- 関
- colony-stimulating factor receptor、CSFR
WordNet
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- carbonの化学記号
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/24 06:25:47」(JST)
[Wiki en表示]
Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.
Contents
- 1 Signal transduction chains
- 2 Examples
- 2.1 Interleukin receptors
- 2.2 Colony stimulating factor receptors
- 2.3 Hormone receptor/neuropeptide receptor
- 2.4 Other
- 3 References
- 4 External links
Signal transduction chains
The signal transducing chains are often shared between different receptors within this receptor family.[1]
- The IL-2 receptor common gamma chain (also known as CD132) is shared between:
- IL-2 receptor
- IL-4 receptor
- IL-7 receptor
- IL-9 receptor
- IL-13 receptor
- IL-15 receptor[2]
- The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors:
- GM-CSF receptor
- IL-3 receptor
- IL-5 receptor.[3]
- The gp130 receptor ([Glycoprotein 130]) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
- IL-6 receptor
- IL-11 receptor
- IL-12 receptor
- IL-27 receptor
- Leukemia inhibitory factor receptor
- Oncostatin M receptor
Examples
Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors
Interleukin receptors
- Interleukin-2 receptor
- Interleukin-3 receptor
- Interleukin-4 receptor
- Interleukin-5 receptor
- Interleukin-6 receptor
- Interleukin-7 receptor
- Interleukin-9 receptor
- Interleukin-11 receptor
- Interleukin-12 receptor
- Interleukin-13 receptor
- Interleukin-15 receptor
- Interleukin-21 receptor
- Interleukin-23 receptor
- Interleukin-27 receptor
Colony stimulating factor receptors
- Erythropoietin receptor
- GM-CSF receptor
- G-CSF receptor
Hormone receptor/neuropeptide receptor
- Growth hormone receptor
- Prolactin receptor
- Leptin receptor[4]
Other
- Oncostatin M receptor
- Leukemia inhibitory factor receptor
References
- ^ Lichtman, Andrew H.; Abbas, Abul K. (2003). Cellular and molecular immunology (5th ed.). Philadelphia: Saunders. ISBN 0-7216-0008-5.
- ^ He YW, Adkins B, Furse RK, Malek TR (1995). "Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor". J. Immunol. 154 (4): 1596–605. PMID 7530740.
- ^ Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF (1998). "Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors". J. Biol. Chem. 273 (2): 1192–9. doi:10.1074/jbc.273.2.1192. PMID 9422786.
- ^ Cirillo, Donatella; Rachiglio, Anna Maria; la Montagna, Raffaele; Giordano, Antonio; Normanno, Nicola (1 November 2008). "Leptin signaling in breast cancer: An overview". Journal of Cellular Biochemistry. 105 (4): 956–964. doi:10.1002/jcb.21911.
External links
- Cytokine Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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Cytokine receptors
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Chemokine receptor
(GPCRs) |
| CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
|
|
| CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
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| Other |
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|
|
| TNF receptor |
| 1-10 |
- TNFR1 (TNFRSF1A)
- TNFR2 (TNFRSF1B)
- LTBR (TNFRSF3)
- CD134 (TNFRSF4)
- CD40 (TNFRSF5)
- Fas receptor (TNFRSF6)
- DcR3 (TNFRSF6B)
- CD27 (TNFRSF7)
- CD30 (TNFRSF8)
- CD137 (TNFRSF9)
|
|
| 11-20 |
- DR4 (TNFRSF10A)
- DR5 (TNFRSF10B)
- DcR1 (TNFRSF10C)
- DcR2 (TNFRSF10D)
- RANK (TNFRSF11A)
- Osteoprotegerin (TNFRSF11B)
- TweakR (TNFRSF12A)
- TACI (TNFRSF13B)
- BAFFR (TNFRSF13C)
- HVEM (TNFRSF14)
- NGFR (TNFRSF16)
- BCMA (TNFRSF17)
- GITR (TNFRSF18)
- TAJ/TROY (TNFRSF19)
|
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| 21-27 |
- DR6 (TNFRSF21)
- DR3 (TNFRSF25)
- EDA2R (TNFRSF27)
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|
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| JAK-STAT |
| Type I |
| γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
|
|
| β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
|
|
| gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
|
|
| IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
|
|
| Other |
- hormone receptor: GH
- prolactin
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|
|
| Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
|
|
|
| Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
|
|
| IL 17 family |
- IL17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
|
|
| S/T |
|
|
JAK-STAT signaling pathway
|
|
| Ligand |
|
|
| Cytokine receptor |
- Type I cytokine receptor
- Type II cytokine receptor
|
|
| Janus kinase |
|
|
| Adaptor proteins |
|
STAT
|
- STAT1
- STAT2
- STAT3
- STAT4
- STAT5
- STAT6
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PIAS
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SOCS
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IRF
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- IRF1
- IRF2
- IRF3
- IRF4
- IRF5
- IRF6
- IRF7
- IRF8
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|
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Cytokine receptor modulators
|
|
| Chemokine |
|
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| CSF |
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Erythropoietin
|
- Agonists: ARA-290
- Asialo erythropoietin
- Carbamylated erythropoietin
- CNTO-530
- Darbepoetin alfa
- Epoetin alfa
- Epoetin beta
- Epoetin delta
- Epoetin epsilon
- Epoetin gamma
- Epoetin kappa
- Epoetin omega
- Epoetin theta
- Epoetin zeta
- Erythropoietin (EPO)
- Erythropoietin-Fc
- Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
- Peginesatide
- Pegol sihematide (EPO-018B)
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|
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G-CSF (CSF3)
|
- Agonists: Filgrastim
- Granulocyte colony-stimulating factor
- Lenograstim
- Leridistim
- Lipegfilgrastim
- Nartograstim
- Pegfilgrastim
- Pegnartograstim
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|
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GM-CSF (CSF2)
|
- Agonists: Ecogramostim
- Granulocyte macrophage colony-stimulating factor
- Milodistim
- Molgramostim
- Regramostim
- Sargramostim
- Antibodies: Mavrilimumab
- MOR103
- Namilumab
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|
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M-CSF (CSF1)
|
- Agonists: Cilmostim
- Interleukin-34
- Lanimostim
- Macrophage colony-stimulating factor
- Mirimostim
- Kinase inhibitors: Agerafenib
|
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SCF (c-Kit)
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Thrombopoietin
|
- Agonists: Eltrombopag
- Pegacaristim
- Promegapoietin
- Romiplostim
- Thrombopoietin (THPO, MGDF)
|
|
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| Interferon |
|
IFNAR (α/β, I)
|
- Agonists: Albinterferon
- Interferon alpha (interferon alfa, IFN-α)
- Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)
- Interferon alfa 2a
- Interferon alfa 2b
- Interferon alfa n1
- Interferon alfacon-1
- Interferon alpha-n3
- Interferon beta (IFN-β) (IFNB1, IFNB3)
- Interferon beta 1a
- Interferon beta 1b
- Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
- Interferon omega (IFN-ω, IFNW1)
- Peginterferon alfa-2a
- Peginterferon alfa-2b
- Antibodies: Anifrolumab
- Faralimomab
- MEDI-545
- Rontalizumab
- Sifalimumab
- Decoy receptors: Bifarcept
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|
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IFNGR (γ, II)
|
- Agonists: Interferon gamma (IFN-γ)
- Interferon gamma 1b
- Antibodies: Emapalumab
- Fontolizumab
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|
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IFNLR (λ, III)
|
- See IL-28R (IFNLR) here instead.
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| Interleukin |
|
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| TGFβ |
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| TNF |
|
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| Others |
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JAK
(inhibitors)
|
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JAK1
|
- Baricitinib
- CYT387
- Filgotinib
- Ruxolitinib
- Tofacitinib (tasocitinib, CP-690550)
- Upadacitinib
|
|
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JAK2
|
- AG-490
- Atiprimod
- AZD-1480
- Baricitinib
- CHZ868
- Cucurbitacin I (elatericin B, JSI-124)
- CYT387
- Lestaurtinib
- NSC-7908
- NSC-33994
- Pacritinib
- Ruxolitinib
- SD-1008
- Tofacitinib (tasocitinib, CP-690550)
|
|
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JAK3
|
- AG-490
- Cercosporamide
- TCS-21311
- Tofacitinib (tasocitinib, CP-690550)
- WHI-P 154
- ZM-39923
- ZM-449829
|
|
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Others
|
- Additional cytokines: Cardiotrophin 1 (CT-1)
- FMS-like tyrosine kinase 3 ligand (FLT3L)
- Leukemia/leukocyte inhibitory factor (LIF)
- Oncostatin M (OSM)
- Thymic stromal lymphopoietin (TSLP)
- Additional cytokine receptor modulators: Emfilermin
- Lestaurtinib
- Midostaurin
- Quizartinib
- Sorafenib
- Sunitinib
|
|
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- See also: Peptide receptor modulators
- Growth factor receptor modulators
|
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Interleukin receptor modulators
|
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| IL-1 |
- Agonists: Interleukin 1 (α, β)
- Mobenakin
- Pifonakin
- Antagonists: AF-12198
- Anakinra
- IL-1RA
- Isunakinra
- Antibodies: Canakinumab
- Gevokizumab
- Lutikizumab
- Decoy receptors: Rilonacept (IL-1 Trap)
|
|
| IL-2 |
- Agonists: Adargileukin alfa
- Aldesleukin
- Celmoleukin
- Denileukin diftitox
- Interleukin 2
- Pegaldesleukin
- Teceleukin
- Tucotuzumab celmoleukin
- Antibodies: Basiliximab
- Daclizumab (dacliximab)
- Inolimomab
|
|
| IL-3 |
- Agonists: Daniplestim
- Interleukin 3
- Leridistim
- Milodistim
- Muplestim
- Promegapoietin
|
|
| IL-4 |
- Agonists: Binetrakin
- Interleukin 4
- Interleukin 13
- Antibodies: Dupilumab
- Pascolizumab
|
|
| IL-5 |
- Antibodies: Benralizumab
- Mepolizumab
- Reslizumab
- Antisense oligonucleotides: TPI ASM8
|
|
| IL-6 |
- Agonists: Atexakin alfa
- Interleukin 6
- Antibodies: ARGX-109
- Clazakizumab
- Elsilimomab
- mAb 1339
- Olokizumab
- Sarilumab
- Siltuximab
- Sirukumab
- Tocilizumab
|
|
| IL-7 |
|
|
| IL-8 |
- See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.
|
|
| IL-9 |
|
|
| IL-10 |
- Agonists: Ilodecakin
- Interleukin 10 (CSIF)
|
|
| IL-11 |
- Agonists: Interleukin 11 (AGIF)
- Oprelvekin
|
|
| IL-12 |
- Agonists: Edodekin alfa
- Interleukin 12
- Antibodies: Briakinumab
- Ustekinumab
|
|
| IL-13 |
- Agonists: Binetrakin
- Cintredekin besudotox
- Interleukin 4
- Interleukin 13
- Antibodies: Anrukinzumab
- Lebrikizumab
- Tralokinumab
|
|
| IL-15 |
- Agonists: ALT-803
- Interleukin 15
|
|
| IL-17 |
- Agonists: Interleukin 17 (A, B, C, D, E (interleukin 25), F)
- Antibodies: Brodalumab
- Ixekizumab
- Perakizumab
- Remtolumab
- Secukinumab
- Vunakizumab
|
|
| IL-18 |
- Agonists: Iboctadekin
- Interleukin 18
- Interleukin 37
- Tadekinig
|
|
| IL-20 |
- Agonists: Interleukin 19
- Interleukin 20
- Interleukin 24
- Antibodies: Fletikumab (against IL-20)
|
|
| IL-21 |
- Agonists: Denenicokin
- Interleukin 21
- Antibodies: NNC0114-0005
- NNC0114-0006
|
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| IL-22 |
- Antibodies: Fezakinumab (against IL-22)
|
|
| IL-23 |
- Agonists: Interleukin 23 (SGRF)
- Antibodies: Brazikumab
- Briakinumab
- Guselkumab
- Tildrakizumab
- Ustekinumab
|
|
| IL-27 |
- Agonists: Interleukin 27 (interleukin 30)
|
|
| IL-28 |
- Agonists: Interferon λ4 (IFN-λ4)
- Interleukin 28 (A (IFN-λ2), B (IFN-λ3))
- Interleukin-29 (IFN-λ1)
|
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| IL-31 |
|
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| IL1RL1 |
|
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| IL1RL2 |
- Agonists: Interleukin 36 (α, β, γ)
- Interleukin 38
|
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| Others |
|
JAK
|
|
|
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Others
|
- Interleukin 14 (taxilin alpha, HMW-BCGF)
- Interleukin 16 (signals through CD4)
- Interleukin 24 (signals through IL-22Rα1/IL-20Rβ heterodimer)
- Interleukin 26 (signals through IL-20Rα/IL-10Rβ heterodimer)
- Interleukin 32
- Interleukin 34 (signals through M-CSFR/CSF1R)
- Interleukin 35
|
|
|
- See also: Cytokine receptor modulators
- Peptide receptor modulators
|
UpToDate Contents
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English Journal
- Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts.
- Kim HJ1, Ohk B2, Yoon HJ2, Kang WY2, Seong SJ2, Kim SY3, Yoon YR4.
- Cellular signalling.Cell Signal.2017 Jan;29:226-232. doi: 10.1016/j.cellsig.2016.11.007. Epub 2016 Nov 9.
- Docosahexaenoic acid (DHA), a component of omega-3 fatty acids, has been reported to protect against inflammatory bone diseases such as osteoporosis and rheumatoid arthritis. However, its exact mechanism in bone resorbing cells has not been elucidated. In this study, we investigated the effects and
- PMID 27836739
- Exogenous fatty acids and niacin on acute prostaglandin D2 production in human myeloid cells.
- Montserrat-de la Paz S1, Bermudez B2, Lopez S3, Naranjo MC3, Romero Y3, Bando-Hidalgo MJ3, Abia R3, Muriana FJ4.
- The Journal of nutritional biochemistry.J Nutr Biochem.2017 Jan;39:22-31. doi: 10.1016/j.jnutbio.2016.09.007. Epub 2016 Sep 28.
- Niacin activates HCA2 receptor that results in the release of PGD2. However, little is known on PGD2-producing cells and the role of fatty acids. Notably M-CSF macrophages exhibited a timely dependent PGD2 production upon niacin challenge. Short pretreatment of M-CSF macrophages with autologous post
- PMID 27741434
- Brain-Derived Neurotrophic Factor Facilitates Functional Recovery from ALS-Cerebral Spinal Fluid-Induced Neurodegenerative Changes in the NSC-34 Motor Neuron Cell Line.
- Shruthi S1, Sumitha R, Varghese AM, Ashok S, Chandrasekhar Sagar BK, Sathyaprabha TN, Nalini A, Kramer BW, Raju TR, Vijayalakshmi K, Alladi PA.
- Neuro-degenerative diseases.Neurodegener Dis.2017;17(1):44-58. Epub 2016 Sep 13.
- BACKGROUND: The survival of motor neurons is dependent upon neurotrophic factors both during childhood and adolescence and during adult life. In disease conditions, such as in patients with amyotrophic lateral sclerosis (ALS), the mRNA levels of trophic factors like brain-derived neurotrophic factor
- PMID 27617773
Japanese Journal
- スフェロイドを伴う遺伝性びまん性白質脳症 (特集 最近話題の認知症性疾患)
- Effect of 1.8-Cineole in Dermatophagoides pteronyssinus-Stimulated Bronchial Epithelial Cells and Mouse Model of Asthma
- RANKL Induces IL-18 Binding Protein Expression in RAW264.7 Cells
Related Links
- 米国CST社の日本法人CSTジャパン株式会社【公式サイト】M-CSF Receptor Antibodyページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。
- 米国CST社の日本法人CSTジャパン株式会社【公式サイト】Phospho-M-CSF Receptor (Tyr708) Antibodyページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。
★リンクテーブル★
[★]
- 英
- colony-stimulating factor receptor、CSF receptor、CSFR
- 同
- CSF受容体 CSF receptor、造血因子受容体 hemopoietic factor receptor
- 関
- コロニー刺激因子レセプター
[★]
- 関
- CSF receptor、CSFR
[★]
- 関
- colony-stimulating factor receptor、CSF receptor
[★]
- 英
- CSF receptor
- 関
- コロニー刺激因子受容体
[★]
- 関
- granulocyte-macrophage colony-stimulating factor receptor
[★]
- 関
- granulocyte colony-stimulating factor receptor
[★]
M-CSF受容体、M-CSFレセプター
- 関
- CSF-1 receptor、macrophage colony-stimulating factor receptor
[★]
[★]
[★]