- 関
- vascular endothelial growth factor receptor-3
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/17 09:31:25」(JST)
[Wiki en表示]
| fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) |
| Identifiers |
| Symbol |
FLT1 |
| Alt. symbols |
FLT |
| Entrez |
2321 |
| HUGO |
3763 |
| OMIM |
165070 |
| RefSeq |
NM_002019 |
| UniProt |
P17948 |
| Other data |
| EC number |
2.7.1.112 |
| Locus |
Chr. 13 q12 |
| kinase insert domain receptor (a type III receptor tyrosine kinase) |
| Identifiers |
| Symbol |
KDR |
| Alt. symbols |
FLK1, VEGFR, VEGFR2, CD309 |
| Entrez |
3791 |
| HUGO |
6307 |
| OMIM |
191306 |
| RefSeq |
NM_002253 |
| UniProt |
P35968 |
| Other data |
| EC number |
2.7.1.112 |
| Locus |
Chr. 4 q11-q12 |
| fms-related tyrosine kinase 4 |
| Identifiers |
| Symbol |
FLT4 |
| Alt. symbols |
VEGFR3, PCL |
| Entrez |
2324 |
| HUGO |
3767 |
| OMIM |
136352 |
| RefSeq |
NM_002020 |
| UniProt |
P35916 |
| Other data |
| EC number |
2.7.1.112 |
| Locus |
Chr. 5 q34-q35 |
|
VEGF receptors are receptors for vascular endothelial growth factor (VEGF).[1][2] There are three main subtypes of VEGFR, numbered 1, 2 and 3. Also, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR), depending on alternative splicing.[3]
Contents
- 1 VEGF
- 2 Receptor biology
- 3 VEGFR antagonists
- 4 References
- 5 External links
VEGF
Main article: Vascular endothelial growth factor
Vascular endothelial growth factor (VEGF) is an important signaling protein involved in both vasculogenesis (the formation of the circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). As its name implies, VEGF activity is restricted mainly to cells of the vascular endothelium, although it does have effects on a limited number of other cell types (e.g. stimulation monocyte/macrophage migration). In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF also enhances microvascular permeability and is sometimes referred to as vascular permeability factor.
Receptor biology
Ligands for different VEGF receptors.
[4][5]
All members of the VEGF family stimulate cellular responses by binding to tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain.
VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF.[1] The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 is to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). In fact, an alternatively spliced form of VEGFR-1 (sFlt1) is not a membrane bound protein but is secreted and functions primarily as a decoy.[6] A third receptor has been discovered (VEGFR-3), however, VEGF-A is not a ligand for this receptor. VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D.
VEGFR antagonists
Some VEGFR antagonists (inhibitors) (for example lenvatinib, motesanib) are under investigation for treating various cancers. Pazopanib was approved for renal cell carcinoma in 2009. Regorafenib was approved for colorectal cancer in Sept 2012.
References
- ^ a b Holmes K, Roberts OL, Thomas AM, Cross MJ. (Oct 2007). "Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.". Cell Signal. 19 (10): 2003–2012. doi:10.1016/j.cellsig.2007.05.013. PMID 17658244.
- ^ Stuttfeld E, Ballmer-Hofer K (September 2009). "Structure and function of VEGF receptors". IUBMB Life 61 (9): 915–22. doi:10.1002/iub.234. PMID 19658168.
- ^ Fujita, N.; Imai, J.; Suzuki, T.; Yamada, M.; Ninomiya, K.; Miyamoto, K.; Iwasaki, R.; Morioka, H.; Matsumoto, M.; Chiba, K.; Watanabe, S.; Suda, T.; Toyama, Y.; Miyamoto, T. (2008). "Vascular endothelial growth factor-A is a survival factor for nucleus pulposus cells in the intervertebral disc". Biochemical and Biophysical Research Communications 372 (2): 367–372. doi:10.1016/j.bbrc.2008.05.044. PMID 18492486. edit
- ^ cancerpublications.com.
- ^ Interactions of VEGF ligands and VEGF receptors ResearchVEGF.com, retrieved on November 13, 2009
- ^ Zygmunt T, Gay CM, Blondelle J, Singh MK, Flaherty KM, Means PC, Herwig L, Krudewig A, Belting HG, Affolter M, Epstein JA, Torres-Vázquez J. (August 2011). "Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1". Dev Cell. 21 (2): 301–314. doi:10.1016/j.devcel.2011.06.033. PMC 3156278. PMID 21802375.
External links
- VEGF Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
- Proteopedia Vascular_Endothelial_Growth_Factor_Receptor - the Vascular Endothelial Growth Factor Receptor Structure in Interactive 3D
|
Protein kinases: tyrosine kinases (EC 2.7.10)
|
|
|
Receptor tyrosine kinases (EC 2.7.10.1)
|
|
| Growth factor receptors |
| EGF receptor family |
|
|
| Insulin receptor family |
|
|
| PDGF receptor family |
- CSF1R
- FLT3
- KIT
- PDGFR (PDGFRA
- PDGFRB)
|
|
| FGF receptor family |
|
|
| VEGF receptors family |
- VEGFR1
- VEGFR2
- VEGFR3
- VEGFR4
|
|
| HGF receptor family |
|
|
| Trk receptor family |
|
|
|
| EPH receptor family |
- EPHA1
- EPHA2
- EPHA3
- EPHA4
- EPHA5
- EPHA6
- EPHA7
- EPHA8
- EPHB1
- EPHB2
- EPHB3
- EPHB4
- EPHB5
- EPHB6
- EPHX
|
|
| LTK receptor family |
|
|
| TIE receptor family |
|
|
| ROR receptor family |
|
|
| DDR receptor family |
|
|
| PTK7 receptor family |
|
|
| RYK receptor family |
|
|
| MuSK receptor family |
|
|
| ROS receptor family |
|
|
| AATYK receptor family |
|
|
| AXL receptor family |
|
|
| RET receptor family |
|
|
| uncatagorised |
|
|
|
|
|
Non-receptor tyrosine kinases (EC 2.7.10.2)
|
|
| ABL family |
|
|
| ACK family |
|
|
| CSK family |
|
|
| FAK family |
|
|
| FES family |
|
|
| FRK family |
|
|
| JAK family |
|
|
| SRC-A family |
|
|
| SRC-B family |
|
|
| TEC family |
|
|
| SYK family |
|
|
|
|
- Biochemistry overview
- Enzymes overview
- By EC (Enzyme Commission number): 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
|
|
|
|
Receptors: growth factor receptors
|
|
| Type I cytokine receptor |
- Nerve growth factors: Ciliary neurotrophic factor
- Erythropoietin
|
|
| Receptor protein serine/threonine kinase |
- TGF pathway: TGF-beta
- Activin
- Bone morphogenetic protein
|
|
| Receptor tyrosine kinase |
|
|
|
- Nerve growth factors: high affinity Trk
|
|
|
|
|
- Somatomedin
- Insulin-like growth factor 1
|
|
- ErbB/Epidermal growth factor
|
|
|
|
|
|
| Tumor necrosis factor receptor |
- Nerve growth factors: Low affinity/p75
|
|
| Ig superfamily |
- Platelet-derived growth factor
- Stem cell factor
|
|
| Other/ungrouped |
- Somatomedin
- Insulin-like growth factor 2
|
|
|
Index of signal transduction
|
|
| Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Lymphangiogenesis Is Induced by Mycobacterial Granulomas via Vascular Endothelial Growth Factor Receptor-3 and Supports Systemic T-Cell Responses against Mycobacterial Antigen.
- Harding J1, Ritter A2, Rayasam A3, Fabry Z1, Sandor M4.
- The American journal of pathology.Am J Pathol.2015 Feb;185(2):432-45. doi: 10.1016/j.ajpath.2014.09.020.
- Granulomatous inflammation is characteristic of many autoimmune and infectious diseases. The lymphatic drainage of these inflammatory sites remains poorly understood, despite an expanding understanding of lymphatic role in inflammation and disease. Here, we show that the lymph vessel growth factor V
- PMID 25597700
- Molecular Controls of Lymphatic VEGFR3 Signaling.
- Deng Y1, Zhang X1, Simons M2.
- Arteriosclerosis, thrombosis, and vascular biology.Arterioscler Thromb Vasc Biol.2015 Feb;35(2):421-9. doi: 10.1161/ATVBAHA.114.304881. Epub 2014 Dec 18.
- OBJECTIVES: Vascular endothelial growth factor receptor 3 (VEGFR3) plays important roles both in lymphangiogenesis and angiogenesis. On stimulation by its ligand VEGF-C, VEGFR3 is able to form both homodimers as well as heterodimers with VEGFR2 and activates several downstream signal pathways, inclu
- PMID 25524775
- Association between VEGFR-3 expression and lymph node metastasis in non-small-cell lung cancer.
- Li J1, Yi H1, Liu Z1, Zhang H1, Zhang D1, Yue W1, Jia H1, Xu S1, Li B1.
- Experimental and therapeutic medicine.Exp Ther Med.2015 Feb;9(2):389-394. Epub 2014 Nov 26.
- Vascular endothelial growth factor receptor (VEGFR)-3 is considered to be associated with lymphangiogenesis. The aim of the present study was to identify the clinical significance of VEGFR-3 expression and lymph node metastasis in patients with non-small-cell lung cancer (NSCLC). Lung tumor tissue s
- PMID 25574203
Japanese Journal
- 前頭骨を破壊し硬膜浸潤を認めたmalignant fibrous histiocytoma（≒undifferentiated pleomorphic sarcoma）の1例
- 土井 直孝,三木田 直哉,増尾 修,梅碕 有砂,中村 靖司,古川 福実,山本 有紀
- Skin Cancer 28(3), 315-319, 2014
- 前頭骨を破壊し硬膜浸潤を認めたmalignant fibrous histiocytoma（MFH）の87歳，男性を報告した。右前額部に皮下腫瘤を認め，前医で切除術施行され未分化肉腫の診断であった。術後一ヵ月で再発し当院に紹介された。画像診断で腫瘍は前頭骨を破壊し，頭蓋骨内部に広がっていたため，骨・硬膜を含め切除した。病理組織学的所見では，多型で大小不同，核異型の高度な細胞よりなる腫瘍で頭蓋骨や硬 …
- NAID 130004697524
- 細野 加奈子,馬嶋 正隆
- 日本薬理學雜誌 = Folia pharmacologica Japonica 141(5), 290-291, 2013-05-01
- NAID 10031171132
- Expression of vascular endothelial growth factor C in human pterygium
- Fukuhara Junichi,Kase Satoru,Ohashi Tsutomu,Ando Ryo,Dong Zhenyu,Noda Kousuke,Ohguchi Takeshi,Kanda Atsuhiro,Ishida Susumu
- Histochemistry and Cell Biology 139(2), 381-389, 2013-02
- … Purpose: Vascular endothelial growth factor C (VEGF-C) and its receptor VEGFR-3 mediate lymphangiogenesis. … In this study, we analyzed the expression of VEGF-C and VEGFR-3 as well as lymphatic vessels in the pterygium and normal conjunctiva of humans. … VEGF-C and VEGFR-3 expression in pterygial and conjunctival tissue proteins was detected by Western blotting. …
- NAID 120005228265
Related Links
- 製品＆受託サービス MACS 細胞解析 抗体・試薬 MACS 抗体 CD310 (VEGFR-3) 抗体 マウス 130-097-385 130-097-383 130-097-387 ... 細胞分離 細胞解析 細胞培養 分子生物学的アプリケーション イメージング 腫瘍血管新生 サンプル調製
- ... としても知られるVEGFR-3は、VEGFの3番目の受容体として発見されました。 VEGFR-3/Flt-4はVEGF-CとVEGF-Dに対応して、リンパ管形成を調節していることが知られています。 本製品は、ヒトの血清、EDTA血漿および細胞培養上 ...
Related Pictures
★リンクテーブル★
[★]
学会メモ
- 概日時計
- 自律性
- 同調性
- 温度補償性
- 哺乳類の場合、mPer1,2,3とmCry1,2がある。
- 培養細胞レベルでも時計機構を有する
- iPS
- iPSとES細胞との違い
- iPSは拒絶されない組織を作ることができるが、ES細胞は拒絶される。
- 現在のガイドラインは、個体作成は認めないこと、神経細胞を大脳皮質に移植しないこと、らしい
- 遺伝子治療
- ベクター系
- Pott症候群
- リンパ管内皮マーカー
特別講演メモ
要調査 080607
- 血中における白血球の比率が変動する遺伝的疾患とは？
[★]
- 英
- vascular endothelial growth factor receptor-3、VEGFR-3
- 関
- 血管内皮増殖因子受容体-3
[★]
血管内皮増殖因子受容体3
- 関
- VEGFR-3
[★]
- 関
- vascular endothelial growth factor receptor、VEGF receptor
[★]
血管内皮増殖因子 vascular endothelial growth factor