サイクリン依存性キナーゼインヒビター

関: cyclin-dependent kinase inhibitor

WordNet

limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
limit the range or extent of; "Contact between the young was inhibited by strict social customs"
relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
contingent on something else (同)dependant, qualified
(of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
a substance that retards or stops an activity
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

PrepTutorEJDIC

〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
『頼っている』,依存している,従属している / 扶養される人(家族)
蛋白(たんばく)質
抑制する人(物) / 化学反応抑制剤

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/05 19:05:48」(JST)

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[Wiki en表示]

This article is about the cell cycle protein. For the medical therapy, see CDK inhibitor.

A cyclin-dependent kinase inhibitor protein is a protein which inhibits cyclin-dependent kinase. Several function as tumor suppressor genes. Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (called CDIs, CKIs or CDKIs). CDIs are involved in cell cycle arrest at the G₁ phase.

Examples

Protein	Gene	Interacts with
p16	CDKN2A	Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p15	CDKN2B	Cyclin-dependent kinase 4
p18	CDKN2C	Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p19	CDKN2D	Cyclin-dependent kinase 4, Cyclin-dependent kinase 6
p21 / WAF1	CDKN1A^[2]	Cyclin E1/Cyclin-dependent kinase 2
p27	CDKN1B	Cyclin D3/Cyclin-dependent kinase 4, Cyclin E1/Cyclin-dependent kinase 2
p57	CDKN1C	Cyclin E1/Cyclin-dependent kinase 2
	CDKN3	Cyclin-dependent kinase 2

References

^ Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature 382 (6589): 325–31. doi:10.1038/382325a0. PMID 8684460.
^ Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene 18 (3): 813–22. doi:10.1038/sj.onc.1202367. PMID 9989833.

External links

Cyclin-Dependent+Kinase+Inhibitor+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

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UpToDate Contents

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1. 黒色腫（メラノーマ）に対する遺伝的感受性 inherited susceptibility to melanoma
2. マントル細胞リンパ腫の病理学 pathobiology of mantle cell lymphoma
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5. 悪性神経膠腫の病因と生物学 pathogenesis and biology of malignant gliomas

English Journal

Overexpression of Zinc-Finger Protein 777 (ZNF777) Inhibits Proliferation at Low Cell Density Through Down-Regulation of FAM129A.

Yuki R1, Aoyama K, Kubota S, Yamaguchi N, Kubota S, Hasegawa H, Morii M, Huang X, Liu K, Williams R, Fukuda MN, Yamaguchi N.
Journal of cellular biochemistry.J Cell Biochem.2015 Jun;116(6):954-68. doi: 10.1002/jcb.25046.
Krüppel-associated box-containing zinc finger proteins (KRAB-ZFPs) regulate a wide range of cellular processes. KRAB-ZFPs have a KRAB domain, which binds to transcriptional corepressors, and a zinc finger domain, which binds to DNA to activate or repress gene transcription. Here, we characterize ZN
PMID 25560148

NGF promotes mouse granulosa cell proliferation by inhibiting ESR2 mediated down-regulation of CDKN1A.

Wang Y1, Liu W2, Du J3, Yu Y4, Liang N1, Liang M1, Yao G1, Cui S5, Huang H6, Sun F7.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 May 5;406:68-77. doi: 10.1016/j.mce.2015.02.024. Epub 2015 Feb 28.
Nerve growth factor (NGF) is known to play key roles in ovarian follicular development, such as the assembly of early follicles and follicular ovulation through its high-affinity receptor, tyrosine kinase receptor A (trkA). Herein, the molecular mechanism controlling NGF-induced granulosa cell (GC)
PMID 25737208

Activation of β2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells.

Wnorowski A1, Sadowska M2, Paul RK3, Singh NS4, Boguszewska-Czubara A5, Jimenez L6, Abdelmohsen K7, Toll L8, Jozwiak K9, Bernier M10, Wainer IW11.
Cellular signalling.Cell Signal.2015 May;27(5):997-1007. doi: 10.1016/j.cellsig.2015.02.012. Epub 2015 Feb 20.
(R,R')-4'-methoxy-1-naphthylfenoterol [(R,R')-MNF] is a highly-selective β2 adrenergic receptor (β2-AR) agonist. Incubation of a panel of human-derived melanoma cell lines with (R,R')-MNF resulted in a dose- and time-dependent inhibition of motility as assessed by in vitro wound healing and xCELLi
PMID 25703025

Japanese Journal

Berberine Inhibits Growth and Induces G1 Arrest and Apoptosis in Human Cholangiocarcinoma QBC939 Cells

He Wei,Wang Bin,Zhuang Yun [他],SHAO Dong,SUN Kewen,CHEN Jianping
Journal of pharmacological sciences 119(4), 341-348, 2012-08-20
… Here we report that in vitro treatment of human cholangiocarcinoma QBC939 cells with berberine, a naturally occurring isoquinoline alkaloid, decreased cell viability and induced cell death in a dose-dependent manner, which was associated with an increase in G1 arrest. … Our western blot analysis showed that berberine-induced G1 cell cycle arrest was mediated through the increased expression of cyclin-dependent kinase inhibitors (Cdki) proteins (Cip1/p21 and Kip1/p27); …
NAID 10031071516

濾胞性リンパ腫におけるユビキチンリガーゼSkp2の発現に関する免疫組織化学的検討

石原里美,本間まゆみ,佐々木陽介 [他],塩沢英輔,野呂瀬朋子,矢持淑子,瀧本雅文
昭和医学会雑誌 72(5), 567-573, 2012
… や再発率に差が出ることが示されている．細胞周期の進行は，ユビキチン–プロテアソーム経路による厳密なタンパク質分解により調節されており，ユビキチンリガーゼの一種であるS-phase kinase-associated protein 2（Skp2）の過剰発現は細胞周期回転を促進し，腫瘍の発生や増殖速度と関連があるとされている．今回われわれは，FLにおける細胞周期関連タンパク質の発現およびGradeとの関連を免疫組織化 …
NAID 130003378219

p21 and Notch Signalings in the Persistently Altered Vagina Induced by Neonatal Diethylstilbestrol Exposure in Mice

NAKAMURA Takeshi,MIYAGAWA Shinichi,KATSU Yoshinao [他],MIZUTANI Takeshi,SATO Tomomi,TAKEUCHI Takashi,IGUCHI Taisen,OHTA Yasuhiko
Journal of Veterinary Medical Science 74(12), 1589-1595, 2012
… The cell cycle-related gene, p21, a cyclin-dependent kinase inhibitor, showed upregulation in the vagina, and p21 protein was localized in the basal layer of the vaginal epithelium in mice exposed neonatally to DES and an estrogen receptor α agonist, propyl pyrazole triol (PPT). …
NAID 130001879705

「cyclin-dependent kinase inhibitor」

Cyclin-dependent kinase inhibitor
	Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Identifiers
Symbol	CDI
Pfam	PF02234
InterPro	IPR003175
SCOP	1jsu
SUPERFAMILY	1jsu
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

　　[★]

サイクリン依存性キナーゼ阻害因子、サイクリン依存性キナーゼインヒビター、サイクリン依存性キナーゼ阻害分子、CDKインヒビター、CDK阻害因子

関: CDKI、CKI、cyclin-dependent kinase inhibitor protein

「サイクリン依存性キナーゼインヒビター」

　　[★]

英: cyclin-dependent kinase inhibitor、cyclin-dependent kinase inhibitor protein
関: サイクリン依存性キナーゼ阻害因子、サイクリン依存性キナーゼ阻害分子、CDKインヒビター、CDK阻害因子

「inhibit」

　　[★]

v.

抑制する、阻害する、阻止する

関: abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression

「inhibitor」

　　[★]

n.

阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関: blocker、depressant、suppressant

「dependent」

　　[★]

adj.

依存性の、依存的な、依存型の、依存の

関: depend、dependence、dependency、dependently

「kinase」

　　[★] キナーゼカイネースリン酸化酵素 phosphoenzyme phosphotransferase 　

「dependent kinase」

　　[★]

依存性キナーゼ、依存性リン酸化酵素

[pmid8684460-1] Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature 382 (6589): 325–31. doi:10.1038/382325a0. PMID 8684460.

[pmid9989833-2] Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene 18 (3): 813–22. doi:10.1038/sj.onc.1202367. PMID 9989833.

リンク元	「cyclin-dependent kinase inhibitor」「サイクリン依存性キナーゼインヒビター」
関連記事	「inhibit」「inhibitor」「dependent」「kinase」「dependent kinase」

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案内

cyclin-dependent kinase inhibitor protein