- 関
- TNF receptor-associated factor、tumor necrosis factor receptor-associated factor
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/16 19:53:03」(JST)
[Wiki en表示]
TNF receptor associated factors also known as TRAFs are a family of proteins primarily involved in the regulation of inflammation, antiviral responses and apoptosis.[1]
Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7.
Except for TRAF7, these proteins share a relatively conserved secondary structure, including a namesake C-terminal TRAF domain that mediates interactions with other signaling components such as the transmembrane TNF receptors and CD40.
See also[edit]
References[edit]
- ^ Inoue J, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, Yamamoto T (January 2000). "Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling". Exp. Cell Res. 254 (1): 14–24. doi:10.1006/excr.1999.4733. PMID 10623461.
External links[edit]
- TRAF Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
Cell signaling: carrier proteins: signal transducing adaptor proteins
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JAK-STAT |
see JAK-STAT signaling pathway
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Growth factor receptor-bound protein |
GRB2 · GRB7 · GRB10
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Other |
14-3-3 (YWHAE, YWHAZ) · Caveolin · Cortactin · Death-inducing signaling complex · Paxillin · Myd88 · SMAD · TRAF (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6) · BIN1 · SH3BP2 · LDB3
CHM · CHML
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- OxLDL inhibits LPS-induced IFNβ expression by Pellino3- and IRAK1/4-dependent modification of TANK.
- Tzieply N, Kuhn AM, Morbitzer D, Namgaladze D, Heeg A, Schaefer L, von Knethen A, Jensen LE, Brüne B.SourceInstitute of Biochemistry I/ZAFES, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.
- Cellular signalling.Cell Signal.2012 Jun;24(6):1141-9. Epub 2012 Feb 10.
- In atherosclerosis macrophages contribute to disease progression. After infiltrating atherosclerotic lesions they accumulate oxLDL (oxidized low density lipoproteins) and differentiate into foam cells. During this process inhibition of TLR4 (Toll-like receptor 4)-dependent IFNβ expression occurs. T
- PMID 22330071
- Spatiotemporal patterns and essential role of TNF receptor-associated factor 5 expression after rat spinal cord Injury.
- Huan W, Wu X, Zhang S, Zhao Y, Xu H, Wang N, Li H, Chen H, Wei H, Wang Y.SourceOrthopedic Department, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, Jiangsu, People's Republic of China.
- Journal of molecular histology.J Mol Histol.2012 Apr 8. [Epub ahead of print]
- TRAF5 (TNF receptor-associated factor 5), which has a tumor necrosis factor receptor-associated factor (TRAF) domain in its carboxyl terminus, was identified CD40-associated factor. It was a signal transducer for NF-κB signal pathway and other pathway. To elucidate the expression and roles of TRAF5
- PMID 22484641
Japanese Journal
- ヒトB細胞活性化におけるSykを介したTLR9シグナルの増幅メカニズム (特集 B細胞の機能発現とその制御分子)
- レギュラトリーT細胞とTRAF6 (特集 レギュラトリーT細胞の分化と機能発現)
- 原発性マクログロブリン血症の診断と治療 (造血器腫瘍学 : 基礎と臨床の最新研究動向) -- (リンパ系腫瘍の臨床)
Related Links
- 米国CST社の日本法人CSTジャパン株式会社【公式サイト】アポトーシス: TRAF ドメイン(領域)ページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。
- News Leadership Change The Board is pleased to announce the appointment of Denise Kehler as TRAF's new President & Chief Executive Officer effective April 1, 2014. Denise comes to us with a wealth of knowledge, having ...
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★リンクテーブル★
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- 関
- TRAF、tumor necrosis factor receptor-associated factor、tumor necrosis factor receptor-associated peptides and proteins
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- TNF receptor-associated factor、TRAF、tumor necrosis factor receptor-associated peptides and proteins
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- 英
- tumor necrosis factor receptor-associated factor、TNF receptor-associated factor、TRAF
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- TNF receptor-associated factor 6
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