WordNet

very bad in degree or extent; "a severe worldwide depression"; "the house suffered severe damage"
unsparing and uncompromising in discipline or judgment; "a parent severe to the pitch of hostility"- H.G.Wells; "a hefty six-footer with a rather severe mien"; "a strict disciplinarian"; "a Spartan upbringing" (同)spartan
intensely or extremely bad or unpleasant in degree or quality; "severe pain"; "a severe case of flu"; "a terrible cough"; "under wicked fire from the enemys guns"; "a wicked cough" (同)terrible, wicked
set or keep apart; "sever a relationship" (同)break_up
detached by cutting; "cut flowers"; "a severed head"; "an old tale of Anne Bolyn walking the castle walls with her poor cut-off head under her arm" (同)cut_off
abnormal development (of organs or cells) or an abnormal structure resulting from such growth

PrepTutorEJDIC

(人・法律などが)『厳しい』,厳格な / (態度・表情が)厳粛な,いかめしい / (病気などが)『重い』,危険な / (様式・趣味などが)簡素な,じみな,飾りのない / (人の体に)厳しくこたえる,激しい / (試験などが)難しい,厳しい
(全体から)…‘を'切断する《+『名』+『from』+『名』》 / (いくつかの部分に)…‘を'分ける《+『名』+『in』(『into』)+『名』》 / 〈関係など〉‘を'断つ / 切れる,分かれる,分裂する

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1. 複合免疫不全 combined immunodeficiencies
2. 気管支肺異形成症の予防 prevention of bronchopulmonary dysplasia
3. 致死的骨格形成異常の出生前診断 prenatal diagnosis of the lethal skeletal dysplasias
4. 骨髄異形成症候群の臨床症状および診断 clinical manifestations and diagnosis of the myelodysplastic syndromes
5. 嚢胞性腎疾患の胎児超音波診断 prenatal sonographic diagnosis of cystic renal disease

Chemoprevention of Head and Neck Cancer with Celecoxib and Erlotinib: Results of a Phase 1b and Pharmacokinetic Study.

Saba N, Hurwitz SJ, Kono S, Yang CS, Zhao Y, Chen Z, Sica GL, Muller S, Moreno-Williams R, Lewis M, Grist W, Chen AY, Moore CE, Owonikoko TK, Ramalingam SS, Beitler JJ, Nannapaneni S, Shin HJ, Grandis JR, Khuri FR, Chen ZG, Shin DM.Source1Hematology & Oncology, Emory University.
Cancer prevention research (Philadelphia, Pa.).Cancer Prev Res (Phila).2013 Oct 3. [Epub ahead of print]
Epidermal growth factor receptor (EGFR) and cyclooxygenase 2 inhibitors synergistically inhibit head and neck squamous cell carcinoma tumorigenesis in preclinical studies. We conducted a phase I and pharmacokinetic study with the erlotinib and celecoxib combination in patients with advanced premalig
PMID 24085777

Treatment of hip dysplasia in patients with mucopolysaccharidosis type I after hematopoietic stem cell transplantation: results of an international consensus procedure.

Langereis EJ, Borgo A, Crushell E, Harmatz PR, van Hasselt PM, Jones SA, Kelly PM, Lampe C, van der Lee JH, Odent T, Sakkers R, Scarpa M, Schafroth MU, Struijs PA, Valayannopoulos V, White KK, Wijburg FA.AbstractBACKGROUND: Mucopolysaccharidosis type I (MPS-I) is a lysosomal storage disorder characterized by progressive multi-organ disease. The standard of care for patients with the severe phenotype (Hurler syndrome, MPS I-H) is early hematopoietic stem cell transplantation (HSCT). However, skeletal disease, including hip dysplasia, is almost invariably present in MPS I-H, and appears to be particularly unresponsive to HSCT. Hip dysplasia may lead to pain and loss of ambulation, at least in a subset of patients, if left untreated. However, there is a lack of evidence to guide the development of clinical guidelines for the follow-up and treatment of hip dysplasia in patients with MPS I-H. Therefore, an international Delphi consensus procedure was initiated to construct consensus-based clinical practice guidelines in the absence of available evidence.
Orphanet journal of rare diseases.Orphanet J Rare Dis.2013 Oct 3;8(1):155. [Epub ahead of print]
BACKGROUND: Mucopolysaccharidosis type I (MPS-I) is a lysosomal storage disorder characterized by progressive multi-organ disease. The standard of care for patients with the severe phenotype (Hurler syndrome, MPS I-H) is early hematopoietic stem cell transplantation (HSCT). However, skeletal disease
PMID 24088413

A Histopathological and Immunohistochemical Study of Basal Membrane Alterations, with Special Reference to Advance of Dysplastic Grading

Tamaki Yoshio,Kuyama Kayo,Sun Yan
International Journal of Oral-Medical Sciences 10(1), 12-19, 2011
… Gingivae from 36 cases (5 normal epithelium, 7 hyperkeratosis, 7 mild dysplasia, 7 moderate dysplasia, 5 severe dysplasia, 5 OSCC) were examined. … Reticulin silver impregnation showed discontinuous and irregular distributions were admitted in severe dysplasia and OSCC. …
NAID 130000769911

G9M.139 医学事典