WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- the 13th letter of the Roman alphabet (同)m
- the imperial dynasty of China from 1368 to 1644 (同)Ming dynasty
- a form of address for a woman (同)Ms.
PrepTutorEJDIC
- 蛋白(たんばく)質
- Mach number / mark[s] / Monsieur
- (中国の)明,明朝(1368‐1644)
- mendeleviumの化学記号
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/08 20:51:09」(JST)
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- 1. 意義未確定の単クローン性免疫グロブリン血症（MGUS）の診断 diagnosis of monoclonal gammopathy of undetermined significance
- 2. Laboratory methods for analyzing monoclonal proteins
- 3. 単クローン性免疫グロブリン関連腎症の診断と治療 diagnosis and treatment of monoclonal gammopathy of renal significance
- 4. 意義不明の単クローン性免疫グロブリン血症の臨床経過およびマネージメント clinical course and management of monoclonal gammopathy of undetermined significance
- 5. 多発性骨髄腫やその他の単クローン性免疫グロブリン血症に伴う腎臓病の臨床的特徴、評価、診断 clinical features evaluation and diagnosis of kidney disease in multiple myeloma and other monoclonal gammopathies
English Journal
- A new strategy for methylated DNA detection based on photoelectrochemical immunosensor using Bi2S3 nanorods, methyl bonding domain protein and anti-his tag antibody.
- Yin H, Sun B, Zhou Y, Wang M, Xu Z, Fu Z, Ai S.SourceCollege of Chemistry and Material Science, Shandong Agricultural University, Taian, Shandong 271018, PR China.
- Biosensors & bioelectronics.Biosens Bioelectron.2014 Jan 15;51:103-8. doi: 10.1016/j.bios.2013.07.040. Epub 2013 Jul 29.
- In this work, we fabricated a novel photoelectrochemical immunosensor for assay of DNA methylation, where Bi2S3 nanorods were used as photoelectric conversion material, MBD1 protein (a kind of methyl bonding domain protein) was used as DNA methylation recognizing unit, anti-his tag antibody was used
- PMID 23948240
- EXTRACTION, PURIFICATION, AND CHARACTERIZATION OF A TRYPSIN INHIBITOR FROM COWPEA SEEDS (Vigna unguiculata).
- Wang J, Li X, Xia X, Li H, Liu J, Li QX, Li J, Xu T.Sourcea College of Resources and Environmental Sciences , China Agricultural University , Beijing , China.
- Preparative biochemistry & biotechnology.Prep Biochem Biotechnol.2014 Jan 2;44(1):1-15. doi: 10.1080/10826068.2013.782041.
- Protease inhibitors against trypsin were extracted from cowpea seeds, purified, and characterized. After the seed powder was defatted with hexane, the cowpea trypsin inhibitor (CpTI) was extracted with 0.15 M NaCl for 30 min. The crude extracts were then heated at 90°C for 10 min, followed by pr
- PMID 24117148
- Oxidative processes during enzymatic hydrolysis of cod protein and their influence on antioxidant and immunomodulating ability.
- Halldorsdottir SM, Sveinsdottir H, Freysdottir J, Kristinsson HG.SourceMatis ohf., Vinlandsleid 12, 113 Reykjavík, Iceland. sigrun.m.halldorsdottir@matis.is
- Food chemistry.Food Chem.2014 Jan 1;142:201-9. doi: 10.1016/j.foodchem.2013.07.053. Epub 2013 Jul 19.
- Fish protein hydrolysates (FPH) have many desirable properties, however heating and shifts in pH can cause oxidation during enzymatic hydrolysis. The objective was to investigate oxidative processes during enzymatic hydrolysis of fish protein and the impact of oxidation on the antioxidant and immuno
- PMID 24001832
Japanese Journal
- 臨床研究・症例報告 解熱後もCRP陽性が遷延した硬膜下水腫合併細菌性髄膜炎の1例
- 森岡 圭太,伊藤 智城,佐野 仁美 [他]
- 小児科臨床 68(7), 1355-1359, 2015-07
- NAID 40020495320
- FOXC2 Expression is Associated with Tumor Proliferation and Invasion Potential in Oral Tongue Squamous Cell Carcinoma
- Imayama Naomi,Yamada Shin-ichi,Yanamoto Souichi,Naruse Tomofumi,Matsushita Yuki,Takahashi Hidenori,Seki Sachiko,Fujita Shuichi,Ikeda Tohru,Umeda Masahiro
- Pathology & Oncology Research 21(3), 783-791, 2015-07
- … Forkhead box protein C2 (FOXC2) is a gene encoding a transcription factor that controls the generation of mesodermal tissue including vascular and lymphatic tissues. …
- NAID 120005613665
- Smarcal1 promotes double-strand-break repair by nonhomologous end-joining.
- Keka Islam Shamima,Mohiuddin,Maede Yuko,Rahman Md Maminur,Sakuma Tetsushi,Honma Masamitsu,Yamamoto Takashi,Takeda Shunichi,Sasanuma Hiroyuki
- Nucleic acids research, 2015-06-18
- … 2015-06-23.Smarcal1 is a SWI/SNF-family protein with an ATPase domain involved in DNA-annealing activities and a binding site for the RPA single-strand-DNA-binding protein. …
- NAID 120005617590
Related Links
- M Protein Myeloma www.aolsearch.com/M+Protein+Myeloma Get your results now! Search M Protein Myeloma Medical Dictionary M protein n. A surface protein present on strep bacteria that prevents white blood cells from ...
- M protein n. A surface protein present on strep bacteria that prevents white blood cells from engulfing and destroying the bacteria. M protein Monoclonal or myeloma protein; IgM that is overproduced in Waldenstrom's ...
Related Pictures
★リンクテーブル★
| リンク元 | 「マクログロブリン血症」「M蛋白」 |
| 拡張検索 | 「M proteinemia」「TRAM protein」 |
| 関連記事 | 「Md」「M」 |
「マクログロブリン血症」
- 英
- macroglobulinemia
- 同
- ワルデンシュトレーム・マクログロブリン血症 Waldenström macroglobulinemia Waldenstrom macroglobulinemia WM、原発性マクログロブリン血症 primary macroglobulinemia、マクログロブリネミア
- 関
- 単クローン性免疫グロブリン血症。高γグロブリン血症
- first aid step1 2006 p.304
- Bence Jones protein：multiple myeloma(κ/λ Ig light chains in urine), Waldenström's macroglobulinemia (IgM)
- monoclonal antibody spike：multiple myeloma (M protein = IgG/IgA), MGUS (monoclonal gammopathy of undetermined significance), Waldenström's macroglobulinemia (M protein = IgM)
| ALL | ALL(バーキット型) | 悪性リンパ腫、CLL | マクログロブリン血症 | 骨髄腫 | |
| 分化段階 | 前駆B細胞 | 未熟B細胞 | 成熟B細胞 | 形質細胞 | |
| 細胞表面免疫グロブリン | － | ＋ | ＋ | ± | － |
| 免疫グロブリン分泌 | － | － | － | ＋ | ＋ |
WCH.2669
| pathologic feature | MCL | B-cell CLL | FL | MZL | WM | MM |
| paraprotein | None | Small IgG or IgM | Usually none | Small IgM | IgM (large) | IgA, IgG |
| morphology | Centrocyte-like; small-to-medium-sized lymphocytes | Small lymphocyte with clumped chromatin | Follicle center cells (follicular pattern) | Monocytoid B cells, heterogeneous | Plasmacytoid lymphocytes and plasma cells | Plasma cells |
| surface Ig | ＋ | ＋ | ＋ | ＋ | ＋ | ＋ |
| cytoplasmic Ig | － | － | － | － | ＋＋ | ＋＋＋ |
| CD19 | ＋ | ＋ | ＋ | ＋ | ＋ | ＋ |
| CD20 | ＋＋ | ＋ | ＋＋ | ＋ | ＋ | 15% CD20+ |
| CD23 | － | ＋ | ± | － | － | － |
| CD22 | ＋ | － | － | ＋ | ＋ | － |
| CD38 | － | ± | － | － | ＋ | ＋＋ |
| CD138 | － | － | － | － | ＋ | ＋＋ |
| CD5 | ＋ | ＋ | － | － | Usually CD5- | － |
| CDlO | ± | － | ＋ | － | － | － |
| cytogenetic aberrations | t(11;14)(q13;q32), cyclin Dl+ | 13q-, 6q-, +12, 11q23- | t(14;18)(q32; q21), bcl-2+ | t(11;18)(q21; q21), +3 | 6q- | t(4;14)(p16.3;q32),t(11;14)(q13;q32),t(14;16)(q32;q23), other +14q32,13q-, aneuploidy |
| somatic hypermutation | ？ | ＋, 50%; -, 50% | ＋＋ | ＋＋ | ＋＋＋ | ＋＋＋ |
| bone marrow involvement (%) | 25 | ～100 | 85 | 50 | ＞90 | 100 |
| bone lytic lesions | No | No | No | No | 5% | 70% |
概念
病因
疫学
- 60-70歳
症状
- also see WCH.2671
- 血管粘稠度上昇 ＋ 病的蛋白質による血管内皮損傷：[眼症状] ソーセージ様の網膜血管のうっ滞・拡張、網膜出血、綿花様白斑、網膜静脈閉塞症、滲出性網膜剥離
- リンパ球の浸潤による症状：weakness, 体重減少、骨痛、肝脾腫、リンパ節腫
診断
鑑別診断
- 慢性リンパ性白血球、骨髄腫(IgM myeloma: bone lesion, CD138+ plamac cell infiltration)、kymphocytic lymphoma
myelomaとの共通点と異差
HIM.706
- 共通点：
- 症状：weakness、疲労、反復感染
- WMに特徴的：
- lymphadenopathy、hepatosplenomegalyがあること。bone lesionや高カルシウム血症は起こさない。(大きさの違いから？)IgMは殆ど人から排泄されないし、-20%の人しかBJPを排泄しないから、腎病変は一般的でない。
- WMでより一般的：
- 鼻出血、視力障害(visual disturbance)、神経症状(めまい、頭痛、一時的な麻痺)
QB.G-269 WCH.2671
| 多発性骨髄腫 | マクログロブリン血症 | ||
| ワルデンシュトレーム・マクログロブリン血症 | |||
| MM | WM | ||
| 病変のfocus | 主に骨髄 | 主にリンパ組織 | 集積することで出現する症状が異なる |
| 腫瘍細胞 | 形質細胞 | やや幼弱なB細胞 | |
| 赤血球連戦形成 | ＋ | ＋＋＋ | IgMのせい |
| 出血傾向 | 少 | 多 | IgMのせい |
| 肝脾腫、リンパ節腫脹 | |||
| 骨破壊 | 70％ | 5％ | |
| 過粘稠度症候群 | 少 | 多 | IgMのせい |
| M蛋白 | IgG,IgA,IgD,IgE,BJP | IgM | |
| 腎障害 | 多 | 少 | IgMは糸球体濾過されにくい |
| 眼底変化 | 少 | 多 | IgMのせい |
| 年齢 | 40-60歳代 | 40-70歳代 |
検査
血算
- 赤沈：高度促進
- 貧血
- 白血球：増多(リンパ球様細胞の増多)
- 血小板：減少 ← MMより頻度は低い、はず。一般的でなく、病気の末期まで出現しない(WCH.2671)。患者のほとんどが正常範囲内で、10万/ul以下であるのはほんの9%の患者であり、本疾患における血小板減少症の有病率は22%と報告されている(WCH.2671)。
血液生化学
尿検査
- 尿タンパク：陽性(10%でBJPが見られる。)
治療
予後
USMLE
- Q book p.246 41
「M蛋白」
- 英
- M protein
- 同
- Mタンパク質、Mタンパク、M蛋白質。M成分 M component、単クローン性蛋白質 monoclonal protein、単クローン性免疫グロブリン monoclonal immunoglobulin
- 関
- [[]]
概念
- LAB.486
- 正常では存在しない。抗体産生細胞の異常により産生される単クローン性免疫グロブリン
原因
臨床関連
「M proteinemia」
「TRAM protein」
- 同
- translocating chain-associated membrane