Janeway lesions are non-tender, small erythematous or haemorrhagic macular or nodular lesions on the palms or soles only a few millimeters in diameter that are indicative of infective endocarditis.[1]
Osler's nodes and Janeway lesions are similar and point to the same diagnostic conclusion. The only noted difference between the two is that Osler's nodes present with tenderness, while Janeway lesions do not.[2]
Contents
1Causes
2Diagnosis
3Etymology
4See also
5References
6External links
Causes
Pathologically, the lesion is described to be a microabscess of the dermis with marked necrosis and inflammatory infiltrate not involving the epidermis.[1] They are caused by septic emboli which deposit bacteria, forming microabscesses.[3] Janeway lesions are distal, flat, ecchymotic, and painless.
Diagnosis
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Etymology
Janeway lesions are named after Edward Janeway (1841–1911), a prominent American physician and pathologist who initially described the lesions.
See also
Roth's spots
Osler's node
References
^ abFarrior, J.B.; Silverman M.E. (1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–243. doi:10.1378/chest.70.2.239. PMID 947688.
^Farrior JB, Silverman ME (August 1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis". Chest. 70 (2): 239–243. doi:10.1378/chest.70.2.239. PMID 947688.
^Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th ed., Churchill Livingstone 2009.
…IE. Relatively uncommon clinical manifestations that are highly suggestive of IE include: Janeway lesions – Nontender erythematous macules on the palms and soles Osler nodes – Tender subcutaneous violaceous …
…lesions found under the nail bed Janeway lesions, Osler nodes, and Roth spots are more specific for IE but are also less common; Roth spots are particularly rare. Janeway lesions are macular, nonblanching, nonpainful …
…forms of septicemia. Lesions typically are acral. Other cutaneous findings, such as petechiae or Janeway lesions, may be present. Atrial myxoma – Atrial myxomas are benign tumors of the heart. Tumor fragments …
…IE as a consequence of immune-mediated disease. Other immunologic sequelae (ie, Roth spots, Janeway lesions, and Osler nodes) are less common in children than they are in adults. These are described in…
…genital ulcers. The acral hemorrhagic pustules of DGI should be distinguished from the acral Janeway lesions and Osler nodes that may occur in infective endocarditis and the hemorrhagic petechiae or pustules…
English Journal
Janeway Lesions: a Painless Manifestation of Infective Endocarditis.
Panginikkod S, Gopalakrishnan V, Parikh M, Gupta N.
Journal of general internal medicine. 2019 Apr;().
Integrated genetic and pharmacologic interrogation of rare cancers.
Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, Kryukov GV, Clemons PA, Tsherniak A, Vazquez F, Crompton BD, Shamji AF, Rodriguez-Galindo C, Janeway KA, Roberts CW, Stegmaier K, van Hummelen P, Cima MJ, Langer RS, Garraway LA, Schreiber SL, Root DE, Hahn WC, Boehm JS.
Nature communications. 2016 06;7()11987.
Identifying therapeutic targets in rare cancers remains challenging due to the paucity of established models to perform preclinical studies. As a proof-of-concept, we developed a patient-derived cancer cell line, CLF-PED-015-T, from a paediatric patient with a rare undifferentiated sarcoma. Here, we
A 50-year-old Japanese man presented with fever and upper respiratory tract symptoms that required urgent inpatient admission. A physical examination revealed conjunctival hemorrhages and peripheral e …
What are Osler nodes and Janeway lesions? Osler nodes and Janeway lesions are two rare but well-known skin manifestations of bacterial endocarditis. They have also rarely been described in systemic lupus erythematosus (SLE ...
The janeway lesion is described as collection of pus that has built up within the tissues of the body with marked localized death of living tissue and inflammatory filtrate not involving the epidermis. These macules are only few ...
