- 関
- CKI、cyclin-dependent kinase inhibitor
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/06 04:11:49」(JST)
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| Cyclin-dependent kinase inhibitor |
|
Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.[1]
|
| Identifiers |
| Symbol |
CDI |
| Pfam |
PF02234 |
| InterPro |
IPR003175 |
| SCOP |
1jsu |
| SUPERFAMILY |
1jsu |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe; PDBj |
| PDBsum |
structure summary |
|
This article is about the cell cycle protein. For the medical therapy, see CDK inhibitor.
A cyclin-dependent kinase inhibitor protein is a protein which inhibits cyclin-dependent kinase. Several function as tumor suppressor genes. Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (called CDIs, CKIs or CDKIs). CDIs are involved in cell cycle arrest at the G1 phase.
Examples
| Protein |
Gene |
Interacts with |
| p16 |
CDKN2A |
Cyclin-dependent kinase 4, Cyclin-dependent kinase 6 |
| p15 |
CDKN2B |
Cyclin-dependent kinase 4 |
| p18 |
CDKN2C |
Cyclin-dependent kinase 4, Cyclin-dependent kinase 6 |
| p19 |
CDKN2D |
Cyclin-dependent kinase 4, Cyclin-dependent kinase 6 |
| p21 / WAF1 |
CDKN1A[2] |
Cyclin E1/Cyclin-dependent kinase 2 |
| p27 |
CDKN1B |
Cyclin D3/Cyclin-dependent kinase 4, Cyclin E1/Cyclin-dependent kinase 2 |
| p57 |
CDKN1C |
Cyclin E1/Cyclin-dependent kinase 2 |
|
CDKN3 |
Cyclin-dependent kinase 2 |
References
- ^ Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature 382 (6589): 325–31. doi:10.1038/382325a0. PMID 8684460.
- ^ Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene 18 (3): 813–22. doi:10.1038/sj.onc.1202367. PMID 9989833.
External links
- Cyclin-Dependent Kinase Inhibitor Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Cell cycle proteins
|
|
| Cyclin |
- A (A1, A2)
- B (B1, B2, B3)
- D (D1, D2, D3)
- E (E1, E2)
|
|
| CDK |
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- CDK-activating kinase
|
|
| CDK inhibitor |
- INK4a/ARF (p14arf/p16, p15, p18, p19)
- cip/kip (p21, p27, p57)
|
|
| P53 p63 p73 family |
|
|
| Other |
- Cdc2
- Cdc25
- Cdc42
- Cellular apoptosis susceptibility protein
- E2F
- Maturation promoting factor
- Wee
- Cullin (CUL7)
|
|
Phases and
checkpoints |
| Interphase |
- G1 phase
- S phase
- G2 phase
|
|
| M phase |
- Mitosis (Preprophase
- Prophase
- Prometaphase
- Metaphase
- Anaphase
- Telophase)
- Cytokinesis
|
|
| Cell cycle checkpoints |
- Restriction point
- Spindle checkpoint
- Postreplication checkpoint
|
|
| Other cellular phases |
- Apoptosis
- G0 phase
- Meiosis
|
|
|
|
Index of genetics
|
|
| Description |
- Gene expression
- DNA
- replication
- cycle
- recombination
- repair
- binding proteins
- Transcription
- factors
- regulators
- nucleic acids
- RNA
- RNA binding proteins
- ribonucleoproteins
- repeated sequence
- modification
- Translation
- ribosome
- modification
- nexins
- Proteins
- domains
- Structure
- primary
- secondary
- tertiary
- quaternary
|
|
| Disease |
- Replication and repair
- Transcription factor
- Transcription
- Translation
|
|
|
UpToDate Contents
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English Journal
- Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents.
- Montanaro G, Bertinaria M, Rolando B, Fruttero R, Lucas CD, Dorward DA, Rossi AG, Megson IL, Gasco A.SourceDipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via P. Giuria 9, 10125 Torino, Italy.
- Bioorganic & medicinal chemistry.Bioorg Med Chem.2013 Apr 1;21(7):2107-16. doi: 10.1016/j.bmc.2013.01.009. Epub 2013 Jan 16.
- Neutrophils play a pivotal role in the pathophysiology of multiple human inflammatory diseases. Novel pharmacological strategies which drive neutrophils to undergo programmed cell death (apoptosis) have been shown to facilitate the resolution of inflammation. Both the cyclin-dependent kinase inhibit
- PMID 23394865
- Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo.
- Lee J, Hoi CS, Lilja KC, White BS, Lee SE, Shalloway D, Tumbar T.SourceDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Mar 19;110(12):4634-9. doi: 10.1073/pnas.1213015110. Epub 2013 Mar 4.
- Mechanisms of tissue stem cell (SC) quiescence control are important for normal homeostasis and for preventing cancer. Cyclin-dependent kinase inhibitors (CDKis) are known inhibitors of cell cycle progression. We document CDKis expression in vivo during hair follicle stem cell (HFSC) homeostasis and
- PMID 23487742
Japanese Journal
- Genetic regulation of proliferation/differentiation characteristics of neural progenitor cells in the developing neocortex
- MITSUHASHI Takayuki,TAKAHASHI Takao
- Brain & development 31(7), 553-557, 2009-08-01
- NAID 10025580725
- p16 and p27 are functionally correlated during the progress of hepatocarcinogenesis
- MATSUDA Yasunobu,ICHIDA Takafumi
- Medical molecular morphology : official journal of the Japanese Society for Clinical Molecular Morphology 39(4), 169-175, 2006-12-01
- NAID 10018659153
- Effects of cis-9, trans-11-Conjugated Linoleic Acid on Cancer Cell Cycle
- LIU Jia Ren,CHEN Bing Qing,YANG Yan Mei,HAN Xiao Hui,XUE Ying Ben,WANG Xuan Ling,ZHENG Yu Mei,LIU Rui Hai
- Environmental health and preventive medicine 7(5), 205-210, 2002-11
- … and p21^<cip/waf1>, cyclin-dependent kinases inhibitors (CDKI), were increased. … Conclusions : The cell growth and proliferation of MCF-7 cells is inhibited by c9, t11-CLA by blocking the cell cycle, which reduces expressions of cyclin A, B_1, D_1 and enhances expressions of CDKI (p16^<ink4a> …
- NAID 110004086069
Related Links
- CDキー（プロダクトキー）の確認方法について 1.ユーザー登録が完了している製品の場合 オンライン登録を済ませている製品のCDキーは、メンバーサイトで確認できます。メンバーサイトにログイン後、[登録済み CyberLink 製品 ...
- デジタル大辞泉 CDキーの用語解説 - 《 CD key 》⇒シリアルナンバー ... この辞書の凡例を見る 監修：松村明 編集委員：池上秋彦、金田弘、杉崎一雄、鈴木丹士郎、中嶋尚、林巨樹、飛田良文
★リンクテーブル★
[★]
サイクリン依存性キナーゼ阻害因子、サイクリン依存性キナーゼインヒビター、サイクリン依存性キナーゼ阻害分子、CDKインヒビター、CDK阻害因子
- 関
- CDKI、CKI、cyclin-dependent kinase inhibitor protein
[★]
- 英
- cyclin-dependent kinase inhibitor、CKI、CDKI
- 関
- サイクリン依存性キナーゼインヒビター、サイクリン依存性キナーゼ阻害分子、CDKインヒビター、CDK阻害因子
[★]
- 関
- CDKI、cyclin-dependent kinase inhibitor
[★]
[★]
サイクリン依存性キナーゼ阻害因子 cyclin-dependent kinase inhibitors
[★]
サイクリン依存性キナーゼ cyclin-dependent protein kinase