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any of several infections of the skin or mucous membrane caused by Blastomyces
a fungal infection characterized by itchy warty nodules on the skin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/02 02:15:55」(JST)

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The term "South American blastomycosis" is sometimes used to describe an infection with Paracoccidioides brasiliensis,^[1] though the term Paracoccidioidomycosis is more frequently used to describe this condition.

Blastomycosis (also known as "North American blastomycosis", "Blastomycetic dermatitis", and "Gilchrist's disease"^[2]) is a fungal infection of humans and other animals, notably dogs and occasionally cats, caused by the organism Blastomyces dermatitidis. Endemic to portions of North America, blastomycosis causes clinical symptoms similar to histoplasmosis.^[3] The disease occurs in several endemic areas the most important of which is in eastern North America, particularly in the western and northern periphery of the Great Lakes Basin, extending eastward along the south shore of the St. Lawrence River Valley and southward in the territory spanned by the central Appalachian Mountains in the east, to the Mississippi River Valley in the west. Sporadic cases have been reported in continental Africa,^[4] the Arabian Peninsula and the Indian subcontinent.

History

Blastomycosis was first described by Thomas Casper Gilchrist^[5] in 1894 and sometimes goes by the eponym Gilchrist's disease.^[6] It is also sometimes referred to as Chicago Disease.

Causative agent

Blastomycosis is caused by the dimorphic microfungus Blastomyces dermatitidis, a member of the phylum Ascomycota in the family Ajellomycetaceae. It has been recognised as the asexual state of Ajellomyces dermatitidis. In endemic areas, the fungus lives in soil and rotten wood near lakes and rivers. Although it has never been directly observed growing in nature, it is thought to grow there as a cottony white mold, similar to the growth seen in artificial culture at 25 °C. The moist, acidic soil in the surrounding woodland harbors the fungus.

Spectrum of disease

Blastomycosis manifests as a primary lung infection in about 70% of cases.^[7] The onset is relatively slow and symptoms are suggestive of pneumonia, often leading to initial treatment with antibacterials. Occasionally, if a lesion is seen on X-ray in a cigarette smoker, the disease may be misdiagnosed as carcinoma, leading to swift excision of the pulmonary lobe involved. Upper lung lobes are involved somewhat more frequently than lower lobes.^[7] If untreated, many cases progress over a period of months to years to become disseminated blastomycosis. In these cases, the large Blastomyces yeast cells translocate from the lungs and are trapped in capillary beds elsewhere in the body, where they cause lesions. The skin is the most common organ affected, being the site of lesions in approximately 60% of cases.^[7] The signature image of blastomycosis in textbooks is the indolent, verrucous or ulcerated dermal lesion seen in disseminated disease. Osteomyelitis is also common (12–60% of cases). Other recurring sites of dissemination are the genitourinary tract (kidney, prostate, epididymis; collectively ca. 25% of cases) and the brain (3–10% of cases).^[7]

An uncommon but very dangerous type of primary blastomycosis manifests as acute respiratory distress syndrome (ARDS); for example, this was seen in 9 of 72 blastomycosis cases studied in northeast Tennessee.^[8] Such cases may follow massive exposure, e.g., during brush clearing operations. The fatality rate in the ARDS cases in the Tennessee study was 89%, while in non-ARDS cases of pulmonary blastomycosis, the fatality rate was 10%.

Blastomycosis also affects an indefinitely broad range of mammalian hosts, and dogs in particular are a highly vulnerable sentinel species.^[7] They generally suffer a disease that begins with acute respiratory symptoms and rapidly progresses to death. Cats are the animals next most frequently detected as infected.^[9]

Pathogenesis

Large, broadly-based budding yeast cells characteristic of Blastomyces dermatitidis in a GMS-stained biopsy section from a human leg.

Inhaled conidia of B. dermatitidis are phagocytosed by neutrophils and macrophages in alveoli. Some of these escape phagocytosis and transform into yeast phase rapidly. Having thick walls, these are resistant to phagocytosis and express glycoprotein, BAD-1, which is a virulence factor as well as an epitope. In lung tissue, they multiply and may disseminate through blood and lymphatics to other organs, including the skin, bone, genitourinary tract, and brain. The incubation period is 30 to 100 days, although infection can be asymptomatic.

Signs and symptoms

Blastomycosis can present in one of the following ways:

a flu-like illness with fever, chills, arthralgia (joint pain), myalgia (muscle pain), headache, and a nonproductive cough which resolves within days.
an acute illness resembling bacterial pneumonia, with symptoms of high fever, chills, a productive cough, and pleuritic chest pain.
a chronic illness that mimics tuberculosis or lung cancer, with symptoms of low-grade fever, a productive cough, night sweats, and weight loss.
a fast, progressive, and severe disease that manifests as ARDS, with fever, shortness of breath, tachypnea, hypoxemia, and diffuse pulmonary infiltrates.
skin lesions, usually asymptomatic, can be verrucous (wart-like) or ulcerated with small pustules at the margins.
bone lytic lesions can cause bone or joint pain.
prostatitis may be asymptomatic or may cause pain on urinating.
laryngeal involvement causes hoarseness.
40% immunocompromised individuals have CNS involvement and present as brain abscess, epidural abscess or meningitis.

Diagnosis

Once suspected, the diagnosis of blastomycosis can usually be confirmed by demonstration of the characteristic broad based budding organisms in sputum or tissues by KOH prep, cytology, or histology.^[10] Tissue biopsy of skin or other organs may be required in order to diagnose extra-pulmonary disease. Blastomycosis is histologically associated with granulomatous nodules. Commercially available urine antigen testing appears to be quite sensitive in suggesting the diagnosis in cases where the organism is not readily detected. While culture of the organism remains the definitive diagnostic standard, its slow growing nature can lead to delays in treatment of up to several weeks. However, sometimes blood and sputum cultures may not detect blastomycosis.

Treatment

Itraconazole given orally is the treatment of choice for most forms of the disease. Ketoconazole may also be used. Cure rates are high, and the treatment over a period of months is usually well tolerated. Amphotericin B is considerably more toxic, and is usually reserved for immunocompromised patients who are critically ill and those with central nervous system disease. Patients who cannot tolerate deoxycholate formulation of Amphotericin B can be given lipid formulations. Fluconazole has excellent CNS penetration and is useful where there is CNS involvement after initial treatment with Amphotericin B.

Prognosis

Mortality rate in treated cases

0-2% in treated cases among immunocompetent patients
29% in immunocompromised patients
40% in the subgroup of patients with AIDS
68% in patients presenting as acute respiratory distress syndrome (ARDS)

Epidemiology

Distribution of blastomycosis in North America based on the map given by Kwon-Chung and Bennett,^[7] with modifications made according to case reports from a series of additional sources.^[11]^[12]^[13]^[14]^[15]^[16]^[17]

Incidences in most endemic areas are circa 0.5 per 100,000 population, with occasional local areas attaining as high as 12 per 100,000.^[7]^[18]^[19]^[20] Most Canadian data fit this picture. In Ontario, Canada, considering both endemic and non-endemic areas, the overall incidence is around 0.3 cases per 100,000; northern Ontario, mostly endemic, has 2.44 per 100,000.^[15] Manitoba is calculated at 0.62 cases per 100,000.^[11] Remarkably higher incidences were shown for the Kenora, Ontario region: 117 per 100,000 overall, with aboriginal reserve communities experiencing 404.9 per 100,000.^[12] In the United States, the incidence of blastomycosis is similarly high in hyperendemic areas. For example, the city of Eagle River, Vilas County, Wisconsin, which has an incidence rate of 101.3 per 100,000; the county as a whole has been shown in two successive studies to have an incidence of ca. 40 cases per 100,000.^[21] An incidence of 277 per 100,000 was roughly calculated based on 9 cases seen in a Wisconsin aboriginal reservation during a time in which extensive excavation was done for new housing construction.^[22] The new case rates are greater in northern states such as Wisconsin, where from 1986 to 1995 there were 1.4 cases per 100,000 people.^[23]

The study of outbreaks as well as trends in individual cases of blastomycosis has clarified a number of important matters. Some of these relate to the ongoing effort to understand the source of infectious inoculum of this species, while others relate to which groups of people are especially likely to become infected. Human blastomycosis is primarily associated with forested areas and open watersheds;^[7]^[24]^[25]^[26] It primarily affects otherwise healthy, vigorous people, mostly middle-aged,^[27] who acquire the disease while working or undertaking recreational activities in sites conventionally considered clean, healthy and in many cases beautiful.^[7]^[18] Repeatedly associated activities include hunting, especially raccoon hunting,^[28] where accompanying dogs also tend to be affected, as well as working with wood or plant material in forested or riparian areas,^[7]^[29] involvement in forestry in highly endemic areas,^[30] excavation,^[21] fishing^[27]^[31] and possibly gardening and trapping.^[12]^[21]

Urban infections

There is also a developing profile of urban and other domestic blastomycosis cases, beginning with an outbreak tentatively attributed to construction dust in Westmont, Illinois.^[32] The city of Rockford, Illinois, was also documented as a hyperendemic area based on incidence rates as high as 6.67 per 100,000 population for some areas of the city. Though proximity to open watersheds was linked to incidence in some areas,^[26] suggesting that outdoor activity within the city may be connected to many cases, there is also an increasing body of evidence that even the interiors of buildings may be risk areas. An early case concerned a prisoner who was confined to prison during the whole of his likely blastomycotic incubation period.^[33] An epidemiological survey found that although many patients who contracted blastomycosis had engaged in fishing, hunting, gardening, outdoor work and excavation, the most strongly linked association in patients was living or visiting near waterways.^[31] Based on a similar finding in a Louisiana study, it has been suggested that place of residence might be the most important single factor in blastomycosis epidemiology in north central Wisconsin.^[34] Follow-up epidemiological and case studies indicated that clusters of cases were often associated with particular domiciles, often spread out over a period of years, and that there were uncommon but regularly occurring cases in which pets kept mostly or entirely indoors, in particular cats, contracted blastomycosis.^[9]^[35] The occurrence of blastomycosis, then, is an issue strongly linked to housing and domestic circumstances.

Seasonal trends

Seasonality and weather also appear to be linked to contraction of blastomycosis. Many studies have suggested an association between blastomycosis contraction and cool to moderately warm, moist periods of the spring and autumn^[7]^[12]^[36] or, in relatively warm winter areas.^[37] However, the entire summer or a known summer exposure date is included in the association in some studies.^[27]^[38] Occasional studies fail to detect a seasonal link.^[39] In terms of weather, both unusually dry weather^[40] and unusually moist weather^[41] have been cited. The seemingly contradictory data can most likely be reconciled by proposing that B. dermatitidis prospers in its natural habitats in times of moisture and moderate warmth, but that inoculum formed during these periods remains alive for some time and can be released into the air by subsequent dust formation under dry conditions. Indeed, dust per se or construction potentially linked to dust has been associated with several outbreaks^[8]^[32]^[42] The data, then, tend to link blastomycosis to all weather, climate and atmospheric conditions except freezing weather, periods of snow cover, and extended periods of hot, dry summer weather in which soil is not agitated.

Gender bias

Sex is another factor inconstantly linked to contraction of blastomycosis: though many studies show more men than women affected,^[7]^[15] some show no sex-related bias.^[12]^[31] As mentioned above, most cases are in middle aged adults, but all age groups are affected, and cases in children are not uncommon.^[7]^[12]^[15]

Ethnic populations

Ethnic group or race is frequently investigated in epidemiological studies of blastomycosis, but is potentially profoundly conflicted by differences in residence and in quality and accessibility of medical care, factors that have not been stringently controlled for to date. In the USA, a disproportionately high incidence and/or mortality rate is occasionally shown for blacks;^[19]^[20]^[43]^[44] whereas aboriginals in Canada are disproportionately linked to blastomycosis in some studies^[12]^[45] but not others.^[11] Incidence in aboriginal children may be unusually high.^[12] The Canadian data in some areas may be confounded or explained by the tendency to establish aboriginal communities in wooded, riparian, northern areas corresponding to the core habitat of B. dermatitidis, often with known B. dermatitidis habitats such as woodpiles and beaver constructions in the near vicinity.

Communicability

There are a very small number of cases of human-to-human transmission of B. dermatitidis related to dermal contact^[46] or sexual transmission of disseminated blastomycosis of the genital tract among spouses.^[7]

Additional images

Budding yeasts in cytoplasm of giant cells at arrows. Broad-based budding and double countoured cell wall seen in the giant cell in the center is characteristic of Blastomyces dermatiditis.
Granuloma with early suppuration. Fungal organisms difficult to recognize at this low magnification.
Large yeast-like fungi seen within giant cells at arrows.
Nodular skin lesions of blastomycosis, one of which is a bullous lesion on top of a nodule.

References

^ "South American Blastomycosis: Overview - eMedicine Dermatology". Retrieved 2009-03-08.
^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 319. ISBN 0-7216-2921-0.
^ Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 676–8. ISBN 0-8385-8529-9.
^ Alvarez G, Burns B, Desjardins M, Salahudeen S, AlRashidi F, Cameron D (2006). "Blastomycosis in a young African man presenting with a pleural effusion". Can Respir J 13 (8): 441–4. PMC 2683332. PMID 17149463.
^ "Thomas Caspar Gilchrist (www.whonamedit.com)". Retrieved 2008-12-10.
^ "Gilchrist's disease (www.whonamedit.com)". Retrieved 2008-12-10.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k ^l ^m ⁿ Kwon-Chung, K.J., Bennett, J.E.; Bennett, John E. (1992). Medical mycology. Philadelphia: Lea & Febiger. ISBN 978-0812114638.
^ ^a ^b Vasquez, JE; Mehta, JB; Agrawal, R; Sarubbi, FA (1998). "Blastomycosis in northeast Tennessee.". Chest 114 (2): 436–43. doi:10.1378/chest.114.2.436. PMID 9726727.
^ ^a ^b Blondin, N; Baumgardner, DJ; Moore, GE; Glickman, LT (2007). "Blastomycosis in indoor cats: suburban Chicago, Illinois, USA.". Mycopathologia 163 (2): 59–66. doi:10.1007/s11046-006-0090-1. PMID 17262169.
^ Veligandla SR, Hinrichs SH, Rupp ME, Lien EA, Neff JR, Iwen PC (October 2002). "Delayed diagnosis of osseous blastomycosis in two patients following environmental exposure in nonendemic areas". Am. J. Clin. Pathol. 118 (4): 536–41. doi:10.1309/JEJ0-3N98-C3G8-21DE. PMID 12375640.
^ ^a ^b ^c Crampton, TL; Light, RB; Berg, GM; Meyers, MP; Schroeder, GC; Hershfield, ES; Embil, JM (2002). "Epidemiology and clinical spectrum of blastomycosis diagnosed at Manitoba hospitals.". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 34 (10): 1310–6. doi:10.1086/340049. PMID 11981725.
^ ^a ^b ^c ^d ^e ^f ^g ^h Dwight, P.J.; Naus, M; Sarsfield, P; Limerick, B (2000). "An outbreak of human blastomycosis: the epidemiology of blastomycosis in the Kenora catchment region of Ontario, Canada.". Canada communicable disease report = Releve des maladies transmissibles au Canada 26 (10): 82–91. PMID 10893821.
^ Kane, J; Righter, J; Krajden, S; Lester, RS (1983). "Blastomycosis: a new endemic focus in Canada.". Canadian Medical Association journal 129 (7): 728–31. PMID 6616383.
^ Lester, RS; DeKoven, JG; Kane, J; Simor, AE; Krajden, S; Summerbell, RC (2000). "Novel cases of blastomycosis acquired in Toronto, Ontario.". CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 163 (10): 1309–12. PMID 11107469.
^ ^a ^b ^c ^d Morris, SK; Brophy, J; Richardson, SE; Summerbell, R; Parkin, PC; Jamieson, F; Limerick, B; Wiebe, L; Ford-Jones, EL (2006). "Blastomycosis in Ontario, 1994-2003.". Emerging Infectious Diseases 12 (2): 274–9. doi:10.3201/eid1202.050849. PMC 3373107. PMID 16494754.
^ Sekhon, AS; Jackson, FL; Jacobs, HJ (1982). "Blastomycosis: report of the first case from Alberta Canada.". Mycopathologia 79 (2): 65–9. doi:10.1007/bf00468081. PMID 6813742.
^ Vallabh, V; Martin, T; Conly, JM (1988). "Blastomycosis in Saskatchewan.". The Western journal of medicine 148 (4): 460–2. PMID 3388850.
^ ^a ^b Rippon, John Willard (1988). Medical mycology : the pathogenic fungi and the pathogenic actinomycetes (3rd ed. ed.). Philadelphia: W.B. Saunders Co. ISBN 9780721624440.
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^ ^a ^b Cano, MV; Ponce-de-Leon, GF; Tippen, S; Lindsley, MD; Warwick, M; Hajjeh, RA (2003). "Blastomycosis in Missouri: epidemiology and risk factors for endemic disease.". Epidemiology and infection 131 (2): 907–14. doi:10.1017/s0950268803008987. PMID 14596532.
^ ^a ^b ^c Baumgardner, DJ; Brockman, K (1998). "Epidemiology of human blastomycosis in Vilas County, Wisconsin. II: 1991-1996.". WMJ : official publication of the State Medical Society of Wisconsin 97 (5): 44–7. PMID 9617309.
^ Baumgardner, DJ; Egan, G; Giles, S; Laundre, B (2002). "An outbreak of blastomycosis on a United States Indian reservation.". Wilderness & environmental medicine 13 (4): 250–2. doi:10.1580/1080-6032(2002)013[0250:aooboa]2.0.co;2. PMID 12510781.
^ Centers for Disease Control and Prevention (CDC) (1996). "Blastomycosis--Wisconsin, 1986-1995". MMWR Morb. Mortal. Wkly. Rep. 45 (28): 601–3. PMID 8676851.
^ DiSalvo, A.F. (1992). Al-Doory, Y., DiSalvo, A.F., ed. Ecology of Blastomyces dermatitidis. Plenum. pp. 43–73.
^ Baumgardner, DJ; Steber, D; Glazier, R; Paretsky, DP; Egan, G; Baumgardner, AM; Prigge, D (2005). "Geographic information system analysis of blastomycosis in northern Wisconsin, USA: waterways and soil.". Medical mycology : official publication of the International Society for Human and Animal Mycology 43 (2): 117–25. doi:10.1080/13693780410001731529. PMID 15832555.
^ ^a ^b Baumgardner, DJ; Knavel, EM; Steber, D; Swain, GR (2006). "Geographic distribution of human blastomycosis cases in Milwaukee, Wisconsin, USA: association with urban watersheds.". Mycopathologia 161 (5): 275–82. doi:10.1007/s11046-006-0018-9. PMID 16649077.
^ ^a ^b ^c Klein, Bruce S.; Vergeront, James M.; Weeks, Robert J.; Kumar, U. Nanda; Mathai, George; Varkey, Basil; Kaufman, Leo; Bradsher, Robert W.; Stoebig, James F.; Davis, Jeffrey P. (1986). "Isolation of Blastomyces dermatitidis in Soil Associated with a Large Outbreak of Blastomycosis in Wisconsin". New England Journal of Medicine 314 (9): 529–534. doi:10.1056/NEJM198602273140901. PMID 3945290.
^ Armstrong, CW; Jenkins, SR; Kaufman, L; Kerkering, TM; Rouse, BS; Miller GB, Jr (1987). "Common-source outbreak of blastomycosis in hunters and their dogs.". The Journal of infectious diseases 155 (3): 568–70. doi:10.1093/infdis/155.3.568. PMID 3805778.
^ Kesselman, EW; Moore, S; Embil, JM (2005). "Using local epidemiology to make a difficult diagnosis: a case of blastomycosis.". CJEM 7 (3): 171–3. PMID 17355674.
^ Vaaler, AK; Bradsher, RW; Davies, SF (1990). "Evidence of subclinical blastomycosis in forestry workers in northern Minnesota and northern Wisconsin.". The American Journal of Medicine 89 (4): 470–6. doi:10.1016/0002-9343(90)90378-q. PMID 2220880.
^ ^a ^b ^c Baumgardner, DJ; Buggy, BP; Mattson, BJ; Burdick, JS; Ludwig, D (1992). "Epidemiology of blastomycosis in a region of high endemicity in north central Wisconsin.". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 15 (4): 629–35. doi:10.1093/clind/15.4.629. PMID 1420675.
^ ^a ^b Kitchen, MS; Reiber, CD; Eastin, GB (1977). "An urban epidemic of North American blastomycosis.". The American Review of Respiratory Disease 115 (6): 1063–6. PMID 262101.
^ Renston, JP; Morgan, J; DiMarco, AF (1992). "Disseminated miliary blastomycosis leading to acute respiratory failure in an urban setting.". Chest 101 (5): 1463–5. doi:10.1378/chest.101.5.1463. PMID 1582324.
^ Lowry, PW; Kelso, KY; McFarland, LM (1989). "Blastomycosis in Washington Parish, Louisiana, 1976-1985.". American Journal of Epidemiology 130 (1): 151–9. PMID 2787106.
^ Baumgardner, DJ; Paretsky, DP (2001). "Blastomycosis: more evidence for exposure near one's domicile.". WMJ : official publication of the State Medical Society of Wisconsin 100 (7): 43–5. PMID 11816782.
^ Rudmann, DG; Coolman, BR; Perez, CM; Glickman, LT (1992). "Evaluation of risk factors for blastomycosis in dogs: 857 cases (1980-1990)". Journal of the American Veterinary Medical Association 201 (11): 1754–9. PMID 1293122.
^ Arceneaux, KA; Taboada, J; Hosgood, G (1998). "Blastomycosis in dogs: 115 cases (1980-1995).". Journal of the American Veterinary Medical Association 213 (5): 658–64. PMID 9731260.
^ Archer, JR; Trainer, DO; Schell, RF (1987). "Epidemiologic study of canine blastomycosis in Wisconsin.". Journal of the American Veterinary Medical Association 190 (10): 1292–5. PMID 3583882.
^ Chapman, SW; Lin, AC; Hendricks, KA; Nolan, RL; Currier, MM; Morris, KR; Turner, HR (1997). "Endemic blastomycosis in Mississippi: epidemiological and clinical studies.". Seminars in respiratory infections 12 (3): 219–28. PMID 9313293.
^ Proctor, ME; Klein, BS; Jones, JM; Davis, JP (2002). "Cluster of pulmonary blastomycosis in a rural community: evidence for multiple high-risk environmental foci following a sustained period of diminished precipitation.". Mycopathologia 153 (3): 113–20. PMID 11998870.
^ De Groote, MA; Bjerke, R; Smith, H; Rhodes III, LV (2000). "Expanding epidemiology of blastomycosis: clinical features and investigation of 2 cases in Colorado.". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 30 (3): 582–4. doi:10.1086/313717. PMID 10722448.
^ Baumgardner, DJ; Burdick, JS (1991). "An outbreak of human and canine blastomycosis.". Reviews of infectious diseases 13 (5): 898–905. doi:10.1093/clinids/13.5.898. PMID 1962106.
^ Dworkin, MS; Duckro, AN; Proia, L; Semel, JD; Huhn, G (2005). "The epidemiology of blastomycosis in Illinois and factors associated with death.". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 41 (12): e107–11. doi:10.1086/498152. PMID 16288388.
^ Lemos, LB; Guo, M; Baliga, M (2000). "Blastomycosis: organ involvement and etiologic diagnosis. A review of 123 patients from Mississippi.". Annals of Diagnostic Pathology 4 (6): 391–406. doi:10.1053/adpa.2000.20755. PMID 11149972.
^ Kepron, MW; Schoemperlen,; Hershfield, ES; Zylak, CJ; Cherniack, RM (1972). "North American blastomycosis in Central Canada. A review of 36 cases.". Canadian Medical Association journal 106 (3): 243–6. PMID 5057959.
^ Bachir, J; Fitch, GL (2006). "Northern Wisconsin married couple infected with blastomycosis.". WMJ : official publication of the State Medical Society of Wisconsin 105 (6): 55–7. PMID 17042422.

External links

Blastomyces at the US National Library of Medicine Medical Subject Headings (MeSH)
http://www.mycology.adelaide.edu.au/Fungal_Descriptions/Dimorphic_Pathogens/Blastomyces/
http://pathmicro.med.sc.edu/mycology/mycology-6.htm
NIH Encyclopedia Blastomycosis
Blastomycosis information and message board

UpToDate Contents

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1. ブラストミセス症の臨床症状および診断 clinical manifestations and diagnosis of blastomycosis
2. ブラストミセス症の治療 treatment of blastomycosis
3. ブラストミセス症の菌学、病因、および疫学 mycology pathogenesis and epidemiology of blastomycosis
4. 成人造血細胞移植レシピエントにおける侵襲性真菌感染症予防 prophylaxis of invasive fungal infections in adult hematopoietic cell transplant recipients
5. 血液悪性腫瘍を有する成人における侵襲性真菌感染症予防 prophylaxis of invasive fungal infections in adults with hematologic malignancies

English Journal

Blastomycosis: the great mimicker.

Hakim H, Apiwattanakul N, Miyairi I, Arnold S.Source1St. Jude Children's Research Hospital, Memphis, TN, USA.
Clinical pediatrics.Clin Pediatr (Phila).2011 Dec;50(12):1156-60.
PMID 22121141

Treatment of chronic pulmonary blastomycosis with caspofungin.

Mardini J, Nguyen B, Ghannoum M, Couture C, Lavergne V.SourceUniversity of Montréal, Montréal, Canada.
Journal of medical microbiology.J Med Microbiol.2011 Dec;60(Pt 12):1875-8. Epub 2011 Aug 18.
Current practice guidelines recommend that pulmonary blastomycosis be treated with antifungal agents such as amphotericin B and itraconazole. Echinocandins are not recommended because of poor in vitro activity against Blastomyces dermatitidis and lack of supporting clinical data. We report a case of
PMID 21852530

Japanese Journal

症例報告増殖型壊疽性膿皮症の1例

神林由美,佐々木喜教,水芦政人 [他]
臨床皮膚科 65(11), 853-856, 2011-10
NAID 40019005549

症例糖尿病に合併したBlastomycosis-Like Pyodermaの1例

服部舞子,石田勝英,辻岡馨 [他]
皮膚科の臨床 50(5), 661-663, 2008-05
NAID 40016049194

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★リンクテーブル★

リンク元	「真菌症」「全身性真菌症」「ブラストミセス症」
拡張検索	「chromoblastomycosis」

「真菌症」

Blastomycosis
	Skin lesions of blastomycosis.
Classification and external resources
ICD-10	B40
ICD-9	116.0
DiseasesDB	1439
MedlinePlus	000102
eMedicine	med/231 ped/254
MeSH	D001759

　　[★]

英: mycosis, mycotic disease
同: 真菌感染症 fungal infection、真菌感染
関: 真菌、抗真菌薬

表在真菌症
皮下真菌症深部皮膚真菌症

スポロトリコーシス sporotrichosis

Sporothrix schenckii

クロモミコーシス chromomycosis 黒色真菌症

Cladosporium carrionii
Fonsecaea compacta
Fonsecaea pedrosoi 日本では起因菌の70%以上を占める(SMB.351)
Phialophora verrucosa
Rhinosladiella aquaspersa

足菌腫 mycetoma マズラ菌症 maduromycosis

深在性真菌症 deep mycosis 全身性真菌症 systemic mycosis

地域流行型真菌症 endemic mycosis
コクシジオイデス症 coccidioidomycosis

Coccidioides immitis

ヒストプラスマ症 histoplasmosis

Histoplasma capsulatum

ブラストミセス症 blastomycosis

Blastomyces dematitidis

Rhizopus oryae

代表的な真菌症 CBT QB vol2 p.193

	白癬	スポロトリコーシス	皮膚カンジダ症	癜風
原因菌	皮膚糸状菌	Sporothrix schenckii	Candida albicans	Malassezia furfur
症状	頭部、顔面、体部、股部、足の白癬	皮下結節→潰瘍化	指趾間びらん、爪周囲炎、粘膜カンジダ	胸・背部に黒・白色斑
検査	KOH法	スポロトリキン反応、PAS染色法	KOH法	KOH法、Wood灯検査
治療	抗真菌薬外用、抗真菌薬内服	ヨードカリ内服、温熱療法、抗真菌薬内服	イミダゾール系抗真菌薬外用	抗真菌薬外用

「全身性真菌症」

　　[★]

英: systemic mycosis
関: 真菌症

first aid step1 2006 p.146

coccidioidomycosis	Southwestern United States, California.
histoplasmosis	Mississippi and Ohio river valleys.
paracoccidioidomycosis	Rural Latin America.
blastomycosis	States east of Mississippi River and Central America.

「ブラストミセス症」

　　[★]

英: blastomycosis
同: 分芽菌症
関: 北アメリカブラストミセス症、パラコクシジオイデス症、北アメリカ分芽菌症、北米型分芽菌症 North American blastomycosis

「chromoblastomycosis」

　　[★] クロモブラストミコーシス　

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案内

blastomycosis