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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/19 23:33:25」(JST)
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Thyrotropic cell |
Identifiers |
Code |
TH H3.08.02.2.00005 |
Anatomical terminology |
Thyrotropes (also called thyrotrophs) are endocrine cells in the anterior pituitary which produce thyroid stimulating hormone (TSH) in response to thyrotropin releasing hormone (TRH). Thyrotropes consist around 5% of the anterior Pituitary lobe cells.[citation needed]
Thyrotropes appear basophilic in histological preparations.
Anatomy of the endocrine system
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Pituitary gland |
Anterior |
- Pars intermedia
- Pars tuberalis
- Pars distalis
- Acidophil cell
- Somatotropic cell
- Prolactin cell
- Basophil cell
- Corticotropic cell
- Gonadotropic cell
- Thyrotropic cell
- Chromophobe cell
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Posterior |
- Pars nervosa
- Median eminence
- Stalk
- Pituicyte
- Herring bodies
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Thyroid gland |
- Thyroid isthmus
- Follicular cell
- Parafollicular cell
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Parathyroid gland |
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Adrenal gland |
Cortex |
- Zona glomerulosa
- Zona fasciculata
- Zona reticularis
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Medulla |
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Gonads |
- Testicle
- Ovary
- Theca interna
- Granulosa cell
- Corpus luteum
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Islets of pancreas |
- Alpha cell
- Beta cell
- Delta cell
- PP cell
- Epsilon cell
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Pineal gland |
- Pinealocyte
- Corpora arenacea
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Other |
- Enteroendocrine cell
- Paraganglia
- Placenta
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Index of hormones
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Description |
- Glands
- Hormones
- thyroid
- mineralocorticoids
- Physiology
- Development
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Disease |
- Diabetes
- Congenital
- Neoplasms and cancer
- Other
- Symptoms and signs
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Treatment |
- Procedures
- Drugs
- calcium balance
- corticosteroids
- oral hypoglycemics
- pituitary and hypothalamic
- thyroid
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Cells in humans derived from ectoderm
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Surface ectoderm |
Skin |
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Anterior pituitary |
- Gonadotrope
- Corticotrope
- Thyrotrope
- Somatotrope
- Lactotroph
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Neural crest |
Peripheral nervous system |
- Neuron
- Glia
- Satellite glial cell)
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Neuroendocrine system |
- Chromaffin cell
- Parafollicular cell
- Glomus cell
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Skin |
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Teeth |
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Eyes |
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Neural tube |
Central nervous system |
- Neuron
- Glia (Oligodendrocyte
- Astrocyte)
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Ependyma |
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Pineal gland |
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Index of developmental medicine
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Description |
- Embryology
- Cell lines
- endoderm
- mesoderm
- ectoderm
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Disease |
- Due to toxins
- Syndromes
- Chromosomal
- Neonate
- Twins
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English Journal
- A rexinoid antagonist increases the hypothalamic-pituitary-thyroid set point in mice and thyrotrope cells.
- Janssen JS, Sharma V, Pugazhenthi U, Sladek C, Wood WM, Haugen BR.SourceDivision of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Denver, School of Medicine, Aurora, CO 80045, USA.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2011 Jun 6;339(1-2):1-6. Epub 2011 Mar 31.
- Retinoid X receptor (RXR) signaling influences thyrotrope function. Synthetic RXR agonists, rexinoids, can cause central hypothyroidism. To test the hypothesis that endogenous rexinoids contribute to the TSH 'set point', TαT1 mouse thyrotrope cells were treated with a rexinoid antagonist, LG101208.
- PMID 21458528
- Thymulin gene therapy prevents the histomorphometric changes induced by thymulin deficiency in the thyrotrope population of mice.
- Martines EV, Reggiani PC, Schwerdt JI, Goya RG, Console GM.SourceDepartment of Cytology, Histology and Embryology B, University of La Plata (UNLP), La Plata, Argentina.
- Cells, tissues, organs.Cells Tissues Organs.2011;194(1):67-75. Epub 2011 Jan 7.
- There is evidence of the existence of a bidirectional relationship between the thymus gland and the thyroid axis. Since the thymic peptide thymulin possesses hypophysiotropic activity, we undertook the task of assessing the histomorphometric changes induced by thymulin deficiency on the thyrotrope p
- PMID 21212643
Japanese Journal
- Impaired Development of Somatotropes, Lactotropes and Thyrotropes in Growth-Retarded (grt) Mice
- Kobayashi Kenichi,Yamamoto Kazutoshi,Kikuyama Sakae,Machida Takeo,Kobayashi Tetsuya
- Journal of Toxicologic Pathology 22(3), 187-194, 2009
- Congenitally primary hypothyroid growth-retarded (grt) mice exhibit a characteristic growth pause followed by delayed onset of pubertal growth. We characterized the developmental pattern of somatotrop …
- NAID 130000137720
- POSSIBLE EXISTENCE OF THYROTROPE-STIMULARING FACTOR IN THE BULLFROG HYPOTHALAMUS
- OKADA Reiko,YAMAMOTO Kazutoshi,KIKUYAMA Sakae
- Proceedings of the Japan Society for Comparative Endocrinology 16, 74, 2001-12-01
- NAID 10008731524
Related Links
- Surface ectoderm · Integumentary system · Trichocyte ・ Keratinocyte · Nervous system · anterior pituitary (Gonadotrope, Corticotrope, Thyrotrope, Somatotrope, Lactotroph ). Neural crest · Endocrine system · Chromaffin cell ・ Parafollicular cell ...
Related Pictures
★リンクテーブル★
[★]
- 英
- anterior pituitary hormone
- 関
- 下垂体前葉、下垂体、下垂体ホルモン、ホルモン
分泌されるホルモン
GOO. chapter 55
HIM.2196
Table 333-1 Anterior Pituitary Hormone Expression and Regulation
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Cell
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corticotrope
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somatotrope
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lactotrope
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thyrotrope
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gonadotrope
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Tissue-specific transcription factor
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T-Pit
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Prop-1, Pit-1
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Prop-1, Pit-1
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Prop-1, Pit-1, TEF
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SF-1, DAX-1
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Fetal appearance
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6 weeks
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8 weeks
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12 weeks
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12 weeks
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12 weeks
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Hormone
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POMC
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GH
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PRL
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TSH
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FSH LH
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Chromosomal locus
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2p
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17q
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6
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-6q; -1p
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-11p; -19q
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Protein
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ポリペプチド
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糖タンパク
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Amino acids
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266 (ACTH 1–39)
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191
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199
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211
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210 204
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Stimulators
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CRH, AVP, gp-130 cytokines
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GHRH, ghrelin, bromocriptine(1)
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estrogen, TRH, VIP
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TRH
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GnRH, activins, estrogen
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Inhibitors
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glucocorticoids
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somatostatin, IGF-I
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dopamine
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T3, T4, dopamine, somatostatin, glucocorticoids
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sex steroids, inhibin
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Target gland
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adrenal
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liver, other tissues
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breast, other tissues
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thyroid
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ovary, testis
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Trophic effect
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steroid production
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IGF-I production, growth induction, insulin antagonism
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milk production
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T4 synthesis and secretion
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sex steroid production, follicle growth, germ cell maturation
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- (1):QB.D-253
分泌の制御