ミトコンドリアAST
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- 1. 肝酵素および肝機能検査値の異常が認められた患者に対するアプローチapproach to the patient with abnormal liver biochemical and function tests [show details]
… assessment of liver fibrosis are presented separately. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin are biochemical markers of liver injury. Albumin …
- 2. Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S)retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations rvcl s [show details]
…urine creatinine via a 24-hour urine collection or spot sample) Liver enzymes, including serum aminotransferases, alkaline phosphatase, and gamma-glutamyltransferase; Complete blood count including hemoglobin …
- 3. Right heart failure: Clinical manifestations and diagnosisright heart failure clinical manifestations and diagnosis [show details]
…minimally elevated with acute RHF, but greater elevations may be seen with chronic severe RHF. Serum aminotransferase levels are elevated in about one-third of patients with congestive hepatopathy. Hypoalbuminemia…
- 4. Coronavirus disease 2019 (COVID-19): Critical care issuescoronavirus disease 2019 covid 19 critical care issues [show details]
…daily examinations, care, and procedures. Common complications include acute kidney injury, mild transaminitis, cardiomyopathy, pericarditis, pericardial effusions, arrhythmias, sudden cardiac death, and superinfection…
- 5. 肝線維症の非侵襲的評価：血清学的検査および画像診断noninvasive assessment of hepatic fibrosis overview of serologic and radiographic tests [show details]
…and Hepascore. The APRI is based on the AST level and platelet count and is easy to calculate . The APRI is calculated using the AST elevation (which is the AST level divided by the upper limit of normal …
English Journal
- Immunological measurement of aspartate/alanine aminotransferase in predicting liver fibrosis and inflammation.
- Kim HJ, Kim SY, Shin SP, Yang YJ, Bang CS, Baik GH, Kim DJ, Ham YL, Choi EY, Suk KT.
- The Korean journal of internal medicine. 2020 Mar;35(2)320-330.
- Enzymatic analysis of aspartate/alanine aminotransferase (AST/ALT) does not exactly represent the progression of liver fibrosis or inflammation. Immunoassay for AST (cytoplasmic [c] AST/mitochondrial [m] AST) and ALT (ALT1/ALT2) has been suggested as one alternatives for enzymatic analysis. The obje
- PMID 30665287
- Serum FABP1 Levels Correlate Positively with Obesity in Chinese Patients After Laparoscopic Sleeve Gastrectomy: a 12-Month Follow-up Study.
- You H, Wen X, Zhu C, Chen M, Dong L, Zhu Y, Yang L, Bu L, Zhang M, Zhou D, Lu L, Du L, Lin Z, Qu S.
- Obesity surgery. 2020 Mar;30(3)931-940.
- The role of liver fatty acid-binding protein (FABP1) in obesity is presently unclear. We investigated the association of FABP1 with obesity and the changes noted after laparoscopic sleeve gastrectomy (LSG) in a Chinese population. The cross-sectional analysis included 187 individuals: 65 had normal
- PMID 31916133
- Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade.
- Liu L, Xie B, Fan M, Candas-Green D, Jiang JX, Wei R, Wang Y, Chen HW, Hu Y, Li JJ.
- Developmental cell. 2020 Jan;52(2)196-209.e9.
- Saturated fatty acids (SFAs) (the "bad" fat), especially palmitate (PA), in the human diet are blamed for potential health risks such as obesity and cancer because of SFA-induced lipotoxicity. However, epidemiological results demonstrate a latent benefit of SFAs, and it remains elusive whether a cer
- PMID 31866205
Japanese Journal
- New Discriminant Method for Identifying the Aggressive Disease Phenotype of Non-alcoholic Fatty Liver Disease
- Kawamura Yusuke,Suzuki Fumitaka,Suzuki Yoshiyuki,Kumada Hiromitsu,Ikeda Kenji,Arase Yasuji,Fujiyama Shunichiro,Hosaka Tetsuya,Kobayashi Masahiro,Saitoh Satoshi,Sezaki Hitomi,Akuta Norio
- Internal Medicine 56(12), 1459-1465, 2017
- … </p><p><b>Results </b>After the analysis, the following function was found to discriminate the disease phenotype: z=0.150×body mass index (kg/m<sup>2</sup>)+0.085×age (years)+1.112×ln (AST) (IU/L)+0.127×ln (m-AST)-12.96. …
- NAID 130006856822
- 硝酸カドミウムとフッ化カドミウムの急性肝毒性:－生化学的および病理組織学的比較検討－
- 山鳥 江美,土手 友太郎,足立 和也,今西 将史,河野 公一
- Biomedical Research on Trace Elements 19(3), 268-271, 2008
- … They were accompanied by increase in the activities of ASL, ALT, m-AST and LDH. …
- NAID 130004456870
- The $L^p$ boundedness of wave operators for Schr\""odinger operators with threshold singularities II. Even dimensional case
- Finco Domenico,Yajima Kenji
- Journal of mathematical sciences, the University of Tokyo 13(3), 277-346, 2006-12-27
- … Let $H_0=-\lap$ and $H=-\lap +V(x)$ be Schr\""odinger operators on $\R^m$ and $m \geq 6$ be even. …
- NAID 120000870400
Related Links
- 臨床意義 AST(GOT:glutamic oxaloacetic transaminase)は，ほとんどの組織に存在する臓器特異性のない細胞内酵素である。細胞内局在については，細胞質(C-AST)とミトコンドリアAST(m-AST)に存在する2種類のアイソザイムがあり，存在比
- ASTには臓器特異的なアイソザイムは存在しないが、細胞内局在を異にするm-AST（ミトコンドリア分画）、s-AST（細胞上清分画）の二つのアイソザイムが存在する。 一般に、健常者では総GOT中に占めるm-GOTの比率は15～30
- m-AST ミトコンドリアAST m-GOT - ミトコンドリア由来のAST。通常のASTと異なり、壊死を伴う肝細胞障害があるときに初めて血中で上昇する。 健康診断・血液検査MAP:新着記事 新規保険収載 デングウイルス抗原定性 デングウイルス抗原 ...
★リンクテーブル★
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- 英
- aspartate aminotransferase, AST
- 同
- グルタミン酸オキサロ酢酸トランスアミナーゼ glutamic oxaloacetic transaminase GOT
- 関
- ALT。s-AST、m-AST、ASTアイソザイム、マクロAST
SOLP → AST = GOT, ALT = GPT
分布
- ほぼ全ての臓器組織細胞中に分布。特に心臓，肝臓，骨格筋に多い。 (⇔ALTは肝臓に特に多い)
基質
- 基質特異性は広く，アミノ基受容体にα-ケトグルタル酸を用いると大抵のアミノ酸に作用して脱アミノする。
- アラニンには作用しない
酵素
- http://www.uniprot.org/uniprot/P17174
基準値
意義
- 急性の肝疾患で高値となる(半減期の短さを反映)。アルコール性の肝疾患や肝硬変でも高値となる。
- アルコール性肝疾患
- アルコール性脂肪肝
- 肝硬変、肝癌：慢性肝炎から肝硬変・管癌に進行するとALT優位(AST<ALT)からAST優位(AST>ALT)(特に肝細胞癌ではAST>>ALT)と変化し、値が低下する (LAB.1360)
- 心筋梗塞、溶血、ショック
|
|
AST
|
ALT
|
| 含有量
|
3
|
1
|
| 局在
|
心筋、肝臓、
骨格筋、腎臓
赤血球
|
肝臓、腎臓、
心臓、骨格筋
|
| 逸脱しやすさ
|
逸脱しにくい
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逸脱しやすい
|
| 血中半減期
|
2日
|
6日
|
| 肝小葉内の分泌
|
中心静脈
|
辺縁
|
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- 同
- m-AST
- 関
- AST、ASTアイソザイム
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アスパラギン酸アミノトランスフェラーゼ aspartate aminotransferase
基準値 QB
AST GOT ≦ 40
ALT GPT ≦ 35
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- 関
- iatrology、medical、medical science、medicine
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