blood coagulation factor

血液凝固因子

WordNet

1. be a contributing factor; "make things factor into a companys profitability"
2. any of the numbers (or symbols) that form a product when multiplied together
3. an independent variable in statistics
4. anything that contributes causally to a result; "a number of factors determined the outcome"
5. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
6. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
7. smear with blood, as in a hunting initiation rite, where the face of a person is smeared with the blood of the kill
8. temperament or disposition; "a person of hot blood"
9. people viewed as members of a group; "we need more young blood in this organization"
10. the fluid (red in vertebrates) that is pumped through the body by the heart and contains plasma, blood cells, and platelets; "blood carries oxygen and nutrients to the tissues and carries away waste products"; "the ancients believed that blood was the sea
11. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
12. a concept whose truth can be proved; "scientific hypotheses are not facts"
13. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
14. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

1. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
2. 『血』,『血』液 / 流血(bloodshed);殺人 / 気質,気性,血気,血潮 / 『血統』,血縁(kinship);生まれ,家柄;《the~》王家の血統 / (人種・出身国の)系 / 〈人〉‘に'初めての経験をさせる / 〈猟犬〉‘に'初めて獲物を血を味わわせる
3. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
4. 純血の,純種の / 《複合語を作って》「…の血(性質)を持った」の意を表す
5. 凝固,凝結

UpToDate Contents

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• 1. Factor V Leiden and activated protein C resistance
• 2. Protein C deficiency
• 3. 血友病患者における第VIIIおよび第IX因子阻害物質 factor viii and factor ix inhibitors in patients with hemophilia
• 4. 静脈血栓症の原因の概要 overview of the causes of venous thrombosis
• 5. 重症患者における血液製剤の使用 use of blood products in the critically ill

English Journal

• A comparison of blood factor XII autoactivation in buffer, protein cocktail, serum, and plasma solutions.

• Golas A, Josh Yeh CH, Pitakjakpipop H, Siedlecki CA, Vogler EA.SourceDepartment of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
• Biomaterials.Biomaterials.2013 Jan;34(3):607-20. doi: 10.1016/j.biomaterials.2012.09.034. Epub 2012 Oct 30.
• Activation of blood plasma coagulation in vitro by contact with material surfaces is demonstrably dependent on plasma-volume-to-activator-surface-area ratio. The only plausible explanation consistent with current understanding of coagulation-cascade biochemistry is that procoagulant stimulus arisin
• PMID 23117212

• Biochemical, histopathological and clinical evaluation of delayed effects caused by methamidophos isoforms and TOCP in hens: ameliorative effects using control of calcium homeostasis.

• Emerick GL, Ehrich M, Jortner BS, Oliveira RV, Deoliveira GH.SourceDepartment of Natural Active Principles and Toxicology, School of Pharmaceutical Science, Univ Estadual Paulista - UNESP, Araraquara, SP, Brazil. glemerick@yahoo.com.br
• Toxicology.Toxicology.2012 Dec 8;302(1):88-95. doi: 10.1016/j.tox.2012.08.002. Epub 2012 Aug 15.
• This work evaluated the potential of the isoforms of methamidophos to cause organophosphorus-induced delayed neuropathy (OPIDN) in hens. In addition to inhibition of neuropathy target esterase (NTE) and acetylcholinesterase (AChE), calpain activation, spinal cord lesions and clinical signs were asse
• PMID 22974967

Japanese Journal

• 第？因子と血液凝固制御 : 第？因子の機能・構造に関する最近の知見 (AYUMI 血液凝固異常研究の進歩)

• 野上 恵嗣,田中 一郎
• 医学のあゆみ 242(2), 188-193, 2012-07-14
• NAID 40019331785

• The genetic mechanisms of warfarin resistance in Rattus rattus found in the wild in Japan

• Tanaka Kazuyuki D.,Kawai Yusuke K.,Ikenaka Yoshinori,Harunari Tsunehito,Tanikawa Tsutomu,Ando Shima,Min Hee Won,Okajima Fumie,Fujita Shoichi,Ishizuka Mayumi
• Pesticide Biochemistry and Physiology 103(2), 144-151, 2012-06
• … It inhibits blood coagulation by inhibiting vitamin K 2,3-epoxide reductase (VKOR) activity leading to hemorrhage. … In this report, we studied mutations in the VKOR gene (including the VKOR complex subunit 1 (VKORC1)), while also analyzing VKOR and clotting factor activity in black rats (Rattus rattus) in order to understand better the mechanism of warfarin resistance in this species. …
• NAID 120004405517

Related Links

• Blood coagulation. - ResearchGate

ABSTRACT The process of tissue factor initiated blood coagulation is discussed. Reactions of the blood coagulation cascade are propagated by complex enzymes containing a vitamin K-dependent serine protease and an accessory ...

• Blood Coagulation: Hemostasis - The Medical Biochemistry Page

The blood coagulation page provides details of the normal processes of hemostasis and mechanisms for therapeutic intervention in abnormal bleeding ... Factor Trivial Name(s) Pathway Characteristic Prekallikrein (PK) Fletcher ...

• blood coagulation factor とは - コトバンク

世界大百科事典 第2版 blood coagulation factorの用語解説 - 一方，血液凝固が血管内に起こると，血栓症あるいは血管内凝固症候群が起こる。[血液凝固因子] 血液凝固に関与する因子群(血液凝固因子blood coagulation factor)は，13 ...

Related Pictures

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★リンクテーブル★

リンク元	「血液凝固因子」
拡張検索	「blood coagulation factor VIII」「blood coagulation factor XIII」「blood coagulation factor XI」「blood coagulation factor inhibitor」
関連記事	「fact」「factor」「coagulation factor」「blood」

「血液凝固因子」

　　[★]

英

coagulation factor (Z), clotting factor, blood coagulation factor, blood coagulation factors

関

ビタミンK

血液凝固因子

• 第I因子
• 第II因子
• 第III因子
• 第IV因子
• 第V因子
• 第VII因子
• 第VIII因子
• 第IX因子
• 第X因子
• 第XI因子
• 第XII因子
• 第XIII因子

表

• PT.261

型	名称	同義語	分子量 (kDa)	血漿中濃度 (μg/ml)	半減期 (day)
内因系のプロ酵素	XII	Hageman因子	80	29	2
	プレカリクレイン	Fletcher因子	88	45
	XI	PTA	160	4	2.5
ビタミンK依存	VII	proconvertin	50	0.5	0.2
凝固プロ酵素	IX	Christmas因子	57	4	1
	X	Stuart因子	57	8	1.5
	II	プロトロンビン	70	150	3
補助因子	III	組織因子		0
	血小板ホスホリピド
	高分子量キニノゲン		120	70
	V	proaccelerin	330	7	1.5
	VIII	抗血友病因子			0.5
フィブリン堆積因子	I	フィブリノゲン	340	2500	4.5
	XIII	フィブリン安定因子	320	8	7
抑制物質	アンチトロンビンIII		58	150	2.5

• 標準血液病学 p.217

15種類ある

凝固因子	慣用語・同義語	ビタミンK依存	血液中半減期(hr)	産生器官	染色体座乗部位
I	fibrinogen		100-150	肝臓	4q26
II	prothronbin	○	50-80	肝臓	11p141-q12
III	tissue thromboplastin			体の各組織	1pter-p21
IV	calcium ion			肝臓
V	labile factor/proaccelerin		24	肝臓	1q21-q25
VII	stable factor/proconvertin	○	6	肝臓	13q34
VIII	antihemophilic factor		12	細網系?	xq28
IX	Christmas factor	○	24	肝臓	xq26.3-q27.2
X	Stuart factor	○	25-60	肝臓	13q34
XI	plasma thromboplastin antecedent		40-80	肝臓	4q35
XII	Hageman factor		50-70	肝臓	5q33-qter
XIII	fibrin stabilizing factor		150	肝臓	6p24-p21.3
prekallikrein	Fletcher factor		35	肝臓	4q35
hight molecular weight kininogen	Fitzgerold factor		150	肝臓	3q26-qter
von Willebrand factor			24	血管内皮 血小板 糸球体	12pter-p12

産生部位

• ほとんどが肝臓
• 例外：

• 第III因子(F III)：組織トロンボプラスチン：組織
• 第VIII因子(F VIII)：組織トロンボプラスチン：細網組織？

臨床関連

• ビタミンK欠乏
• 妊娠により第XI因子、第XIII因子を除き、血液凝固因子の濃度が上昇する

-凝固因子

「blood coagulation factor VIII」

　　[★]

• 血液凝固第VIII因子

関

antihemophilic factor、coagulation factor VIII、factor VIII

「blood coagulation factor XIII」

　　[★]

• 血液凝固第XIII因子

関

coagulation factor XIII、factor XIII

「blood coagulation factor XI」

　　[★]

• 血液凝固第XI因子

関

coagulation factor XI、factor XI

「blood coagulation factor inhibitor」

　　[★]

• 血液凝固因子阻害物質

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「coagulation factor」

　　[★] 血液凝固因子

同

coagulation factors

「blood」

　　[★] 血液