- 関
- granulocyte colony-stimulating factor receptor
WordNet
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- a unit of force equal to the force exerted by gravity; used to indicate the force to which a body is subjected when it is accelerated (同)gee, g-force
- the 7th letter of the Roman alphabet (同)g
PrepTutorEJDIC
- carbonの化学記号
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/21 21:48:45」(JST)
[Wiki en表示]
| Colony stimulating factor 3 receptor (granulocyte) |
PDB rendering based on 2d9q. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1AZ7, 2D9Q
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| Identifiers |
| Symbols |
CSF3R ; CD114; GCSFR |
| External IDs |
OMIM: 138971 MGI: 1339755 HomoloGene: 601 ChEMBL: 1996 GeneCards: CSF3R Gene |
| Gene ontology |
| Molecular function |
• receptor activity
• cytokine receptor activity
• protein binding
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| Cellular component |
• extracellular region
• integral component of plasma membrane
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| Biological process |
• defense response
• cell adhesion
• signal transduction
• cytokine-mediated signaling pathway
• neutrophil chemotaxis
• odontogenesis of dentin-containing tooth
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
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| Entrez |
1441 |
12986 |
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| Ensembl |
ENSG00000119535 |
ENSMUSG00000028859 |
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| UniProt |
Q99062 |
P40223 |
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| RefSeq (mRNA) |
NM_000760 |
NM_001252651 |
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| RefSeq (protein) |
NP_000751 |
NP_001239580 |
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| Location (UCSC) |
Chr 1:
36.93 – 36.95 Mb |
Chr 4:
126.02 – 126.04 Mb |
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| PubMed search |
[1] |
[2] |
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The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene.[1] G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).[2] The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family.The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.
The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.
Contents
- 1 Isoforms
- 2 Clinical significance
- 3 Interactions
- 4 See also
- 5 References
- 6 Further reading
- 7 External links
Isoforms
The class IV isoform defective for both internalization and differentiation signaling.
Clinical significance
Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.[3]
Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.[4]
In clinical medicine, there is a suggestion that use of GCSF should be avoided, at least in children and adolescents and perhaps adults, when G-CSFR isoform IV is overexpressed.[5]
Interactions
Granulocyte colony-stimulating factor receptor has been shown to interact with Grb2,[6] HCK[7] and SHC1.[6]
See also
- Cluster of differentiation
References
- ^ Tweardy D, Anderson K, Cannizzaro L, Steinman R, Croce C, Huebner K (March 1992). "Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34". Blood 79 (5): 1148–54. PMID 1371413.
- ^ "Entrez Gene: CSF3R colony stimulating factor 3 receptor (granulocyte)".
- ^ Zeidler C, Welte K (April 2002). "Kostmann syndrome and severe congenital neutropenia". Semin. Hematol. 39 (2): 82–8. doi:10.1053/shem.2002.31913. PMID 11957189.
- ^ Beekman R, Touw I (June 2010). "G-CSF and its receptor in myeloid malignancy". Blood 115 (25): 5131–6. doi:10.1182/blood-2010-01-234120. PMID 20237318.
- ^ Ehlers S, Herbst C, Zimmermann M, Scharn N, Germeshausen M, von Neuhoff N et al. (May 2010). "Granulocyte colony-stimulating factor (G-CSF) treatment of childhood acute myeloid leukemias that overexpress the differentiation-defective G-CSF receptor isoform IV is associated with a higher incidence of relapse". J. Clin. Oncol. 28 (15): 2591–7. doi:10.1200/JCO.2009.25.9010. PMID 20406937.
- ^ a b Ward A, Monkhouse J, Hamilton J, Csar X (November 1998). "Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor". Biochim. Biophys. Acta 1448 (1): 70–6. doi:10.1016/S0167-4889(98)00120-7. PMID 9824671.
- ^ Ward A, Monkhouse J, Csar X, Touw I, Bello P (October 1998). "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor". Biochem. Biophys. Res. Commun. 251 (1): 117–23. doi:10.1006/bbrc.1998.9441. PMID 9790917.
Further reading
- Tsuji K, Ebihara Y (2002). "Expression of G-CSF receptor on myeloid progenitors.". Leuk. Lymphoma 42 (6): 1351–7. doi:10.3109/10428190109097763. PMID 11911419.
- Kimura A, Sultana T (2005). "Granulocyte colony-stimulating factor receptors on CD34++ cells in patients with myelodysplastic syndrome (MDS) and MDS-acute myeloid leukemia.". Leuk. Lymphoma 45 (10): 1995–2000. doi:10.1080/10428190410001714034. PMID 15370243.
- Tweardy D, Anderson K, Cannizzaro L, Steinman R, Croce C, Huebner K (1992). "Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34.". Blood 79 (5): 1148–54. PMID 1371413.
- Seto Y, Fukunaga R, Nagata S (1992). "Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor.". J. Immunol. 148 (1): 259–66. PMID 1530796.
- Fukunaga R, Seto Y, Mizushima S, Nagata S (1991). "Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.". Proc. Natl. Acad. Sci. U.S.A. 87 (22): 8702–6. doi:10.1073/pnas.87.22.8702. PMC 55027. PMID 1701053.
- Fukunaga R, Ishizaka-Ikeda E, Pan C, Seto Y, Nagata S (1991). "Functional domains of the granulocyte colony-stimulating factor receptor.". EMBO J. 10 (10): 2855–65. PMC 452996. PMID 1717255.
- Inazawa J, Fukunaga R, Seto Y, Nakagawa H, Misawa S, Abe T et al. (1991). "Assignment of the human granulocyte colony-stimulating factor receptor gene (CSF3R) to chromosome 1 at region p35-p34.3.". Genomics 10 (4): 1075–8. doi:10.1016/0888-7543(91)90202-P. PMID 1833306.
- Larsen A, Davis T, Curtis B, Gimpel S, Sims J, Cosman D et al. (1991). "Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.". J. Exp. Med. 172 (6): 1559–70. doi:10.1084/jem.172.6.1559. PMC 2188748. PMID 2147944.
- Uzumaki H, Okabe T, Sasaki N, Hagiwara K, Takaku F, Tobita M et al. (1990). "Identification and characterization of receptors for granulocyte colony-stimulating factor on human placenta and trophoblastic cells.". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9323–6. doi:10.1073/pnas.86.23.9323. PMC 298487. PMID 2480598.
- Nicholson S, Oates A, Harpur A, Ziemiecki A, Wilks A, Layton J (1994). "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 2985–8. doi:10.1073/pnas.91.8.2985. PMC 43499. PMID 7512720.
- Dong F, Hoefsloot L, Schelen A, Broeders C, Meijer Y, Veerman A et al. (1994). "Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia.". Proc. Natl. Acad. Sci. U.S.A. 91 (10): 4480–4. doi:10.1073/pnas.91.10.4480. PMC 43809. PMID 7514305.
- Dong F, Brynes R, Tidow N, Welte K, Löwenberg B, Touw I (1995). "Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia.". N. Engl. J. Med. 333 (8): 487–93. doi:10.1056/NEJM199508243330804. PMID 7542747.
- Shimoda K, Okamura S, Harada N, Kondo S, Okamura T, Niho Y (1993). "Identification of a functional receptor for granulocyte colony-stimulating factor on platelets.". J. Clin. Invest. 91 (4): 1310–3. doi:10.1172/JCI116330. PMC 288100. PMID 7682568.
- Zhao Y, Wagner F, Frank S, Kraft A (1995). "The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain.". J. Biol. Chem. 270 (23): 13814–8. doi:10.1074/jbc.270.23.13814. PMID 7775438.
- Corey S, Burkhardt A, Bolen J, Geahlen R, Tkatch L, Tweardy D (1994). "Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 4683–7. doi:10.1073/pnas.91.11.4683. PMC 43852. PMID 8197119.
- Haniu M, Horan T, Arakawa T, Le J, Katta V, Rohde M (1996). "Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region.". Arch. Biochem. Biophys. 324 (2): 344–56. doi:10.1006/abbi.1995.0047. PMID 8554326.
- Horan T, Wen J, Narhi L, Parker V, Garcia A, Arakawa T et al. (1996). "Dimerization of the extracellular domain of granuloycte-colony stimulating factor receptor by ligand binding: a monovalent ligand induces 2:2 complexes.". Biochemistry 35 (15): 4886–96. doi:10.1021/bi9525841. PMID 8664280.
- McCracken S, Layton J, Shorter S, Starkey P, Barlow D, Mardon H (1996). "Expression of granulocyte-colony stimulating factor and its receptor is regulated during the development of the human placenta.". J. Endocrinol. 149 (2): 249–58. doi:10.1677/joe.0.1490249. PMID 8708536.
- Haniu M, Horan T, Arakawa T, Le J, Katta V, Hara S et al. (1996). "Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor.". Biochemistry 35 (40): 13040–6. doi:10.1021/bi960213u. PMID 8855939.
- Bonaldo M, Lennon G, Soares M (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
External links
- CSF3R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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PDB gallery
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2d9q: Crystal Structure of the Human GCSF-Receptor Signaling Complex
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Cytokine receptors
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Chemokine receptor
(GPCRs) |
| CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
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| CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
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| Other |
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| TNF receptor |
| 1-10 |
- TNFRSF1 (CD120)
- TNFRSF1A (CD120a)
- TNFRSF1B (CD120b)
- TNFRSF3 (Lymphotoxin beta receptor)
- TNFRSF4 (CD134)
- TNFRSF5 (CD40)
- TNFRSF6 (FAS)
- TNFRSF6B
- TNFRSF7 (CD27)
- TNFRSF8 (CD30)
- TNFRSF9 (CD137)
|
|
| 11-20 |
- TNFRSF10A (CD261)
- TNFRSF10B (CD262)
- TNFRSF10C (CD263)
- TNFRSF10D (CD264)
- TNFRSF11A (CD265/RANK)
- TNFRSF11B (Osteoprotegerin)
- TNFRSF12A (CD266)
- TNFRSF13B (CD267)
- TNFRSF13C
- TNFRSF14 (CD268)
- TNFRSF16 (Nerve growth factor receptor)
- TNFRSF17 (CD269)
- TNFRSF18
- TNFRSF19
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| 21-25 |
- TNFRSF21
- TNFRSF25
- TNFRSF27
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| JAK-STAT |
| Type I |
| γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
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| β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
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| gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
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| IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
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| Other |
- hormone receptor: GH
- prolactin
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| Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
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| Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
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| IL 17 family |
- IL-17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
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| S/T |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- FACS binding assay for analysing GDNF interactions.
- Quintino L, Baudet A, Larsson J, Lundberg C.SourceCNS Gene Therapy, Department of Experimental Medical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
- Journal of neuroscience methods.J Neurosci Methods.2013 Aug 15;218(1):25-8. doi: 10.1016/j.jneumeth.2013.04.006. Epub 2013 May 10.
- Glial cell-line derived neurotrophic factor (GDNF) is a secreted protein with great therapeutic potential. However, in order to analyse the interactions between GDNF and its receptors, researchers have been mostly dependent of radioactive binding assays. We developed a FACS-based binding assay for G
- PMID 23669067
- Selective JAK/STAT3 signalling regulates transcription of colony stimulating factor-2 and -3 in Concanavalin-A-activated mesenchymal stromal cells.
- Zgheib A, Pelletier-Bonnier E, Levros LC Jr, Annabi B.SourceLaboratoire d'Oncologie Moléculaire, Centre de recherche BIOMED, Département de Chimie, Université du Québec à Montréal, Québec, Canada.
- Cytokine.Cytokine.2013 Aug;63(2):187-93. doi: 10.1016/j.cyto.2013.04.027. Epub 2013 May 17.
- Human bone marrow-derived mesenchymal stromal cells (MSCs) express Toll-like receptors (TLRs) and produce cytokines and chemokines, all of which contribute to these cells' immunomodulatory and proangiogenic properties. Among the secreted cytokines, colony-stimulating factors (CSFs) regulate angiogen
- PMID 23688618
- Endothelin receptor antagonists attenuate the inflammatory response of human pulmonary vascular smooth muscle cells to bacterial endotoxin.
- Knobloch J, Feldmann M, Wahl C, Jungck D, Behr J, Stoelben E, Koch A.SourceDepartment of Internal Medicine III for Pneumology, Allergology, Sleep and Respiratory Medicine, University Hospital Bergmannsheil, Bürkle-de-la-Camp-Platz 1, D-44789, Bochum; Germany. andrea.koch@bergmannsheil.de.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2013 Aug;346(2):290-9. doi: 10.1124/jpet.112.202358. Epub 2013 May 29.
- Bacterial infections induce exacerbations in chronic lung diseases, e.g., chronic obstructive pulmonary disease (COPD), by enhancing airway inflammation. Exacerbations are frequently associated with right heart decompensation and accelerate disease progression. Endothelin receptor antagonists (ERAs)
- PMID 23720457
Japanese Journal
- 造血幹細胞ニッチの神経系制御におけるビタミンD受容体の役割
- 第72回日本血液学会学術集会 学会奨励賞受賞論文 造血幹細胞ニッチの神経系制御におけるビタミンD受容体の役割
- EGFRシグナル伝達阻害によるG-CSF誘導性造血幹細胞動員の増強
Related Links
- The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. ... GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, ...
- Abstract. The mechanisms that regulate hematopoietic progenitor cell (HPC) mobilization from the bone marrow to blood have not yet been defined. HPC mobilization by granulocyte colony-stimulating factor (G-CSF), cyclophosphamide (CY), ...
★リンクテーブル★
[★]
- 英
- granulocyte colony-stimulating factor receptor、G-CSF receptor
- 関
- 顆粒球コロニー刺激因子レセプター、G-CSF受容体、G-CSFレセプター
[★]
- 英
- granulocyte colony-stimulating factor receptor、G-CSF receptor
- 関
- 顆粒球コロニー刺激因子受容体、G-CSF受容体、G-CSFレセプター
[★]
- 英
- G-CSF receptor
- 関
- 顆粒球コロニー刺激因子受容体、顆粒球コロニー刺激因子レセプター、G-CSFレセプター
[★]
- 英
- G-CSF receptor
- 関
- 顆粒球コロニー刺激因子受容体、顆粒球コロニー刺激因子レセプター、G-CSF受容体
[★]
- 関
- G-CSF receptor
[★]
[★]
[★]
[★]
[★]
- 関
- colony-stimulating factor receptor、CSFR