WordNet

a three-dimensional shape with six square or rectangular sides (同)cube
(computer science) a sector or group of sectors that function as the smallest data unit permitted; "since blocks are often defined as a single sector, the terms `block and `sector are sometimes used interchangeably"
support, secure, or raise with a block; "block a plate for printing"; "block the wheels of a car"
a solid piece of something (usually having flat rectangular sides); "the pyramids were built with large stone blocks"
housing in a large building that is divided into separate units; "there is a block of classrooms in the west wing"
a rectangular area in a city surrounded by streets and usually containing several buildings; "he lives in the next block" (同)city block
an inability to remember or think of something you normally can do; often caused by emotional tension; "I knew his name perfectly well but I had a temporary block" (同)mental_block
a number or quantity of related things dealt with as a unit; "he reserved a large block of seats"; "he held a large block of the companys stock"
interrupt the normal function of by means of anesthesia; "block a nerve"; "block a muscle"
run on a block system; "block trains"
shape by using a block; "Block a hat"; "block a garment"
shape into a block or blocks; "block the graphs so one can see the results clearly"
stamp or emboss a title or design on a book with a block; "block the book cover"
relating to or being the keynote of a major or minor scale; "tonic harmony"
a medicine that strengthens and invigorates (同)restorative
(music) the first note of a diatonic scale (同)keynote
lime- or lemon-flavored carbonated water containing quinine (同)tonic_water, quinine water
used of syllables; "a tonic syllables carries the main stress in a word" (同)accented
employing variations in pitch to distinguish meanings of otherwise similar words; "Chinese is a tonal language" (同)tonal
of or relating to or producing normal tone or tonus in muscles or tissue; "a tonic reflex"; "tonic muscle contraction"
completely obstructed or closed off; "the storm was responsible for many blocked roads and bridges"; "the drain was plugged" (同)plugged
closed to traffic; "the repaving results in many blocked streets" (同)out of use
a group of countries in special alliance (同)axis

PrepTutorEJDIC

(木・石などの,通例平らな面のある)『かたまり』 / 《米》(四団を街路に囲まれた)『区画』,街区 / 街区の1辺の距離(一般に40メートル前後) / 《英》ブロック(アパート・事務所・商店などに区切られている大きな建物) / 『妨害物』,障害物(obstacle);(障害によって生じた)停滞,渋滞 / 台木,台(まないた・肉切り台・まき割り台・せり売り台・帽子の木型など);《the~》炭頭台 / (特にアメリカンフットボールで)ブロック(相手の選手の突進を阻止する) / 滑車(pulley) / (座席券・株券などの)一組《+『of』+『名』》 / 〈通路など〉'を'『ふさぐ』,〈通行・進行など〉'を'妨げる / 〈帽子など〉の型取りをする / (特にアメリカンフットボールで)〈相手選手の突進〉'を'ブロックする;(ボクシングで)〈相手のパンチ〉'を'ブロックする
強壮剤;養毛剤,ヘアトニック / (精神的に)元気付けるもの / =tonic water / 主音(音階の中心となる第1音) / 強壮にする,元気付ける / 音調の / (音楽で)主音の
ブロック,圏(地理・共通の利害・政治・経済上の目的などのために団結した団体・国家などの結合体)
(重量単位の)『トン』 / (容積単位の)トン(物によって異なり,木材では40立方フィート,小麦では20立方フィート) / 《話》大量(の…),多数(の…)《+of+名》

UpToDate Contents

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1. 慢性二枝ブロックの経過および治療 course and treatment of chronic bifascicular block
2. 先天性第3度（完全）房室ブロック congenital third degree complete atrioventricular block
3. 第2度房室ブロック：モビッツII型 second degree atrioventricular block mobitz type ii
4. 陰部神経ブロックおよび傍子宮頸管ブロック pudendal and paracervical block
5. 房室ブロックの原因 etiology of atrioventricular block

English Journal

In response to Melgari et al. "hERG potassium channel inhibition by ivabradine requires channel gating".

Lees-Miller JP1, Guo J1, Wang Y2, Perissinotti LL2, Noskov SY3, Duff HJ4.
Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2015 Aug 20;87:192-193. doi: 10.1016/j.yjmcc.2015.08.003. [Epub ahead of print]
PMID 26299838

Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.

Lees-Miller JP1, Guo J1, Wang Y2, Perissinotti LL2, Noskov SY3, Duff HJ4.
Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2015 Aug;85:71-8. doi: 10.1016/j.yjmcc.2015.05.009. Epub 2015 May 16.
In Europe, ivabradine has recently been approved to treat patients with angina who have intolerance to beta blockers and/or heart failure. Ivabradine is considered to act specifically on the sinoatrial node by inhibiting the If current (the funny current) to slow automaticity. However, in vitro stud
PMID 25986146

Generalized seizures and transient contralateral hemiparesis following retrobulbar anesthesia: a case report.

Dettoraki M1, Dimitropoulou C2, Nomikarios N1, Moschos MM1, Brοuzas D3.
BMC anesthesiology.BMC Anesthesiol.2015 Jul 28;15:108. doi: 10.1186/s12871-015-0084-y.
BACKGROUND: Retrobulbar block is a local anesthetic technique widely used for intraocular surgery. Although retrobulbar anesthesia is considered to be relatively safe, a number of serious adverse events have been reported. To our knowledge, immediate onset of generalized seizures with contralateral
PMID 26215739

Japanese Journal

Enhancing Effects of Salicylate on Quinidine-Induced Block of Human Wild Type and LQT3 Related Mutant Cardiac Na+ Channels

Urashima Tadashi,Hisatome Ichiro,Mizuta Einosuke,Miake Junichiro,Adachi Masamitsu,Ogura Kazuyoshi,Kato Masaru,Yano Akio,Kato Masahiko
Journal of Arrhythmia 27(Supplement), OP04_3, 2011
… To study the enhancing action of salicylate on local anesthetics, we investigated salicylate effects on quinidine-induced block of human cardiac and skeletal muscle Na<SUP>+</SUP> … Salicylate enhanced the quinidine-induced tonic block and UDB of both wild-type hH1 and hSkM1 currents at a holding potential (HP) of −100 mV but not at a HP of −140 mV. …
NAID 130002130439

Effects of Ginseng Total Saponins on Pacemaker Currents of Interstitial Cells of Cajal from the Small Intestine of Mice(Pharmacology)

Kim Hyun Soo,Parajuli Shankar Prasad,Yeum Cheol Ho [他],PARK Jong Seong,JEONG Han Seong,SO Insuk,KIM Ki Whan,JUN Jae Yeoul,CHOI Seok
Biological & pharmaceutical bulletin 30(11), 2037-2042, 2007-11-01
… Externally applied ginseng total saponins (GTS) produced membrane depolarization in the current-clamp mode and increased tonic inward pacemaker currents in the voltage-clamp mode. … The application of flufenamic acid or niflumic acid abolished the generation of pacemaker currents, but only treatment with flufenamic acid inhibited the GTS-induced tonic inward currents. …
NAID 110006473479

State-Dependent Blocking Actions of Azimilide Dihydrochloride (NE-10064) on Human Cardiac Na^+ Channels

Miake Junichiro,Kurata Yasutaka,Iizuka Kazuhiko,Furuichi Hitomi,Manabe Kasumi,Sasaki Norihito,Yamamoto Yasutaka,Hoshikawa Yoshiko,Taniguchi Shin-ichi,Yoshida Akio,Igawa Osamu,Makita Naomasa,Shiota Goshi,Nanba Eiji,Ohgi Shigetsugu,Narahashi Toshio,Hisatome Ichiro
Circulation journal : official journal of the Japanese Circulation Society 68(7), 703-711, 2004-06-20
… Methods and Results The kinetic properties of the azimilide block of the wild-type human Na^+ channels (WT: hH1) and mutant ΔKPQ Na^+ channels (ΔKPQ) expressed in COS7 cells were investigated using the whole-cell patch clamp technique and a Markovian state model. … Azimilide induced tonic block of WT currents by shifting the h∞ curve in the hyperpolarizing direction and caused phasic block of WT currents with intermediate recovery time constant. …
NAID 110002692181