重症熱性血小板減少症候群 severe fever with thrombocytopenia syndrome, SFTS
WordNet
- very bad in degree or extent; "a severe worldwide depression"; "the house suffered severe damage"
- unsparing and uncompromising in discipline or judgment; "a parent severe to the pitch of hostility"- H.G.Wells; "a hefty six-footer with a rather severe mien"; "a strict disciplinarian"; "a Spartan upbringing" (同)spartan
- intensely or extremely bad or unpleasant in degree or quality; "severe pain"; "a severe case of flu"; "a terrible cough"; "under wicked fire from the enemys guns"; "a wicked cough" (同)terrible, wicked
- set or keep apart; "sever a relationship" (同)break_up
- a message whose ingenuity or verbal skill or incongruity has the power to evoke laughter (同)humor, humour, witticism, wittiness
- a rise in the temperature of the body; frequently a symptom of infection (同)febrility, febricity, pyrexia, feverishness
- intense nervous anticipation; "in a fever of resentment"
PrepTutorEJDIC
- (人・法律などが)『厳しい』,厳格な / (態度・表情が)厳粛な,いかめしい / (病気などが)『重い』,危険な / (様式・趣味などが)簡素な,じみな,飾りのない / (人の体に)厳しくこたえる,激しい / (試験などが)難しい,厳しい
- 《随伴・協調》…『と』,と共に,といっしょに / 《所有・所持》…『を持っている』,がある,の付いた / 《道具・手段》…『で』,を使って / 《財料・供給物》…『で』,を与えて / …を支持して,に賛成して / …『に反対(敵対)して』,を相手として / …『と同時に』,と同様に / …『に比べて』,に比例して / 《様態》《名詞を伴い副詞句として》『…で』,を示して,をもって / 《付帯状競》…『して』,しながら / 《譲歩》…がありながら,にもかかわらず / 『…が原因で』,のために,…で / …に任せて,のもとにあずけて,のところに / …に関して,について / …から離れて / 《連結・混合》…と / 《副詞と共に命令文で》
- (全体から)…‘を'切断する《+『名』+『from』+『名』》 / (いくつかの部分に)…‘を'分ける《+『名』+『in』(『into』)+『名』》 / 〈関係など〉‘を'断つ / 切れる,分かれる,分裂する
- 知る(know)
- 〈U〉『機知』,機転,ウィット / 〈C〉『機知に富む人』,機転のきく人 / 《複数形で;単数扱い》『理解(表現)力』,知性 / 《複数形で》(物事を見抜いたりもくろんだりする)才覚,才知 / 《複数形で;単数扱い》正気
- 〈U〉《しばしばa fever》(身体の異常な)『熱』,発熱 / 〈U〉『熱病』 / 〈U〉〈C〉(…に対する)『興奮』,熱狂《+『for』+『名』》
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/08 09:19:19」(JST)
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- 1. 血小板減少症候群ウイルスによる重度の発熱 severe fever with thrombocytopenia syndrome virus
- 2. デング熱ウイルス感染症の臨床症状および診断 clinical manifestations and diagnosis of dengue virus infections
- 3. 軟部組織肉腫の臨床所見、病理組織学的検査、診断的評価、および病期分類 clinical presentation histopathology diagnostic evaluation and staging of soft tissue sarcoma
English Journal
- Novel bunyavirus in domestic and captive farmed animals, Minnesota, USA.
- Xing Z, Murtaugh M.KEYWORDS: Heartland virus, Minnesota, USA, animals, bunyavirus, infection, large mammals, novel bunyavirus, phlebovirus, severe fever with thrombocytopenia syndrome virus, sftsv, viruses
- Emerging infectious diseases.Emerg Infect Dis.2014 Feb;20(2):336-7. doi: 10.3201/eid2002.131790.
- PMID 24447797
- Detection of new bunyavirus RNA by reverse transcription-loop-mediated isothermal amplification.
- Huang XY, Hu XN, Ma H, Du YH, Ma HX, Kang K, You AG, Wang HF, Zhang L, Chen HM, Dumler JS, Xu BL.Author information Center for Disease Control and Prevention of Henan Province, Zhengzhou, China.AbstractSevere fever with thrombocytopenia syndrome (SFTS) is a newly emerging and epidemic infectious disease in central and northeast China. It is caused by New Bunyavirus and carries an average 12% case fatality rate. Early and rapid detection is critical for prevention and control of New Bunyavirus infection, since no vaccine or antiviral drugs are currently available, and prevention requires careful attention to control of the suspected tick vector. In this study, a simple and sensitive reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay was developed for rapid detection of New Bunyavirus. The detection limit of the RT-LAMP assay was approximately 10(3) 50% tissue culture infective doses/ml of New Bunyavirus in culture supernatants, and no cross-reactive amplification of other viruses known to cause similar clinical manifestations was observed. The assay was further evaluated using 138 specimens from clinically suspected SFTS and 40 laboratory-proven hantavirus infection with fever and renal syndrome patients, and the assay exhibited 97% agreement compared to real-time RT-PCR and conventional RT-PCR. Using real-time RT-PCR as the diagnostic gold standard, RT-LAMP was 99% sensitive and 100% specific. The RT-LAMP assay could become a useful alternative in clinical diagnosis of SFTS caused by New Bunyavirus, especially in resource-limited hospitals or rural clinics of China.
- Journal of clinical microbiology.J Clin Microbiol.2014 Feb;52(2):531-5. doi: 10.1128/JCM.01813-13. Epub 2013 Dec 4.
- Severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging and epidemic infectious disease in central and northeast China. It is caused by New Bunyavirus and carries an average 12% case fatality rate. Early and rapid detection is critical for prevention and control of New Bunyavirus infe
- PMID 24478484
- The pathogenesis of severe Fever with thrombocytopenia syndrome virus infection in alpha/beta interferon knockout mice: insights into the pathologic mechanisms of a new viral hemorrhagic Fever.
- Liu Y, Wu B, Paessler S, Walker DH, Tesh RB, Yu XJ.Author information Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.AbstractSevere fever with thrombocytopenia syndrome virus (SFTSV) is a newly discovered Phlebovirus causing an emerging hemorrhagic fever in East Asia, with reported case fatality rates up to 30%. Despite the high case fatality rate and large number of persons at risk of infection, the pathobiology of the disease is unknown, and no effective animal model has been available for investigating its pathogenesis. We have studied mice and hamsters as potential small-animal models of SFTSV infection following subcutaneous, intraperitoneal, or intracerebral inoculation. Animal tissues were processed for viral load determination, histopathology, immunohistochemistry, and confocal microscopic studies. We found that immunocompetent adult mice and hamsters did not become ill after SFTSV infection. However, alpha/beta interferon receptor knockout (IFNAR(-/-)) mice were highly susceptible to SFTSV infection, and all mice died within 3 to 4 days after subcutaneous inoculation of 10(6) focus-forming units of SFTSV. Histologic examination of tissues of IFNAR(-/-) mice infected with SFTSV showed no detectable lesions. In contrast, by immunohistochemistry virus antigen was found in liver, intestine, kidney, spleen, lymphoid tissue, and brain, but not in the lungs. Mesenteric lymph nodes and spleen were the most heavily infected tissues. Quantitative reverse transcription-PCR (RT-PCR) confirmed the presence of virus in these tissues. Confocal microscopy showed that SFTSV colocalized with reticular cells but did not colocalize with dendritic cells, monocytes/macrophages, neutrophils, or endothelium. Our results indicate that SFTSV multiplied in all organs except for lungs and that mesenteric lymph nodes and spleen were the most heavily infected tissues. The major target cells of SFTSV appear to be reticular cells in lymphoid tissues of intestine and spleen.
- Journal of virology.J Virol.2014 Feb;88(3):1781-6. doi: 10.1128/JVI.02277-13. Epub 2013 Nov 20.
- Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly discovered Phlebovirus causing an emerging hemorrhagic fever in East Asia, with reported case fatality rates up to 30%. Despite the high case fatality rate and large number of persons at risk of infection, the pathobiology of the d
- PMID 24257618
Japanese Journal
- Factors Associated with Dengue Shock Syndrome: A Systematic Review and Meta-Analysis
- Huy Nguyen Tien,Van Giang Tran,Thuy Dinh Ha Duy,Kikuchi Mihoko,Hien Tran Tinh,Zamora Javier,Hirayama Kenji
- PLoS Neglected Tropical Diseases 7(9), e2412, 2013-09-26
- … Background:The pathogenesis of dengue shock syndrome (DSS, grade 3 and 4) is not yet completely understood. … Several factors are reportedly associated with DSS, a more severe form of dengue infection that reportedly causes 50 times higher mortality compared to that of dengue patients without DSS. …
- NAID 120005343853
- ダニ媒介性ウイルス感染症
- 髙島 郁夫
- 衛生動物 = Medical entomology and zoology 64(2), 61-66, 2013-06-15
- NAID 40019766729
- 日本における重症熱性血小板減少症候群
- 下島 昌幸,福士 秀悦,谷 英樹 [他]
- ウイルス 63(1), 7-11, 2013-06
- NAID 40019768105
Related Links
- 更新日 2013年9月27日 1 重症熱性血小板減少症候群（severe fever with thrombocytopenia syndrome , SFTS）とは 発熱や血小板減少等の症状を呈することが特徴である疾患で、2011年に中国でSFTSと命名されたダニが媒介する ...
- 14 重症熱性血小板減少症候群（病原体がフレボウイルス属SFTSウイルスであるものに限 る。） （1）定義 ブニヤウイルス科フレボウイルス属の重症熱性血小板減少症候群（Severe Fever with Thrombocytopenia Syndrome: SFTS） ...
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★リンクテーブル★
| リンク元 | 「重症熱性血小板減少症候群」「SFTS」 |
| 関連記事 | 「severe」「sever」「syndrome」 |
「重症熱性血小板減少症候群」
定義
- 2013/1/30厚労省健康局結核感染症課長通知
- 1. 38°C以上の発熱
- 2. 消化器症状(嘔吐、嘔気、腹痛、下痢、下血のいずれか)
- 3. 血小板減少(10万/μL未満)
- 4. 白血球減少(4000/μL未満)
- 5. AST,ALT,LDHの上昇(いずれも病院の基準上限を超える値)
- 6. 他に明らかな原因がない
- 7. 集中治療を要する/要した、または死亡した
参考
「SFTS」
[★] 重症熱性血小板減少症候群 severe fever with thrombocytopenia syndrome
「severe」
- adj.
- 重篤な、重症の、重度の、激しい、苛酷な
- 1.
- 厳しい、厳格な。厳密な(⇔mild)。容赦しない、血も涙もない、痛烈な
- ひどい、猛烈な。骨の折れる。過酷な
- 2
- 簡素な、地味な、渋い。厳粛な
- 関
- critically ill、grave、heavily、intense、life-threatening、rampant、serious、seriously、severe disease、severely、strenuous、severeness
「sever」
- v.
- 切断する
- 関
- ablate、ablation、amputate、amputation、break、breakage、cleavage、cleave、scission、transection、truncate、truncation
「syndrome」
- n.