WordNet
- stated explicitly or in detail; "needed a specific amount"
- a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria"
- (sometimes followed by `to'
- being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements"
- relating to or distinguishing or constituting a taxonomic species; "specific characters"
- a tiny grain
- the chief phagocytic leukocyte; stains with either basic or acid dyes (同)neutrophile
PrepTutorEJDIC
- 《名詞の前にのみ用いて》『特定の』,一定の・『明確な』,明白な・(そのものに)『特有の』,独特の《+『to』+『名』》・〈C〉(…の)特効薬《+『for』+『名』》・《複数形で》明細,細部(details)
- 〈U〉〈C〉(…の)(量・額などの)不足,欠乏《+『of』(『in』)+『名』》 / 〈C〉不足分,不足量,不足額 / 〈C〉(精神・肉体などの)欠陥
- 小粒,微粒
UpToDate Contents
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- 1. 好中球二次顆粒欠損症 neutrophil specific granule deficiency
- 2. 貧食細胞機能の原発性疾患：概要 primary disorders of phagocytic function an overview
- 3. 免疫系の臨床検査評価 laboratory evaluation of the immune system
- 4. 感染症を繰り返す成人に対するアプローチ approach to the adult with recurrent infections
English Journal
- Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections.
- Liu Z, Petersen R, Devireddy L.SourceCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA.
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2013 May 1;190(9):4692-706. doi: 10.4049/jimmunol.1202411. Epub 2013 Mar 29.
- Lipocalin 24p3 (24p3) is a neutrophil secondary granule protein. 24p3 is also a siderocalin, which binds several bacterial siderophores. It was therefore proposed that synthesis and secretion of 24p3 by stimulated macrophages or release of 24p3 upon neutrophil degranulation sequesters iron-laden sid
- PMID 23543755
- Neutrophil-specific granule deficiency.
- McIlwaine L, Parker A, Sandilands G, Gallipoli P, Leach M.SourceDepartment of Haematology, Glasgow Royal Infirmary, Glasgow, UK. louisa.mcilwaine@ggc.scot.nhs.uk
- British journal of haematology.Br J Haematol.2013 Mar;160(6):735. doi: 10.1111/bjh.12207. Epub 2013 Jan 8.
- PMID 23294125
- C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice.
- Kyme P, Thoennissen NH, Tseng CW, Thoennissen GB, Wolf AJ, Shimada K, Krug UO, Lee K, Müller-Tidow C, Berdel WE, Hardy WD, Gombart AF, Koeffler HP, Liu GY.SourceDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. pierre.kyme@gmail.com
- The Journal of clinical investigation.J Clin Invest.2012 Sep 4;122(9):3316-29. doi: 10.1172/JCI62070. Epub 2012 Aug 27.
- The myeloid-specific transcription factor, CCAAT/enhancer-binding protein ε (C/EBPε) is a critical mediator of myelopoiesis. Mutation of this gene is responsible for neutrophil-specific granule deficiency in humans, a condition that confers susceptibility to Staphylococcus aureus infection. We fou
- PMID 22922257
Japanese Journal
- Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP (ε)
- GOMBART AF
- Curr Opin Hematol 9, 36-42, 2002
- NAID 30018769275
- Neutrophil-specific granule deficiency : Homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein-ε
- GOMBART A. F.
- Blood 97, 2561-2567, 2001
- NAID 30022493109
- Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon
- LEKSTROM-HIMES JA.
- J Exp Med 189, 1847-1852, 1999
- NAID 30017416719
Related Links
- Neutrophil-specific granule deficiency (SGD, previously called lactoferrin deficiency) is a rare congenital disorder. The cardinal clinical feature is increased susceptibility to pyogenic infections. Patients often present with large ...
- Your Questions Answered by the Genetic and Rare Diseases Information Center Please contact us with your questions about Neutrophil-specific granule deficiency. We will answer your question and update these pages ...
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| 関連記事 | 「deficiency」「specific」「granule」 |
「deficiency」
- n.
- 不足、欠乏、欠失、欠如、欠損、不十分。栄養不足、栄養素欠乏、欠乏症。(遺伝子)(染色体内の)遺伝子欠失
- 欠けているもの、不足している物。不足分。不完全なもの、欠点のあるもの
- 関
- absence, agenesis, dearth, defect, defective, deficient, deficit, delete, deletion, deletional, depletion, deprivation, deprive, lack, miss, missing, morphological defect, paucity, scarce, scarcity, starve
「specific」
- adj.
- (～に関して)明確な、はっきりとした(exact precise)、具体的な(in, about)
- (比較)(限定)特定の(particular)、一定の(⇔general)
- (～に)特有の、独特の(to)
- (比較)(医学)(～に)渡航のある(for)。特殊な
- (生物)(生物)種の
- 医学)特異の
- (物理)比の。物質固有の。単位質量・長さ・面積・容積で
n.
「granule」
- 関
- granular