同: TC-II

WordNet

the 9th letter of the Roman alphabet (同)i

PrepTutorEJDIC

〈U〉〈C〉(…の)(量・額などの)不足,欠乏《+『of』(『in』)+『名』》 / 〈C〉不足分,不足量,不足額 / 〈C〉(精神・肉体などの)欠陥
『私は』私が
iodineの化学記号

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 有機酸血症 organic acidemias
2. ビタミンB12欠乏や葉酸欠乏の原因と病態生理 causes and pathophysiology of vitamin b12 and folate deficiencies
3. 好中球二次顆粒欠損症 neutrophil specific granule deficiency
4. 疾患予防におけるビタミン補給 vitamin supplementation in disease prevention

English Journal

Neurological disorders in vitamin B12 deficiency.

Pavlov CS, Damulin IV, Shulpekova YO, Andreev EA.
Terapevticheskii arkhiv. 2019 May;91(4)122-129.
The review discusses thesteps of vitamin B12 metabolism and its role in maintaining of neurological functions. The term "vitamin B12 (cobalamin)" refers to several substances (cobalamins) of a very similar structure. Cobalamin enters the body with animal products. On the peripherу cobalamin circula
PMID 31094486

Early changes in vitamin B12 uptake and biomarker status following Roux-en-Y gastric bypass and sleeve gastrectomy.

Kornerup LS, Hvas CL, Abild CB, Richelsen B, Nexo E.
Clinical nutrition (Edinburgh, Scotland). 2019 Apr;38(2)906-911.
Bariatric surgery increases the risk of micronutrient deficiencies, including vitamin B12 (B12) deficiency. We analysed early changes in biomarkers of B12 status following bariatric surgery. We prospectively included adult patients (n = 27) referred for either Roux-en-Y Gastric Bypass (RYGB) (n =
PMID 29506877

Homologous G776G Variant of Transcobalamin-II Gene is Linked to Vitamin B12 Deficiency.

Al-Batayneh KM, Salim Al Zoubi M, Al-Trad B, Hussein E, Al Khateeb W, Aljabali AAA, Bodoor K, Shehab M, Al Hamad MA, Eaton GJ, Cornelison CT.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 2019 Feb;()1-5.
Vitamin B12 (Cobalamin) deficiency, due to improper internalization of cobalamin, is a metabolic disorder prevalent in impoverished and elderly populations and is associated with megaloblastic anemia and dementia. It has been suggested that mutations in transcobalamin II ( TCN2) or gastric intrinsic
PMID 30761942

Japanese Journal

TC II deficiency : avoidance of false-negative molecular genetics by RNA-based investigations

Haberle Johannes,Pauli Silke,Berning Christoph [他],KOCH Hans G,LINNEBANK Michael
Journal of human genetics 54(6), 331-334, 2009-06-01
NAID 10030730631

胃切除後大球性貧血症例におけるvitamin B12結合蛋白測定の意義

野村勝俊,野口芳一,大島貴,吉川貴己,福沢邦康,牧野達郎,円谷彰,松本昭彦
日本消化器外科学会雑誌 29(9), 1868-1872, 1996-09-01
… に比し増加しており,この傾向は血中B12濃度の正常な症例においても認められた.またVit.B12を組織中に移行させ得る唯一の蛋白であるtranscobalamin II(以下,Tc II)は胃切除群において変化を認めなかったが,Vit.B12と結合しているholo-Tc IIは減少する傾向にあった.これらの結果から胃切除後に血中濃度には反映されなくとも,体内のVit.B12欠乏が進行している可能性が考え …
NAID 110001320930

Related Links

Transcobalamin II deficiency - NIH Genetic Testing Registry ...

Transcobalamin II deficiency is an autosomal recessive disorder with onset in early infancy characterized by failure to thrive, megaloblastic anemia, and pancytopenia. Other features include methylmalonic aciduria, recurrent infections, and vomiting and diarrhea. Treatment with cobalamin results in clinical improvement, but the untreated ...

Transcobalamin deficiency: MedlinePlus Genetics

Description. Transcobalamin deficiency is a disorder that impairs the transport of cobalamin (also known as vitamin B12) within the body. Cobalamin is obtained from the diet; this vitamin is found in animal products such as meat, eggs, and shellfish. An inability to transport cobalamin within the body results in cells that lack cobalamin, which ...

Transcobalamin II deficiency at birth - PubMed

Transcobalamin II deficiency (# MIM 275350) is a rare, recessively inherited disorder of cobalamin transport that leads to intracellular cobalamin depletion with secondary impairment of methionine synthetase and methyl-malonyl CoA mutase activities. Affected individuals may suffer from long-term neu …