vascular endothelial growth factor receptor

血管内皮増殖因子受容体、血管内皮増殖因子レセプター

関

VEGF receptor、VEGFR

WordNet

1. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
2. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
3. become attached by or as if by the process of growth; "The tree trunks had grown together"
4. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
5. cause to grow or develop; "He grows vegetables in his backyard"
6. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
7. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
8. (pathology) an abnormal proliferation of tissue (as in a tumor)
9. a progression from simpler to more complex forms; "the growth of culture"
10. something grown or growing; "a growth of hair"
11. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
12. be a contributing factor; "make things factor into a companys profitability"
13. any of the numbers (or symbols) that form a product when multiplied together
14. an independent variable in statistics
15. anything that contributes causally to a result; "a number of factors determined the outcome"
16. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
17. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
18. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
19. a concept whose truth can be proved; "scientific hypotheses are not facts"
20. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
21. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
22. of or relating to or having vessels that conduct and circulate fluids; "vascular constriction"; "a vascular bundle"

PrepTutorEJDIC

1. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
2. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
3. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
4. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
5. (血液・樹液などを運ぶ)管の,導管の,血管の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/28 07:47:33」(JST)

wiki en

[Wiki en表示]

fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Identifiers Symbol FLT1 Alt. symbols FLT Entrez 2321 HUGO 3763 OMIM 165070 RefSeq NM_002019 UniProt P17948 Other data EC number 2.7.1.112 Locus Chr. 13 q12 kinase insert domain receptor (a type III receptor tyrosine kinase) Identifiers Symbol KDR Alt. symbols FLK1, VEGFR, VEGFR2, CD309 Entrez 3791 HUGO 6307 OMIM 191306 RefSeq NM_002253 UniProt P35968 Other data EC number 2.7.1.112 Locus Chr. 4 q11-q12 fms-related tyrosine kinase 4 Identifiers Symbol FLT4 Alt. symbols VEGFR3, PCL Entrez 2324 HUGO 3767 OMIM 136352 RefSeq NM_002020 UniProt P35916 Other data EC number 2.7.1.112 Locus Chr. 5 q34-q35

VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Also, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR), depending on alternative splicing.

VEGF

Main article: Vascular endothelial growth factor

Vascular endothelial growth factor (VEGF) is an important signaling protein involved in both vasculogenesis (the formation of the circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). As its name implies, VEGF activity is restricted mainly to cells of the vascular endothelium, although it does have effects on a limited number of other cell types (e.g. stimulation monocyte/macrophage migration). In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF also enhances microvascular permeability and is sometimes referred to as vascular permeability factor.

Receptor biology

Ligands for different VEGF receptors.

All members of the VEGF family stimulate cellular responses by binding to tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain.

VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 is to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In fact, an alternatively spliced form of VEGFR-1 (sFlt1) is not a membrane bound protein but is secreted and functions primarily as a decoy. A third receptor has been discovered (VEGFR-3), however, VEGF-A is not a ligand for this receptor. VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D.

VEGFR antagonists

Some VEGFR antagonists (inhibitors) (for example lenvatinib, motesanib) are under investigation for treating various cancers. Pazopanib was approved for renal cell carcinoma in 2009. Regorafenib was approved for colorectal cancer in Sept 2012.

References

External links

• VEGF Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
• Proteopedia Vascular_Endothelial_Growth_Factor_Receptor - the Vascular Endothelial Growth Factor Receptor Structure in Interactive 3D

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

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English Journal

• Domain I-IV of β2-glycoprotein I inhibits advanced glycation end product-induced angiogenesis by down-regulating vascular endothelial growth factor 2 signaling.

• Wang QQ, Zhou SJ, Meng ZX, Wang J, Chen R, Lv L, Li CJ, Yu DM, Yu P.
• Molecular medicine reports.Mol Med Rep.2015 Mar;11(3):2167-72. doi: 10.3892/mmr.2014.2970. Epub 2014 Nov 18.
• Advanced glycation end products (AGEs) are a contributing factor in the angiogenesis that is characteristic of proliferative diabetic retinopathy. However, a previous study made a promising observation that domain I‑IV of β2‑glycoprotein I (DI‑IV) inhibits angiogenesis in human umbilical vei
• PMID 25405610

• Multiplexed electrochemical coding of DNA-protein bindings.

• Jiang B1, Wang M2, Li F2, Yu L2, Xie J2.
• Biosensors & bioelectronics.Biosens Bioelectron.2015 Feb 15;64:429-33. doi: 10.1016/j.bios.2014.09.051. Epub 2014 Sep 28.
• A simple, sensitive and multiplexed electrochemical sensor for the detection of DNA-protein binding based on the exonuclease protection strategy is described. Two electroactive species, methylene blue (MB)- and ferrocene (Fc)-labeled dsDNA probes are self-assembled on a gold electrode to prepare the
• PMID 25282396

• Epigenetic reprogramming in atherosclerosis.

• Grimaldi V1, Vietri MT, Schiano C, Picascia A, De Pascale MR, Fiorito C, Casamassimi A, Napoli C.
• Current atherosclerosis reports.Curr Atheroscler Rep.2015 Feb;17(2):476. doi: 10.1007/s11883-014-0476-3.
• Recent data support the involvement of epigenetic alterations in the pathogenesis of atherosclerosis. The most widely investigated epigenetic mechanism is DNA methylation although also histone code changes occur during the diverse steps of atherosclerosis, such as endothelial cell proliferation, vas
• PMID 25433555

Japanese Journal

• Bee Venom Promotes Hair Growth in Association with Inhibiting 5α-Reductase Expression

• Biological and Pharmaceutical Bulletin 39(6), 1060-1068, 2016
• NAID 130005155148

• Mechanical Stress Regulates Endothelial Progenitor Cell Angiogenesis Through VEGF Receptor Endocytosis

• International Heart Journal 57(3), 356-362, 2016
• NAID 130005153699

• Suppression of Allograft Rejection with Soluble VEGF Receptor 2 Chimeric Protein in a Mouse Model of Corneal Transplantation

• The Tohoku Journal of Experimental Medicine 239(1), 81-88, 2016
• NAID 130005152117

Related Links

• Vascular endothelial growth factor - Wikipedia, the free encyclopedia

Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates vasculogenesis and .... Circulating VEGFxxx then binds to VEGF Receptors on endothelial cells, triggering a Tyrosine Kinase Pathway leading to ...

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★リンクテーブル★

リンク元	「VEGF receptor」「血管内皮増殖因子受容体」「血管内皮増殖因子レセプター」「VEGFR」
拡張検索	「vascular endothelial growth factor receptor-1」「vascular endothelial growth factor receptor-2」「vascular endothelial growth factor receptor-3」
関連記事	「grow」「vascular」「fact」「factor」「endothelial」

「VEGF receptor」

　　[★]

• 血管内皮増殖因子受容体、血管内皮増殖因子レセプター、VEGF受容体、VEGFレセプター

関

vascular endothelial growth factor receptor、VEGFR

「血管内皮増殖因子受容体」

　　[★]

英

vascular endothelial growth factor receptor、VEGF receptor、VEGFR

関

血管内皮増殖因子レセプター、VEGF受容体、VEGFレセプター

「血管内皮増殖因子レセプター」

　　[★]

英

vascular endothelial growth factor receptor、VEGF receptor

関

血管内皮増殖因子受容体、VEGF受容体、VEGFレセプター

「VEGFR」

　　[★]

• 血管内皮増殖因子受容体

関

vascular endothelial growth factor receptor、VEGF receptor

「vascular endothelial growth factor receptor-1」

　　[★]

血管内皮増殖因子受容体1

関

VEGFR-1

「vascular endothelial growth factor receptor-2」

　　[★]

血管内皮増殖因子受容体2

関

VEGFR-2

「vascular endothelial growth factor receptor-3」

　　[★]

血管内皮増殖因子受容体3

関

VEGFR-3

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「vascular」

　　[★]

• adj.

• (生物・解剖)導管の、脈管の、血管の

関

angio、blood vessel、fibrovascular bundle、vascular bundle、vasculogenic、vein、vessel

　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「endothelial」

　　[★]

• adj.

• 内皮の

関

endodermis、endothelia、endothelium