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the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system

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carbonの化学記号
case[s]

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/15 19:42:00」(JST)

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The granular, cytoplasmic staining pattern of c-ANCA

c-ANCAs, or Cytoplasmic antineutrophil cytoplasmic antibodies, are a type of autoantibody, an antibody produced by the body that acts against one of its own proteins. These antibodies show a diffusely granular, cytoplasmic staining pattern under microscopy. This pattern results from binding of ANCAs to antigen targets throughout the neutrophil cytoplasm, the most common protein target being proteinase 3 (PR3). For example, PR3 is the most common antigen target of ANCA in patients with Wegener's granulomatosis. In active Wegener's, c-ANCA is found over 90% of the time.^[1] Other antigens may also occasionally result in a c-ANCA pattern.

References

^ Thomas M. Habermann (26 June 2006). Mayo Clinic internal medicine review, 2006-2007. CRC Press. pp. 935–. ISBN 978-0-8493-9059-3. http://books.google.com/books?id=hOBQNjyGVBQC&pg=PA935. Retrieved 1 November 2010.

UpToDate Contents

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1. 抗好中球細胞質抗体の臨床的な意味 clinical spectrum of antineutrophil cytoplasmic antibodies
2. 多発血管炎性肉芽腫症（ウェゲナー肉芽腫症）における気道病変 respiratory tract involvement in granulomatosis with polyangiitis wegeners
3. 多発血管炎性肉芽腫症を伴う肉芽腫症および関連血管炎の病因 pathogenesis of granulomatosis with polyangiitis and related vasculitides
4. びまん性肺胞出血症候群 the diffuse alveolar hemorrhage syndromes
5. 多発血管炎性肉芽腫症および顕微鏡的多発血管炎における再発性疾患の同定およびマネージメント identification and management of relapsing disease in granulomatosis with polyangiitis and microscopic polyangiitis

English Journal

IgA nephropathy with anti-neutrophil cytoplasmic antibody seropositivity.

Huang X, Wang Y, Xie L, Zhang Y, Tang S, Yin S, Gao X, Cai J, Wang W, Zhang J, Zhao J, Huang Y, Li Y, Zhang J.
Clinical nephrology.Clin Nephrol.2015 Aug 7. [Epub ahead of print]
BACKGROUND: There are few reports of IgA nephropathy (IgAN) with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis.METHODS: The authors report the clinical and pathological findings in 14 patients with IgAN and ANCA seropositivity.RESULTS: These retrospective cases consisted o
PMID 26249551

Levamisole-Induced Vasculitis: A Characteristic Cutaneous Vasculitis Associated With Levamisole-Adulterated Cocaine.

Roberts JA, Chévez-Barrios P1.
Archives of pathology & laboratory medicine.Arch Pathol Lab Med.2015 Aug;139(8):1058-61. doi: 10.5858/arpa.2014-0107-RS.
Levamisole-induced vasculitis is a characteristic cutaneous vasculitis syndrome associated with the use of levamisole-adulterated cocaine. Patients will typically present with a painful, purpuric rash in a retiform or stellate pattern with or without central necrosis involving the extremities, trunk
PMID 26230600

ANCA-associated vasculitis in patients with primary Sjögren's syndrome: detailed analysis of 7 new cases and systematic literature review.

Guellec D1, Cornec-Le Gall E2, Groh M3, Hachulla E4, Karras A5, Charles P6, Dunogué B3, Abad S7, Alvarez F8, Gérard F1, Devauchelle-Pensec V9, Pers JO10, Puéchal X3, Guillevin L3, Saraux A9, Cornec D11; CRI (Club Rhumatismes et Inflammation) and the French Vasculitis Study Group.
Autoimmunity reviews.Autoimmun Rev.2015 Aug;14(8):742-50. doi: 10.1016/j.autrev.2015.04.009. Epub 2015 Apr 24.
OBJECTIVES: To describe the clinical presentation, management and prognosis of patients diagnosed with both primary Sjögren's syndrome (pSS) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).METHODS: French nation-wide survey completed by a systematic literature review.RES
PMID 25916811

Japanese Journal

胸部下行大動脈に動脈瘤を合併したWegener 肉芽腫症の1 例

戸田正夫,増田浩之,田中彩絵,大西祥五,鹿島隆一,町田優,原澤寛,中元隆明,池野義彦,梅津貴史,倉沢和宏,福田健
Dokkyo journal of medical sciences 38(1), 119-126, 2011-03-25
… ,鼻閉の既往,空洞を伴う両下肺の浸潤影,顕微鏡的血尿,急速進行する腎機能障害およびPR3-ANCA 高値を示し,Wegener 肉芽腫症( WG) と診断された.一時シクロフォスファミド併用を含む,高用量副腎ステロイド療法が開始され,臨床および検査所見は改善した.ステロイド薬は漸減され,3 ヶ月後にはC-ANCA は陰性化した.WG は寛解していたが,8 ヶ月後に胸部下行大動脈瘤形成を認め,その1 …
NAID 110008462904

耳症状のみで発症したウェゲナー肉芽腫症疑い例

高岡麻里絵,萩原晃,長谷川達哉,小川恭生,西山信宏,鈴木衞
耳鼻咽喉科臨床 103(3), 201-208, 2010-03-01
… Systemic examination shared slightly elevated serum P-ANCA but negative C-ANCA. …
NAID 10026216819

耳症状で初発し肥厚性硬膜炎を合併したWegener肉芽腫症疑い例

深美悟,春名眞一,平林秀樹,月舘利治,岡田真由美,金谷洋明
Otology Japan 20(3), 173-179, 2010
… 耳症状を初発とし、C-ANCA、P-ANCA陰性で、鼓室開放術での組織検査でも特徴的所見がなく、経過中に肥厚性硬膜炎を合併したWegener肉芽腫症疑い症例を経験した。 … 経過中にC-ANCAの上昇、脳MRIで肥厚性硬膜炎を認め、肥厚性硬膜炎を伴ったWegener肉芽腫症疑い例と診断した。 …
NAID 130001471717

Related Pictures

★リンクテーブル★

リンク元	「まぎらわしい用語」「p-ANCA」「PR3-ANCA」「細胞質型抗好中球細胞質抗体」「cytoplasmic anti-neutrophil cytoplasmic antibody」
関連記事	「C」「ANCA」「AN」「ANC」「c」