WordNet

a geographical area politically controlled by a distant country (同)dependency
a body of people who settle far from home but maintain ties with their homeland; inhabitants remain nationals of their home state but are not literally under the home states system of government; "the American colony in Paris" (同)settlement
(microbiology) a group of organisms grown from a single parent cell
a group of organisms of the same type living or growing together
a place where a group of people with the same interest or occupation are concentrated; "a nudist colony"; "an artists colony"
be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
the basic unit of money in Costa Rica; equal to 100 centimos (同)Costa Rican colon
the basic unit of money in El Salvador; equal to 100 centavos (同)El Salvadoran colon
a punctuation mark (:) used after a word introducing a series or an example or an explanation (or after the salutation of a business letter)
the part of the large intestine between the cecum and the rectum; it extracts moisture from food residues before they are excreted
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

『植民地』 / 植民団,居留民;(外国人の)集団居留地 / (同ど人種・宗教・職業などの人たちが住む)『集団』,部落 / (動物・鳥・虫などの)集団;(生物の)群体,群落《+『of』+『名』》 / 《the Colonies》アメリカ合衆国を形成した13州のイギリス植民地
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
コロン(:)(句読点の一種で,文中においてセミコロン以上を分離を示すほか,対照,例証,引用文などを示すのに用いる)
(大腸の)結腸[部]
=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/27 08:19:01」(JST)

wiki en

[Wiki en表示]

The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene.^[1] G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).^[2] The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family.The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.

The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.

IsoformsEdit

The class IV isoform defective for both internalization and differentiation signaling.

Clinical significanceEdit

Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.^[3]

Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.^[4]

In clinical medicine, there is a suggestion that use of GCSF should be avoided, at least in children and adolescents and perhaps adults, when G-CSFR isoform IV is overexpressed.^[5]

InteractionsEdit

Granulocyte colony-stimulating factor receptor has been shown to interact with Grb2,^[6] HCK^[7] and SHC1.^[6]

ReferencesEdit

^ Tweardy DJ, Anderson K, Cannizzaro LA, Steinman RA, Croce CM, Huebner K (March 1992). "Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34". Blood 79 (5): 1148–54. PMID 1371413.
^ "Entrez Gene: CSF3R colony stimulating factor 3 receptor (granulocyte)".
^ Zeidler C, Welte K (April 2002). "Kostmann syndrome and severe congenital neutropenia". Semin. Hematol. 39 (2): 82–8. doi:10.1053/shem.2002.31913. PMID 11957189.
^ Beekman R, Touw IP (June 2010). "G-CSF and its receptor in myeloid malignancy". Blood 115 (25): 5131–6. doi:10.1182/blood-2010-01-234120. PMID 20237318.
^ Ehlers S, Herbst C, Zimmermann M, Scharn N, Germeshausen M, von Neuhoff N, Zwaan CM, Reinhardt K, Hollink IH, Klusmann JH, Lehrnbecher T, Roettgers S, Stary J, Dworzak M, Welte K, Creutzig U, Reinhardt D (May 2010). "Granulocyte colony-stimulating factor (G-CSF) treatment of childhood acute myeloid leukemias that overexpress the differentiation-defective G-CSF receptor isoform IV is associated with a higher incidence of relapse". J. Clin. Oncol. 28 (15): 2591–7. doi:10.1200/JCO.2009.25.9010. PMID 20406937.
^ ^a ^b Ward AC, Monkhouse JL, Hamilton JA, Csar XF (November 1998). "Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor". Biochim. Biophys. Acta 1448 (1): 70–6. doi:10.1016/S0167-4889(98)00120-7. PMID 9824671.
^ Ward AC, Monkhouse JL, Csar XF, Touw IP, Bello PA (October 1998). "The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor". Biochem. Biophys. Res. Commun. 251 (1): 117–23. doi:10.1006/bbrc.1998.9441. PMID 9790917.

External linksEdit

CSF3R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 骨髄造血の制御 regulation of myelopoiesis
2. 複合免疫不全 combined immunodeficiencies
3. 化学療法による好中球減少症を有する成人患者と、急性白血病、骨髄異形成症候群、造血細胞移植以外の病態を有する成人患者における顆粒球コロニー刺激因子の利用 use of granulocyte colony stimulating factors in adult patients with chemotherapy induced neutropenia and conditions other than acute leukemia myelodysplastic syndrome and hematopoietic cell transplantation
4. 敗血症に対する治験剤および無効剤 investigational and ineffective therapies for sepsis
5. 小児における肺胞蛋白症 pulmonary alveolar proteinosis in children

English Journal

High-dosage granulocyte colony stimulating factor treatment alters monocyte trafficking to the brain after experimental stroke.

Weise G1, Pösel C2, Möller K2, Kranz A2, Didwischus N3, Boltze J4, Wagner DC5.
Brain, behavior, and immunity.Brain Behav Immun.2017 Feb;60:15-26. doi: 10.1016/j.bbi.2016.08.008. Epub 2016 Aug 11.
Ischemic stroke elicits a prompt inflammatory response that is characterized by a well-timed recruitment of peripheral immune cells to the brain. Among these, monocytes play a particularly important, but multifaceted role and have been increasingly recognized to affect stroke outcome. Granulocyte co
PMID 27524669

Frontline treatment of acute myeloid leukemia in adults.

Tamamyan G1, Kadia T2, Ravandi F2, Borthakur G2, Cortes J2, Jabbour E2, Daver N2, Ohanian M2, Kantarjian H2, Konopleva M2.
Critical reviews in oncology/hematology.Crit Rev Oncol Hematol.2017 Feb;110:20-34. doi: 10.1016/j.critrevonc.2016.12.004. Epub 2016 Dec 11.
Recent years have highlighted significant progress in understanding the underlying genetic and epigenetic signatures of acute myeloid leukemia(AML). Most importantly, novel chemotherapy and targeted strategies have led to improved outcomes in selected genetic subsets. AML is a remarkably heterogeneo
PMID 28109402

Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies.

Dwivedi P1, Greis KD2.
Experimental hematology.Exp Hematol.2017 Feb;46:9-20. doi: 10.1016/j.exphem.2016.10.008. Epub 2016 Oct 24.
Granulocyte colony-stimulating factor is a hematopoietic cytokine that stimulates neutrophil production and hematopoietic stem cell mobilization by initiating the dimerization of homodimeric granulocyte colony-stimulating factor receptor. Different mutations of CSF3R have been linked to a unique spe
PMID 27789332

Japanese Journal

HMGB1-TLR4シグナルによる骨髄由来免疫抑制細胞の機能制御

薬学雑誌 138(2), 143-148, 2018
NAID 130006328031

Moderate, but not low and high, level of insulin stimulates GMCSF and MIF expression in bovine oviduct epithelial cells

日本繁殖生物学会　講演要旨集 109(0), OR2-21-OR2-21, 2016
NAID 130007025012

Effect of <i>1.8-Cineole</i> in <i>Dermatophagoides pteronyssinus</i>-Stimulated Bronchial Epithelial Cells and Mouse Model of Asthma

Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 39(6), 946-952, 2016
NAID 130005155144

★リンクテーブル★

リンク元	「G-CSF receptor」「顆粒球コロニー刺激因子受容体」「顆粒球コロニー刺激因子レセプター」
関連記事	「fact」「factor」「stimulating」「colony」「colon」

「G-CSF receptor」

Colony stimulating factor 3 receptor (granulocyte)
	PDB rendering based on 2d9q.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1AZ7, 2D9Q
Identifiers
Symbols	CSF3R ; CD114; GCSFR
External IDs	OMIM: 138971 MGI: 1339755 HomoloGene: 601 ChEMBL: 1996 GeneCards: CSF3R Gene
Gene ontology
Molecular function	• receptor activity; • cytokine receptor activity; • protein binding;
Cellular component	• extracellular region; • integral component of plasma membrane;
Biological process	• defense response; • cell adhesion; • signal transduction; • cytokine-mediated signaling pathway; • neutrophil chemotaxis; • regulation of myeloid cell differentiation; • amelogenesis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;