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any skin disorder involving abnormal redness

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/25 06:52:31」(JST)

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Erythroderma (also known as "Exfoliative dermatitis," "Dermatitis exfoliativa," and "Red man syndrome") is an inflammatory skin disease with erythema and scaling that affects nearly the entire cutaneous surface.^[1]^:436^[2]^:215

In ICD-10, a distinction is made between "exfoliative dermatitis" at L26, and "erythroderma" at L53.9.

Causes

Erythroderma is generalized exfoliative dermatitis, which involves 90% or more of the patient's skin.^[3] The most common cause of erythroderma is exacerbation of an underlying skin disease, such as psoriasis, contact dermatitis, seborrheic dermatitis, lichen planus, pityriasis rubra pilaris or a drug reaction. Primary erythroderma is less frequent and is usually seen in cases of cutaneous T-cell lymphoma, in particular in Sézary's disease.^[4]

The most common causes of exfoliative dermatitis are best remembered by the mnemonic device ID-SCALP. ^[5] . The causes and their frequencies are as follows:

Idiopathic - 30%

Drug allergy - 28%

Seborrheic dermatitis - 2%

Contact dermatitis - 3%

Atopic dermatitis - 10%

Lymphoma and leukemia - 14%

Psoriasis - 8%

Differential diagnosis in patients with erythroderma may be difficult.^{[citation needed]}

Treatment

The treatment is dependent on the cause.^{[citation needed]} Topical steroids are the primary category of medications used to treat exfoliative dermatitis (ED). A sedative antihistamine may be a useful adjunct for pruritic patients, since it helps patients to sleep at night, thus limiting nocturnal scratching and excoriations. Antimicrobial agents often are used if an infection is suspected to be precipitating or complicating exfoliative dermatitis. Other drugs specifically indicated for management of underlying etiology of exfoliative dermatitis may be necessary.6

History

The classification of exfoliative dermatitis into Wilson-Brocq (chronic relapsing), Hebra or pityriasis rubra (progressive), and Savill (self-limited) types may have had historical value, but it currently lacks pathophysiologic or clinical utility.^[1]^:436

References

^ ^a ^b Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
^ [emedicine.medscape.com/article/1106906-overview Erythroderma (Generalized Exfoliative Dermatitis)]. August 24, 2009.
^ http://books.google.com/books?id=WgkZH4Hse6gC&pg=PA40&dq=erythroderma
^ http://emedicine.medscape.com/article/1106906-overview

UpToDate Contents

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1. 成人における紅皮症 erythroderma in adults
2. 新生児および乳児の紅皮症 neonatal and infantile erythroderma
3. 薬物による過敏症および好酸球増多症（DRESS） drug reaction with eosinophilia and systemic symptoms dress
4. 薬疹 drug eruptions
5. 好酸球の生物学および好酸球増多症の原因 eosinophil biology and causes of eosinophilia

English Journal

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Is cutaneous phenotype a prognostic marker for outcome? A review of clinicopathological features of 27 cases.

Walsh S, Diaz-Cano S, Higgins E, Morris-Jones R, Bashir S, Bernal W, Creamer D.SourceDepartments of Dermatology, Histopathology, King's College Hospital, Denmark Hill, London SE5 9RS Departments of Hepatology, King's College Hospital, Denmark Hill, London SE5 9RS.
The British journal of dermatology.Br J Dermatol.2012 Oct 3. doi: 10.1111/bjd.12081. [Epub ahead of print]
Introduction: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) describes a heterogenous group of severe adverse reactions to medications. The cutaneous phenotype has a number of guises, accompanied by a variety of systemic features including fever, haematological abnormalities and vi
PMID 23034060

Erythroderma: A Clinical and Prognostic Study.

Li J, Zheng HY.SourceDepartment of Dermatology and Venereology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Dermatology (Basel, Switzerland).Dermatology.2012 Oct 2. [Epub ahead of print]
Background: Erythroderma is a rare skin disorder and studies on its causes and prognosis are rare in the literature. Objectives: We reviewed the clinical, laboratory and biopsy materials of 260 patients diagnosed with erythroderma who were treated in our department over an 11-year period. Patients w
PMID 23037884

Japanese Journal

皮膚病性リンパ節症 (特集見逃されやすい頸部リンパ節腫脹の原因疾患)

血液内科 = Hematology 71(3), 357-362, 2015-09
NAID 40020613554

症例報告副腎皮質ステロイド外用薬により二次性副腎皮質機能低下症を示した乾癬性紅皮症の1例

臨床皮膚科 = Japanese journal of clinical dermatology 69(9), 648-653, 2015-08
NAID 40020546046

両側顎関節強直症を呈した乾癬性関節炎の1例

日本口腔外科学会雑誌 61(4), 237-240, 2015
NAID 130005102753

Related Pictures

★リンクテーブル★

リンク元	「紅皮症」「erythrodermic」
拡張検索	「nonbullous congenital ichthyosiform erythroderma」「Wilson-Brocq erythroderma primarium subacutum」「non-bullous congenital ichthyosiform erythroderma」

「紅皮症」

Erythroderma
	Classification and external resources
ICD-10	L26, L53.9
ICD-9	695.9
DiseasesDB	29735
MedlinePlus	001610
eMedicine	derm/142
MeSH	D003873

　　[★]

英: erythroderma
同: 剥脱性皮膚炎 exfoliative dermatitis

定義

(1)全身(体表の80%以上)の持続性の炎症性発赤(潮紅)し、健常部皮膚を殆ど残さず、(2)粃糠様・落葉状の落屑が持続する病態

原因

起こしやすい疾患 (2009 CBT QB2 p.116)

(%)は紅皮症に占める割合

湿疹続発性(約50%)	アトピー性皮膚炎、自家感作性皮膚炎など
各種疾患続発性	乾癬(数%)、毛孔性紅色粃糠疹、天疱瘡など
中毒性	薬疹(約10%)(ピラゾロン、INH、SMなど)、ウイルスなどの感染症、GVHD
落屑性	ビタミンB群欠乏症
腫瘍性	T細胞リンパ腫(Sezary症候群、菌状息肉腫)