関: prekallikrein

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
prolific English dramatist who collaborated with Francis Beaumont and many other dramatists (1579-1625) (同)John Fletcher

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/30 23:09:43」(JST)

wiki en

Prekallikrein (PK), also known as Fletcher factor, is an 85,000 Mr serine protease that complexes with high-molecular-weight kininogen. PK is the precursor of plasma kallikrein, which is a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII (Hageman factor).^[1]

Prekallikrein deficiency

Hereditary deficiencies in PK are very rare. They can cause a prolonged APTT, which can be corrected by incubation of the patient’s plasma.

Deficiencies in PK can also be acquired due to some disease states, such as angioedema, infection, DIC, and sickle-cell disease.^[1]

Although most cases of prekallikrein deficiency are asymptomatic, a few reports link severe prekallikrein deficiency with thrombotic phenomena and recurrent pregnancy loss. More recently, a case of prekallikrein deficiency was shown to be associated with severe mucosal bleeding.^[2]

Discovery of prekallikrein

PK was initially described by Hathaway et al. in 1965 after encountering a Kentucky family who exhibited strikingly abnormal APTT results, but showed no bleeding symptoms. The family appeared to have a hereditary deficiency in an unknown coagulation factor, dubbed “Fletcher factor” after the family. In 1973 Kirk Wuepper determined that Fletcher factor and prekallikrein were the same.^[3]

References

^ ^a ^b Goodnight, S.H.; Hathaway, W.E. (2001). Disorders of Hemostasis & Thrombosis: A Clinical Guide (2nd ed.). McGraw Hill Professional. ISBN 0071348344.
^ Dasanu CA, Alexandrescu DT (November 2009). "A case of prekallikrein deficiency resulting in severe recurrent mucosal hemorrhage". Am. J. Med. Sci. 338 (5): 429–30. doi:10.1097/MAJ.0b013e3181b270bb. PMID 19773642.
^ Online 'Mendelian Inheritance in Man' (OMIM) KALLIKREIN B, PLASMA, 1; KLKB1 -229000

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 出血性素因を有する成人患者へのアプローチ approach to the adult patient with a bleeding diathesis
2. 出血症状を有する小児に対するアプローチ approach to the child with bleeding symptoms
3. 止血の概要 overview of hemostasis
4. 凝固検査の臨床使用 clinical use of coagulation tests
5. 第ⅩＩ因子欠乏症 factor xi deficiency

English Journal

Genetic Variants in Platelet Factor 4 Modulate Inflammatory and Platelet Activation Biomarkers.

Bhatnagar P, Lu X, Evans MK, Laveist TA, Zonderman AB, Carter DL, Arking DE, Fletcher CA.Source1 Johns Hopkins University School of Medicine, Baltimore, MD;
Circulation. Cardiovascular genetics.Circ Cardiovasc Genet.2012 Jul 4. [Epub ahead of print]
BACKGROUND: -African Americans suffer from higher prevalence and severity of atherosclerosis compared to Whites, highlighting racial and ethnic disparities in cardiovascular disease. Previous studies have pointed to the role of vascular inflammation and platelet activation in the formation of athero
PMID 22763266

Plasma prolylcarboxypeptidase (angiotensinase C) is increased in obesity and diabetes mellitus and related to cardiovascular dysfunction.

Xu S, Lind L, Zhao L, Lindahl B, Venge P.SourceSections of Clinical Chemistry.
Clinical chemistry.Clin Chem.2012 Jul;58(7):1110-5. Epub 2012 Apr 26.
BACKGROUND: Prolylcarboxypeptidase (PRCP) (angiotensinase C) has 3 major targets, angiotensin II, prekallikrein, and α-melanocyte stimulating hormone(1-13). The truncation of the latter leads to loss in appetite regulation and obesity in experimental animals. The objectives of this study were to pu
PMID 22539806

Japanese Journal

フレッチャー因子,フィッツジェラルド因子 (広範囲血液・尿化学検査免疫学的検査(第7版・2)その数値をどう読むか) -- (血液凝固・線溶系検査)

齋藤英彦
日本臨床 68(-) (970), 729-731, 2010-01
NAID 40016932942

3431 有限要素法による曲がり管の大たわみ解析(G03-5 応力解析,G03 材料力学)

大滝誠一,小原理太郎
年次大会講演論文集 : JSME annual meeting 2006(1), 573-574, 2006-09-15
… The forth-order total potential energy expressed in terms of displacement components is minimized by Davidon-Fletcher-Powell method, and unknown displacements of the nodal points can be obtained. … Numerical examples are shown for the pipe bends subjected to in-plane bending to show the effects of the increase of the the stress intensification factor on the geometrical nonlinearity. …
NAID 110006634538

「血液凝固因子」

　　[★]

英: coagulation factor (Z), clotting factor, blood coagulation factor, blood coagulation factors
関: ビタミンK

血液凝固因子

表

PT.261

型	名称	同義語	分子量 (kDa)	血漿中濃度 (μg/ml)	半減期 (day)
内因系のプロ酵素	XII	Hageman因子	80	29	2
	プレカリクレイン	Fletcher因子	88	45
	XI	PTA	160	4	2.5
ビタミンK依存	VII	proconvertin	50	0.5	0.2
凝固プロ酵素	IX	Christmas因子	57	4	1
	X	Stuart因子	57	8	1.5
	II	プロトロンビン	70	150	3
補助因子	III	組織因子		0
	血小板ホスホリピド
	高分子量キニノゲン		120	70
	V	proaccelerin	330	7	1.5
	VIII	抗血友病因子			0.5
フィブリン堆積因子	I	フィブリノゲン	340	2500	4.5
	XIII	フィブリン安定因子	320	8	7
抑制物質	アンチトロンビンIII		58	150	2.5

標準血液病学 p.217

15種類ある

凝固因子	慣用語・同義語	ビタミンK依存	血液中半減期(hr)	産生器官	染色体座乗部位
I	fibrinogen		100-150	肝臓	4q26
II	prothronbin	○	50-80	肝臓	11p141-q12
III	tissue thromboplastin			体の各組織	1pter-p21
IV	calcium ion			肝臓
V	labile factor/proaccelerin		24	肝臓	1q21-q25
VII	stable factor/proconvertin	○	6	肝臓	13q34
VIII	antihemophilic factor		12	細網系?	xq28
IX	Christmas factor	○	24	肝臓	xq26.3-q27.2
X	Stuart factor	○	25-60	肝臓	13q34
XI	plasma thromboplastin antecedent		40-80	肝臓	4q35
XII	Hageman factor		50-70	肝臓	5q33-qter
XIII	fibrin stabilizing factor		150	肝臓	6p24-p21.3
prekallikrein	Fletcher factor		35	肝臓	4q35
hight molecular weight kininogen	Fitzgerold factor		150	肝臓	3q26-qter
von Willebrand factor			24	血管内皮血小板糸球体	12pter-p12