第XIII因子。フィブリン安定化因子 fibrin stabilizing factor

WordNet

be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/30 23:57:45」(JST)

wiki en

[Wiki en表示]

Factor XIII crosslinks fibrin

Factor XIII or fibrin stabilizing factor is an enzyme (EC 2.3.2.13) of the blood coagulation system that crosslinks fibrin.

Function

Factor XIII is a transglutaminase that circulates in the plasma as a heterotetramer of two catalytic A subunits and two carrier B subunits. When thrombin has converted fibrinogen to fibrin, the latter forms a proteinaceous network in which every E-unit is crosslinked to only one D-unit. Factor XIII is activated by thrombin into factor XIIIa; its activation into Factor XIIIa requires calcium as a cofactor. A cleavage by thrombin between residue Arg37 and Gly38 on the N-terminus of the A subunit, leads to the release of the activation peptide (MW 4000 da). In the presence of calcium the carrier subunits dissociate from the catalytic subunits, leading to a 3D change in conformation of factor XIII and hence the exposure of catalytic cysteine residue. Upon activation by thrombin, factor XIIIa acts on fibrin to form γ-glutamyl-Є-lysyl amide cross links between fibrin molecules to form an insoluble clot.^{[citation needed]}

Discovery

FXIII is known also as Laki-Lorand factor, after the scientists who first proposed its existence in 1948.^[1] A 2005 conference recommended standardization of nomenclature.^[2]

Genetics

Zymogen factor XIII is a 320kDa glycoprotein tetramer consisting of twice two subunits (2 A and 2 B),^[2] the genes for which are on different chromosomes:

A subunit (6p25-p24). The transglutaminase part; this adds an alkyl group to the nitrogen on a glutamine residue, which binds in turn with a lysine on the other chain. The molecular weight of the A chain is approximately 83kDa.
B subunit (1q31-q32.1). This has no clear enzymatic activity, and may serve as a carrier for the A subunit. The molecular weight of the B chain is approximately 76.5kDa.

Physiology

Typical concentrations of FXIII in plasma is 10 μg/ml (2A2B heterodimer), while the concentration of free B chain is 22 μg/ml. FXIII has a long half life, ranging from 5–9 days. It is present in plasma, platelets, and monocytes, as well as macrophages and bone marrow precursors of these cell types.^[2]

A clot that has not been stabilized by FXIIIa is soluble in 5 mol/L urea, while a stabilized clot is resistant to this phenomenon.^[1]

Diagnostic use

Factor XIII levels are not measured routinely, but may be considered in patients with an unexplained bleeding tendency. As the enzyme is quite specific for monocytes and macrophages, determination of the presence of factor XIII may be used to identify and classify malignant diseases involving these cells.^[2]

References

^ ^a ^b Laki K, Lóránd L (September 1948). "On the Solubility of Fibrin Clots". Science 108 (2802): 280. doi:10.1126/science.108.2802.280. PMID 17842715.
^ ^a ^b ^c ^d Muszbek L, Ariëns RA, Ichinose A (January 2007). "Factor XIII: recommended terms and abbreviations". J. Thromb. Haemost. 5 (1): 181–3. doi:10.1111/j.1538-7836.2006.02182.x. PMID 16938124.

External links

Factor XIII deficiency at hemophilia.org
med/3491 at eMedicine

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 稀な遺伝性凝固異常 rare inherited coagulation disorders
2. 後天性の凝固因子阻害物質 acquired inhibitors of coagulation
3. 出血症状を有する小児に対するアプローチ approach to the child with bleeding symptoms
4. 止血の概要 overview of hemostasis
5. 心因性紫斑病（ガードナーダイヤモンド症候群） psychogenic purpura gardner diamond syndrome

English Journal

Protein predictive signatures for lymph node metastasis of gastric cancer.

Li W, Ye F, Wang D, Sun X, Tong W, Lian G, Jiang J, Suo J, Zhang DY.SourceDepartment of General Surgery, The First Hospital, Jilin University, Changchun, Jilin, China.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 Apr 15;132(8):1851-9. doi: 10.1002/ijc.27864. Epub 2012 Oct 25.
Lymph node status remains one of most crucial indicators of gastric cancer prognosis and treatment planning. Current imaging methods have limited accuracy in predicting lymph node metastasis. We sought to identify protein markers in primary gastric cancer and to define a risk model to predict lymph
PMID 23011604

The effect of whole-body cooling on hematological and coagulation parameters in asphyxic newborns.

Oncel MY, Erdeve O, Calisici E, Oguz SS, Canpolat FE, Uras N, Dilmen U.SourceDivision of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital , Ankara , Turkey.
Pediatric hematology and oncology.Pediatr Hematol Oncol.2013 Apr;30(3):246-52. doi: 10.3109/08880018.2013.771240. Epub 2013 Feb 27.
Although moderate therapeutic hypothermia is the only proven neuroprotective therapy in neonatal hypoxic ischemic encephalopathy secondary to perinatal asphyxia (PA), there is lack of data for its effect on hemostasis. To investigate the effect of neonatal asphyxia on hemostasis and to evaluate the
PMID 23445486

Factor XIII improves platelet adhesion to fibrinogen by protein disulfide isomerase-mediated activity.

Lahav J, Tvito A, Bagoly Z, Dardik R, Inbal A.SourceHemostasis Laboratory, Rabin Medical Center, Beilinson Hospital, Petach Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Thrombosis research.Thromb Res.2013 Apr;131(4):338-41. doi: 10.1016/j.thromres.2012.12.003. Epub 2012 Dec 28.
BACKGROUND: Factor XIII (FXIII), a plasma pro-transglutaminase, consists of two A subunits and two B subunits (FXIIIA2B2). Following activation by thrombin, it cross-links fibrin chains at the final step of coagulation. We previously reported that FXIII subunit A (FXIIIA) serves as a protein disulfi
PMID 23276530

Japanese Journal

新規D-dimer試薬LPIAジェネシスDダイマーの基礎性能評価および試薬特性

下仮屋雄二,渡邊真希,坂口茜,西川美有,秋月基伸,桜井錠治,森本誠,中谷中
医学検査 68(1), 85-91, 2019
… 凝固第XIII因子欠乏血漿を凝固させた後に線溶させた結果，経過時間に伴う測定値の上昇を認めるがACE-DDより低値であった。 …
NAID 130007557519

New Biomarkers for Prediction of Disseminated Intravascular Coagulation in Patients With Sepsis

Wakabayashi Ichiro,Mambo Naomi,Ueda Takahiro,Nonaka Daisuke,Lee Lyang-Ja,Tanaka Kenji,Kotani Joji
Clinical and Applied Thrombosis/Hemostasis 24(9S), 223S-229S, 2018-12-01
… The peptides were fragments of serum amyloid A-2 protein, α2-HS-glycoprotein, fibrinogen α chain, fibrinogen β chain, serum albumin, collagen α1 (I) chain, collagen α1 (III) chain, and coagulation factor XIII A chain. …
NAID 120006550268

血液凝固第XIII因子製剤投与が有効であった胃切除術後難治性乳糜腹水の1例

砂川祐輝,鹿野敏雄,寺本仁,丸山浩高,蜂須賀丈博
日本臨床外科学会雑誌 79(7), 1453-1458, 2018
… なかった．血液凝固第XIII因子活性が62％と低値であったため，術後24～28日目に血液凝固第XIII因子製剤を投与した．術後31日目に食事を再開したが，ドレーン排液の白濁化は認めず，その後も腹水増加を疑う所見を認めず，乳糜腹水は改善した．<BR>乳糜腹水は腹部手術後の合併症の一つで，その治療に難渋することがある．乳糜腹水に対し血液凝固第XIII因子製剤を投与した報 …
NAID 130007585159

Related Pictures

★リンクテーブル★

リンク元	「第XIII因子」「fibrin stabilizing factor」
拡張検索	「blood coagulation factor XIII」「coagulation factor XIII」「factor XIIIa」
関連記事	「fact」「factor」

「第XIII因子」

coagulation factor XIII,; B polypeptide
Identifiers
Symbol	F13B
Entrez	2165
HUGO	3534
OMIM	134580
RefSeq	NM_001994
UniProt	P05160
Other data
Locus	Chr. 1 q31-q32.1

coagulation factor XIII,; A1 polypeptide
Identifiers
Symbol	F13A1
Alt. symbols	F13A
Entrez	2162
HUGO	3531
OMIM	134570
RefSeq	NM_000129
UniProt	P00488
Other data
Locus	Chr. 6 p24.2-p23