WordNet

much greater than the normal; "abnormal profits"; "abnormal ambition"
not normal; not typical or usual or regular or conforming to a norm; "abnormal powers of concentration"; "abnormal amounts of rain"; "abnormal circumstances"; "an abnormal interest in food" (同)unnatural
departing from the normal in e.g. intelligence and development; "they were heartbroken when they learned their child was abnormal"; "an abnormal personality"
an impairment of health or a condition of abnormal functioning
the organic process of synthesizing and releasing some substance (同)secernment
a functionally specialized substance (especially one that is not a waste) released from a gland or cell
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
gonadotropic hormone secreted by the anterior pituitary; in females it stimulates growth of the mammary glands and lactation after parturition (同)lactogenic_hormone, luteotropin

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Lopez Vicchi F1, Luque GM1, Brie B1, Nogueira JP2, Garcia Tornadu I1, Becu-Villalobos D3.
Pharmacological research.Pharmacol Res.2016 Jul;109:74-80. doi: 10.1016/j.phrs.2015.12.029. Epub 2015 Dec 31.
The importance of dopamine in central nervous system function is well known, but its effects on glucose homeostasis and pancreatic β cell function are beginning to be unraveled. Mutant mice lacking dopamine type 2 receptors (D2R) are glucose intolerant and have abnormal insulin secretion. In humans
PMID 26748034

Role of abnormal anterior pituitary hormones-growth hormone and prolactin in active systemic lupus erythematosus.

Zhu X1, Xu J1, Li S1, Huang W1, Li F1.
International journal of clinical and experimental medicine.Int J Clin Exp Med.2015 Oct 15;8(10):19223-31. eCollection 2015.
BACKGROUND: The role of anterior pituitary hormones in systemic lupus erythematosus (SLE) remains controversial.AIMS AND OBJECTIVES: We determined the expression levels of human growth hormone (GH), prolactin (PRL), and their receptors in subjects presenting with SLE, and modulation of disease sever
PMID 26770558

Trypanosoma cruzi disrupts thymic homeostasis by altering intrathymic and systemic stress-related endocrine circuitries.

Lepletier A1, de Carvalho VF, Rodrigues e Silva PM, Villar S, Pérez AR, Savino W, Morrot A.
PLoS neglected tropical diseases.PLoS Negl Trop Dis.2013 Nov 14;7(11):e2470. doi: 10.1371/journal.pntd.0002470. eCollection 2013.
We have previously shown that experimental infection caused by Trypanosoma cruzi is associated with changes in the hypothalamus-pituitary-adrenal axis. Increased glucocorticoid (GC) levels are believed to be protective against the effects of acute stress during infection but result in depletion of C
PMID 24324845

吉本尚規,魚住徹
Neurologia medico-chirurgica 29(6), 490-495, 1989
… Radioimmunoassays were employed to measure the secretion of growth hormone and cortisol during insulin tolerance testing (regular insulin, 0.15 to 0.20 U/kg), luteinizing hormone and follicle stimulating hormone under administration of luteinizing hormone-releasing hormone (100 μg), and thyroid stimulating hormone and prolactin under administration of thyroid-releasing hormone (500 μg) . …
NAID 110002277906

リンク元	「プロラクチン分泌異常症」
関連記事	「disease」「abnormal」「secretion」「prolactin」

==疫学

プロラクチン分泌過剰症：下垂体のプロラクチン産生細胞の異常、あるいは視床下部の調節機構の異常によりおこるが、最も多い原因はドパミン拮抗作用を持つ薬物の影響、次いでプロラクチン産生下垂体腺腫(プロラクチノーマ)である。

基礎血中プロラクチン値(早朝空腹時)：≧20ng/ml以上。≧200ng/ml以上はプロラクチン産生下垂体腺腫が示唆され、視床下部性、薬剤性ではまずない。微小下垂体腺腫では30-100ng/mlの場合がある。慢性腎不全では100-200ng/mlであることがある。
プロラクチン日内変化の消失：正常では夜間睡眠時高値