臭化メチルホマトロピン、ホマトロピンメチルブロミド、ホマトロピンメチルブロマイド

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/02 14:17:47」(JST)

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Homatropine methylbromide or Methylhomatropine bromide is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It does not cross the blood–brain barrier. It is used, in addition to papaverine, as component of mild drugs that help "flush" the bile.

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount homatropine methylbromide to discourage intentional overdose.^[1]

Contraindications

Untreated glaucoma
Myasthenia gravis
Severe heart failure
Thyrotoxicosis

References

^ "Hydromet (Hydrocodone Bitartrate and Homatropine Methylbromide)". DailyMed. NIH. http://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?id=5209&type=display.

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English Journal

Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature.

Zhu Z1, Yang L, Zhao XM, Luo DQ, Zhang HT, Zhou CW.
The British journal of radiology.Br J Radiol.2014 Jun;87(1038):20130712. doi: 10.1259/bjr.20130712. Epub 2014 Mar 27.
OBJECTIVE: To display and analyse the imaging features of myomatous hepatic angiomyolipomas (MHAMLs).METHODS: The imaging features (CT = 9; MRI = 10; ultrasound = 10; contrast-enhanced ultrasound = 4) of 14 patients with pathologically proven MHAMLs were reviewed retrospectively.RESULTS: MHAMLs were
PMID 24670055

Is surgery necessary for patients with hepatic angiomyolipoma? Retrospective analysis from eight Chinese cases.

Yang L1, Xu Z, Dong R, Fan J, Du Y, Zhang Y, Wang X, Cheng X, Guo J.
Journal of gastroenterology and hepatology.J Gastroenterol Hepatol.2013 Oct;28(10):1648-53. doi: 10.1111/jgh.12289.
BACKGROUND AND AIM: Hepatic angiomyolipoma (AML) is a rare, hepatic mesenchymal neoplasm. Its preoperative diagnosis is very difficult, and the treatment is still controversial. The aim is to summarize experience in diagnosis and management of hepatic AML from a cancer center.METHODS: We retrospecti
PMID 23731017

NMDA receptors in the lateral hypothalamus have an inhibitory influence on the tachycardiac response to acute restraint stress in rats.

Deolindo MV1, Reis DG, Crestani CC, Tavares RF, Resstel LB, Corrêa FM.
The European journal of neuroscience.Eur J Neurosci.2013 Aug;38(3):2374-81. doi: 10.1111/ejn.12246. Epub 2013 May 13.
The aim of the present study was to investigate the role of the lateral hypothalamus (LH) and its local glutamatergic neurotransmission in the cardiovascular adjustments observed when rats are submitted to acute restraint stress. Bilateral microinjection of the nonspecific synaptic inhibitor CoCl2 (
PMID 23668726

Japanese Journal

腹腔鏡補助下肝部分切除および右腎摘出術を行った血友病Aの1例

日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 73(8), 2156-2161, 2012-08-25
NAID 10031123782

Hepatic Angiomyolipoma with a Giant Hemangioma

Journal of Nippon Medical School 78(5), 317-321, 2011
NAID 130004147113

Hepatic Angiomyolipoma : a case report

Hiroshima Journal of Medical Sciences 59(1), 17-19, 2010-03
NAID 120005323944

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リンク元	「臭化メチルホマトロピン」「ホマトロピンメチルブロミド」「ホマトロピンメチルブロマイド」

「臭化メチルホマトロピン」

Homatropine methyl bromide
Systematic (IUPAC) name
	(N,N-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate bromide
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	80-49-9
ATC code	A02BX03
PubChem	CID 6646
DrugBank	DB00725
ChemSpider	6394
UNII	68JRS2HC1C
ChEMBL	CHEMBL1200851
Chemical data
Formula	C17H24BrNO3
Mol. mass	356.26 g/mol
	SMILES CN3[C@H]1CC[C@@H]3C[C@@H](C1)OC(=O)C(O)c2ccccc2;
	InChI InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1/t13-,14+,15+,16?; ; Key:ZTVIKZXZYLEVOL-MCOXGKPRSA-N ;
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