WordNet

a three-dimensional shape with six square or rectangular sides (同)cube
(computer science) a sector or group of sectors that function as the smallest data unit permitted; "since blocks are often defined as a single sector, the terms `block and `sector are sometimes used interchangeably"
support, secure, or raise with a block; "block a plate for printing"; "block the wheels of a car"
a solid piece of something (usually having flat rectangular sides); "the pyramids were built with large stone blocks"
housing in a large building that is divided into separate units; "there is a block of classrooms in the west wing"
a rectangular area in a city surrounded by streets and usually containing several buildings; "he lives in the next block" (同)city block
an inability to remember or think of something you normally can do; often caused by emotional tension; "I knew his name perfectly well but I had a temporary block" (同)mental_block
a number or quantity of related things dealt with as a unit; "he reserved a large block of seats"; "he held a large block of the companys stock"
interrupt the normal function of by means of anesthesia; "block a nerve"; "block a muscle"
run on a block system; "block trains"
shape by using a block; "Block a hat"; "block a garment"
shape into a block or blocks; "block the graphs so one can see the results clearly"
stamp or emboss a title or design on a book with a block; "block the book cover"
seek or achieve an end by using to ones advantage; "She uses her influential friends to get jobs"; "The presidents wife used her good connections"
the act of using; "he warned against the use of narcotic drugs"; "skilled in the utilization of computers" (同)usage, utilization, utilisation, employment, exercise
a particular service; "he put his knowledge to good use"; "patrons have their uses"
(law) the exercise of the legal right to enjoy the benefits of owning property; "we were given the use of his boat" (同)enjoyment
use up, consume fully; "The legislature expended its time on school questions" (同)expend
take or consume (regularly or habitually); "She uses drugs rarely" (同)habituate
put into service; make work or employ for a particular purpose or for its inherent or natural purpose; "use your head!"; "we only use Spanish at home"; "I cant use this tool"; "Apply a magnetic field here"; "This thinking was applied to many projects"; "How do you utilize this tool?"; "I apply this rule to get good results"; "use the plastic bags to store the food"; "He doesnt know how to use a computer" (同)utilize, utilise, apply, employ
habitually do something (use only in the past tense); "She used to call her mother every week but now she calls only occasionally"; "I used to get sick when I ate in that dining hall"; "They used to vacation in the Bahamas"
relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
contingent on something else (同)dependant, qualified
(of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
completely obstructed or closed off; "the storm was responsible for many blocked roads and bridges"; "the drain was plugged" (同)plugged
closed to traffic; "the repaving results in many blocked streets" (同)out of use

PrepTutorEJDIC

(木・石などの,通例平らな面のある)『かたまり』 / 《米》(四団を街路に囲まれた)『区画』,街区 / 街区の1辺の距離(一般に40メートル前後) / 《英》ブロック(アパート・事務所・商店などに区切られている大きな建物) / 『妨害物』,障害物(obstacle);(障害によって生じた)停滞,渋滞 / 台木,台(まないた・肉切り台・まき割り台・せり売り台・帽子の木型など);《the~》炭頭台 / (特にアメリカンフットボールで)ブロック(相手の選手の突進を阻止する) / 滑車(pulley) / (座席券・株券などの)一組《+『of』+『名』》 / 〈通路など〉'を'『ふさぐ』,〈通行・進行など〉'を'妨げる / 〈帽子など〉の型取りをする / (特にアメリカンフットボールで)〈相手選手の突進〉'を'ブロックする;(ボクシングで)〈相手のパンチ〉'を'ブロックする
〈道具など〉‘を'『使う』,用いる / …‘を'『費す』,消費する / 《副詞[句]を伴って》〈人など〉‘を'『扱う』 / …‘を'自分の都合のいいように合用する / 〈U〉『使用』,利用 / 〈U〉『役に立つこと』,効用,利益(usefulness) / 〈U〉使う必要(場合),使用する機会,入り用 / 〈C〉〈U〉使用の目的,用途 / 〈U〉使用する権利 / 〈U〉使い方 / 〈U〉(身体などを)使う能力
『頼っている』,依存している,従属している / 扶養される人(家族)
『使い古しの』,使用した
(…に)『慣れている』《+to+名(doing)》
『…するのが常だった』,よく…したものだ / 『以前は…した』

UpToDate Contents

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1. 後天性ＱＴ延長症候群 acquired long qt syndrome
2. 不整脈治療におけるカルシウムチャネル遮断剤拮抗剤 calcium channel blockers in the treatment of cardiac arrhythmias
3. ソタロールの治療使用および主な副作用 therapeutic use and major side effects of sotalol
4. イブチリドの治療使用 therapeutic use of ibutilide
5. 持続性単形性心室頻拍：診断および評価 sustained monomorphic ventricular tachycardia diagnosis and evaluation

English Journal

Inhibitory effects of cholinesterase inhibitor donepezil on the Kv1.5 potassium channel.

Li K1,2, Cheng N1, Li XT1.
Scientific reports.Sci Rep.2017 Feb 13;7:41509. doi: 10.1038/srep41509.
Kv1.5 channels carry ultra-rapid delayed rectifier K+ currents in excitable cells, including neurons and cardiac myocytes. In the current study, the effects of cholinesterase inhibitor donepezil on cloned Kv1.5 channels expressed in HEK29 cells were explored using whole-cell recording technique. Exp
PMID 28198801

Biophysical, Molecular, and Pharmacological Characterization of Voltage-Dependent Sodium Channels From Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Moreau A1, Mercier A1, Thériault O1, Boutjdir M2, Burger B3, Keller DI4, Chahine M5.
The Canadian journal of cardiology.Can J Cardiol.2017 Feb;33(2):269-278. doi: 10.1016/j.cjca.2016.10.001. Epub 2016 Oct 11.
BACKGROUND: The ability to differentiate patient-specific human induced pluripotent stem cells in cardiac myocytes (hiPSC-CM) offers novel perspectives for cardiovascular research. A number of studies, that reported mainly on current-voltage curves used hiPSC-CM to model voltage-gated Na+ channel (N
PMID 27998617

Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.

De Bellis M1, Carbonara R1, Roussel J1, Farinato A1, Massari A1, Pierno S1, Muraglia M2, Corbo F2, Franchini C2, Carratù MR3, De Luca A1, Conte Camerino D1, Desaphy JF4.
Neuropharmacology.Neuropharmacology.2017 Feb;113(Pt A):206-216. doi: 10.1016/j.neuropharm.2016.10.013. Epub 2016 Oct 13.
Although the sodium channel blocker, mexiletine, is the first choice drug in myotonia, some myotonic patients remain unsatisfied due to contraindications, lack of tolerability, or incomplete response. More therapeutic options are thus needed for myotonic patients, which require clinical trials based
PMID 27743929