限局性結節性過形成, FNH
WordNet
- of or relating to a focus; "focal length"
- having or localized centrally at a focus; "focal point"; "focal infection"
- relating to or characterized by or having nodules; "Nodular vaginitis"
- having nodules or occurring in the form of nodules; "nodular ores" (同)nodulated, noduled
- abnormal increase in number of cells
PrepTutorEJDIC
- 焦点の
- 節(ふし)の[ような]
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/11/15 00:11:43」(JST)
[Wiki en表示]
Focal nodular hyperplasia |
Classification and external resources |
Micrograph of focal nodular hyperplasia. H&E stain.
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DiseasesDB |
33467 |
eMedicine |
radio/286 |
MeSH |
D020518 |
Focal nodular hyperplasia (FNH) is a benign tumour of the liver (hepatic tumour), which is the second most prevalent tumour of the liver (the first is hepatic hemangioma). It is usually asymptomatic, rarely grows or bleeds, and has no malignant potential. This tumour was once often resected because it was difficult to distinguish from hepatic adenoma, but with modern multiphase imaging is usually now diagnosed by strict imaging criteria and not resected.
Presentation[edit]
Ultrasound of malformed vessels within the fibrous scar of FNH.
Focal nodular hyperplasia's most recognizable gross feature is a central stellate scar seen in 60–70% of cases. Microscopically, a lobular proliferation of bland-appearing hepatocytes with a bile ductular proliferation and malformed vessels within the fibrous scar is the most common pattern. Other patterns include telangiectatic, hyperplastic-adenomatous, and lesions with focal large-cell dysplasia.[1] Rarely, these lesions may be multiple or can occur as part of a syndrome with hemangiomas, epithelioid hemangioendothelioma, hepatic adenomas, fibrolamellar hepatocellular carcinoma, vascular malformations of the brain, meningiomas, and/or astrocytomas.[1]
Notes[edit]
- ^ a b Nguyen BN, Flejou JF, Terris B, Belghiti J, Degott C (December 1999). "Focal nodular hyperplasia of the liver: a comprehensive pathologic study of 305 lesions and recognition of new histologic forms". Am. J. Surg. Pathol. 23 (12): 1441–54. PMID 10584697.
References[edit]
- Hsee LC, McCall JL, Koea JB (2005). "Focal nodular hyperplasia: what are the indications for resection?". HPB (Oxford) 7 (4): 298–302. doi:10.1080/13651820500273624. PMC 2043107. PMID 18333211.
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This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (August 2007) |
Tumors: digestive system neoplasia (C15–C26/D12–D13, 150–159/211)
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GI tract |
Upper GI tract |
Esophagus |
- Squamous cell carcinoma
- Adenocarcinoma
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Stomach |
- Gastric carcinoma
- Signet ring cell carcinoma
- Gastric lymphoma
- Linitis plastica
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Lower GI tract |
Small intestine |
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Appendix |
- Carcinoid
- Pseudomyxoma peritonei
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Colon/rectum |
- colorectal polyp: Peutz–Jeghers syndrome
- Juvenile polyposis syndrome
- Familial adenomatous polyposis/Gardner's syndrome
- Cronkhite–Canada syndrome
- neoplasm: Adenocarcinoma
- Familial adenomatous polyposis
- Hereditary nonpolyposis colorectal cancer
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Anus |
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Upper and/or lower |
- Gastrointestinal stromal tumor
- Krukenberg tumor (metastatic)
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Accessory |
Liver |
- malignant: Hepatocellular carcinoma
- Hepatoblastoma
- benign: Hepatocellular adenoma
- Cavernous hemangioma
- hyperplasia: Focal nodular hyperplasia
- Nodular regenerative hyperplasia
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Biliary tract |
- bile duct: Cholangiocarcinoma
- Klatskin tumor
- gallbladder: Gallbladder cancer
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Pancreas |
- exocrine pancreas: Adenocarcinoma
- Pancreatic ductal carcinoma
- cystic neoplasms: Serous microcystic adenoma
- Intraductal papillary mucinous neoplasm
- Mucinous cystic neoplasm
- Solid pseudopapillary neoplasm
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Peritoneum |
- Primary peritoneal carcinoma
- Peritoneal mesothelioma
- Desmoplastic small round cell tumor
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anat (t, g, p)/phys/devp/enzy
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noco/cong/tumr, sysi/epon
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proc, drug (A2A/2B/3/4/5/6/7/14/16), blte
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UpToDate Contents
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English Journal
- Focal nodular hyperplasia and hepatic regenerating nodules in pediatric oncology patients: how much invasive approach is necessary?
- De Pasquale MD, Monti L, D'Andrea ML.SourceDepartment of Pediatric Hematology-Oncology, IRCCS, Ospedale Bambino Gesù, Rome, Italy.
- Annals of hepatology.Ann Hepatol.2013 Mar;12(2):308-14.
- Introduction. Hepatic regenerating nodules (HRN) and focal nodular hyperplasia (FNH) are benign regenerating lesions of the liver that rarely occur in children. An increased incidence of these lesions is reported in children treated for cancer. Material and methods. Eight children who developed FNH
- PMID 23396743
- Quantitative analysis of contrast-enhanced ultrasonography: differentiating focal nodular hyperplasia from hepatocellular carcinoma.
- Pei XQ, Liu LZ, Xiong YH, Zou RH, Chen MS, Li AH, Cai MY.SourceDepartment of Ultrasound, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China.
- The British journal of radiology.Br J Radiol.2013 Mar;86(1023):20120536. doi: 10.1259/bjr.20120536. Epub 2013 Feb 7.
- Objective: To explore the potential of quantitative analysis of contrast-enhanced ultrasonography (CEUS) in differentiating focal nodular hyperplasia (FNH) from hepatocellular carcinoma (HCC). Methods: 34 cases of FNH and 66 cases of HCC (all lesions <5 cm) were studied using CEUS to evaluate
- PMID 23392189
- Hepatic angiomyolipoma: clinical, imaging and pathological features in 178 cases.
- Yang X, Li A, Wu M.SourceDivision of Special Treatment II, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, China. ehbh_yangxy@163.com
- Medical oncology (Northwood, London, England).Med Oncol.2013 Mar;30(1):416. doi: 10.1007/s12032-012-0416-4. Epub 2013 Jan 6.
- The aim of the study was to review the main clinical, imaging and pathological features of hepatic angiomyolipoma (HAML). We retrospectively analyzed the imaging, pathological and clinical features of 178 patients who underwent surgical resection for HAML. Forty-three males and 135 females with a me
- PMID 23292871
Japanese Journal
- Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis
- Maylee Hsu,Harada Kenichi,Igarashi Saya,Tohda Gen,Yamamoto Makoto,Ren Xiang shan,Osawa Takeshi,Hasegawa Yasuhiro,Takahashi Norio,Nakanuma Yasuni
- Hepatology Research 42(6), 611-618, 2012-06
- … A type of HCA, inflammatory HCA, is also known as telangiectatic HCA and was previously referred to as telangiectatic focal nodular hyperplasia. …
- NAID 120004161541
- アルコール性肝疾患を背景にしたfocal nodular hyperplasia-like noduleの一例
Related Links
- Focal nodular hyperplasia (FNH) is a benign tumour of the liver (hepatic tumour), which is the second most prevalent tumour of the liver (the first is hepatic hemangioma). It is usually asymptomatic, rarely grows or bleeds, and has no malignant ...
- 20 Apr 2011 ... Imaging in Focal Nodular Hyperplasia. Focal nodular hyperplasia (FNH) is the second most common tumor of the liver, surpassed in prevalence only by hepatic hemangioma.
Related Pictures
★リンクテーブル★
[★]
- 英
- liver tumor, hepatic tumor, hepatic neoplasm, liver neoplasm, tumor of the liver
- 関
- 肝癌、肝臓癌
分類
- SRA.472
-
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肝細胞癌の鑑別疾患となる良性腫瘍
- SSUR.594
検査
- 超音波エコー:(肝細胞癌)線維性被膜を有する境界明瞭な腫瘤でモザイクパターンを呈する。(転移性肝癌)低エコーの結節病変の中心に高エコーを有するbull's eye signを認める。
参考
- 1. Fat-containing lesions of the liver: radiologic-pathologic correlation.
- Prasad SR, Wang H, Rosas H, Menias CO, Narra VR, Middleton WD, Heiken JP.SourceDepartment of Radiology, University of Texas Health Science Center at San Antonio, USA.
- Radiographics : a review publication of the Radiological Society of North America, Inc.Radiographics.2005 Mar-Apr;25(2):321-31.
- Fat-containing tumors of the liver are a heterogeneous group of tumors with characteristic histologic features, variable biologic profiles, and variable imaging findings. Benign liver lesions that contain fat include focal or geographic fatty change (steatosis), pseudolesions due to postoperative pa
- PMID 15798052
- 脂肪を含む肝腫瘍は画像検査で鑑別診断を狭めることが可能である。
[★]
- 英
- focal nodular hyperplasia, FNH
- 関
- 肝腫瘍
概念
病理
- 肝皮膜下に好発し、皮膜を有しない(参考3)
- 境界明瞭
- 病変内に網内系細胞を有する (SRA.466)
- 単発性(80-95%)(参考3)
- 腫瘤の辺縁へと向かって走る車軸上の血管像を有する
検査
- CTや造影超音波検査で「中心瘢痕」と呼ばれる像が認められる
- 単純CT:低濃度
- 造影CT:(動脈相)濃染
- 超音波エコー:ドップラーエコーで腫瘤中心から離れる血流が明らかとなる。
鑑別疾患
参考
- http://www.shiga-med.ac.jp/~hqradio/students/c-12.html
- 2. 症例報告 術前診断に苦慮した限局性結節性過形成の1 切除例 日消外会誌41(9):1692~1697,2008年
- http://journal.jsgs.or.jp/pdf/041091692.pdf
- http://www.ususus.sakura.ne.jp/062-001focalnodularhyperplasia0.html
- 4. [charged] Focal nodular hyperplasia - uptodate [1]
[★]
限局性結節性過形成 focal nodular hyperplasia
[★]
- 焦点の、焦点を通る
- (病変が)限局性の、局所の、病巣の、巣状の
- 関
- circumscribed、definite、focal point、focally、foci、focus、local、localized、locally、nidal、nidus、topical、topically
[★]
- 関
- nodal、nodosity、nodule、tophaceous、tubercular、varicose