WordNet

set the speed, duration, or execution of; "we time the process to manufacture our cars very precisely"
a period of time considered as a resource under your control and sufficient to accomplish something; "take time to smell the roses"; "I didnt have time to finish"; "it took more than half my time"
a suitable moment; "it is time to go"
adjust so that a force is applied and an action occurs at the desired time; "The good player times his swing so as to hit the ball squarely"
an indefinite period (usually marked by specific attributes or activities); "he waited a long time"; "the time of year for planting"; "he was a great actor in his time"
regulate or set the time of; "time the clock"
the continuum of experience in which events pass from the future through the present to the past
an instance or single occasion for some event; "this time he succeeded"; "he called four times"; "he could do ten at a clip" (同)clip
a persons experience on a particular occasion; "he had a time holding back the tears"; "they had a good time together"
assign a time for an activity or event; "The candidate carefully timed his appearance at the disaster scene"
a special situation; "this thing has got to end"; "it is a remarkable thing"
a separate and self-contained entity
an action; "how could you do such a thing?"
an artifact; "how does this thing work?"
an entity that is not named specifically; "I couldnt tell what the thing was"
any attribute or quality considered as having its own existence; "the thing I like about her is ..."
a persistent illogical feeling of desire or aversion; "he has a thing about seafood"; "she has a thing about him"
a special abstraction; "a thing of the spirit"; "things of the heart"
a special objective; "the thing is to stay in bounds"
a statement regarded as an object; "to say the same thing in other terms"; "how can you say such a thing?"
an event; "a funny thing happened on the way to the..."
through a range downward; "children six and under will be admitted free"
further down; "see under for further discussion" (同)below
below some quantity or limit; "fifty dollars or under"
below the horizon; "the sun went under"
down below; "get under quickly!"
down to defeat, death, or ruin; "their competitors went under"
in or into a state of subordination or subjugation; "we must keep our disappointment under"
into unconsciousness; "this will put the patient under"
lower in rank, power, or authority; "an under secretary"
the extent of a 2-dimensional surface enclosed within a boundary; "the area of a rectangle"; "it was about 500 square feet in area" (同)expanse, surface_area
a part of a structure having some specific characteristic or function; "the spacious cooking area provided plenty of room for servants"
a particular geographical region of indefinite boundary (usually serving some special purpose or distinguished by its people or culture or geography); "it was a mountainous area"; "Bible country" (同)country
a part of an animal that has a special function or is supplied by a given artery or nerve; "in the abdominal region" (同)region
a subject of study; "it was his area of specialization"; "areas of interest include..."
the spatial property of being crowded together (同)density, denseness, tightness, compactness
bringing together military forces
strengthening the concentration (as of a solute in a mixture) by removing diluting material
the strength of a solution; number of molecules of a substance in a given volume
complete attention; intense mental effort (同)engrossment, absorption, immersion
increase in density

PrepTutorEJDIC

〈U〉《冠詞をつけずに》(空間に対しての)『時間』,時 / 〈U〉(時計で示される)『時刻』 / 〈U〉(ある方式で決められる)『時間』,標準時 / 〈C〉〈U〉(特定の)『時』,おり,ころ / 〈U〉《しばしば A ~》(ある長さの)『時間』,期間 / 〈U〉(要する)『時間』;暇 / 《しばしば複数形で》(歴史上の)『時代』 / 《複数形で》時勢,景気 / 《one's ~》(個人の)一生;若いころ;生涯の特定の時期 / 〈U〉《しばしば A ~》(ある経験をした)『時間』 / 〈C〉『…回』,度 / 〈C〉『…倍』 / …の時間を定める / (…に)…の調子を合わせる《+名+to+名》 / …の時間を計る
〈C〉(形のある)『物』,物体;(生物に対しての)『無生物』 / 〈C〉(形のない)『もの』,事,事柄,でき事 / 《複数形で》事情,事態,状勢,状況 / 《複数形で》(すべての)事物,事柄 / 《通例 the~》(努力・活動などの)目的,目標 / 〈C〉衣服,衣類・《one's things》持ち物,所持品,身の回り品 / 《複数形で》道具,用具・〈C〉《親愛・哀れみ・軽べつなどの感情をこめて》人,者,やつ / 《the~》《話》(…の)流行《+in+名》
《下方の場所・位置》『…の下に』,に覆われて / 《内部の位置》『…の内側に』,の下に / (重荷・苦痛など)『を負って』,に圧迫されて / (支配・保護・影響など)『…を受けて』,のもとで,の状態で / 《受動状態の継続》『…中』 / (分類項目)『の中に』,に属して / (地位・数量などが)『…に劣る』,より下の / (行動などの基準)に従って,基づいて / 『下へ』,下に / 下位に,抑圧されて,従属して / 下の,下部の;下位の,劣った
〈U〉〈C〉『面積』 / 〈C〉『地域』,『地方』(region, district) / 〈C〉(活動・研究・興味などの及ぶ)『範囲』,『領域』(range)《+『of』+『名』》 / 〈C〉《英》=areaway 1
〈U〉(…への)(光線・注意などの)集中;(仕事などへの)専念,専心《+『on』+『名』》 / 〈C〉(人口などの)集中 / 〈U〉濃縮;〈液体の〉濃度

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1. 成人における抗癌剤の投与 dosing of anticancer agents in adults
2. 化学療法関連腎毒性および腎不全患者における用量調整 chemotherapy related nephrotoxicity and dose modification in patients with renal insufficiency
3. アミノグリコシド（非経口）の用量および投与 dosing and administration of parenteral aminoglycosides
4. Vancomycin: Parenteral dosing and serum concentration monitoring in adults
5. 血清クレアチニン濃度と慢性腎疾患の関係 reciprocal serum creatinine concentration and chronic kidney disease

English Journal

Decreased exposure of atorvastatin in diabetic rats partly due to induction of hepatic Cyp3a and Oatp2.

Shu N1, Hu M1, Liu C2, Zhang M1, Ling Z1, Zhang J3, Xu P1, Zhong Z1, Chen Y1, Liu L1, Liu X1.
Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2016 Oct;46(10):875-81. doi: 10.3109/00498254.2016.1141437. Epub 2016 Feb 10.
1. Atorvastatin is frequently prescribed for lowering blood cholesterol and for prevention of events associated with cardiovascular disease. The aim of this study was to investigate the pharmacokinetics of atorvastatin in diabetic rats. 2. Diabetes was induced in rats by combination of high-fat diet
PMID 26864241

Evaluation of drug-drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males.

Wang L1, Wu C2, Shen L1, Liu H3, Chen Y3, Liu F4, Wang Y5, Yang J1.
Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2016 Aug;46(8):703-8. doi: 10.3109/00498254.2015.1113576. Epub 2015 Nov 26.
1. Henagliflozin is a novel sodium-glucose transporter 2 inhibitor and presents a complementary therapy to metformin for patients with T2DM due to its insulin-independent mechanism of action. This study evaluated the potential pharmacokinetic drug-drug interaction between henagliflozin and metform
PMID 26608671

Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis.

Sandborn WJ1,2, Bhandari BR3, Fogel R4, Onken J5, Yen E6, Zhao X6, Jiang Z6, Ge D6, Xin Y6, Ye Z6, French D6, Silverman JA6, Kanwar B6, Subramanian GM6, McHutchison JG6, Lee SD7, Shackelton LM1, Pai RK8, Levesque BG1, Feagan BG1,9,10.
Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2016 Jul;44(2):157-69. doi: 10.1111/apt.13653. Epub 2016 May 24.
BACKGROUND: Matrix metalloproteinase-9 is a proteolytic enzyme whose expression is increased in ulcerative colitis.AIM: To evaluate the safety and efficacy of GS-5745, a fully humanised anti-matrix metalloproteinase-9 monoclonal antibody, in moderately-to-severely active ulcerative colitis.METHODS:
PMID 27218676