1116, 2011-03-20
- 膵頭部癌術後Roux-en-Y再建の輸入脚に腹膜転移による狭窄を来たし閉塞性黄疸となった1例を経験した．本例では，ダブルバルーン内視鏡（DBE）を介して挿入したオーバーチューブとガイドワイヤーを用いて10cm×20mmのnoncovered metallic stentを輸入脚狭窄部位に留置することで症状の改善をみた．DBEを用いれば術後再建の輸入脚狭窄に対しても金属ステント留置が可能と思われた．
- NAID 10028053333
- 症例報告 黄疸の猫に対して小建中湯を用いた1例
- 目黒 芳信
- 日本伝統獣医学会誌 19(1), 17-19, 2011
- NAID 40019036308
Related Links
- icterusとは。意味や和訳。[名][U]《病理(学)》黄疸(おうだん)(jaundice). - goo英和辞書は14万項目以上を収録し、発音、音声、慣用句、例文が分かる英和辞書です。
- Icterus definition, jaundice (def 1). See more. Thesaurus Translator Reference Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out Log In follow Dictionary.com Dictionary Thesaurus Translator More... Quotes ...
Related Pictures
★リンクテーブル★
| リンク元 | 「黄疸」「高ビリルビン血症」「icteric」「jaundice」 |
| 拡張検索 | 「nuclear icterus」「icterus gravis neonatorum」 |
「黄疸」
- 基準値：総ビリルビン(TB) 0.2-1.2 mg/dl
- 総ビリルビンが2.0 mg/dl を超えると肉眼的に黄疸が認められる
黄疸の原因 (内科診断学 第2版)
| 間接ビリルビン優位 | 産生過剰 | 網内系赤血球破壊 | 先天性溶血性貧血 |
| 後天性溶血性貧血 | |||
| 血管内溶血 | 発作性夜間血色素尿症 | ||
| 寒冷凝集素症 | |||
| 血液型不適合溶血 | |||
| 血栓性血小板減少性紫斑病 | |||
| 骨髄内無効造血 | シャントビリルビン血症 | ||
| 悪性貧血 | |||
| 肝臓摂取障害 | シャント形成 | 肝硬変 | |
| 抱合障害 | Crigler-Najjar症候群(I,II型) | ||
| Gilbert症候群 | |||
| 直接ビリルビン優位 | 排泄障害 | Rotor症候群 | |
| Dubin-Johnson症候群 | |||
| 肝細胞障害 | 急性肝炎 | ||
| 慢性肝炎 | |||
| 肝硬変 | |||
| 胆管障害 | 肝内胆汁うっ滞 | 原発性胆汁性肝硬変 | |
| 原発性硬化性胆管炎 | |||
| 薬物性胆汁うっ滞 | |||
| 閉塞性黄疸 | |||
- 同
- jaundice
- 同
- 付録16
「高ビリルビン血症」
分類
- 新生児における本症では、皮膚の色は緑がかった生糸路なり、眼球結膜の黄染が目立つ。本症に対して光線療法は禁忌 (SPE.113)
「icteric」
- adj.
- 黄疸の、黄疸性の、黄疸にかかった
「jaundice」