WordNet
- being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
- of long duration; "chronic money problems" (同)continuing
- habitual; "a chronic smoker" (同)inveterate
PrepTutorEJDIC
- (病気が)長期にわたる,慢性の / 《名詞の前にのみ用いて》常習の,癖になった
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- 1. 慢性移植片対宿主病の臨床症状、診断、および重症度分類 clinical manifestations diagnosis and grading of chronic graft versus host disease
- 2. 慢性移植片対宿主病の治療 treatment of chronic graft versus host disease
- 3. 移植片対宿主病（GVHD）の皮膚症状 cutaneous manifestations of graft versus host disease gvhd
- 4. 造血細胞移植後のサラセミア患者の長期マネージメント long term management of the thalassemic patient after hematopoietic cell transplantation
- 5. 造血細胞移植レシピエントにおける感染予防 prevention of infections in hematopoietic cell transplant recipients
English Journal
- Case-matched comparison with standard versus reduced intensity conditioning regimen in chronic myeloid leukemia patients.
- Topcuoglu P, Arat M, Ozcan M, Arslan O, Ilhan O, Beksac M, Gurman G.SourceStem Cell Transplantation Unit, Department of Hematology, Faculty of Medicine, Ankara University, Cebeci Campus, 06590, Ankara, Turkey, topcuogl@medicine.ankara.edu.tr.
- Annals of hematology.Ann Hematol.2012 Apr;91(4):577-86. Epub 2011 Oct 5.
- This retrospective case-matched study evaluated the efficacy of reduced intensity conditioning (RIC) regimen on early and late allogeneic transplant outcome in chronic myeloid leukemia (CML) patients. Twenty-eight patients conditioned with RIC regimen were matched to 56 patients who received a myelo
- PMID 21971669
- Inhibition of Cathepsin S Reduces Allogeneic T Cell Priming but Not Graft-versus-Host Disease Against Minor Histocompatibility Antigens.
- Fujii H, Ivison SM, Shimizu H, Kajiwara R, Kariminia A, Yan M, Dutz JP, Schultz KR.SourceDivision of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2012 Apr;18(4):546-56. Epub 2011 Dec 14.
- Cathepsin (Cathepsin) S, L, and B proteases mediate antigen presentation on major histocompatibility complex (MHC) class II by degrading the invariant chain Ii, which blocks peptide loading. The ability of the Cathepsin S inhibitor LHVS (morpholinurea-leucine-homophenylalanine-vinylsulfone phenyl) t
- PMID 22178962
Japanese Journal
- Successful reduced-intensity SCT from unrelated cord blood in three patients with X-linked SCID
- Iguchi Akihiro,Kawamura Nobuaki,Kobayashi Ryoji,Takezaki Shun-ichiro,Ohkura Yuka,Inamoto Jun,Ohshima Junjiro,Ichikawa Mizuho,Sato Tomonobu,Kaneda Makoto,Cho Yuko,Yamada Masafumi,Kobayashi Ichiro,Ariga Tadashi
- Bone Marrow Transplantation 46(12), 1526-1531, 2011-12
- … Only one patients developed acute GVHD grade III, which resolved by increasing the dose of oral corticosteroid. … None of the patients have developed chronic GVHD during the follow up for 21 to 77 months. …
- NAID 120004123464
- Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab
- NISHIDA Sumiyuki,KAWASAKI Tomio,KASHIWAGI Hirokazu,MORISHIMA Atsuyoshi,HISHITANI Yoshihiro,KAWAI Mari,HIRANO Toru,ISHII Taeko,HAGIHARA Keisuke,SHIMA Yoshihito,NARAZAKI Masashi,OGATA Atsushi,OKA Yoshihiro,KISHIMOTO Tadamitsu,TANAKA Toshio
- Modern rheumatology 21(4), 420-422, 2011-08-01
- NAID 10029513073
Related Pictures
★リンクテーブル★
| リンク元 | 「移植片対宿主病」「慢性移植片対宿主病」「chronic graft-versus-host disease」 |
| 関連記事 | 「chronic」「GVHD」「GVH」 |
「移植片対宿主病」
- first aid step1 2006 p.191
概念
移植片 が 宿主 に対して 免疫反応を起こす
- 皮膚(→紅斑)、肝臓(→黄疸)、小腸(→下痢)の障害が起こる
分類
発症時期
- 急性移植片対宿主病 急性GVHD acute GVHD
- 慢性移植片対宿主病 慢性GVHD chronic GVHD
重症度
| GVHDの臨床病期 | ||||
| Stage | 皮膚 | 肝臓(ビリルビン) | 消化管 | |
| + | 斑状丘疹 | 体表の25%以下 | 2-3 mg/dl | 下痢 > 500 ml/day |
| ++ | 斑状丘疹 | 25-50% | 3-6 mg/dl | 下痢 > 1000 ml/day |
| +++ | 全身紅皮症 | 50-75% | 6-15 mg/dl | 下痢 > 1500 ml/day |
| ++++ | 全身紅皮症 | 水疱, 落屑 | >15 mg/dl | 激しい腹痛and/orイレウス |
| GVHDの重症度 | |||
| Grade | 皮膚 | 肝/消化管 | 全身状態 |
| I | + ～ ++ | - ～ - | 問題なし |
| II | + ～ +++ | + and/or + | 軽度の悪化 |
| III | ++ ～ +++ | ++ ～ +++ and/or ++ ～ +++ | 高度の悪化 |
| IV | ++ ～ ++++ | ++ ～ ++++ and ++ ～ ++++ | 極度の悪化 |
メモ
- 再生不良性貧血ではGVHDは起きない方が良いけど、悪性リンパ腫や白血病では起きた方が予後が良いこともある。GVHDが全く起きない場合に、DLI(donor lymphocyte infusion)でGVHDを誘発する治療がある。
USMLE
- Q book p.192 28
「慢性移植片対宿主病」
- PED.172 NDE.133 uptodate.1
- 移植後100日以降に出現。
- 全身の臓器が標的となる。
- 口腔(口内炎、異味感、無味感、異常刺激、乾燥性口内炎、舌の扁平苔癬様変化・びらん・潰瘍)、眼(痒み、充血、涙分泌低下)、皮膚(乾燥、硬化、びらん、潰瘍、扁平苔癬、白斑など)、肝臓(肝臓胆道系酵素上昇)、気道(閉塞性細気管支炎(BO)、器質化肺炎をともなう閉塞性細気管支炎(BOOP)、間質性肺炎)などに症状が出現する
参考
uptodate
国試
「chronic graft-versus-host disease」
「chronic」
- adj.
- 慢性の、慢性的な、慢性型の
「GVHD」
[★] 移植片対宿主病 graft versus host disease
「GVH」
- 同
- graft versus host
- 関