a special situation; "this thing has got to end"; "it is a remarkable thing"
a separate and self-contained entity
an action; "how could you do such a thing?"
an artifact; "how does this thing work?"
an entity that is not named specifically; "I couldnt tell what the thing was"
any attribute or quality considered as having its own existence; "the thing I like about her is ..."
a persistent illogical feeling of desire or aversion; "he has a thing about seafood"; "she has a thing about him"
a special abstraction; "a thing of the spirit"; "things of the heart"
a special objective; "the thing is to stay in bounds"
a statement regarded as an object; "to say the same thing in other terms"; "how can you say such a thing?"
an event; "a funny thing happened on the way to the..."
type genus of the family Cancridae (同)genus Cancer
the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 (同)Cancer the Crab, Crab
(astrology) a person who is born while the sun is in Cancer (同)Crab
a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream (同)malignant neoplastic disease
Cervical cancer is a cancer arising from the cervix.[1] It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body.[11] Early on, typically no symptoms are seen.[1] Later symptoms may include abnormal vaginal bleeding, pelvic pain or pain during sexual intercourse.[1] While bleeding after sex may not be serious, it may also indicate the presence of cervical cancer.[12]
Human papillomavirus infection (HPV) causes more than 90% of cases;[4][5] most people who have had HPV infections, however, do not develop cervical cancer.[2][13] Other risk factors include smoking, a weak immune system, birth control pills, starting sex at a young age and having many sexual partners, but these are less important.[1][3] Cervical cancer typically develops from precancerous changes over 10 to 20 years.[2] About 90% of cervical cancer cases are squamous cell carcinomas, 10% are adenocarcinoma and a small number are other types.[3] Diagnosis is typically by cervical screening followed by a biopsy.[1] Medical imaging is then done to determine whether or not the cancer has spread.[1]
HPV vaccines protect against two-to-seven high-risk strains of this family of viruses and may prevent up to 90% of cervical cancers.[8][14][15] As a risk of cancer still exists, guidelines recommend continuing regular Pap tests.[8] Other methods of prevention include having few or no sexual partners and the use of condoms.[7] Cervical cancer screening using the Pap test or acetic acid can identify precancerous changes which when treated can prevent the development of cancer.[16] Treatment of cervical cancer may consist of some combination of surgery, chemotherapy and radiation therapy.[1] Five-year survival rates in the United States are 68%.[17] Outcomes, however, depend very much on how early the cancer is detected.[3]
Worldwide, cervical cancer is both the fourth most common cause of cancer and the fourth most common cause of death from cancer in women.[2] In 2012, an estimated 528,000 cases of cervical cancer occurred, with 266,000 deaths.[2] This is about 8% of the total cases and total deaths from cancer.[18] About 70% of cervical cancers occur in developing countries and 90% of deaths.[2][19] In low-income countries, it is one of the most common causes of cancer death.[16] In developed countries, the widespread use of cervical screening programs has dramatically reduced rates of cervical cancer.[20] In medical research, the most famous immortalized cell line, known as HeLa, was developed from cervical cancer cells of a woman named Henrietta Lacks.[21]
Contents
1Signs and symptoms
2Causes
2.1Human papillomavirus
2.2Smoking
2.3Oral contraceptives
2.4Multiple pregnancies
3Diagnosis
3.1Biopsy
3.2Precancerous lesions
3.3Cancer subtypes
3.4Staging
4Prevention
4.1Screening
4.2Barrier protection
4.3Vaccination
4.4Nutrition
5Treatment
6Prognosis
6.1Stage
6.2By country
7Epidemiology
7.1Australia
7.2Canada
7.3India
7.4European Union
7.5United Kingdom
7.6United States
8History
9Society and culture
9.1Australia
9.2United States
10References
11Further reading
12External links
Signs and symptoms
The early stages of cervical cancer may be completely free of symptoms.[4][20] Vaginal bleeding, contact bleeding (one most common form being bleeding after sexual intercourse), or (rarely) a vaginal mass may indicate the presence of malignancy. Also, moderate pain during sexual intercourse and vaginal discharge are symptoms of cervical cancer.[22] In advanced disease, metastases may be present in the abdomen, lungs, or elsewhere.
Symptoms of advanced cervical cancer may include: loss of appetite, weight loss, fatigue, pelvic pain, back pain, leg pain, swollen legs, heavy vaginal bleeding, bone fractures, and (rarely) leakage of urine or feces from the vagina.[23] Bleeding after douching or after a pelvic exam is a common symptom of cervical cancer.[24]
Causes
In most cases, cells infected with the HPV virus heal on their own. In some cases, however, the virus continues to spread and becomes an invasive cancer.
Cervix in relation to upper part of vagina and posterior portion of uterus., showing difference in covering epithelium of inner structures.
Infection with some types of HPV is the greatest risk factor for cervical cancer, followed by smoking.[25] HIV infection is also a risk factor.[25] Not all of the causes of cervical cancer are known, however, and several other contributing factors have been implicated.[26][27]
Human papillomavirus
Human papillomavirus types 16 and 18 are the cause of 75% of cervical cancer cases globally, while 31 and 45 are the causes of another 10%.[28]
Women who have sex with men who have many other sexual partners or women who have many sexual partners have a greater risk.[29][30]
Of the 150-200 types of HPV known,[31][32] 15 are classified as high-risk types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82), three as probable high-risk (26, 53, and 66), and 12 as low-risk (6, 11, 40, 42, 43, 44, 54, 61, 70, 72, 81, and CP6108).[33]
Genital warts, which are a form of benign tumor of epithelial cells, are also caused by various strains of HPV. However, these serotypes are usually not related to cervical cancer. It is common to have multiple strains at the same time, including those that can cause cervical cancer along with those that cause warts.
Infection with HPV is generally believed to be required for cervical cancer to occur.[34]
Smoking
Cigarette smoking, both active and passive, increases the risk of cervical cancer. Among HPV-infected women, current and former smokers have roughly two to three times the incidence of invasive cancer. Passive smoking is also associated with increased risk, but to a lesser extent.[35]
Smoking has also been linked to the development of cervical cancer.[36][37][38] Smoking can increase the risk in women a few different ways, which can be by direct and indirect methods of inducing cervical cancer.[36][38][39] A direct way of contracting this cancer is a smoker has a higher chance of CIN3 occurring which has the potential of forming cervical cancer.[36] When CIN3 lesions lead to cancer, most of them have the assistance of the HPV virus, but that is not always the case, which is why it can be considered a direct link to cervical cancer.[39] Heavy smoking and long-term smoking seem to have more of a risk of getting the CIN3 lesions than lighter smoking or not smoking at all.[40] Although smoking has been linked to cervical cancer, it aids in the development of HPV which is the leading cause of this type of cancer.[38] Also, not only does it aid in the development of HPV, but also if the woman is already HPV-positive, she is at an even greater likelihood of contracting cervical cancer.[40]
Oral contraceptives
Long-term use of oral contraceptives is associated with increased risk of cervical cancer. Women who have used oral contraceptives for 5 to 9 years have about three times the incidence of invasive cancer, and those who used them for 10 years or longer have about four times the risk.[35]
Multiple pregnancies
Having many pregnancies is associated with an increased risk of cervical cancer. Among HPV-infected women, those who have had seven or more full-term pregnancies have around four times the risk of cancer compared with women with no pregnancies, and two to three times the risk of women who have had one or two full-term pregnancies.[35]
Diagnosis
Cervical cancer seen on a T2-weighted sagittal MR image of the pelvis
Biopsy
The Pap test can be used as a screening test, but produces a false negative in up to 50% of cases of cervical cancer.[41][42] Other concerns is the cost of doing pap tests which make it unaffordable in many areas of the world.[43]
Confirmation of the diagnosis of cervical cancer or precancer requires a biopsy of the cervix. This is often done through colposcopy, a magnified visual inspection of the cervix aided by using a dilute acetic acid (e.g. vinegar) solution to highlight abnormal cells on the surface of the cervix,[4] with visual contrast provided by staining the normal tissues a mahogany brown with Lugol's iodine.[44] Medical devices used for biopsy of the cervix include punch forceps among others.
Colposcopic impression, the estimate of disease severity based on the visual inspection, forms part of the diagnosis.
Further diagnostic and treatment procedures are loop electrical excision procedure and cervical conization, in which the inner lining of the cervix is removed to be examined pathologically. These are carried out if the biopsy confirms severe cervical intraepithelial neoplasia.
This large squamous carcinoma (bottom of picture) has obliterated the cervix and invaded the lower uterine segment. The uterus also has a round leiomyoma up higher.
Often before the biopsy, the doctor asks for medical imaging to rule out other causes of woman's symptoms. Imaging modalities such as ultrasound, CT scan and MRI have been used to look for alternating disease, spread of the tumor and effect on adjacent structures. Typically, they appear as heterogeneous mass on the cervix.[45]
Precancerous lesions
Histopathologic image (H&E stain) of carcinoma in situ (also called CIN III), stage 0: The normal architecture of stratified squamous epithelium is replaced by irregular cells that extend throughout its full thickness. Normal columnar epithelium is also seen.
Cervical intraepithelial neoplasia, the potential precursor to cervical cancer, is often diagnosed on examination of cervical biopsies by a pathologist. For premalignant dysplastic changes, cervical intraepithelial neoplasia grading is used.
The naming and histologic classification of cervical carcinoma precursor lesions has changed many times over the 20th century. The World Health Organization classification[46][47] system was descriptive of the lesions, naming them mild, moderate, or severe dysplasia or carcinoma in situ (CIS). The term, cervical intraepithelial neoplasia (CIN) was developed to place emphasis on the spectrum of abnormality in these lesions, and to help standardize treatment.[47] It classifies mild dysplasia as CIN1, moderate dysplasia as CIN2, and severe dysplasia and CIS as CIN3. More recently, CIN2 and CIN3 have been combined into CIN2/3. These results are what a pathologist might report from a biopsy.
These should not be confused with the Bethesda system terms for Pap test (cytopathology) results. Among the Bethesda results: Low-grade Squamous Intraepithelial Lesion (LSIL) and High-grade Squamous Intraepithelial Lesion (HSIL). An LSIL Pap may correspond to CIN1, and HSIL may correspond to CIN2 and CIN3,[47] however, they are results of different tests, and the Pap test results need not match the histologic findings.
Cancer subtypes
Cervical cancer with uterine leiomyoma
Histologic subtypes of invasive cervical carcinoma include the following:[48][49] Though squamous cell carcinoma is the cervical cancer with the most incidence, the incidence of adenocarcinoma of the cervix has been increasing in recent decades.[4]
squamous cell carcinoma (about 80–85%[50][51])
adenocarcinoma (about 15% of cervical cancers in the UK[46])
adenosquamous carcinoma
small cell carcinoma
neuroendocrine tumour
glassy cell carcinoma
villoglandular adenocarcinoma
Noncarcinoma malignancies which can rarely occur in the cervix include melanoma and lymphoma. The FIGO stage does not incorporate lymph node involvement in contrast to the TNM staging for most other cancers.
For cases treated surgically, information obtained from the pathologist can be used in assigning a separate pathologic stage, but is not to replace the original clinical stage.
Staging
Main article: Cervical cancer staging
Cervical cancer is staged by the International Federation of Gynecology and Obstetrics (FIGO) staging system, which is based on clinical examination, rather than surgical findings. It allows only these diagnostic tests to be used in determining the stage: palpation, inspection, colposcopy, endocervical curettage, hysteroscopy, cystoscopy, proctoscopy, intravenous urography, and X-ray examination of the lungs and skeleton, and cervical conization.
Stage 1A cervical cancer
Stage 1B cervical cancer
Stage 2A cervical cancer
Stage 2B cervical cancer
Stage 3B cervical cancer
Stage 4A cervical cancer
Stage 4B cervical cancer
Prevention
Screening
Cervical screening test vehicle in Taiwan
Negative visual inspection with acetic acid of the cervix
Positive visual inspection with acetic acid of the cervix for CIN-1
Main articles: Cervical screening and Pap test
Checking cervical cells with the Papanicolaou test (Pap test) for cervical pre-cancer has dramatically reduced the number of cases of, and mortality from, cervical cancer.[20] Liquid-based cytology may reduced the number of inadequate samples.[52][53][54] Pap test screening every three to five years with appropriate follow-up can reduce cervical cancer incidence up to 80%.[55] Abnormal results may suggest the presence of precancerous changes, allowing examination and possible preventive treatment, known as colposcopy. The treatment of low-grade lesions may adversely affect subsequent fertility and pregnancy.[35] Personal invitations encouraging women to get screened are effective at increasing the likelihood they will do so. Educational materials also help increase the likelihood women will go for screening, but they are not as effective as invitations.[56]
According to the 2010 European guidelines, the age at which to start screening ranges between 20 and 30 years of age, but preferentially not before age 25 or 30 years, and depends on burden of the disease in the population and the available resources.[57]
In the United States, screening is recommended to begin at age 21, regardless of age at which a woman began having sex or other risk factors.[58] Pap tests should be done every three years between the ages of 21 and 65.[58] In women over the age of 65, screening may be discontinued if no abnormal screening results were seen within the previous 10 years and no history of CIN 2 or higher exists.[58][59][60] HPV vaccination status does not change screening rates.[59]
There are a number of recommended options for screening those 30 to 65.[61] This includes cervical cytology every 3 years, HPV testing every 5 years, or HPV testing together with cytology every 5 years.[61][59] Screening is not beneficial before age 25 as the rate of disease is low. Screening is not beneficial in women older than 60 years if they have a history of negative results.[35] The American Society of Clinical Oncology (ASCO) guideline has recommend for different levels of resource availability.[62]
Pap tests have not been as effective in developing countries.[63] This is in part because many of these countries have an impoverished health care infrastructure, too few trained and skilled professionals to obtain and interpret Pap tests, uninformed women who get lost to follow-up, and a lengthy turn-around time to get results.[63] Visual inspection with acetic acid and HPV DNA testing have been tried, though with mixed success.[63]
Barrier protection
Barrier protection or spermicidal gel use during sexual intercourse decreases, but does not eliminate risk of transmitting the infection,[35] though condoms may protect against genital warts.[64] They also provide protection against other STIs, such as HIV and Chlamydia, which are associated with greater risks of developing cervical cancer.
Vaccination
Three HPV vaccines (Gardasil, Gardasil 9, and Cervarix) reduce the risk of cancerous or precancerous changes of the cervix and perineum by about 93% and 62%, respectively.[65] The vaccines are between 92% and 100% effective against HPV 16 and 18 up to at least 8 years.[35]
HPV vaccines are typically given to age 9 to 26, as the vaccine is most effective if given before infection occurs. The duration of effectiveness and whether a booster will be needed is unknown. The high cost of this vaccine has been a cause for concern. Several countries have considered (or are considering) programs to fund HPV vaccination. The American Society of Clinical Oncology (ASCO) guideline has recommendations for different levels of resource availability.[66]
Since 2010, young women in Japan have been eligible to receive the cervical cancer vaccination for free.[67] In June 2013, the Japanese Ministry of Health, Labor and Welfare mandated that, before administering the vaccine, medical institutions must inform women that the Ministry does not recommend it.[67] However, the vaccine is still available at no cost to Japanese women who choose to accept the vaccination.[67]
Nutrition
Vitamin A is associated with a lower risk[68] as are vitamin B12, vitamin C, vitamin E, and beta-Carotene.[69]
Treatment
Cervical cryotherapy
The treatment of cervical cancer varies worldwide, largely due to access to surgeons skilled in radical pelvic surgery, and the emergence of fertility-sparing therapy in developed nations. Because cervical cancers are radiosensitive, radiation may be used in all stages where surgical options do not exist. Surgical intervention may have better outcomes than radiological approaches.[70] In addition, chemotherapy can be used to treat cervical cancer, and has been found to be more effective than radiation alone.[71]
Microinvasive cancer (stage IA) may be treated by hysterectomy (removal of the whole uterus including part of the vagina).[citation needed] For stage IA2, the lymph nodes are removed, as well. Alternatives include local surgical procedures such as a loop electrical excision procedure or cone biopsy.[72][73]
If a cone biopsy does not produce clear margins[74] (findings on biopsy showing that the tumor is surrounded by cancer free tissue, suggesting all of the tumor is removed), one more possible treatment option for women who want to preserve their fertility is a trachelectomy.[75] This attempts to surgically remove the cancer while preserving the ovaries and uterus, providing for a more conservative operation than a hysterectomy. It is a viable option for those in stage I cervical cancer which has not spread; however, it is not yet considered a standard of care,[76] as few doctors are skilled in this procedure. Even the most experienced surgeon cannot promise that a trachelectomy can be performed until after surgical microscopic examination, as the extent of the spread of cancer is unknown. If the surgeon is not able to microscopically confirm clear margins of cervical tissue once the woman is under general anesthesia in the operating room, a hysterectomy may still be needed. This can only be done during the same operation if the woman has given prior consent. Due to the possible risk of cancer spread to the lymph nodes in stage 1b cancers and some stage 1a cancers, the surgeon may also need to remove some lymph nodes from around the uterus for pathologic evaluation.[citation needed]
A radical trachelectomy can be performed abdominally[77] or vaginally[78] and opinions are conflicting as to which is better.[79] A radical abdominal trachelectomy with lymphadenectomy usually only requires a two- to three-day hospital stay, and most women recover very quickly (about six weeks). Complications are uncommon, although women who are able to conceive after surgery are susceptible to preterm labor and possible late miscarriage.[80] A wait of at least one year is generally recommended before attempting to become pregnant after surgery.[81] Recurrence in the residual cervix is very rare if the cancer has been cleared with the trachelectomy.[76] Yet, women are recommended to practice vigilant prevention and follow-up care including Pap screenings/colposcopy, with biopsies of the remaining lower uterine segment as needed (every 3–4 months for at least 5 years) to monitor for any recurrence in addition to minimizing any new exposures to HPV through safe sex practices until one is actively trying to conceive.[citation needed]
Early stages (IB1 and IIA less than 4 cm) can be treated with radical hysterectomy with removal of the lymph nodes or radiation therapy. Radiation therapy is given as external beam radiotherapy to the pelvis and brachytherapy (internal radiation). Women treated with surgery who have high-risk features found on pathologic examination are given radiation therapy with or without chemotherapy to reduce the risk of relapse.[citation needed]
Brachytherapy for cervical cancer
Larger early-stage tumors (IB2 and IIA more than 4 cm) may be treated with radiation therapy and cisplatin-based chemotherapy, hysterectomy (which then usually requires adjuvant radiation therapy), or cisplatin chemotherapy followed by hysterectomy. When cisplatin is present, it is thought to be the most active single agent in periodic diseases.[82] Such addition of platinum-based chemotherapy to chemoradiation seems not only to improve survival but also reduces risk of recurrence in women with early stage cervical cancer (IA2-IIA).[83]
Advanced-stage tumors (IIB-IVA) are treated with radiation therapy and cisplatin-based chemotherapy. On June 15, 2006, the US Food and Drug Administration approved the use of a combination of two chemotherapy drugs, hycamtin and cisplatin, for women with late-stage (IVB) cervical cancer treatment.[84] Combination treatment has significant risk of neutropenia, anemia, and thrombocytopenia side effects.[citation needed]
For surgery to be curative, the entire cancer must be removed with no cancer found at the margins of the removed tissue on examination under a microscope.[85] This procedure is known as exenteration.[85]
Diagram showing the area removed with a posterior surgery
Diagram showing the area removed with a total operation
Diagram showing the area removed with an anterior operation
Prognosis
Stage
Prognosis depends on the stage of the cancer. The chance of a survival rate is nearly 100% for women with microscopic forms of cervical cancer.[86] With treatment, the five-year relative survival rate for the earliest stage of invasive cervical cancer is 92%, and the overall (all stages combined) five-year survival rate is about 72%. These statistics may be improved when applied to women newly diagnosed, bearing in mind that these outcomes may be partly based on the state of treatment five years ago when the women studied were first diagnosed.[87]
With treatment, 80-90% of women with stage I cancer and 60-75% of those with stage II cancer are alive 5 years after diagnosis. Survival rates decrease to 30-40% for women with stage III cancer and 15% or fewer of those with stage IV cancer five years after diagnosis.[88] Recurrent cervical cancer detected at its earliest stages might be successfully treated with surgery, radiation, chemotherapy, or a combination of the three. About 35% of women with invasive cervical cancer have persistent or recurrent disease after treatment.[89]
By country
Five year survival in the United States for White women is 69% and for Black women is 57%.[90]
Regular screening has meant that precancerous changes and early-stage cervical cancers have been detected and treated early. Figures suggest that cervical screening is saving 5,000 lives each year in the UK by preventing cervical cancer.[91]
About 1,000 women per year die of cervical cancer in the UK. All of the Nordic countries have cervical cancer-screening programs in place.[92] The Pap test was integrated into clinical practice in the Nordic countries in the 1960s.[92]
In Africa outcomes are often worse as diagnosis is frequently at a latter stage of disease.[93]
Epidemiology
Age-standardized death from cervical cancer per 100,000 inhabitants in 2004[94]
no data
<2.4
2.4-4.8
4.8-7.2
7.2-9.6
9.6-12
12-14.4
14.4-16.8
16.8-19.2
19.2-21.6
21.6–24
24–26.4
>26.4
Worldwide, cervical cancer is both the fourth-most common cause of cancer and deaths from cancer in women.[2] In 2018, 570,000 cases of cervical cancer were estimated to have occurred, with over 300,000 deaths.[95] It is the second-most common cause of female-specific cancer after breast cancer, accounting for around 8% of both total cancer cases and total cancer deaths in women.[18] About 80% of cervical cancers occur in developing countries.[96] It is the most frequently detected cancer during pregnancy, with an occurrence of 1.5 to 12 for every 100,000 pregnancies.[97]
Australia
Australia had 734 cases of cervical cancer in 2005. The number of women diagnosed with cervical cancer has dropped on average by 4.5% each year since organised screening began in 1991 (1991–2005).[98] Regular twice-yearly Pap tests can reduce the incidence of cervical cancer up to 90% in Australia, and save 1,200 Australian women from dying from the disease each year.[99] It is predicted that because of the success of the primary HPV testing programme there will be fewer than four new cases per 100 000 women annually by 2028.[100]
Canada
In Canada, an estimated 1,300 women will have been diagnosed with cervical cancer in 2008 and 380 will have died.[101]
India
In India, the number of people with cervical cancer is rising, but overall the age-adjusted rates are decreasing.[102] Usage of condoms in the female population has improved the survival of women with cancers of the cervix.[103]
European Union
In the European Union, about 34,000 new cases per year and over 16,000 deaths due to cervical cancer occurred in 2004.[55]
United Kingdom
Cervical cancer is the 12th-most common cancer in women in the UK (around 3,100 women were diagnosed with the disease in 2011), and accounts for 1% of cancer deaths (around 920 died in 2012).[104] With a 42% reduction from 1988–1997, the NHS-implemented screening programme has been highly successful, screening the highest-risk age group (25–49 years) every 3 years, and those ages 50–64 every 5 years.
United States
An estimated 13,170 new cervical cancers and 4,250 cervical cancer deaths will occur in the United States in 2019.[105] The median age at diagnosis is 50. The rates of new cases in the United States was 7.3 per 100,000 women, based on rates from 2012-2016. Cervical cancer deaths decreased by approximately 74% in the last 50 years, largely due to widespread Pap test screening.[106] The annual direct medical cost of cervical cancer prevention and treatment prior to introduction of the HPV vaccine was estimated at $6 billion.[106]
History
See also: Timeline of cervical cancer
400 BCE — Hippocrates noted that cervical cancer was incurable
1925 — Hinselmann invented the colposcope
1928 — Papanicolaou developed the Papanicolaou technique
1941 — Papanicolaou and Traut: Pap test screening began
1946 — Aylesbury spatula was developed to scrape the cervix, collecting the sample for the Pap test
1951 — First successful in-vitro cell line, HeLa, derived from biopsy of cervical cancer of Henrietta Lacks
1976 — Harald zur Hausen and Gisam found HPV DNA in cervical cancer and genital warts; Hausen later won the Nobel Prize for his work[107]
1988 — Bethesda System for reporting Pap results was developed
2006 — First HPV vaccine was approved by the FDA
2015 — HPV Vaccine shown to protect against infection at multiple body sites[108]
2018 — Evidence for single-dose protection with HPV vaccine [109]
Epidemiologists working in the early 20th century noted that cervical cancer behaved like a sexually transmitted disease. In summary:
Cervical cancer was noted to be common in female sex workers.
It was rare in nuns, except for those who had been sexually active before entering the convent. (Rigoni in 1841)
It was more common in the second wives of men whose first wives had died from cervical cancer.
It was rare in Jewish women.[110]
In 1935, Syverton and Berry discovered a relationship between RPV (Rabbit Papillomavirus) and skin cancer in rabbits. (HPV is species-specific and therefore cannot be transmitted to rabbits)[citation needed]
These historical observations suggested that cervical cancer could be caused by a sexually transmitted agent. Initial research in the 1940s and 1950s attributed cervical cancer to smegma (e.g. Heins et al. 1958).[111] During the 1960s and 1970s it was suspected that infection with herpes simplex virus was the cause of the disease. In summary, HSV was seen as a likely cause because it is known to survive in the female reproductive tract, to be transmitted sexually in a way compatible with known risk factors, such as promiscuity and low socioeconomic status.[112] Herpes viruses were also implicated in other malignant diseases, including Burkitt's lymphoma, Nasopharyngeal carcinoma, Marek's disease and the Lucké renal adenocarcinoma. HSV was recovered from cervical tumour cells.
A description of human papillomavirus (HPV) by electron microscopy was given in 1949, and HPV-DNA was identified in 1963.[113] It was not until the 1980s that HPV was identified in cervical cancer tissue.[114] It has since been demonstrated that HPV is implicated in virtually all cervical cancers.[115] Specific viral subtypes implicated are HPV 16, 18, 31, 45 and others.
In work that was initiated in the mid 1980s, the HPV vaccine was developed, in parallel, by researchers at Georgetown University Medical Center, the University of Rochester, the University of Queensland in Australia, and the U.S. National Cancer Institute.[116] In 2006, the U.S. Food and Drug Administration (FDA) approved the first preventive HPV vaccine, marketed by Merck & Co. under the trade name Gardasil.
Society and culture
Australia
In Australia, Aboriginal women are more than five times more likely to die from cervical cancer than non-Aboriginal women, suggesting that Aboriginal women are less likely to have regular Pap tests.[117] There are several factors that may limit indigenous women from engaging in regular cervical screening practices, including sensitivity in discussing the topic in Aboriginal communities, embarrassment, anxiety and fear about the procedure.[118] Difficulty in accessing screening services (for example, transport difficulties) and a lack of female GPs, trained Pap test providers and trained female Aboriginal Health Workers are also issues.[118]
The Australian Cervical Cancer Foundation (ACCF), founded in 2008, promotes 'women’s health by eliminating cervical cancer and enabling treatment for women with cervical cancer and related health issues, in Australia and in developing countries.'[119] Ian Frazer, one of the developers of the Gardasil cervical cancer vaccine, is the scientific advisor to ACCF.[120] Janette Howard, the wife of former Australian Prime Minister John Howard, was diagnosed with cervical cancer in 1996, and first spoke on her battle with the disease in 2006.[121]
United States
A 2007 survey of American women found 40% had heard of HPV infection and less than half of those knew it causes cervical cancer.[122] Over a longitudinal study from 1975-2000, it was found that people of lower socioeconomic census brackets had higher rates of late-stage cancer diagnosis and higher morbidity rates. After controlling for stage, there still existed differences in survival rates.[123]
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Further reading
Arbyn, M.; Castellsague, X.; de Sanjose, S.; Bruni, L.; Saraiya, M.; Bray, F.; Ferlay, J. (6 April 2011). "Worldwide burden of cervical cancer in 2008". Annals of Oncology. 22 (12): 2675–2686. doi:10.1093/annonc/mdr015. PMID 21471563.
Chuang, L. T.; Temin, S.; Camacho, R.; Duenas-Gonzalez, A.; Feldman, S.; Gultekin, M.; Gupta, V.; Horton, S.; Jacob, G.; Kidd, E. A.; Lishimpi, K.; Nakisige, C.; Nam, J.-H.; Ngan, H. Y. S.; Small, W.; Thomas, G.; Berek, J. S. (25 May 2016). "Management and Care of Women With Invasive Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline". Journal of Global Oncology. 2 (5): 311–340. doi:10.1200/JGO.2016.003954. PMC 5493265. PMID 28717717.
Peto J, Gilham C, Fletcher O, Matthews FE (2004). "The cervical cancer epidemic that screening has prevented in the UK". Lancet. 364 (9430): 249–56. doi:10.1016/S0140-6736(04)16674-9. PMID 15262102.
Pimenta, Jeanne M; Galindo, Claudia; Jenkins, David; Taylor, Sylvia M (21 November 2013). "Estimate of the global burden of cervical adenocarcinoma and potential impact of prophylactic human papillomavirus vaccination". BMC Cancer. 13 (1): 553. doi:10.1186/1471-2407-13-553. PMC 3871005. PMID 24261839.
External links
Classification
D
ICD-10: C53
ICD-9-CM: 180
OMIM: 603956
MeSH: D002583
DiseasesDB: 2278
External resources
MedlinePlus: 000893
eMedicine: med/324 radio/140
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Penile
Head and neck cancer (HPV-positive oropharyngeal cancer)
…cell cancer , others found a similar risk increase with increasing duration of oral contraceptives for both adeno- and squamous cell carcinomas . In contrast to squamous cell cancer of the cervix, cigarette …
… cervical cancer in general are covered elsewhere. Following staging, locally advanced cervical cancer is defined by the presence of any of the following findings : Confined to the cervix with a …
… size or local spread in cervical cancer as accumulation of the tracer in the bladder obscures visualization of the uterine cervix. In locally advanced cervical cancer (stages IB2 to IVA), correlation …
… treatment of women with early-stage or locally advanced cervical cancer. Early-stage cervical cancer is defined as disease confined to the cervix measuring less than 4 cm in size (stage IA to IB1; ). These …
…neuroendocrine carcinoma of the cervix. Because of the rarity of other neuroendocrine tumors of the cervix, they will not be discussed further. The management of squamous cell cervical cancer and adenocarcinoma …
English Journal
Phytochemical analysis, antiproliferative and antioxidant activities of Chrozophora tinctoria: a natural dye plant.
… <p> With population aging, the number of patients with pelvic genital prolapse is increasing. … Thecervix remains as an anchoring point for fixing the mesh in LSC. … We encountered a case of cervical adenocarcinoma arising from the remaining cervix after LSC surgery. …
Cervical Cancer Overview The uterine cervix is the lowest portion of a woman's uterus (womb), connecting the uterus with the vagina. Cervical cancer occurs when the cells of the cervix grow abnormally and invade other ...
Cervical cancer is a cancer that arises in the cervix of the uterus (womb) In the early stages of cervical cancer, it may not cause symptoms. As the cancer progresses, the most common signs and symptoms of cervical ...
Screening with Pap tests can reduce the risk of this cancer that begins in the cervix. Learn more about symptoms, causes, prevention and treatment. ... Cervical cancer begins when healthy cells in the cervix develop changes ...