正赤芽球
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/02 06:10:35」(JST)
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An erythroblast is a type of red blood cell which still retains a cell nucleus. It is the immediate precursor of a normal erythrocyte.
Contents
- 1 Nomenclature
- 2 Development
- 3 Additional images
- 4 See also
- 5 External links
Nomenclature
The term normoblast is sometimes used as a synonym for erythroblast, but at other times it is considered a subcategory. In the latter context, there are two types of erythroblasts:
- "normoblasts" - develop as expected
- "megaloblasts" - unusually large erythroblasts that can be associated with vitamin B12 deficiency (as in pernicious anemia) or folic acid deficiency (collectively called megaloblastic anemia)
Development
There are four stages in the development of a normoblast.
A comprehensive diagram of human hematopoiesis
Illustration |
Description |
Image |
|
Pronormoblast |
|
Basophilic normoblast |
|
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Polychromatic normoblast (also polychromatophilic) |
|
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Orthochromatic normoblast (also orthochromatophilic) |
|
Additional images
See also
- Erythropoiesis
- Hemopoiesis
- Pluripotential hemopoietic stem cell
External links
- Normoblasts at the US National Library of Medicine Medical Subject Headings (MeSH)
- Histology image: 01804loa – Histology Learning System at Boston University - "Bone Marrow and Hemopoiesis bone marrow smear, erythroblast series with proerythroblast "
- Histology at uiowa.edu
Myeloid lineage - Blood (WBC and RBC)
|
|
Cellular/
HSCs |
Myeloid/
CFU-GEMM |
CFU-GM |
CFU-G:
Granulocytes |
|
|
CFU-M:
Monocytes/
MPS |
Macrophages |
- Histiocytes
- Kupffer cells
- Alveolar macrophage
- Microglia
- Osteoclasts
- Epithelioid cells
- giant cells
- Langhans giant cells, Foreign-body giant cell
- Touton giant cells
|
|
CFU-DL |
- Dendritic cells
- Langerhans cell
|
|
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Common |
|
|
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CFU-Baso |
|
|
CFU-Eos |
|
|
MEP |
CFU-Meg |
- Megakaryoblast
- Megakaryocyte
- Platelets
|
|
CFU-E |
|
|
|
CFU-Mast |
|
|
|
|
Noncellular |
|
|
Index of cells from bone marrow
|
|
Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
|
|
Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
|
|
Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
|
|
|
Myeloid physiology
|
|
Hematopoiesis |
Myelopoiesis
(CFU-GEMM) |
CFU-GM |
- Granulopoiesis
- Myeloblast
- Promyelocyte
- Myelocyte
- Metamyelocyte
- Band cell
|
|
|
|
|
MEP |
- Thrombopoiesis
- Megakaryoblast
- Promegakaryocyte
|
|
- Erythropoiesis
- Proerythroblast
- Normoblast
- Reticulocyte
|
|
|
|
General |
- Extramedullary hematopoiesis
|
|
|
Hemostasis |
- Coagulation
- Clot retraction
- Platelet adhesiveness
|
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Other |
|
|
Index of cells from bone marrow
|
|
Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
|
|
Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
|
|
Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
|
|
|
UpToDate Contents
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English Journal
- Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells.
- Shin JW, Spinler KR, Swift J, Chasis JA, Mohandas N, Discher DE.SourceMolecular and Cell Biophysics Laboratory, University of Pennsylvania, Philadelphia, PA 19104.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Nov 4. [Epub ahead of print]
- Hematopoietic stem and progenitor cells, as well as nucleated erythroblasts and megakaryocytes, reside preferentially in adult marrow microenvironments whereas other blood cells readily cross the endothelial barrier into the circulation. Because the nucleus is the largest organelle in blood cells, w
- PMID 24191023
- Blood parameters changes in cord blood of newborns of hypertensive mothers.
- Bolat A, Gursel O, Kurekci E, Atay A, Ozcan O.SourceDepartment of Pediatrics, Gulhane Military Medical Academy and Medical Faculty, Ankara, Turkey.
- European journal of pediatrics.Eur J Pediatr.2013 Nov;172(11):1501-9. doi: 10.1007/s00431-013-2072-x. Epub 2013 Jun 29.
- The aim of this study was to investigate the changes in the peripheral blood of newborns of hypertensive mothers. The umbilical cord blood from newborns of 31 hypertensive mothers and 32 healthy mothers were examined. In all subjects, complete blood count, peripheral blood smear, reticulocyte count,
- PMID 23812509
- Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis.
- Satchwell TJ, Pellegrin S, Bianchi P, Hawley BR, Gampel A, Mordue KE, Budnik A, Fermo E, Barcellini W, Stephens DJ, van den Akker E, Toye AM.Sourceash.m.toye@bristol.ac.uk.
- Haematologica.Haematologica.2013 Nov;98(11):1788-96. doi: 10.3324/haematol.2013.085522. Epub 2013 Aug 9.
- Congenital dyserythropoietic anemia type II is an autosomally recessive form of hereditary anemia caused by SEC23B gene mutations. Patients exhibit characteristic phenotypes including multinucleate erythroblasts, erythrocytes with hypoglycosylated membrane proteins and an apparent double plasma memb
- PMID 23935019
Japanese Journal
- Expression of α-hemoglobin stabilizing protein and cellular prion protein in a subclone of murine erythroleukemia cell line MEL
- Otsuka Yayoi,Ito Daisuke,Katsuoka Kayoko,Arashiki Nobuto,Komatsu Tomohiko,Inaba Mutsumi
- Japanese Journal of Veterinary Research 56(2), 75-84, 2008-08-00
- … Moreover, MELhipod8 cells exhibit greater effective erythroid differentiation with a population of hemoglobinized normoblast-like cells than that observed for the parental MEL cells. …
- NAID 120000947262
- Ineffective erythropoiesis in β-thalassemia major is due to apoptosis at the polychromatophilic normoblast stage
- Quantitative Studies on the Effects of Radiophosphorus (P-32) on Bone Marrow of Swiss Albino Mice during Postnatal Development
- KUMAR ASHOK,SRIVASTAVA P.N.
- Journal of Radiation Research 18(4), 280-292, 1977-11-00
- … Animals were autopsied at weekly intervals upto six weeks and quantitative study of pronormoblast, normoblast, granulocyte and lymphocyte counts have been made. …
- NAID 110002325717
Related Links
- normoblast /nor·mo·blast/ (nor´mo-blast) 1. orthochromatic erythroblast. 2. term now often used as a synonym of erythroblast; sometimes more specifically, a nucleated cell in the normal course of erythrocyte maturation, as opposed ...
- normoblast nor·mo·blast (nôr'mə-blāst') n. A nucleated red blood cell, the immediate precursor of a normal red blood cell in humans.
Related Pictures
★リンクテーブル★
[★]
有核赤血球
- 関
- erythroblast、normoblast、nucleated red cell、proerythroblast、pronormoblast
[★]
- 英
- normoblast
- 関
- erythroblast、nucleated erythrocyte、proerythroblast、pronormoblast
[★]
- 英
- normoblast
- 関
- 赤芽球
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前正赤芽球
- 関
- erythroblast、normoblast、nucleated erythrocyte、proerythroblast