"Mycoses" redirects here. For the journal, see Mycoses (journal).
| Mycosis |
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Micrograph showing a mycosis (aspergillosis). The Aspergillus (which is spaghetti-like) is seen in the center and surrounded by inflammatory cells and necrotic debris. H&E stain.
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| Classification and external resources |
| Specialty |
Infectious disease |
| ICD-10 |
B35-B49 |
| ICD-9-CM |
110-118.99 |
| DiseasesDB |
28821 |
| MeSH |
D009181 |
Mycosis (plural: mycoses) is a fungal infection of animals, including humans.[1] Mycoses are common and a variety of environmental and physiological conditions can contribute to the development of fungal diseases. Inhalation of fungal spores or localized colonization of the skin may initiate persistent infections; therefore, mycoses often start in the lungs or on the skin.[2]
Fungal infections of the skin was the 4th most common disease in 2010 affecting 984 million people.[3]
Contents
- 1 Causes
- 2 Classification
- 2.1 Superficial mycoses
- 2.2 Cutaneous mycoses
- 2.3 Subcutaneous mycoses
- 2.4 Systemic mycoses due to primary pathogens
- 2.5 Systemic mycoses due to opportunistic pathogens
- 3 Prevention
- 4 Treatment
- 5 Epidemiology
- 6 See also
- 7 References
- 8 External links
Causes
Antibiotics are a risk factor for fungal infections.[4]
Individuals with weakened immune systems are also at risk of developing fungal infections. This is the case of people with HIV/AIDS, people under steroid treatments, and people taking chemotherapy. People with diabetes also tend to develop fungal infections.[5] Very young and very old people, also, are groups at risk.[6]
Classification
Mycoses are classified according to the tissue levels initially colonized.
Superficial mycoses
Superficial mycoses are limited to the outermost layers of the skin and hair.[7]
An example of such a fungal infection is Tinea versicolor, a fungus infection that commonly affects the skin of young people, especially the chest, back, and upper arms and legs. Tinea versicolor is caused by a fungus that lives in the skin of some adults. It does not usually affect the face. This fungus produces spots that are either lighter than the skin or a reddish-brown.[8] This fungus exists in two forms, one of them causing visible spots. Factors that can cause the fungus to become more visible include high humidity, as well as immune or hormone abnormalities. However, almost all people with this very common condition are healthy.
Cutaneous mycoses
Cutaneous mycoses extend deeper into the epidermis, and also include invasive hair and nail diseases. These diseases are restricted to the keratinized layers of the skin, hair, and nails. Unlike the superficial mycoses, host immune responses may be evoked resulting in pathologic changes expressed in the deeper layers of the skin. The organisms that cause these diseases are called dermatophytes. The resulting diseases are often called ringworm (even though there is no worm involved) or tinea. Cutaneous mycoses are caused by Microsporum, Trichophyton, and Epidermophyton fungi, which together comprise 41 species.
One common disease is the athlete's foot which most commonly affects children before puberty[citation needed]. It is divided in three categories: chronic interdigital athlete's foot, chronic scaly athlete's foot, and acute vesicular athlete's foot.[9]
Subcutaneous mycoses
Subcutaneous mycoses involve the dermis, subcutaneous tissues, muscle and fascia. These infections are chronic and can be initiated by piercing trauma to the skin which allows the fungi to enter. These infections are difficult to treat and may require surgical interventions such as debridement.
Systemic mycoses due to primary pathogens
Systemic mycoses due to primary pathogens originate primarily in the lungs and may spread to many organ systems. Organisms that cause systemic mycoses are inherently virulent. In general primary pathogens that cause systemic mycoses are dimorphic.
Systemic mycoses due to opportunistic pathogens
Systemic mycoses due to opportunistic pathogens are infections of patients with immune deficiencies who would otherwise not be infected. Examples of immunocompromised conditions include AIDS, alteration of normal flora by antibiotics, immunosuppressive therapy, and metastatic cancer. Examples of opportunistic mycoses include Candidiasis, Cryptococcosis and Aspergillosis.
Prevention
Keeping the skin clean and dry, as well as maintaining good hygiene, will help larger topical mycoses. Because fungal infections are contagious, it is important to wash after touching other people or animals. Sports clothing should also be washed after use.
Treatment
Antifungal drugs are used to treat mycoses. Depending on the nature of the infection, a topical or systemic agent may be used.
Example of antifungals include: fluconazole which is the basis of many over-the-counter antifungal treatments. Another example is amphotericin B which is more potent and used in the treatment of the most severe fungal infections that show resistance to other forms of treatment and it is administered intravenously.[10]
Drugs to treat skin infections are ketoconazole, itraconazole, terbinafine among others.[11]
Yeast infections in the vagina, caused by Candida albicans, can be treated with medicated suppositories such as tioconazole and pessaries whereas skin yeast infections are treated with medicated ointments.[12]
Epidemiology
Fungal infections of the skin were the 4th most common disease in 2010 affecting 984 million people.[3]
See also
- Pathogenic fungi
- Fungal infection in plants#Fungi
- Zygomycosis
References
- ^ "Dorlands Medical Dictionary:mycosis".
- ^ "What Is a Fungal Infection?". Retrieved May 26, 2010.
- ^ a b Hay, RJ; Johns, NE; Williams, HC; Bolliger, IW; Dellavalle, RP; Margolis, DJ; Marks, R; Naldi, L; Weinstock, MA; Wulf, SK; Michaud, C; J L Murray, C; Naghavi, M (Oct 28, 2013). "The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions.". The Journal of investigative dermatology 134 (6): 1527–34. doi:10.1038/jid.2013.446. PMID 24166134.
- ^ Acute Care Surgery. 2012. p. 186. ISBN 9781451153934.
- ^ "Thrush in Men". NHS. Retrieved 2013-07-13.
- ^ "Fungal infections: Introduction". Retrieved May 26, 2010.
- ^ Malcolm D. Richardson, David W. Warnock. "Introduction". Fungal Infection: Diagnosis and Management. John Wiley & Sons, 2012. p. 5.
- ^ "Tinea versicolor" (PDF). Royal Berkshire NHS. Retrieved July 12, 2013.
- ^ "Athlete's Foot". Retrieved May 26, 2010.
- ^ "What is a mycosis? causes, symptoms and treatments". Retrieved May 26, 2010.
- ^ "Therapy". Retrieved May 26, 2010.
- ^ "How Are Yeast Infections Treated?". Retrieved May 26, 2010.
External links
- Guide to Fungal Infections - Patient-oriented, educational website written by dermatologists.
- Doctor Fungus - An educational website sponsored through unrestricted educational grants by numerous pharmaceutical companies
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Infectious disease and microbiology
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Disciplines
(pathogens)
Major diseases |
| Bacteriology (bacteria) |
- Cholera
- Diphtheria
- Leprosy
- Syphilis
- Tuberculosis
|
|
| Virology (viruses, prions) |
- AIDS
- Creutzfeldt–Jakob disease
- Influenza
- Measles
- Polio
- Smallpox
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|
| Mycology (fungi) |
- Aspergillosis
- Candidiasis
- Tinea
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| Parasitology (protozoa, helminths) |
- Amoebic dysentery
- Hookworm
- Malaria
- Schistosomiasis
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| Entomology (ectoparasites) |
|
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| People |
- Alexander Fleming
- Robert Koch
- Louis Pasteur
- Ignaz Semmelweis
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| Related topics |
- Antibiotics
- Eradication
- Pandemic
- Transmission
- Vaccination
- Zoonosis
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Pathology: Medical conditions and ICD code
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(Disease / Disorder / Syndrome / Sequence, Symptom / Sign, Injury, etc.)
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| (A/B, 001–139) |
- Infectious disease/Infection: Bacterial disease
- Viral disease
- Parasitic disease
- Protozoan infection
- Helminthiasis
- Ectoparasitic infestation
- Mycosis
- Zoonosis
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(C/D,
140–239 &
279–289) |
| Cancer (C00–D48, 140–239) |
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| Myeloid hematologic (D50–D77, 280–289) |
|
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| Lymphoid immune (D80–D89, 279) |
- Immunodeficiency
- Immunoproliferative disorder
- Hypersensitivity
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| (E, 240–278) |
- Endocrine disease
- Nutrition disorder
- Inborn error of metabolism
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| (F, 290–319) |
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| (G, 320–359) |
- Nervous system disease
- Neuromuscular disease
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| (H, 360–389) |
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| (I, 390–459) |
- Cardiovascular disease
- Heart disease
- Vascular disease
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| (J, 460–519) |
- Respiratory disease
- Obstructive lung disease
- Restrictive lung disease
- Pneumonia
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| (K, 520–579) |
- Oral and maxillofacial pathology
- Tooth disease
- salivary gland disease
- tongue disease
- Digestive disease
- Esophageal
- Stomach
- Enteropathy
- Liver
- Pancreatic
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| (L, 680–709) |
- Skin disease
- skin appendages
- Nail disease
- Hair disease
- Sweat gland disease
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| (M, 710–739) |
- Musculoskeletal disorders: Myopathy
- Arthropathy
- Osteochondropathy
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| (N, 580–629) |
- Urologic disease
- Nephropathy
- Urinary bladder disease
- Male genital disease
- Breast disease
- Female genital disease
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| (O, 630–679) |
- Complications of pregnancy
- Obstetric labor complication
- Puerperal disorder
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| (P, 760–779) |
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| (Q, 740–759) |
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| (R, 780–799) |
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| (S/T, 800–999) |
- Bone fracture
- Joint dislocation
- Sprain
- Strain
- Subluxation
- Head injury
- Chest trauma
- Poisoning
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Fungal infection and mesomycetozoea (B35–B49, 110–118)
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Superficial and
cutaneous
(dermatomycosis):
Tinea = skin;
Piedra (exothrix/
endothrix) = hair |
| Ascomycota |
Dermatophyte
(Dermatophytosis) |
| By location |
- Tinea barbae/tinea capitis
- Tinea corporis
- Tinea cruris
- Tinea manuum
- Tinea pedis (athlete's foot)
- Tinea unguium/onychomycosis
- White superficial onychomycosis
- Distal subungual onychomycosis
- Proximal subungual onychomycosis
- Tinea corporis gladiatorum
- Tinea faciei
- Tinea imbricata
- Tinea incognito
- Favus
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| By organism |
- Epidermophyton floccosum
- Microsporum canis
- Microsporum audouinii
- Trichophyton interdigitale/mentagrophytes
- Trichophyton tonsurans
- Trichophyton schoenleini
- Trichophyton rubrum
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| Other |
- Hortaea werneckii
- Piedraia hortae
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| Basidiomycota |
- Malassezia furfur
- Tinea versicolor
- Pityrosporum folliculitis
- Trichosporon
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Subcutaneous,
systemic,
and opportunistic |
| Ascomycota |
Dimorphic
(yeast+mold) |
| Onygenales |
- Coccidioides immitis/Coccidioides posadasii
- Coccidioidomycosis
- Disseminated coccidioidomycosis
- Primary cutaneous coccidioidomycosis. Primary pulmonary coccidioidomycosis
- Histoplasma capsulatum
- Histoplasmosis
- Primary cutaneous histoplasmosis
- Primary pulmonary histoplasmosis
- Progressive disseminated histoplasmosis
- Histoplasma duboisii
- Lacazia loboi
- Paracoccidioides brasiliensis
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| Other |
- Blastomyces dermatitidis
- Blastomycosis
- North American blastomycosis
- South American blastomycosis
- Sporothrix schenckii
- Penicillium marneffei
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| Yeast-like |
- Candida albicans
- Candidiasis
- Oral
- Esophageal
- Vulvovaginal
- Chronic mucocutaneous
- Antibiotic candidiasis
- Candidal intertrigo
- Candidal onychomycosis
- Candidal paronychia
- Candidid
- Diaper candidiasis
- Congenital cutaneous candidiasis
- Perianal candidiasis
- Systemic candidiasis
- Erosio interdigitalis blastomycetica
- C. glabrata
- C. tropicalis
- C. lusitaniae
- Pneumocystis jirovecii
- Pneumocystosis
- Pneumocystis pneumonia
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| Mold-like |
- Aspergillus
- Aspergillosis
- Aspergilloma
- Allergic bronchopulmonary aspergillosis
- Primary cutaneous aspergillosis
- Exophiala jeanselmei
- Fonsecaea pedrosoi/Fonsecaea compacta/Phialophora verrucosa
- Geotrichum candidum
- Pseudallescheria boydii
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| Basidiomycota |
- Cryptococcus neoformans
- Cryptococcosis
- Trichosporon spp
- Trichosporonosis
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Zygomycota
(Zygomycosis) |
Mucorales
(Mucormycosis) |
- Rhizopus oryzae
- Mucor indicus
- Lichtheimia corymbifera
- Syncephalastrum racemosum
- Apophysomyces variabilis
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Entomophthorales
(Entomophthoramycosis) |
- Basidiobolus ranarum
- Conidiobolus coronatus/Conidiobolus incongruus
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Microsporidia
(Microsporidiosis) |
- Enterocytozoon bieneusi/Encephalitozoon intestinalis
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| Mesomycetozoea |
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| Ungrouped |
- Alternariosis
- Fungal folliculitis
- Fusarium
- Granuloma gluteale infantum
- Hyalohyphomycosis
- Otomycosis
- Phaeohyphomycosis
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Index of fungal disease
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| Description |
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| Disease |
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| Treatment |
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