WordNet
- without undue constriction as from e.g. tenseness or inhibition; "the clarity and resonance of an open tone"; "her natural and open response"
- a clear or unobstructed space or expanse of land or water; "finally broke out of the forest into the open" (同)clear
- information that has become public; "all the reports were out in the open"; "the facts had been brought to the surface" (同)surface
- a tournament in which both professionals and amateurs may play
- become available; "an opportunity opened up" (同)open_up
- become open; "The door opened" (同)open_up
- cause to open or to become open; "Mary opened the car door" (同)open_up
- make available; "This opens up new possibilities" (同)open_up
- start to operate or function or cause to start operating or functioning; "open a business" (同)open_up
- not sealed or having been unsealed; "the letter was already open"; "the opened package lay on the table" (同)opened
- used of mouth or eyes; "keep your eyes open"; "his mouth slightly opened" (同)opened
- not brought to a conclusion; subject to further thought; "an open question"; "our position on this bill is still undecided"; "our lawsuit is still undetermined" (同)undecided, undetermined, unresolved
- affording unobstructed entrance and exit; not shut or closed; "an open door"; "they left the door open" (同)unfastened
- (set theory) of an interval that contains neither of its endpoints
- accessible to all; "open season"; "an open economy"
- affording free passage or access; "open drains"; "the road is open to traffic"; "open ranks"
- begin or set in action, of meetings, speeches, recitals, etc.; "He opened the meeting with a long speech"
- display the contents of a file or start an application as on a computer
- have an opening or passage or outlet; "The bedrooms open into the hall"
- having no protecting cover or enclosure; "an open boat"; "an open fire"; "open sports cars"
- make the opening move; "Kasparov opened with a standard opening"
- not having been filled; "the job is still open"
- not requiring union membership; "an open shop employs nonunion workers"
- open to or in view of all; "an open protest"; "an open letter to the editor"
- ready for business; "the stores are open"
- a three-dimensional shape with six square or rectangular sides (同)cube
- (computer science) a sector or group of sectors that function as the smallest data unit permitted; "since blocks are often defined as a single sector, the terms `block and `sector are sometimes used interchangeably"
- support, secure, or raise with a block; "block a plate for printing"; "block the wheels of a car"
- a solid piece of something (usually having flat rectangular sides); "the pyramids were built with large stone blocks"
- housing in a large building that is divided into separate units; "there is a block of classrooms in the west wing"
- a rectangular area in a city surrounded by streets and usually containing several buildings; "he lives in the next block" (同)city block
- an inability to remember or think of something you normally can do; often caused by emotional tension; "I knew his name perfectly well but I had a temporary block" (同)mental_block
- a number or quantity of related things dealt with as a unit; "he reserved a large block of seats"; "he held a large block of the companys stock"
- interrupt the normal function of by means of anesthesia; "block a nerve"; "block a muscle"
- run on a block system; "block trains"
- shape by using a block; "Block a hat"; "block a garment"
- shape into a block or blocks; "block the graphs so one can see the results clearly"
- stamp or emboss a title or design on a book with a block; "block the book cover"
- first or beginning; "the memorable opening bars of Beethovens Fifth"; "the plays opening scene"
- opportunity especially for employment or promotion; "there is an opening in the sales department"
- a recognized sequence of moves at the beginning of a game of chess; "he memorized all the important chess openings" (同)chess opening
- a vacant or unobstructed space that is man-made; "they left a small opening for the cat at the bottom of the door"
- becoming open or being made open; "the opening of his arms was the sign I was waiting for"
- the act of opening something; "the ray of light revealed his cautious opening of the door"
- an open or empty space in or between things; "there was a small opening between the trees"; "the explosion made a gap in the wall" (同)gap
- the first performance (as of a theatrical production); "the opening received good critical reviews" (同)opening_night, curtain raising
- a ceremony accompanying the start of some enterprise
- the initial part of the introduction; "the opening established the basic theme"
- direct the flow of; "channel information towards a broad audience" (同)canalize, canalise
- a television station and its programs; "a satellite TV channel"; "surfing through the channels"; "they offer more than one hundred channels" (同)television channel, TV channel
- a passage for water (or other fluids) to flow through; "the fields were crossed with irrigation channels"; "gutters carried off the rainwater into a series of channels under the street"
- (often plural) a means of communication or access; "it must go through official channels"; "lines of communication were set up between the two firms" (同)communication channel, line
- a path over which electrical signals can pass; "a channel is typically what you rent from a telephone company" (同)transmission channel
- a deep and relatively narrow body of water (as in a river or a harbor or a strait linking two larger bodies) that allows the best passage for vessels; "the ship went aground in the channel"
- a class of drugs that inhibit (block) some biological process (同)blocking_agent
- a football player whose responsibility is to block players attempting to stop an offensive play
PrepTutorEJDIC
- …‘を'『開く』,開ける;…‘の'ふた(おおい)をとる / …‘を'『切り開いて作る』,開拓する;…‘を'全開通させる《+『名』+『up,』+『名』+『up』》 / …‘を'『広げる』《+『up』+(『out』)+『名,』+『名』+『up』(『out』)》 / …‘を'『始める』 / …‘を'開業する,開店する,開場する / (人に)〈心など〉‘を'打ち明ける,〈秘密など〉‘を'漏らす《+『名』+『to』+『名』》 / (新思想などに)〈心・目〉‘を'開く《+『名』+『to』+『名』》 / 〈戸などが〉『開く』,あく / 〈花・つぼみが〉開く《+『out』》 / 〈学校などが〉『始まる』;〈店などが〉開く / 〈道路などが〉開通する / (…に)向かって開いている,(…に)通じている《+『out』『on』(『upon,to,onto』)+『名』》 / 《副詞[句]を伴って》〈風景などが〉広がる,ひらける / 本を開く;(…)ページを開く《+『to』(《英》『at』)+『名』》 / (窓・口などが)『開いた』,開いている;(包みなどが)広げられて / (花が)咲いた / (店などが)『開いている』,開業している;(催し物が)『公開の』,だれでも入れる / 《名詞の前にのみ用いて》ふたのしてない,屋根のない,おおいのない / 広く開いた,さえぎるものがない / 公然の / 率直な,遠慮しない / さらされている,無防備の / 《補語にのみ用いて》(職・地位などが)空位の;(時間などが)あいている / (問題・議事などが)未解決の / 凍結しない,雪や霜の降らない;温和な / (漁・猟が)解禁の / (音声が)開口音の;開音節の / 《the~》戸外,野外 / 空き地;(樹木のない)開けた場所,平野
- (木・石などの,通例平らな面のある)『かたまり』 / 《米》(四団を街路に囲まれた)『区画』,街区 / 街区の1辺の距離(一般に40メートル前後) / 《英》ブロック(アパート・事務所・商店などに区切られている大きな建物) / 『妨害物』,障害物(obstacle);(障害によって生じた)停滞,渋滞 / 台木,台(まないた・肉切り台・まき割り台・せり売り台・帽子の木型など);《the~》炭頭台 / (特にアメリカンフットボールで)ブロック(相手の選手の突進を阻止する) / 滑車(pulley) / (座席券・株券などの)一組《+『of』+『名』》 / 〈通路など〉'を'『ふさぐ』,〈通行・進行など〉'を'妨げる / 〈帽子など〉の型取りをする / (特にアメリカンフットボールで)〈相手選手の突進〉'を'ブロックする;(ボクシングで)〈相手のパンチ〉'を'ブロックする
- 〈C〉(森・垣根・壁などの)空いている所;空き地;すき間,穴 / 〈C〉(物語・会議などの)始め,出だし,冒頭(beginning) / 〈C〉(…の地位の)空き,就職口《+『for』(『at, in』)+『名』》(vacant) / 〈C〉(劇などの)初演 / 〈U〉(…が)開くこと,あくこと《+『of』+『名』》 / 〈C〉(…の)よい機会,好機《+『for』+『名』》 / 初めの,開始の
- 〈C〉『水路』(川・湾・運河の船の通行ができる深い部分) / 〈U〉河床・川底 / 〈C〉『海峡』 / 〈C〉みぞ(groove),(道路の)水渠(すいきょ) / 《複数形で》(運搬・伝達の)正式の経路(手続き);(一般に)経路 / 〈C〉(テレビ・ラジオの)チャンネル / …‘に'水路を開く / …‘に'みぞを堀る / …'を'伝える,流す
UpToDate Contents
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English Journal
- Optimising management of hypertension in primary care: The Valsartan Intensified Primary Care Reduction of Blood Pressure (Viper-Bp) Study.
- Stewart S, Carrington MJ, Swemmer C, Kurstjens N, Jennings GL.SourcePreventative Health, Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
- International journal of cardiology.Int J Cardiol.2011 Dec 15;153(3):317-22. Epub 2011 Jan 6.
- BACKGROUND: The Valstartan Intensified Primary CarE Reduction of Blood Pressure Study (VIPER-BP) Study is an open-label, randomised controlled trial comparing usual primary care management with an intensive BP management strategy using three forms of valsartan-based therapy (mono-therapy, thiazide d
- PMID 21215482
- H2O2-Induced Dilation in Human Coronary Arterioles: Role of Protein Kinase G Dimerization and Large-Conductance Ca2+-Activated K+ Channel Activation.
- Zhang DX, Borbouse L, Gebremedhin D, Mendoza SA, Zinkevich NS, Li R, Gutterman DD.SourceDepartment of Medicine, Cardiovascular Center, Department of Physiology, Department of Pathology, Medical College of Wisconsin, Milwaukee, and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin.
- Circulation research.Circ Res.2011 Dec 8. [Epub ahead of print]
- Rationale:Hydrogen peroxide (H(2)O(2)) serves as a key endothelium-derived hyperpolarizing factor mediating flow-induced dilation in human coronary arterioles (HCAs). The precise mechanisms by which H(2)O(2) elicits smooth muscle hyperpolarization are not well understood. An important mode of action
- PMID 22158710
Japanese Journal
- Azelnidipine and Amlodipine Anti-Coronary Atherosclerosis Trial in Hypertensive Patients Undergoing Coronary Intervention by Serial Volumetric Intravascular Ultrasound Analysis in Juntendo University (ALPS-J)
- KOJIMA Takahiko,MIYAUCHI Katsumi,YOKOYAMA Takayuki,YOKOYAMA Ken,KURATA Takeshi,SUWA Satoru,KAWAMURA Masaki,TAMURA Hiroshi,OKAZAKI Shinya,INOUE Kenji,FUJIWARA Yasumasa,SUMIYOSHI Masataka,TANIMOTO Kosei,NAKAZATO Yuji,YAMAGAMI Shinichiro,HIRO Takafumi,KOMIYAMA Nobuyuki,DAIDA Hiroyuki
- Circulation journal : official journal of the Japanese Circulation Society 75(5), 1071-1079, 2011-04-25
- … The goal of this multicenter study was to determine which calcium-channel blockers (CCBs) other than amlodipine attenuated the progression of plaque volume (PV) accessed by intravascular ultrasound (IVUS). … Methods and Results: ALPS-J was a prospective, randomized open-label study conducted at 5 centers. …
- NAID 10028147283
- Kv1.5 Open Channel Block by the Antiarrhythmic Drug Disopyramide : Molecular Determinants of Block
- ARECHIGA Ivan A.,BARRIO-ECHAVARRIA Gabriel F.,RODRIGUEZ-MENCHACA Aldo A.,MORENO-GALINDO Eloy G.,DECHER Niels,TRISTANI-FIROUZI Martin,SANCHEZ-CHAPULA Jose A.,NAVARRO-POLANCO Ricardo A.
- Journal of pharmacological sciences 108(1), 49-55, 2008-09-20
- … Disopyramide acting from the cytoplasmic side of the membrane produced blocking effects on Kv1.5 that exhibited several features typical of an open channel blocker. … Ala-scanning mutagenesis of the Kv1.5 pore domain combined with macroscopic current analysis suggested that disopyramide interacted only with the Val512 residue that faces to the central cavity of the channel. …
- NAID 10024322331
Related Links
- Mesoridazine: an open-channel blocker of human ether-a-go-go-related gene K + channel Zhi Su, , Ruth Martin, Bryan F. Cox, Gary Gintant Department of Integrative Pharmacology, Abbott Laboratories, 100 Abbott Park Road, Abbott ...
- 必应词典为您提供open-channel-blocker的释义，网络释义： 阻断剂； ... 什么意思_英语open... ... Open-channel routing 明渠演算 open-channel blocker 阻断剂 Open ion channel 离子通道呈开放状态 ...
★リンクテーブル★
[★]
- 英
- open channel blocker
- 関
- オープンチャネルブロッカー
[★]
- 英
- open channel blocker
- 関
- 開口チャネル阻害薬
[★]
- 関
- blockade、blockage、deter、inhibit、inhibition、lump、prevent、prevention、repress、repression、seal、turn off
[★]
- 関
- aperture、liberal、opening、orificial
[★]
- 川床、川底。水路、河道
- 海峡
- 水管、導管
- 溝
- 経路、ルート。道筋、方向
- 関
- ion channel、ionic channel
[★]
- 関
- antagonist、blocking agent、inhibitor
[★]
- 関
- aperture、open、orificial