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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/19 23:25:02」(JST)

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Prekallikrein (PK), also known as Fletcher factor, is an 85,000 Mr serine protease that complexes with high-molecular-weight kininogen. PK is the precursor of plasma kallikrein, which is a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII (Hageman factor). ^[1]

Prekallikrein deficiency[edit]

Hereditary deficiencies in PK are very rare. They can cause a prolonged APTT, which can be corrected by incubation of the patient’s plasma.

Deficiencies in PK can also be acquired due to some disease states, such as angioedema, infection, DIC, and sickle-cell disease.^[1]

Although most cases of prekallikrein deficiency are asymptomatic, a few reports link severe prekallikrein deficiency with thrombotic phenomena and recurrent pregnancy loss. More recently, a case of prekallikrein deficiency was shown to be associated with severe mucosal bleeding.^[2]

Discovery of prekallikrein[edit]

PK was initially described by Hathaway et al. in 1965 after encountering a Kentucky family who exhibited strikingly abnormal APTT results, but showed no bleeding symptoms. The family appeared to have a hereditary deficiency in an unknown coagulation factor, dubbed “Fletcher factor” after the family. In 1973 Kirk Wuepper determined that Fletcher factor and prekallikrein were the same.^[3]

References[edit]

^ ^a ^b Goodnight, SH Jr, Hathaway, WE. Disorders of Hemostasis and Thrombosis. Second edition. 2001.
^ Dasanu CA, et al. "A Case of Prekallikrein Deficiency Resulting in Severe Recurrent Mucosal Hemorrhage". American Journal of Medical Sciences, 2009.
^ OMIM article on prekallikrein deficiency

UpToDate Contents

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1. 出血性素因を有する成人患者へのアプローチ approach to the adult patient with a bleeding diathesis
2. 凝固検査の臨床使用 clinical use of coagulation tests
3. 止血の概要 overview of hemostasis
4. 第ⅩＩ因子欠乏症 factor xi deficiency
5. 出血症状を有する小児に対するアプローチ approach to the child with bleeding symptoms

English Journal

PF-04886847 (an Inhibitor of Plasma Kallikrein) Attenuates Inflammatory Mediators and Activation of Blood Coagulation in Rat Model of Lipopolysaccharide (LPS) - Induced Sepsis.

Kolte D, Bryant JW, Gibson GW, Wang J, Shariat-Madar Z.SourceThe University of Mississippi, University, MS 38677-1848, USA. madar@olemiss.edu.
Cardiovascular & hematological agents in medicinal chemistry.Cardiovasc Hematol Agents Med Chem.2012 Jun 1;10(2):154-66.
The plasma kallikrein-mediated proteolysis regulates both thrombosis and inflammation. Previous study has shown that PF-04886847 is a potent and competitive inhibitor of kallikrein, suggesting that it might be useful for the treatment of kallikrein-kinin mediated inflammatory and thrombotic disorder
PMID 22352684

Plasma Prolylcarboxypeptidase (Angiotensinase C) is Increased in Obesity and Diabetes Mellitus and Related to Cardiovascular Dysfunction.

Xu S, Lind L, Zhao L, Lindahl B, Venge P.SourceSections of Clinical Chemistry.
Clinical chemistry.Clin Chem.2012 Apr 26. [Epub ahead of print]
BACKGROUND: Prolylcarboxypeptidase (PRCP) (angiotensinase C) has 3 major targets, angiotensin II, prekallikrein, and α-melanocyte stimulating hormone(1-13). The truncation of the latter leads to loss in appetite regulation and obesity in experimental animals. The objectives of this study were to pu
PMID 22539806

Japanese Journal

Prekallikrein Deficiency in a Dog

OKAWA Takumi,YANASE Takuma,SHIMOKAWA MIYAMA Takako,HIRAOKA Hiroko,BABA Kenji,TANI Kenji,OKUDA Masaru,MIZUNO Takuya
Journal of Veterinary Medical Science advpub(0), 1008180313, 2010
… Prekallikrein (PK) deficiency is an uncommon disorder in dogs. …
NAID 130000307711

高齢になってから診断された先天性プレカリクレイン欠乏症の1症例

長屋聡美,森下英理子,高見昭良,丸山慶子,關谷暁子,朝倉英策,中尾眞二,大竹茂樹
日本老年医学会雑誌 46(4), 348-351, 2009-07-25
NAID 10025638506

Related Pictures

★リンクテーブル★

リンク元	「血液凝固因子」「プレカリクレイン」

「血液凝固因子」

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英: coagulation factor (Z), clotting factor, blood coagulation factor, blood coagulation factors
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