WordNet
- a substance for packing a joint or coating a porous surface to make it impervious to gas or liquid (同)luting
- chordophone consisting of a plucked instrument having a pear-shaped body, a usually bent neck, and a fretted fingerboard
- a collection of writings; "he edited the Hemingway corpus"
- the main part of an organ or other bodily structure
- the secretion of an endocrine gland that is transmitted by the blood to the tissue on which it has a specific effect (同)endocrine, internal_secretion
PrepTutorEJDIC
- リュート(17世紀ごろまで用いられたギターに似た弦楽器)
- 封泥(ふうでい)(破れ目や穴をふさぐもの) / …‘を'封泥でふさぐ
- (特定の事に関する,または特殊の性質の)文書資料の集成 / (研究用に収集した)資料
- ホルモン
UpToDate Contents
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- 1. 正常月経周期の生理学 physiology of the normal menstrual cycle
- 2. 正常月経周期の超音波評価 ultrasound evaluation of the normal menstrual cycle
- 3. 分娩の生理学 physiology of parturition
- 4. 性腺刺激ホルモン（ゴナドトロピン）放出ホルモンの生理学 physiology of gonadotropin releasing hormone
- 5. 卵巣過剰刺激症候群の予防 prevention of ovarian hyperstimulation syndrome
English Journal
- Low-dose gold nanoparticles exert subtle endocrine-modulating effects on the ovarian steroidogenic pathway ex vivo independent of oxidative stress.
- Larson JK1, Carvan MJ 3rd, Teeguarden JG, Watanabe G, Taya K, Krystofiak E, Hutz RJ.Author information 1University of Wisconsin-Milwaukee, Biological Sciences , Milwaukee, WI , USA.AbstractGold nanoparticles (GNPs) have gained considerable attention for application in science and industry. However, the untoward effects of such particles on female fertility remain unclear. The objectives of this study were to (1) examine the effects of 10-nm GNPs on progesterone and estradiol-17β accumulation by rat ovaries ex vivo and (2) to identify the locus/loci whereby GNPs modulate steroidogenesis via multiple-reference gene quantitative real-time RT-PCR. Regression analyses indicated a positive relationship between both Star (p < 0.05, r(2) = 0.278) and Cyp11a1 (p < 0.001, r(2) = 0.366) expression and P4 accumulation upon exposure to 1.43 × 10(6) GNPs/mL. Additional analyses showed that E2 accumulation was positively associated with Hsd3b1 (p < 0.05, r(2) = 0.181) and Cyp17a1 (p < 0.01, r(2) = 0.301) expression upon exposure to 1.43 × 1(3) and 1.43 × 10(9) GNPs/mL, respectively. These results suggest a subtle treatment-dependent impact of low-dose GNPs on the relationship between progesterone or estradiol-17β and specific steroidogenic target genes, independent of oxidative stress or inhibin.
- Nanotoxicology.Nanotoxicology.2014 Dec;8(8):856-66. doi: 10.3109/17435390.2013.837208.
- Gold nanoparticles (GNPs) have gained considerable attention for application in science and industry. However, the untoward effects of such particles on female fertility remain unclear. The objectives of this study were to (1) examine the effects of 10-nm GNPs on progesterone and estradiol-17β accu
- PMID 23992423
- Dissolution properties, solid-state transformation and polymorphic crystallization: progesterone case study.
- Araya-Sibaja AM1, Paulino AS, Rauber GS, Campos CE, Cardoso SG, Monti GA, Heredia V, Bianco I, Beltrano D, Cuffini SL.Author information 1Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina , Florianópolis , Brasil .AbstractProgesterone is a natural steroid hormone and a poor soluble drug which presents two polymorphs (forms 1 and 2). Different methods to obtain form 2 were tested and a complete solid-state characterization of both polymorphs (forms 1 and 2) was conducted. X-ray powder diffraction, hot stage microscopy, Fourier transform infrared, dispersive Raman, (13)C solid-state nuclear magnetic resonance spectroscopy, thermal analysis, scanning electron microscopy techniques and intrinsic dissolution rates (IDR) were applied to investigate physical-chemical and dissolution properties of these two polymorphs. Form 2 was obtained from diluted solutions and from melting after cooling at room temperature. Form 1 was obtained from concentrated solutions and, a mixture of both polymorphs was crystallized from intermediate solutions. The crystal habit was not a distinctive characteristic of each polymorph. The effect of mechanical stress was evaluated in the metastable polymorph (form 2). We observed that grinding form 2 produced seeds of form 1 that induced the transformation of form 2 into form 1 at high temperature. The polymorphic quantification from XRD patterns of ground samples were carried out by the Rietveld method. After grinding and at room temperature conditions (∼25 °C), it was observed the transformation of 17% of form 2 into form 1 in 10 days.
- Pharmaceutical development and technology.Pharm Dev Technol.2014 Nov;19(7):779-88. doi: 10.3109/10837450.2013.829096. Epub 2013 Sep 13.
- Progesterone is a natural steroid hormone and a poor soluble drug which presents two polymorphs (forms 1 and 2). Different methods to obtain form 2 were tested and a complete solid-state characterization of both polymorphs (forms 1 and 2) was conducted. X-ray powder diffraction, hot stage microscopy
- PMID 24032356
- 1,3-Dichloro-2-propanol inhibits progesterone production through the expression of steroidogenic enzymes and cAMP concentration in Leydig cells.
- Sun J1, Bai S2, Bai W3, Zou F2, Zhang L2, Li G2, Hu Y2, Li M2, Yan R2, Su Z4, Huang Y2.Author information 1Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China; Department of Food Science and Engineering, Department of Developmental and Regenerative Biology, Biopharmaceutical R&D Center, Jinan University, Guangzhou 510632, China.2Department of Food Science and Engineering, Department of Developmental and Regenerative Biology, Biopharmaceutical R&D Center, Jinan University, Guangzhou 510632, China.3Department of Food Science and Engineering, Department of Developmental and Regenerative Biology, Biopharmaceutical R&D Center, Jinan University, Guangzhou 510632, China. Electronic address: baiweibin@163.com.4Department of Food Science and Engineering, Department of Developmental and Regenerative Biology, Biopharmaceutical R&D Center, Jinan University, Guangzhou 510632, China. Electronic address: su_zhijian@126.com.Abstract1,3-Dichloro-2-propanol (1,3-DCP) is a well-known food processing contaminant that has been shown to impede male reproductive function. However, its mechanism of action remains elusive. In this study, the effects of 1,3-DCP on progesterone production were investigated using the R2C Leydig cell model. 1,3-DCP significantly reduced cell viability from 7.48% to 97.4% at doses comprised between 0.5 and 6mM. Single cell gel/comet assays and atomic force microscopy assays showed that 1,3-DCP induced early phase cell apoptosis. In addition, 1,3-DCP significantly reduced progesterone production detected by radioimmunoassay (RIA). The results from quantitative polymerase chain reaction and western blotting demonstrated that the mRNA expression levels of steroidogenic acute regulatory protein (StAR), cytochrome P450 side-chain cleavage enzyme and 3β-hydroxysteroid dehydrogenase were significantly down-regulated in R2C cells. Particularly, the change rhythm of Star expression was highly consistent with progesterone production. Furthermore, the cyclic adenosine monophosphate (cAMP) and the mitochondrial membrane potential mediated by ROS, which are involved in regulating progesterone synthesis were also decreased in response to the 1,3-DCP treatment. Overall, the data presented here suggested that 1,3-DCP interferes with the male steroidogenic capacity mainly by down-regulating the level of cAMP and the key enzymes involved in the androgen synthesis pathway.
- Food chemistry.Food Chem.2014 Jul 1;154:330-6. doi: 10.1016/j.foodchem.2014.01.017. Epub 2014 Jan 14.
- 1,3-Dichloro-2-propanol (1,3-DCP) is a well-known food processing contaminant that has been shown to impede male reproductive function. However, its mechanism of action remains elusive. In this study, the effects of 1,3-DCP on progesterone production were investigated using the R2C Leydig cell model
- PMID 24518350
Japanese Journal
- Inhibitory Effect of Insulin-like Growth Factor-binding Protein-7 (IGFBP7) on In Vitro Angiogenesis of Vascular Endothelial Cells in the Rat Corpus Luteum
- TAMURA Kazuhiro,YOSHIE Mikihiro,HASHIMOTO Keisuke,TACHIKAWA Eiichi
- Journal of Reproduction and Development, 2014
- … Angiogenesis in the developing corpus luteum (CL) is a prerequisite for establishment and maintenance of an early pregnancy. … To explore the physiological significance of insulin-like growth factor-binding protein-7 (IGFBP7) in the developing CL, the effects of IGFBP7 on vascular endothelial growth factor (VEGFA)- and luteinizing hormone (LH)-induced in vitro tube formation were tested using isolated luteal microvascular endothelial cells (LECs). …
- NAID 130004687238
- Effects of Different Five-day Progesterone-based Fixed-time AI Protocols on Follicular/Luteal Dynamics and Fertility in Dairy Cows
- GARCIA-ISPIERTO Irina,LÓPEZ-GATIUS Fernando
- Journal of Reproduction and Development, 2014
- … The protocols consisted of a progesterone intravaginal device fitted for five days, along with the administration of different combinations of gonadotropin releasing hormone, equine chorionic gonadotropin and a single or double dose (24 h apart) of prostaglandin F2α. … Based on the odds ratio, the likelihood of ovulation failure was lower (by a factor of 0.1) in cows showing at least one corpus luteum (CL) upon treatment than in cows lacking a CL; …
- NAID 130004687236
- Relationships Between the Appearances and Changes of Estrous Signs and the Estradiol-17β Peak, Luteinizing Hormone Surge and Ovulation During the Periovulatory Period in Lactating Dairy Cows Kept in Tie-stalls
- SUMIYOSHI Toshiaki,TANAKA Tomomi,KAMOMAE Hideo
- Journal of Reproduction and Development 60(2), 106-114, 2014
- … Rectal examination, ultrasonography and blood sampling were conducted every other day and then daily after the day on which diameter of the corpus luteum decreased. … Most of the estrous signs became obvious with the increase in estradiol-17β (E2) and became most remarkable 24 to 30 hours before ovulation, at which point the E2 peak and luteinizing hormone (LH) surge were achieved, and then weakened which progression to ovulation. …
- NAID 130003390822
Related Links
- corpus luteum hormone n. See progesterone. hormone [hor´mōn] a chemical transmitter substance produced by cells of the body and transported by the bloodstream to the cells and organs on which it has a specific regulatory effect ...
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Related Pictures
★リンクテーブル★
| リンク元 | 「プロゲステロン」「lutropin」 |
| 関連記事 | 「corpus」 |
「プロゲステロン」
- 英
- progesterone (Z), P4
- 同
- 黄体ホルモン corpus luteum hormone、プロジェステロン
- 商
- プロゲホルモン ルテウム プロゲストン, Crinone, Prochieve, Progestasert
- 関
- エストロゲン、月経周期、ホルモン
分類
性状
産生組織
- G10M.37
標的組織
生理作用
| エストロゲン | プロゲステロン | |
| 子宮内膜 | 増殖期：増殖 分泌期：プロゲステロンと協調して分泌期維持 |
分泌期：分泌期誘導 |
| 卵巣 | 卵胞の成長 顆粒細胞に作用してエストロゲン受容体発現↑ →エストロゲンの正のフィードバック →エストロゲンの大量分泌 |
|
| 子宮筋 | オキシトシンに対する感受性↓ 肥大増殖 |
オキシトシンに対する感受性↑ |
| 中枢神経への作用 | 視床下部、下垂体 少量→負のフィードバック 多量→正のフィードバック |
視床下部体温中枢 刺激 |
| その他 | ・子宮頚管粘液 量：↑、牽引性：↑、羊歯葉状結晶：↑ ・膣スメアの変化 成熟した表層細胞の出現 角化、核濃縮、好酸性 |
・乳腺 腺房発育 |
- 子宮内膜：プロスタグランジンの合成を制御(増殖期には低値、月経期には高値) → 月経前症候群・月経困難症との関連
- 妊娠中には下垂体前葉に作用してLHの分泌を抑制し、排卵を抑制する。(G10M.37)
- 乳腺組織のPRL受容体を減少させ、乳汁分泌を抑制する。(G10M.37)
作用機序
分泌調節
性周期・月経・妊娠との関連
非妊時
- 卵胞期：低値
- 排卵期～黄体期：高値
- 黄体期後期：漸減
妊娠時
- 妊娠時には0-10週にかけてなだらかに上昇してから下降するが、以降漸増する。(NGY.47)
- 妊娠時には10週までなだらかに増加し、以降増加。(G10M.37)
LAB.724
| エストロゲン | プロゲステロン | ||||
| エストロン | エストラジオール | エストリオール | |||
| (pg/ml) | (pg/ml) | (pg/ml) | (ng/ml) | ||
| 女性 | 卵胞期 | 10～60 | 10～150 | 0～20 | 0.5～1.5 |
| 排卵期 | 25～100 | 50～380 | 5～40 | 1.5～6.8 | |
| 黄体期 | 25～80 | 30～300 | 5～40 | 5.0～28.0 | |
| 更年期 | 20～80 | 10～50 | 0～20 | 0.3～0.4 | |
| 男性 | 30～60 | 10～60 | 0～15 | 0.2～0.4 | |
「lutropin」
「corpus」