corticotrope

• 副腎皮質刺激因子

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/15 18:45:45」(JST)

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Corticotropic cell
Identifiers
Code	TH H3.08.02.2.00009
Anatomical terminology [edit on Wikidata]

Corticotropes (or corticotrophs) are basophilic cells in the anterior pituitary that produce melanocyte-stimulating hormone, adrenocorticotropic hormone (ACTH) and lipotropin. The cells produce pro-opiomelanocortin (POMC) which undergoes cleavage to ACTH and β-lipotropin (β-LPH). These cells respond to corticotropin releasing hormone (CRH) and make up about 20% of the cells in the anterior pituitary.

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• 1. クッシング症候群の原因の特定 establishing the cause of cushings syndrome
• 2. 持続性および再発性クッシング病：外科的副腎摘出 persistent or recurrent cushings disease surgical adrenalectomy

English Journal

• Corticotropin-releasing hormone (CRH) stimulates cocaine- and amphetamine-regulated transcript gene (CART1) expression through CRH type 1 receptor (CRHR1) in chicken anterior pituitary.

• Mo C1, Cai G1, Huang L1, Deng Q1, Lin D1, Cui L1, Wang Y1, Li J2.
• Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Dec 5;417:166-77. doi: 10.1016/j.mce.2015.09.007. Epub 2015 Sep 9.
• Cocaine- and amphetamine-regulated transcript (CART) peptide(s) is generally viewed as neuropeptide(s) and can control food intake in vertebrates, however, our recent study revealed that CART1 peptide is predominantly expressed in chicken anterior pituitary, suggesting that cCART1 peptide is a novel
• PMID 26363222

• Immunohistochemical localization of anterior pituitary cell types of vervet monkey (Chlorocebus aethiops) following sub-chronic cathinone exposure.

• Nyongesa A1, Oduma J2, al'Absi M3, Chirwa S4.
• Journal of ethnopharmacology.J Ethnopharmacol.2015 Nov 4;174:168-77. doi: 10.1016/j.jep.2015.08.007. Epub 2015 Aug 12.
• ETHNOPHARMACOLOGICAL RELEVANCE: Khat (Catha edulis) contains cathinone, an active principal that is customarily used as a psychostimulant that wards off fatigue and to some extent used as an aphrodisiac.AIM OF STUDY: To investigate effects of escalating doses of cathinone on hormone expression by di
• PMID 26277490

• The Complementary Role of Transcription Factors in the Accurate Diagnosis of Clinically Nonfunctioning Pituitary Adenomas.

• Nishioka H1,2, Inoshita N3,4, Mete O5, Asa SL5, Hayashi K6, Takeshita A6,4, Fukuhara N7, Yamaguchi-Okada M7, Takeuchi Y6,4, Yamada S7,4.
• Endocrine pathology.Endocr Pathol.2015 Oct 19. [Epub ahead of print]
• Clinically nonfunctioning pituitary adenomas (NFAs) may be hormonally inactive tumors of differentiated cells, mainly not only gonadotroph adenomas (GAs) but also silent corticotroph adenomas (SCAs) and other differentiated silent adenomas. Recently, the use of transcription factors has been recomme
• PMID 26481628

Japanese Journal

• Comparative Aspects of Intracellular Proteolytic Processing of Peptide Hormone Precursors : Studies of Proopiomelanocortin Processing

• Zoological science 20(10), 1183-1198, 2003-10-25
• NAID 110006162802

• Molecular Cloning and Expression of Prohormone Convertases PC1 and PC2 in the Pituitary Gland of the Bullfrog, Rana catesbeiana(Endocrinology)

• Zoological science 20(9), 1139-1151, 2003-09-25
• NAID 110006162798

• Immunocytochemical localization of prohormone convertases PC1 and PC2 in anuran pituitary gland-subcellular localization in corticotrope and melanotrope cells

• Cell Tissue Res 288, 485-496, 1997
• NAID 10011704782

Related Links

• Corticotropes | definition of Corticotropes by Medical dictionary

corticotroph [kor´tĭ-ko-trōf] a type of acidophil found in the anterior lobe of the pituitary gland that secretes corticotropin; it is synthesized as a large prohormone containing both corticotropin and β-lipotropin. corticotrope a cell of the ...

• Corticotroph | definition of corticotroph by Medical dictionary

corticotroph [kor´tĭ-ko-trōf] a type of acidophil found in the anterior lobe of the pituitary gland that secretes corticotropin; it is synthesized as a large prohormone containing both corticotropin and β-lipotropin. cor·ti·co·troph (kōr'ti-kō-trof), ...

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★リンクテーブル★

リンク元	「下垂体前葉ホルモン」

「下垂体前葉ホルモン」

　　[★]

英

anterior pituitary hormone

関

下垂体前葉、下垂体、下垂体ホルモン、ホルモン

分泌されるホルモン

• 単純ペプチドホルモン

• 成長ホルモン(growth hormone, GH)
• 副腎皮質刺激ホルモン(adrenocorticotropic hormone, ACTH)
• プロラクチン(prolactin)

• 糖タンパク質ホルモン

• 甲状腺刺激ホルモン(thyroid-stimulating hormone,TSH)
• 卵胞刺激ホルモン(follicle-stimulating hormone,FSH)
• 黄体形成ホルモン(luteinizing hormone, LH)

GOO. chapter 55

名称		構造	分泌細胞	下垂体前葉細胞 全細胞に対する 産生細胞の割合	染色性		サブユニット	残基数 (aa.)	分子量 (kDa)	その他
成長ホルモン	GH	ペプチド	somatotroph	40-50%	好酸性		1	191	22
プロラクチン	PRL		mammotroph	10-25%	好酸性		1	199	23
副腎皮質刺激ホルモン	ACTH		corticotroph	0.1	好塩基性	嫌色素性	1	39	4.5	POMC由来
甲状腺刺激ホルモン	TSH	糖タンパク	thyrotroph	0.05	好塩基性		2	α: 92, β:118	28	αサブユニットは共通
卵胞刺激ホルモン	FSH		gonadotroph	10-15%	好塩基性		2	α: 92, β:111	32.6
黄体形成ホルモン	LH				好塩基性		2	α: 92, β:121	29.4

HIM.2196

Table 333-1 Anterior Pituitary Hormone Expression and Regulation
Cell	corticotrope	somatotrope	lactotrope	thyrotrope	gonadotrope
Tissue-specific transcription factor	T-Pit	Prop-1, Pit-1	Prop-1, Pit-1	Prop-1, Pit-1, TEF	SF-1, DAX-1
Fetal appearance	6 weeks	8 weeks	12 weeks	12 weeks	12 weeks
Hormone	POMC	GH	PRL	TSH	FSH LH
Chromosomal locus	2p	17q	6	－6q; －1p	－11p; －19q
Protein	ポリペプチド			糖タンパク
Amino acids	266 (ACTH 1–39)	191	199	211	210 204
Stimulators	CRH, AVP, gp-130 cytokines	GHRH, ghrelin, bromocriptine(1)	estrogen, TRH, VIP	TRH	GnRH, activins, estrogen
Inhibitors	glucocorticoids	somatostatin, IGF-I	dopamine	T3, T4, dopamine, somatostatin, glucocorticoids	sex steroids, inhibin
Target gland	adrenal	liver, other tissues	breast, other tissues	thyroid	ovary, testis
Trophic effect	steroid production	IGF-I production, growth induction, insulin antagonism	milk production	T4 synthesis and secretion	sex steroid production, follicle growth, germ cell maturation

(1):QB.D-253