WordNet
- a class of transferases that catalyze transamination (that transfer an amino group from an amino acid to another compound) (同)aminotransferase, aminopherase
PrepTutorEJDIC
- getの過去・過去分詞
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- 1. 肝細胞障害を検出するための肝臓生化学検査 liver biochemical tests that detect injury to hepatocytes
- 2. Antiseizure drugs: Mechanism of action, pharmacology, and adverse effects
- 3. 妊娠時の急性脂肪肝 acute fatty liver of pregnancy
- 4. 糖尿病および遺伝的糖尿病症候群の分類 classification of diabetes mellitus and genetic diabetic syndromes
- 5. メープルシロップ尿症の概要 overview of maple syrup urine disease
English Journal
- The Role of RAAS Inhibition by Aliskiren on Paracetamol-Induced Hepatotoxicity Model in Rats.
- Karcioglu SS1, Palabiyik SS2, Bayir Y3, Karakus E4, Mercantepe T5, Halici Z1, Albayrak A1.
- Journal of cellular biochemistry.J Cell Biochem.2016 Mar;117(3):638-46. doi: 10.1002/jcb.25313. Epub 2015 Sep 1.
- Paracetamol is one of the most popular and widely used analgesic and antipyretic agents, but an overdose can cause hepatotoxicity and lead to acute liver failure. Aliskiren directly inhibits renin which downregulates the renin-angiotensin-aldosterone system (RAAS). Recent findings suggest that RAAS
- PMID 26280784
- Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level.
- Sookoian S1, Castaño GO2, Scian R3, Fernández Gianotti T4, Dopazo H5, Rohr C5, Gaj G6, San Martino J6, Sevic I7, Flichman D7, Pirola CJ8.
- The American journal of clinical nutrition.Am J Clin Nutr.2016 Feb;103(2):422-34. doi: 10.3945/ajcn.115.118695. Epub 2016 Jan 20.
- BACKGROUND: Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental characteristics of this relation are currently unknown.OBJECTIVE: We aimed to explore the role of liver
- PMID 26791191
- Monoclonal antibody against macrophage colony-stimulating factor suppresses circulating monocytes and tissue macrophage function but does not alter cell infiltration/activation in cutaneous lesions or clinical outcomes in patients with cutaneous lupus erythematosus.
- Masek-Hammerman K1, Peeva E2, Ahmad A2, Menon S2, Afsharvand M2, Peng Qu R3, Cheng JB4, Syed J1, Zhan Y1, O'Neil SP1, Pleasic-Williams S4, Cox LA5, Beidler D2.
- Clinical and experimental immunology.Clin Exp Immunol.2016 Feb;183(2):258-70. doi: 10.1111/cei.12705. Epub 2015 Nov 9.
- This study's objective was to assess the effects of PD-0360324, a fully human immunoglobulin G2 monoclonal antibody against macrophage colony-stimulating factor in cutaneous lupus erythematosus (CLE). Patients with active subacute CLE or discoid lupus erythematosus were randomized to receive 100 or
- PMID 26376111
Japanese Journal
- Anti-Obesity Properties of a Sasa quelpaertensis Extract in High-Fat Diet-Induced Obese Mice
- KANG Seong-Il,SHIN Hye-Sun,KIM Hyo-Min [他],HONG Youn-Suk,YOON Seon-A,KANG Seung-Woo,KIM Jeong-Hwan,KO Hee-Chul,KIM Se-Jae
- Bioscience, biotechnology, and biochemistry 76(4), 755-761, 2012-04-23
- … SQE administration also reduced the serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and lactate dehydrogenase, and the accumulation of lipid droplets in the liver, suggesting a protective effect against HFD-induced hepatic steatosis. …
- NAID 10030751808
- Immature Citrus sunki Peel Extract Exhibits Antiobesity Effects by .BETA.-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice
- Kang Seong-Il,Shin Hye-Sun,Kim Hyo-Min [他],Hong Youn-Suk,Yoon Seon-A,Kang Seung-Woo,Kim Jeong-Hwan,Kim Moo-Han,Ko Hee-Chul,Kim Se-Jae
- Biological and Pharmaceutical Bulletin 35(2), 223-230, 2012
- … Also, CSE supplementation reduced serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and lactate dehydrogenase. …
- NAID 130001872297
- ホルスタイン種体細胞クローン牛の初産泌乳期における血液生化学成分の推移
- 小西 一之,米内 美晴,金山 佳奈子 [他],別府 哲郎,今井 敬
- 日本畜産學會報 = The Japanese journal of zootechnical science 82(1), 17-24, 2011-02-25
- 同一ドナー細胞由来のホルスタイン種体細胞クローン牛6頭の生理機能における正常性と牛群の斉一性を検証するため， 初産次泌乳期間の血液生化学成分9項目（アルブミン（ALB）， 尿素窒素（BUN），グルコース（GLU），総コレステロール（TCHO），遊離脂肪酸（FFA），β-ヒドロキシ酪酸，GOT, γ-GTP, カルシウム（Ca））の濃度とその推移を調べた．対照牛群として，人工授精で生産されたホルスタ …
- NAID 10029741489
Related Links
- Looking for online definition of glutamic-oxaloacetic transaminase in the Medical Dictionary? glutamic-oxaloacetic transaminase explanation free. What is glutamic-oxaloacetic transaminase? Meaning of glutamic-oxaloacetic ? ...
- Serum glutamic oxaloacetic transaminase (SGOT): An enzyme that is normally present in liver and heart cells. SGOT is released into blood when the liver or heart is damaged. The blood SGOT levels are thus elevated with liver ...
Related Pictures
★リンクテーブル★
| リンク元 | 「アスパラギン酸アミノトランスフェラーゼ」「got」「GOT」 |
| 関連記事 | 「glutamic」「transaminase」 |
「アスパラギン酸アミノトランスフェラーゼ」
- 英
- aspartate aminotransferase, AST
- 同
- グルタミン酸オキサロ酢酸トランスアミナーゼ glutamic oxaloacetic transaminase GOT
- 関
- ALT。s-AST、m-AST、ASTアイソザイム、マクロAST
SOLP → AST = GOT, ALT = GPT
- アスパラギン酸(L-aspartate)＋2-オキソグルタル酸(2-oxoglutarate)＝オキサロ酢酸(oxaloacetate)＋グルタミン酸(L-glutamate)
- 補酵素：ピリドキサルリン酸（VB6)
分布
- ほぼ全ての臓器組織細胞中に分布。特に心臓，肝臓，骨格筋に多い。 (⇔ALTは肝臓に特に多い)
基質
- 基質特異性は広く，アミノ基受容体にα-ケトグルタル酸を用いると大抵のアミノ酸に作用して脱アミノする。
- アラニンには作用しない
酵素
- EC 2.6.1.1。
- 分子量46,248Da
基準値
- 12-38 U/L(HIM A-3)
意義
- 急性の肝疾患で高値となる(半減期の短さを反映)。アルコール性の肝疾患や肝硬変でも高値となる。
- アルコール性肝疾患
- アルコール性脂肪肝
- 肝硬変、肝癌：慢性肝炎から肝硬変・管癌に進行するとALT優位(AST<ALT)からAST優位(AST>ALT)(特に肝細胞癌ではAST>>ALT)と変化し、値が低下する (LAB.1360)
- 心筋梗塞、溶血、ショック
| AST | ALT | |
| 含有量 | 3 | 1 |
| 局在 | 心筋、肝臓、 骨格筋、腎臓 赤血球 |
肝臓、腎臓、 心臓、骨格筋 |
| 逸脱しやすさ | 逸脱しにくい | 逸脱しやすい |
| 血中半減期 | 2日 | 6日 |
| 肝小葉内の分泌 | 中心静脈 | 辺縁 |
「got」
- v.
- getの過去形
- アスパラギン酸アミノトランスフェラーゼ aspartate aminotransferase AST ← グルタミン酸オキサロ酢酸トランスアミナーゼ glutamic oxaloacetic transaminase GOT
「GOT」
[★] アスパラギン酸アミノトランスフェラーゼ aspartate aminotransferase = glutamic oxaloacetic transaminase
「glutamic」
- グルタミン酸の