発現細胞
- B細胞、T細胞サブセット(naive T cells), 単球
分子量
- 205-220
機能
- isoform of CD45 containing the A exon
ファミリー
- fibronectin type II
UpToDate Contents
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- 1. T細胞前リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of t cell prolymphocytic leukemia
- 2. 関節リウマチのT細胞標的療法 t cell targeted therapies for rheumatoid arthritis
- 3. 新生児における原発性免疫不全のスクリーニング newborn screening for primary immunodeficiencies
- 4. 特発性CD4陽性リンパ球減少症 idiopathic cd4 lymphocytopenia
- 5. 大顆粒T細胞リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of t cell large granular lymphocyte leukemia
English Journal
- CD8 T-Cell Activation Is Associated With Lipodystrophy and Visceral Fat Accumulation in Antiretroviral Therapy-Treated Virologically Suppressed HIV-Infected Patients.
- Guaraldi G, Luzi K, Bellistrì GM, Zona S, Domingues da Silva AR, Bai F, Garlassi E, Marchetti G, Capeau J, Monforte Ad.Source*Department of Medical and Surgical Sciences for Adults and Children, Clinic of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy; †Department of Medicine, Surgery and Dentistry, Clinic of Infectious and Tropical Diseases, University of Milano, Milan, Italy; ‡Serviço de Doenças Infecciosas, Hospital de Joaquim Urbano, Porto, Portugal; and §Biochimie et Hormonologie, Hôpital Tenon AP-HP Paris, CDR Saint-Antoine, Inserm U938, Université Paris6-UPMC, Faculté de Médecine Pierre et Marie Curie, Paris, France.
- Journal of acquired immune deficiency syndromes (1999).J Acquir Immune Defic Syndr.2013 Dec 1;64(4):360-6. doi: 10.1097/QAI.0000000000000001.
- OBJECTIVE: HIV-infected patients receiving antiretroviral treatment frequently accumulate fat at the abdominal level. It is unknown whether T-cell activation and immune phenotypes are associated with fat accumulation. Thus, the aim of the study was to search for an association between the presence o
- PMID 24129368
- CD4⁺CD25⁺ T regs with acetylated FoxP3 are associated with immune suppression in human leprosy.
- Kumar S, Naqvi RA, Ali R, Rani R, Khanna N, Rao DN.SourceDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi 110029, India.
- Molecular immunology.Mol Immunol.2013 Dec;56(4):513-20. doi: 10.1016/j.molimm.2013.04.015. Epub 2013 Aug 1.
- Leprosy is a chronic human disease that results from infection of Mycobacterium leprae. T reg cells have been shown to have important implications in various diseases. However, in leprosy, it is still unclear whether T regs can mediate immune suppression during progression of the disease. In the pre
- PMID 23911408
- Probability state modeling of memory CD8(+) T-cell differentiation.
- Inokuma MS, Maino VC, Bagwell CB.SourceBD Biosciences, 2350 Qume Drive, San Jose, CA 95131, USA. Electronic address: Margaret_Inokuma@bd.com.
- Journal of immunological methods.J Immunol Methods.2013 Nov 29;397(1-2):8-17. doi: 10.1016/j.jim.2013.08.003. Epub 2013 Aug 14.
- Flow cytometric analysis enables the simultaneous single-cell interrogation of multiple biomarkers for phenotypic and functional identification of heterogeneous populations. Analysis of polychromatic data has become increasingly complex with more measured parameters. Furthermore, manual gating of mu
- PMID 23954473
Japanese Journal
- Failure of Effector Function of Human CD8+ T Cells in NOD/SCID/JAK3−/− Immunodeficient Mice Transplanted with Human CD34+ Hematopoietic Stem Cells
- Yoshinori Sato,Hiroshi Takata,Naoki Kobayashi,Sayaka Nagata,Naomi Nakagata,Takamasa Ueno,Masafumi Takiguchi,サトウ ヨシノリ,タカタ ヒロシ,コバヤシ ナオキ,ナガタ サヤカ,ナカガタ ナオミ,ウエノ タカマサ,タキグチ マサフミ,佐藤 義則,高田 比呂志,小林 直樹,永 田 紗矢香,中潟 直己,上野 貴将,滝口 雅文
- PLoS ONE 5(10), 2010-10-01
- … Multicolor flow cytometric analysis demonstrated that human CD8+T cells generated from the CD34+ HSCs comprised only 3 subtypes, i.e., CD27highCD28+CD45RA++CCR7+, CD27+CD28++CD45R-A2CCR7+, and CD27 +CD28+CD45RA-CCR7- and had 3 phenotypes for 3 lytic molecules, i.e., perforin(Per)-granzymeA(GraA)-granzymeB(GraB)-, Per-GraA+GraB-, and PerlowGraA+GraB+. …
- NAID 120003256064
- Interplay between CD45RA^+ regulatory T cells and TNF-α in the regulation of human T_h17 differentiation
- BABA Nobuyasu,RUBIO Manuel,SARFATI Marika
- International immunology 22(4), 237-244, 2010-04-01
- NAID 10027392110
Related Links
- CD45RAエピトープは、エクソンAを発現するすべての限定発現CD45分子（ABC及びABアイソフォーム）に存在します。ほとんどのBリンパ球はCD45RAアイソフォームを発現します。Tリンパ球の機能の相違に対応して、CD45アイソフォームの ...
- 第 5 回国際 CD ワークショップにおいて CD45RA に分類されています。 CD45 ファミリーに属し、白血球共通抗原 (LCA) の 205kD と 220kD の Isoform を認識します。主に造血器細胞のうち有核細胞（リンパ球、単球、顆粒球）に発現が ...
Related Pictures
★リンクテーブル★
| リンク元 | 「CD45RO」「naive CD4 T cell」 |
| 関連記事 | 「CD45」「CD45R」 |
「CD45RO」
発現細胞
分子量
- 180
機能
- isoform of CD45 containing the A, B, and C exons
ファミリー
- fibronectin type II
発現の強度
- 記憶T細胞では強く発現するので、マーカーとして使われる。
| naive T cell | effector T cell | memory T cell | |
| CD45RO | ＋ | ＋＋＋ | ＋＋＋ |
| CD45RA | ＋ | ＋＋＋ | ＋＋＋ |
「naive CD4 T cell」
- 関
- T細胞、late double-positive thymocyte<-->memory CD4 T cell
- TCRを備え、胸腺から出てた抗原刺激をまだ受けていないT細胞。
細胞表面マーカー=
「CD45」
発現細胞
- 全ての造血細胞
分子量
- 180-240 kDa
機能
- tyrosine phosphatase, augments sinnaling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing
ファミリー
- fibronectin type III
疾患との関連
- ホジキンリンパ腫：CD45は発現していない。