vascular endothelial growth factor receptor-2

血管内皮増殖因子受容体2

関

VEGFR-2

WordNet

1. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
2. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
3. become attached by or as if by the process of growth; "The tree trunks had grown together"
4. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
5. cause to grow or develop; "He grows vegetables in his backyard"
6. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
7. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
8. (pathology) an abnormal proliferation of tissue (as in a tumor)
9. a progression from simpler to more complex forms; "the growth of culture"
10. something grown or growing; "a growth of hair"
11. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
12. be a contributing factor; "make things factor into a companys profitability"
13. any of the numbers (or symbols) that form a product when multiplied together
14. an independent variable in statistics
15. anything that contributes causally to a result; "a number of factors determined the outcome"
16. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
17. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
18. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
19. a concept whose truth can be proved; "scientific hypotheses are not facts"
20. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
21. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
22. of or relating to or having vessels that conduct and circulate fluids; "vascular constriction"; "a vascular bundle"

PrepTutorEJDIC

1. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
2. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
3. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
4. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
5. (血液・樹液などを運ぶ)管の,導管の,血管の

UpToDate Contents

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• 1. 血管新生阻害剤の概要 overview of angiogenesis inhibitors
• 2. 進行腎細胞癌または転移性腎細胞癌に対する抗血管新生療法および分子標的療法 anti angiogenic and molecularly targeted therapy for advanced or metastatic renal cell carcinoma
• 3. 分子標的薬である血管新生阻害剤の毒性：心血管系への影響 toxicity of molecularly targeted antiangiogenic agents cardiovascular effects
• 4. Metastatic pancreatic neuroendocrine tumors and poorly differentiated gastroenteropancreatic neuroendocrine carcinomas: Systemic therapy options to control tumor growth and symptoms of hormone hypersecretion
• 5. Metastatic gastrointestinal neuroendocrine tumors: Systemic therapy options to control tumor growth and symptoms of hormone hypersecretion

English Journal

• Urocortin increased LPS-induced endothelial permeability by regulating the cadherin-catenin complex via corticotrophin-releasing hormone receptor 2.

• Wan R, Guo R, Chen C, Jin L, Zhu C, Zhang Q, Xu Y, Li S.SourceDepartment of Pharmacology, Jiangsu Provincial Key Lab of Cardiovascular Diseases and Molecular Intervention, Nanjing Medical University, Nanjing, P.R. China.
• Journal of cellular physiology.J Cell Physiol.2013 Jun;228(6):1295-303. doi: 10.1002/jcp.24286.
• Urocortin (Ucn1), a member of corticotrophin-releasing hormone (CRH) family, has been reported to be upregulated in inflammatory diseases and function as an autocrine or paracrine inflammatory mediator. Growing evidence shows that Ucn1 increases the endothelial permeability in inflammatory condition
• PMID 23168683

• A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein.

• Matsui H, Sakurai F, Katayama K, Abe Y, Machitani M, Kurachi S, Tachibana M, Mizuguchi H.SourceLaboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
• Biomaterials.Biomaterials.2013 May;34(16):4191-201. doi: 10.1016/j.biomaterials.2013.02.046. Epub 2013 Mar 6.
• A major drawback of adenovirus (Ad) vectors is their nonspecific transduction into various types of cells or tissue after in vivo application, which might lead to unexpected toxicity and tissue damage. To overcome this problem, we developed a fiber-mutant Ad vector displaying a monobody specific fo
• PMID 23473963

• Current approaches and future directions in the treatment of HER2-positive breast cancer.

• Hurvitz SA, Hu Y, O'Brien N, Finn RS.SourceUniversity of California at Los Angeles, Los Angeles, CA 90095, USA. shurvitz@mednet.ucla.edu
• Cancer treatment reviews.Cancer Treat Rev.2013 May;39(3):219-29. doi: 10.1016/j.ctrv.2012.04.008. Epub 2012 May 31.
• Human epidermal growth factor receptor 2 (HER2), a member of the ErbB family of transmembrane receptor tyrosine kinases, is amplified in 20-30% of invasive breast cancers. HER2 amplification is associated with metastasis and reduced survival. Two HER2-directed therapies have been approved by the Uni
• PMID 22658319

Japanese Journal

• Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells

• Ishikura Kazuhide,Misu Hirofumi,Kumazaki Masafumi,Takayama Hiroaki,Matsuzawa-Nagata Naoto,Tajima Natsumi,Chikamoto Keita,Lan Fei,Ando Hitoshi,Ota Tsuguhito,Sakurai Masaru,Takeshita Yumie,Kato Kenichiro,Fujimura Akio,Miyamoto Ken-ichi,Saito Yoshiro,Kameo Satomi,Okamoto Yasuo,Takuwa Yoh,Takahashi Kazuhiko,Kidoya Hiroyasu,Takakura Nobuyuki,Kaneko Shuichi,Takamaura Toshinari
• Diabetologia 57(9), 1968-1976, 2014-09
• … Aims/hypothesis Impaired angiogenesis induced by vascular endothelial growth factor (VEGF) resistance is a hallmark of vascular complications in type 2 diabetes; … Levels of serum SeP and hepatic expression of SEPP1 are elevated in type 2 diabetes. …
• NAID 120005463349

• RNAi-mediated gene knockdown and anti-angiogenic therapy of RCCs using a cyclic RGD-modified liposomal-siRNA system

• Sakurai Yu,Hatakeyama Hiroto,Sato Yusuke,Hyodo Mamoru,Akita Hidetaka,Ohga Noritaka,Hida Kyoko,Harashima Hideyoshi
• Journal of controlled release 173, 110-118, 2014-01-10
• … Angiogenesis is one of crucial processes associated with tumor growth and development, and consequently a prime target for cancer therapy. … Although tumor endothelial cells (TECs) play a key role in pathological angiogenesis, investigating phenotypical changes in neovessels when a gene expression in TEC is suppressed is a difficult task. …
• NAID 120005476193

• Isolation and characterization of canine tumor endothelial cells

• IZUMI Yusuke,HOSHINO Yuki,HOSOYA Kenji,TAKAGI Satoshi,OKUMURA Masahiro
• Journal of Veterinary Medical Science, 2014
• … The present study involved the isolation and characterization of canine tumor endothelial cells (TECs) from two malignancies. … TECs were isolated using magnetic cell sorting following FITC labeling with UEA1 lectin, and they were characterized by measuring genetic and histopathological endothelial markers. …
• NAID 130004713007

Related Links

• Vascular endothelial growth factor receptor-2: its unique signaling ...

Vascular endothelial growth factor receptor-2 (VEGFR-2/KDR/Flk-1) is a high- affinity receptor for vascular endothelial growth factor-A (VEGF-A), and mediates most of the endothelial growth and survival signals from VEGF-A. VEGFR-2 has a ...

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★リンクテーブル★

リンク元	「血管内皮増殖因子受容体2」「血管内皮増殖因子受容体-2」「VEGFR-2」
関連記事	「grow」「vascular」「fact」「factor」「endothelial」

「血管内皮増殖因子受容体2」

　　[★]

英

vascular endothelial growth factor receptor-2、VEGFR-2

関

血管内皮増殖因子受容体-2

「血管内皮増殖因子受容体-2」

　　[★]

英

vascular endothelial growth factor receptor-2

関

血管内皮増殖因子受容体2

「VEGFR-2」

　　[★]

• 血管内皮増殖因子受容体2

関

vascular endothelial growth factor receptor-2

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「vascular」

　　[★]

• adj.

• (生物・解剖)導管の、脈管の、血管の

関

angio、blood vessel、fibrovascular bundle、vascular bundle、vasculogenic、vein、vessel

　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「endothelial」

　　[★]

• adj.

• 内皮の

関

endodermis、endothelia、endothelium